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Protein

Sodium-dependent noradrenaline transporter

Gene

Slc6a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi71 – 711Sodium 1; via carbonyl oxygenBy similarity
Metal bindingi73 – 731Sodium 2; via carbonyl oxygenBy similarity
Metal bindingi74 – 741Sodium 1; via carbonyl oxygenBy similarity
Metal bindingi78 – 781Sodium 2By similarity
Metal bindingi318 – 3181Sodium 2By similarity
Metal bindingi350 – 3501Sodium 2By similarity
Metal bindingi415 – 4151Sodium 1; via carbonyl oxygenBy similarity
Metal bindingi418 – 4181Sodium 1By similarity
Metal bindingi419 – 4191Sodium 1By similarity

GO - Molecular functioni

GO - Biological processi

  • monoamine transport Source: MGI
  • neurotransmitter transport Source: MGI
  • norepinephrine transport Source: GO_Central
  • response to pain Source: MGI
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Keywords - Ligandi

Metal-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name:
NET
Solute carrier family 6 member 2
Gene namesi
Name:Slc6a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1270850. Slc6a2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262CytoplasmicBy similarityAdd
BLAST
Transmembranei63 – 8826Helical; Name=1By similarityAdd
BLAST
Topological domaini89 – 924ExtracellularBy similarity
Transmembranei93 – 11624Helical; Name=2By similarityAdd
BLAST
Topological domaini117 – 13519CytoplasmicBy similarityAdd
BLAST
Transmembranei136 – 16631Helical; Name=3By similarityAdd
BLAST
Topological domaini167 – 23367ExtracellularBy similarityAdd
BLAST
Transmembranei234 – 25421Helical; Name=4By similarityAdd
BLAST
Topological domaini255 – 2573CytoplasmicBy similarity
Transmembranei258 – 28225Helical; Name=5By similarityAdd
BLAST
Topological domaini283 – 30624ExtracellularBy similarityAdd
BLAST
Transmembranei307 – 33226Helical; Name=6By similarityAdd
BLAST
Topological domaini333 – 3386CytoplasmicBy similarity
Transmembranei339 – 36224Helical; Name=7By similarityAdd
BLAST
Topological domaini363 – 40240ExtracellularBy similarityAdd
BLAST
Transmembranei403 – 42826Helical; Name=8By similarityAdd
BLAST
Topological domaini429 – 44315CytoplasmicBy similarityAdd
BLAST
Transmembranei444 – 46421Helical; Name=9By similarityAdd
BLAST
Topological domaini465 – 4651ExtracellularBy similarity
Transmembranei466 – 49227Helical; Name=10By similarityAdd
BLAST
Topological domaini493 – 52230CytoplasmicBy similarityAdd
BLAST
Transmembranei523 – 54523Helical; Name=11By similarityAdd
BLAST
Topological domaini546 – 5483ExtracellularBy similarity
Transmembranei549 – 56921Helical; Name=12By similarityAdd
BLAST
Topological domaini570 – 61748CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Sodium-dependent noradrenaline transporterPRO_0000214749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi176 ↔ 185By similarity
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO55192.
PaxDbiO55192.
PeptideAtlasiO55192.
PRIDEiO55192.

PTM databases

iPTMnetiO55192.
PhosphoSiteiO55192.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055368.
GenevisibleiO55192. MM.

Interactioni

Subunit structurei

Interacts with PRKCABP.By similarity

Protein-protein interaction databases

MINTiMINT-1770608.
STRINGi10090.ENSMUSP00000072709.

Chemistry

BindingDBiO55192.

Structurei

3D structure databases

ProteinModelPortaliO55192.
SMRiO55192. Positions 56-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO55192.
KOiK05035.
OMAiPPWANWV.
OrthoDBiEOG091G08PX.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLARMNPQV QPELGGADPL PEQPLRPCKT ADLLVVKERN GVQCLLASQD
60 70 80 90 100
SDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
110 120 130 140 150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF
160 170 180 190 200
YYNVIIAWSL YYLFASFTLN LPWTNCGHSW NSPNCTDPKL LNASVLGDHT
210 220 230 240 250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVIVVLYF
260 270 280 290 300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY
310 320 330 340 350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN
360 370 380 390 400
CVTSFISGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG
410 420 430 440 450
STFWAVLFFL MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTCVVT
460 470 480 490 500
ISTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR
510 520 530 540 550
FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYTY
560 570 580 590 600
PPWANWVGWG IALSSMILVP AYVIYKFLSI RGSLWERVAY GITPENEHHL
610
VAQRDVRQFQ LRHWLAI
Length:617
Mass (Da):69,255
Last modified:July 27, 2011 - v2
Checksum:i591641246B8DA59C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti609 – 6124FQLR → LPLQ in AAB94302 (PubMed:9603188).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76306 mRNA. Translation: AAB94302.1.
AY525777 mRNA. Translation: AAS17725.1.
AY525778 mRNA. Translation: AAS17726.1.
CH466525 Genomic DNA. Translation: EDL11093.1.
CCDSiCCDS22525.1.
RefSeqiNP_033235.3. NM_009209.3.
UniGeneiMm.57040.

Genome annotation databases

EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368.
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368.
GeneIDi20538.
KEGGimmu:20538.
UCSCiuc009muh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76306 mRNA. Translation: AAB94302.1.
AY525777 mRNA. Translation: AAS17725.1.
AY525778 mRNA. Translation: AAS17726.1.
CH466525 Genomic DNA. Translation: EDL11093.1.
CCDSiCCDS22525.1.
RefSeqiNP_033235.3. NM_009209.3.
UniGeneiMm.57040.

3D structure databases

ProteinModelPortaliO55192.
SMRiO55192. Positions 56-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1770608.
STRINGi10090.ENSMUSP00000072709.

Chemistry

BindingDBiO55192.
ChEMBLiCHEMBL2370.

PTM databases

iPTMnetiO55192.
PhosphoSiteiO55192.

Proteomic databases

MaxQBiO55192.
PaxDbiO55192.
PeptideAtlasiO55192.
PRIDEiO55192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368.
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368.
GeneIDi20538.
KEGGimmu:20538.
UCSCiuc009muh.2. mouse.

Organism-specific databases

CTDi6530.
MGIiMGI:1270850. Slc6a2.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO55192.
KOiK05035.
OMAiPPWANWV.
OrthoDBiEOG091G08PX.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

ChiTaRSiSlc6a2. mouse.
PROiO55192.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055368.
GenevisibleiO55192. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC6A2_MOUSE
AccessioniPrimary (citable) accession number: O55192
Secondary accession number(s): Q6QU62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.