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O55193

- CCR2_RAT

UniProt

O55193 - CCR2_RAT

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Protein

C-C chemokine receptor type 2

Gene

Ccr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the CCL2, CCL7 and CCL12 chemokines. Transduces a signal by increasing intracellular calcium ion levels (By similarity).By similarity

GO - Molecular functioni

  1. C-C chemokine binding Source: RGD
  2. C-C chemokine receptor activity Source: RGD
  3. chemokine binding Source: RGD
  4. protein homodimerization activity Source: RGD

GO - Biological processi

  1. blood vessel remodeling Source: RGD
  2. cellular calcium ion homeostasis Source: RGD
  3. cellular homeostasis Source: BHF-UCL
  4. chemokine-mediated signaling pathway Source: RGD
  5. cytokine-mediated signaling pathway Source: RGD
  6. G-protein coupled receptor signaling pathway Source: RGD
  7. inflammatory response Source: RGD
  8. inflammatory response to antigenic stimulus Source: RGD
  9. negative regulation of angiogenesis Source: BHF-UCL
  10. negative regulation of eosinophil degranulation Source: BHF-UCL
  11. negative regulation of type 2 immune response Source: BHF-UCL
  12. positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
  13. positive regulation of astrocyte chemotaxis Source: BHF-UCL
  14. positive regulation of CD8-positive, alpha-beta T cell extravasation Source: BHF-UCL
  15. positive regulation of hematopoietic stem cell migration Source: BHF-UCL
  16. positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
  17. positive regulation of inflammatory response Source: BHF-UCL
  18. positive regulation of interferon-gamma production Source: BHF-UCL
  19. positive regulation of interleukin-2 production Source: BHF-UCL
  20. positive regulation of MAPK cascade Source: RGD
  21. positive regulation of monocyte chemotaxis Source: UniProtKB
  22. positive regulation of monocyte extravasation Source: BHF-UCL
  23. positive regulation of T cell activation Source: BHF-UCL
  24. positive regulation of T cell chemotaxis Source: BHF-UCL
  25. positive regulation of T-helper 1 type immune response Source: BHF-UCL
  26. positive regulation of tumor necrosis factor biosynthetic process Source: BHF-UCL
  27. positive regulation of tumor necrosis factor production Source: RGD
  28. regulation of vascular endothelial growth factor production Source: BHF-UCL
  29. response to hyperoxia Source: RGD
  30. response to hypoxia Source: RGD
  31. T-helper 17 cell chemotaxis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 2
Short name:
C-C CKR-2
Short name:
CC-CKR-2
Short name:
CCR-2
Short name:
CCR2
Alternative name(s):
CD_antigen: CD192
Gene namesi
Name:Ccr2
Synonyms:Cmkbr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620876. Ccr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6060ExtracellularSequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini82 – 9110CytoplasmicSequence Analysis
Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini113 – 12816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini150 – 17021CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini192 – 22029ExtracellularSequence AnalysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini242 – 25615CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini278 – 30124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini323 – 37351CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytosol Source: RGD
  2. dendrite Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. neuronal cell body Source: RGD
  5. perikaryon Source: RGD
  6. perinuclear region of cytoplasm Source: RGD
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373C-C chemokine receptor type 2PRO_0000069235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 290PROSITE-ProRule annotation
Disulfide bondi126 ↔ 203PROSITE-ProRule annotation
Modified residuei152 – 1521Phosphotyrosine; by JAK2By similarity

Post-translational modificationi

Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

PTM databases

PhosphoSiteiO55193.

Expressioni

Tissue specificityi

Expressed in lung, spleen, kidney, thymus and macrophages.

Inductioni

In animals in which experimental allergic encephalomyelitis (EAE) has been induced.

Gene expression databases

GenevestigatoriO55193.

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008843.

Structurei

3D structure databases

ProteinModelPortaliO55193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148353.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO55193.
KOiK04177.
PhylomeDBiO55193.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55193-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDSNMLPQF IHGILSTSHS LFPRSIQELD EGATTPYDYD DGEPCHKTSV
60 70 80 90 100
KQIGAWILPP LYSLVFIFGF VGNMLVIIIL ISCKKLKSMT DIYLFNLAIS
110 120 130 140 150
DLLFLLTLPF WAHYAANEWV FGNIMCKLFT GLYHIGYFGG IFFIILLTID
160 170 180 190 200
RYLAIVHAVF ALKARTVTFG VITSVVTWVV AVFASLPGII FTKSEQEDDQ
210 220 230 240 250
HTCGPYFPTI WKNFQTIMRN ILSLILPLLV MVICYSGILH TLFRCRNEKK
260 270 280 290 300
RHRAVRLIFA IMIVYFLFWT PYNIVLFLTT FQEFLGMSNC VVDMHLDQAM
310 320 330 340 350
QVTETLGMTH CCVNPIIYAF VGEKFRRYLS IFFRKHIAKN LCKQCPVFYR
360 370
ETADRVSSTF TPSTGEQEVS VGL
Length:373
Mass (Da):42,763
Last modified:June 1, 1998 - v1
Checksum:i2E7BB012F5D6FD09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77349 Genomic DNA. Translation: AAC03242.1.
RefSeqiNP_068638.1. NM_021866.1.
UniGeneiRn.211983.

Genome annotation databases

GeneIDi60463.
KEGGirno:60463.
UCSCiRGD:620876. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77349 Genomic DNA. Translation: AAC03242.1 .
RefSeqi NP_068638.1. NM_021866.1.
UniGenei Rn.211983.

3D structure databases

ProteinModelPortali O55193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008843.

Chemistry

BindingDBi O55193.
ChEMBLi CHEMBL1293204.
GuidetoPHARMACOLOGYi 59.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O55193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 60463.
KEGGi rno:60463.
UCSCi RGD:620876. rat.

Organism-specific databases

CTDi 729230.
RGDi 620876. Ccr2.

Phylogenomic databases

eggNOGi NOG148353.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi O55193.
KOi K04177.
PhylomeDBi O55193.
TreeFami TF330966.

Miscellaneous databases

NextBioi 612222.
PROi O55193.

Gene expression databases

Genevestigatori O55193.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
    Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
    J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCCR2_RAT
AccessioniPrimary (citable) accession number: O55193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: October 1, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3