Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O55193

- CCR2_RAT

UniProt

O55193 - CCR2_RAT

Protein

C-C chemokine receptor type 2

Gene

Ccr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for the CCL2, CCL7 and CCL12 chemokines. Transduces a signal by increasing intracellular calcium ion levels By similarity.By similarity

    GO - Molecular functioni

    1. C-C chemokine binding Source: RGD
    2. C-C chemokine receptor activity Source: RGD
    3. chemokine binding Source: RGD
    4. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. blood vessel remodeling Source: RGD
    2. cellular calcium ion homeostasis Source: RGD
    3. cellular homeostasis Source: BHF-UCL
    4. chemokine-mediated signaling pathway Source: RGD
    5. cytokine-mediated signaling pathway Source: RGD
    6. G-protein coupled receptor signaling pathway Source: RGD
    7. inflammatory response Source: RGD
    8. inflammatory response to antigenic stimulus Source: RGD
    9. negative regulation of angiogenesis Source: BHF-UCL
    10. negative regulation of eosinophil degranulation Source: BHF-UCL
    11. negative regulation of type 2 immune response Source: BHF-UCL
    12. positive regulation of alpha-beta T cell proliferation Source: BHF-UCL
    13. positive regulation of astrocyte chemotaxis Source: BHF-UCL
    14. positive regulation of CD8-positive, alpha-beta T cell extravasation Source: BHF-UCL
    15. positive regulation of hematopoietic stem cell migration Source: BHF-UCL
    16. positive regulation of immune complex clearance by monocytes and macrophages Source: BHF-UCL
    17. positive regulation of inflammatory response Source: BHF-UCL
    18. positive regulation of interferon-gamma production Source: BHF-UCL
    19. positive regulation of interleukin-2 production Source: BHF-UCL
    20. positive regulation of MAPK cascade Source: RGD
    21. positive regulation of monocyte chemotaxis Source: UniProtKB
    22. positive regulation of monocyte extravasation Source: BHF-UCL
    23. positive regulation of T cell activation Source: BHF-UCL
    24. positive regulation of T cell chemotaxis Source: BHF-UCL
    25. positive regulation of T-helper 1 type immune response Source: BHF-UCL
    26. positive regulation of tumor necrosis factor biosynthetic process Source: BHF-UCL
    27. positive regulation of tumor necrosis factor production Source: RGD
    28. regulation of vascular endothelial growth factor production Source: BHF-UCL
    29. response to hyperoxia Source: RGD
    30. response to hypoxia Source: RGD
    31. T-helper 17 cell chemotaxis Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 2
    Short name:
    C-C CKR-2
    Short name:
    CC-CKR-2
    Short name:
    CCR-2
    Short name:
    CCR2
    Alternative name(s):
    CD_antigen: CD192
    Gene namesi
    Name:Ccr2
    Synonyms:Cmkbr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620876. Ccr2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. dendrite Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: RGD
    5. perikaryon Source: RGD
    6. perinuclear region of cytoplasm Source: RGD
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373C-C chemokine receptor type 2PRO_0000069235Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 290PROSITE-ProRule annotation
    Disulfide bondi126 ↔ 203PROSITE-ProRule annotation
    Modified residuei152 – 1521Phosphotyrosine; by JAK2By similarity

    Post-translational modificationi

    Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    PTM databases

    PhosphoSiteiO55193.

    Expressioni

    Tissue specificityi

    Expressed in lung, spleen, kidney, thymus and macrophages.

    Inductioni

    In animals in which experimental allergic encephalomyelitis (EAE) has been induced.

    Gene expression databases

    GenevestigatoriO55193.

    Interactioni

    Subunit structurei

    Interacts with ARRB1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008843.

    Structurei

    3D structure databases

    ProteinModelPortaliO55193.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6060ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini82 – 9110CytoplasmicSequence Analysis
    Topological domaini113 – 12816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini150 – 17021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini192 – 22029ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 25615CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 30124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 37351CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei61 – 8121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148353.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiO55193.
    KOiK04177.
    PhylomeDBiO55193.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002237. Chemokine_CCR2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01107. CHEMOKINER2.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55193-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDSNMLPQF IHGILSTSHS LFPRSIQELD EGATTPYDYD DGEPCHKTSV    50
    KQIGAWILPP LYSLVFIFGF VGNMLVIIIL ISCKKLKSMT DIYLFNLAIS 100
    DLLFLLTLPF WAHYAANEWV FGNIMCKLFT GLYHIGYFGG IFFIILLTID 150
    RYLAIVHAVF ALKARTVTFG VITSVVTWVV AVFASLPGII FTKSEQEDDQ 200
    HTCGPYFPTI WKNFQTIMRN ILSLILPLLV MVICYSGILH TLFRCRNEKK 250
    RHRAVRLIFA IMIVYFLFWT PYNIVLFLTT FQEFLGMSNC VVDMHLDQAM 300
    QVTETLGMTH CCVNPIIYAF VGEKFRRYLS IFFRKHIAKN LCKQCPVFYR 350
    ETADRVSSTF TPSTGEQEVS VGL 373
    Length:373
    Mass (Da):42,763
    Last modified:June 1, 1998 - v1
    Checksum:i2E7BB012F5D6FD09
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77349 Genomic DNA. Translation: AAC03242.1.
    RefSeqiNP_068638.1. NM_021866.1.
    UniGeneiRn.211983.

    Genome annotation databases

    GeneIDi60463.
    KEGGirno:60463.
    UCSCiRGD:620876. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77349 Genomic DNA. Translation: AAC03242.1 .
    RefSeqi NP_068638.1. NM_021866.1.
    UniGenei Rn.211983.

    3D structure databases

    ProteinModelPortali O55193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008843.

    Chemistry

    BindingDBi O55193.
    ChEMBLi CHEMBL1293204.
    GuidetoPHARMACOLOGYi 59.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O55193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 60463.
    KEGGi rno:60463.
    UCSCi RGD:620876. rat.

    Organism-specific databases

    CTDi 729230.
    RGDi 620876. Ccr2.

    Phylogenomic databases

    eggNOGi NOG148353.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi O55193.
    KOi K04177.
    PhylomeDBi O55193.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 612222.
    PROi O55193.

    Gene expression databases

    Genevestigatori O55193.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002237. Chemokine_CCR2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01107. CHEMOKINER2.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis."
      Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.
      J. Neuroimmunol. 86:1-12(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiCCR2_RAT
    AccessioniPrimary (citable) accession number: O55193
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3