SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O55192

- SC6A2_MOUSE

UniProt

O55192 - SC6A2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium-dependent noradrenaline transporter

Gene
Slc6a2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

  1. monoamine transmembrane transporter activity Source: MGI
  2. neurotransmitter:sodium symporter activity Source: InterPro
  3. norepinephrine transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. monoamine transport Source: MGI
  2. neurotransmitter transport Source: MGI
  3. norepinephrine transport Source: Ensembl
  4. response to drug Source: Ensembl
  5. response to pain Source: MGI
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name:
NET
Solute carrier family 6 member 2
Gene namesi
Name:Slc6a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1270850. Slc6a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei65 – 8521Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei93 – 11220Helical; Name=2; Reviewed predictionAdd
BLAST
Transmembranei136 – 15621Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini157 – 23478Extracellular Reviewed predictionAdd
BLAST
Transmembranei235 – 25319Helical; Name=4; Reviewed predictionAdd
BLAST
Transmembranei262 – 27918Helical; Name=5; Reviewed predictionAdd
BLAST
Transmembranei315 – 33218Helical; Name=6; Reviewed predictionAdd
BLAST
Transmembranei344 – 36522Helical; Name=7; Reviewed predictionAdd
BLAST
Transmembranei398 – 41720Helical; Name=8; Reviewed predictionAdd
BLAST
Transmembranei444 – 46219Helical; Name=9; Reviewed predictionAdd
BLAST
Transmembranei478 – 49821Helical; Name=10; Reviewed predictionAdd
BLAST
Transmembranei519 – 53820Helical; Name=11; Reviewed predictionAdd
BLAST
Transmembranei557 – 57519Helical; Name=12; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of plasma membrane Source: InterPro
  3. membrane raft Source: Ensembl
  4. neuron projection Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Sodium-dependent noradrenaline transporterPRO_0000214749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO55192.
PRIDEiO55192.

PTM databases

PhosphoSiteiO55192.

Expressioni

Gene expression databases

ArrayExpressiO55192.
BgeeiO55192.
GenevestigatoriO55192.

Interactioni

Subunit structurei

Interacts with PRKCABP By similarity.

Protein-protein interaction databases

MINTiMINT-1770608.

Structurei

3D structure databases

ProteinModelPortaliO55192.
SMRiO55192. Positions 56-594.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00740000115174.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ6QU62.
KOiK05035.
OMAiAYCITPE.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55192-1 [UniParc]FASTAAdd to Basket

« Hide

MLLARMNPQV QPELGGADPL PEQPLRPCKT ADLLVVKERN GVQCLLASQD    50
SDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL 100
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF 150
YYNVIIAWSL YYLFASFTLN LPWTNCGHSW NSPNCTDPKL LNASVLGDHT 200
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVIVVLYF 250
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 300
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN 350
CVTSFISGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG 400
STFWAVLFFL MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTCVVT 450
ISTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR 500
FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYTY 550
PPWANWVGWG IALSSMILVP AYVIYKFLSI RGSLWERVAY GITPENEHHL 600
VAQRDVRQFQ LRHWLAI 617
Length:617
Mass (Da):69,255
Last modified:July 27, 2011 - v2
Checksum:i591641246B8DA59C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti609 – 6124FQLR → LPLQ in AAB94302. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76306 mRNA. Translation: AAB94302.1.
AY525777 mRNA. Translation: AAS17725.1.
AY525778 mRNA. Translation: AAS17726.1.
CH466525 Genomic DNA. Translation: EDL11093.1.
CCDSiCCDS22525.1.
RefSeqiNP_033235.3. NM_009209.3.
UniGeneiMm.57040.

Genome annotation databases

EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368.
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368.
GeneIDi20538.
KEGGimmu:20538.
UCSCiuc009muh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76306 mRNA. Translation: AAB94302.1 .
AY525777 mRNA. Translation: AAS17725.1 .
AY525778 mRNA. Translation: AAS17726.1 .
CH466525 Genomic DNA. Translation: EDL11093.1 .
CCDSi CCDS22525.1.
RefSeqi NP_033235.3. NM_009209.3.
UniGenei Mm.57040.

3D structure databases

ProteinModelPortali O55192.
SMRi O55192. Positions 56-594.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1770608.

Chemistry

BindingDBi O55192.
ChEMBLi CHEMBL2370.

PTM databases

PhosphoSitei O55192.

Proteomic databases

PaxDbi O55192.
PRIDEi O55192.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072939 ; ENSMUSP00000072709 ; ENSMUSG00000055368 .
ENSMUST00000165470 ; ENSMUSP00000129869 ; ENSMUSG00000055368 .
GeneIDi 20538.
KEGGi mmu:20538.
UCSCi uc009muh.2. mouse.

Organism-specific databases

CTDi 6530.
MGIi MGI:1270850. Slc6a2.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00740000115174.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q6QU62.
KOi K05035.
OMAi AYCITPE.
OrthoDBi EOG793B71.
TreeFami TF343812.

Miscellaneous databases

ChiTaRSi SLC6A2. mouse.
NextBioi 298815.
PROi O55192.
SOURCEi Search...

Gene expression databases

ArrayExpressi O55192.
Bgeei O55192.
Genevestigatori O55192.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of the murine norepinephrine transporter."
    Fritz J.D., Jayanthi L.D., Thoreson M.A., Blakely R.D.
    J. Neurochem. 70:2241-2251(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice."
    Haughey H.M., Kaiser A.L., Johnson T.E., Bennett B., Sikela J.M., Zahniser N.R.
    Alcohol. Clin. Exp. Res. 29:1759-1768(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSC6A2_MOUSE
AccessioniPrimary (citable) accession number: O55192
Secondary accession number(s): Q6QU62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi