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O55193 (CCR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 2

Short name=C-C CKR-2
Short name=CC-CKR-2
Short name=CCR-2
Short name=CCR2
Alternative name(s):
CD_antigen=CD192
Gene names
Name:Ccr2
Synonyms:Cmkbr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the CCL2, CCL7 and CCL12 chemokines. Transduces a signal by increasing intracellular calcium ion levels By similarity.

Subunit structure

Interacts with ARRB1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in lung, spleen, kidney, thymus and macrophages.

Induction

In animals in which experimental allergic encephalomyelitis (EAE) has been induced.

Post-translational modification

Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 18584881. Source: RGD

T-helper 17 cell chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

blood vessel remodeling

Inferred from expression pattern PubMed 15178559. Source: RGD

cellular calcium ion homeostasis

Inferred from direct assay PubMed 15978006. Source: RGD

cellular homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

chemokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 18584881. Source: RGD

cytokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 16174730. Source: RGD

inflammatory response

Inferred from direct assay Ref.1. Source: RGD

inflammatory response to antigenic stimulus

Inferred from expression pattern PubMed 14674010. Source: RGD

negative regulation of angiogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of eosinophil degranulation

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of type 2 immune response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of CD8-positive, alpha-beta T cell extravasation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of MAPK cascade

Inferred from direct assay PubMed 18584881. Source: RGD

positive regulation of T cell activation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T cell chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T-helper 1 type immune response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of alpha-beta T cell proliferation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of astrocyte chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of hematopoietic stem cell migration

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of immune complex clearance by monocytes and macrophages

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of inflammatory response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interferon-gamma production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-2 production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of monocyte chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of monocyte extravasation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of tumor necrosis factor biosynthetic process

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of vascular endothelial growth factor production

Inferred from sequence or structural similarity. Source: BHF-UCL

response to hypoxia

Inferred from expression pattern PubMed 18446360. Source: RGD

   Cellular_componentcytosol

Inferred from direct assay PubMed 15978006. Source: RGD

dendrite

Inferred from direct assay PubMed 15978006PubMed 16196033PubMed 18584881. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from direct assay PubMed 15978006. Source: RGD

perikaryon

Inferred from direct assay PubMed 16196033. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 15978006. Source: RGD

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionC-C chemokine binding

Inferred from mutant phenotype PubMed 16196033. Source: RGD

C-C chemokine receptor activity

Inferred from mutant phenotype PubMed 16196033. Source: RGD

chemokine binding

Inferred from mutant phenotype PubMed 18584881. Source: RGD

protein homodimerization activity

Inferred from direct assay PubMed 15978006. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373C-C chemokine receptor type 2
PRO_0000069235

Regions

Topological domain1 – 6060Extracellular Potential
Transmembrane61 – 8121Helical; Name=1; Potential
Topological domain82 – 9110Cytoplasmic Potential
Transmembrane92 – 11221Helical; Name=2; Potential
Topological domain113 – 12816Extracellular Potential
Transmembrane129 – 14921Helical; Name=3; Potential
Topological domain150 – 17021Cytoplasmic Potential
Transmembrane171 – 19121Helical; Name=4; Potential
Topological domain192 – 22029Extracellular Potential
Transmembrane221 – 24121Helical; Name=5; Potential
Topological domain242 – 25615Cytoplasmic Potential
Transmembrane257 – 27721Helical; Name=6; Potential
Topological domain278 – 30124Extracellular Potential
Transmembrane302 – 32221Helical; Name=7; Potential
Topological domain323 – 37351Cytoplasmic Potential

Amino acid modifications

Modified residue1521Phosphotyrosine; by JAK2 By similarity
Disulfide bond45 ↔ 290 By similarity
Disulfide bond126 ↔ 203 By similarity

Sequences

Sequence LengthMass (Da)Tools
O55193 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 2E7BB012F5D6FD09

FASTA37342,763
        10         20         30         40         50         60 
MEDSNMLPQF IHGILSTSHS LFPRSIQELD EGATTPYDYD DGEPCHKTSV KQIGAWILPP 

        70         80         90        100        110        120 
LYSLVFIFGF VGNMLVIIIL ISCKKLKSMT DIYLFNLAIS DLLFLLTLPF WAHYAANEWV 

       130        140        150        160        170        180 
FGNIMCKLFT GLYHIGYFGG IFFIILLTID RYLAIVHAVF ALKARTVTFG VITSVVTWVV 

       190        200        210        220        230        240 
AVFASLPGII FTKSEQEDDQ HTCGPYFPTI WKNFQTIMRN ILSLILPLLV MVICYSGILH 

       250        260        270        280        290        300 
TLFRCRNEKK RHRAVRLIFA IMIVYFLFWT PYNIVLFLTT FQEFLGMSNC VVDMHLDQAM 

       310        320        330        340        350        360 
QVTETLGMTH CCVNPIIYAF VGEKFRRYLS IFFRKHIAKN LCKQCPVFYR ETADRVSSTF 

       370 
TPSTGEQEVS VGL 

« Hide

References

[1]"Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77349 Genomic DNA. Translation: AAC03242.1.
RefSeqNP_068638.1. NM_021866.1.
UniGeneRn.211983.

3D structure databases

ProteinModelPortalO55193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000008843.

Chemistry

BindingDBO55193.
ChEMBLCHEMBL1293204.
GuidetoPHARMACOLOGY59.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO55193.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID60463.
KEGGrno:60463.
UCSCRGD:620876. rat.

Organism-specific databases

CTD729230.
RGD620876. Ccr2.

Phylogenomic databases

eggNOGNOG148353.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidO55193.
KOK04177.
PhylomeDBO55193.
TreeFamTF330966.

Gene expression databases

GenevestigatorO55193.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612222.
PROO55193.

Entry information

Entry nameCCR2_RAT
AccessionPrimary (citable) accession number: O55193
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries