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O55192 (SC6A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name=NET
Solute carrier family 6 member 2
Gene names
Name:Slc6a2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subunit structure

Interacts with PRKCABP By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Sodium-dependent noradrenaline transporter
PRO_0000214749

Regions

Topological domain1 – 6464Cytoplasmic Potential
Transmembrane65 – 8521Helical; Name=1; Potential
Transmembrane93 – 11220Helical; Name=2; Potential
Transmembrane136 – 15621Helical; Name=3; Potential
Topological domain157 – 23478Extracellular Potential
Transmembrane235 – 25319Helical; Name=4; Potential
Transmembrane262 – 27918Helical; Name=5; Potential
Transmembrane315 – 33218Helical; Name=6; Potential
Transmembrane344 – 36522Helical; Name=7; Potential
Transmembrane398 – 41720Helical; Name=8; Potential
Transmembrane444 – 46219Helical; Name=9; Potential
Transmembrane478 – 49821Helical; Name=10; Potential
Transmembrane519 – 53820Helical; Name=11; Potential
Transmembrane557 – 57519Helical; Name=12; Potential

Amino acid modifications

Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict609 – 6124FQLR → LPLQ in AAB94302. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O55192 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 591641246B8DA59C

FASTA61769,255
        10         20         30         40         50         60 
MLLARMNPQV QPELGGADPL PEQPLRPCKT ADLLVVKERN GVQCLLASQD SDAQPRETWG 

        70         80         90        100        110        120 
KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL FLIIAGMPLF YMELALGQYN 

       130        140        150        160        170        180 
REGAATVWKI CPFFKGVGYA VILIALYVGF YYNVIIAWSL YYLFASFTLN LPWTNCGHSW 

       190        200        210        220        230        240 
NSPNCTDPKL LNASVLGDHT KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC 

       250        260        270        280        290        300 
LMVVIVVLYF SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 

       310        320        330        340        350        360 
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN CVTSFISGFA 

       370        380        390        400        410        420 
IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG STFWAVLFFL MLLALGLDSS 

       430        440        450        460        470        480 
MGGMEAVITG LADDFQVLKR HRKLFTCVVT ISTFLLALFC ITKGGIYVLT LLDTFAAGTS 

       490        500        510        520        530        540 
ILFAVLMEAI GVSWFYGVDR FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF 

       550        560        570        580        590        600 
KPLTYDDYTY PPWANWVGWG IALSSMILVP AYVIYKFLSI RGSLWERVAY GITPENEHHL 

       610 
VAQRDVRQFQ LRHWLAI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and chromosomal mapping of the murine norepinephrine transporter."
Fritz J.D., Jayanthi L.D., Thoreson M.A., Blakely R.D.
J. Neurochem. 70:2241-2251(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice."
Haughey H.M., Kaiser A.L., Johnson T.E., Bennett B., Sikela J.M., Zahniser N.R.
Alcohol. Clin. Exp. Res. 29:1759-1768(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U76306 mRNA. Translation: AAB94302.1.
AY525777 mRNA. Translation: AAS17725.1.
AY525778 mRNA. Translation: AAS17726.1.
CH466525 Genomic DNA. Translation: EDL11093.1.
RefSeqNP_033235.3. NM_009209.3.
UniGeneMm.57040.

3D structure databases

ProteinModelPortalO55192.
SMRO55192. Positions 56-594.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1770608.

Chemistry

BindingDBO55192.
ChEMBLCHEMBL2370.

PTM databases

PhosphoSiteO55192.

Proteomic databases

PaxDbO55192.
PRIDEO55192.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368.
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368.
GeneID20538.
KEGGmmu:20538.
UCSCuc009muh.2. mouse.

Organism-specific databases

CTD6530.
MGIMGI:1270850. Slc6a2.

Phylogenomic databases

eggNOGCOG0733.
GeneTreeENSGT00740000115174.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ6QU62.
KOK05035.
OMANSCQISC.
OrthoDBEOG793B71.
TreeFamTF343812.

Gene expression databases

ArrayExpressO55192.
BgeeO55192.
GenevestigatorO55192.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC6A2. mouse.
NextBio298815.
PROO55192.
SOURCESearch...

Entry information

Entry nameSC6A2_MOUSE
AccessionPrimary (citable) accession number: O55192
Secondary accession number(s): Q6QU62
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot