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O55192

- SC6A2_MOUSE

UniProt

O55192 - SC6A2_MOUSE

Protein

Sodium-dependent noradrenaline transporter

Gene

Slc6a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

    GO - Molecular functioni

    1. monoamine transmembrane transporter activity Source: MGI
    2. neurotransmitter:sodium symporter activity Source: InterPro
    3. norepinephrine transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. monoamine transport Source: MGI
    2. neurotransmitter transport Source: MGI
    3. norepinephrine transport Source: Ensembl
    4. response to drug Source: Ensembl
    5. response to pain Source: MGI

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent noradrenaline transporter
    Alternative name(s):
    Norepinephrine transporter
    Short name:
    NET
    Solute carrier family 6 member 2
    Gene namesi
    Name:Slc6a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1270850. Slc6a2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of plasma membrane Source: InterPro
    3. membrane raft Source: Ensembl
    4. neuron projection Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617Sodium-dependent noradrenaline transporterPRO_0000214749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO55192.
    PRIDEiO55192.

    PTM databases

    PhosphoSiteiO55192.

    Expressioni

    Gene expression databases

    ArrayExpressiO55192.
    BgeeiO55192.
    GenevestigatoriO55192.

    Interactioni

    Subunit structurei

    Interacts with PRKCABP.By similarity

    Protein-protein interaction databases

    MINTiMINT-1770608.

    Structurei

    3D structure databases

    ProteinModelPortaliO55192.
    SMRiO55192. Positions 56-594.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6464CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 23478ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei65 – 8521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25319Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 27918Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33218Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei344 – 36522Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 41720Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei444 – 46219Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei519 – 53820Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei557 – 57519Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00740000115174.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ6QU62.
    KOiK05035.
    OMAiAYCITPE.
    OrthoDBiEOG793B71.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002435. Na/ntran_symport_noradrenaline.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01201. NORTRANSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55192-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLARMNPQV QPELGGADPL PEQPLRPCKT ADLLVVKERN GVQCLLASQD    50
    SDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL 100
    FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF 150
    YYNVIIAWSL YYLFASFTLN LPWTNCGHSW NSPNCTDPKL LNASVLGDHT 200
    KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVIVVLYF 250
    SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 300
    RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN 350
    CVTSFISGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG 400
    STFWAVLFFL MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTCVVT 450
    ISTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR 500
    FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYTY 550
    PPWANWVGWG IALSSMILVP AYVIYKFLSI RGSLWERVAY GITPENEHHL 600
    VAQRDVRQFQ LRHWLAI 617
    Length:617
    Mass (Da):69,255
    Last modified:July 27, 2011 - v2
    Checksum:i591641246B8DA59C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti609 – 6124FQLR → LPLQ in AAB94302. (PubMed:9603188)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76306 mRNA. Translation: AAB94302.1.
    AY525777 mRNA. Translation: AAS17725.1.
    AY525778 mRNA. Translation: AAS17726.1.
    CH466525 Genomic DNA. Translation: EDL11093.1.
    CCDSiCCDS22525.1.
    RefSeqiNP_033235.3. NM_009209.3.
    UniGeneiMm.57040.

    Genome annotation databases

    EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368.
    ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368.
    GeneIDi20538.
    KEGGimmu:20538.
    UCSCiuc009muh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76306 mRNA. Translation: AAB94302.1 .
    AY525777 mRNA. Translation: AAS17725.1 .
    AY525778 mRNA. Translation: AAS17726.1 .
    CH466525 Genomic DNA. Translation: EDL11093.1 .
    CCDSi CCDS22525.1.
    RefSeqi NP_033235.3. NM_009209.3.
    UniGenei Mm.57040.

    3D structure databases

    ProteinModelPortali O55192.
    SMRi O55192. Positions 56-594.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1770608.

    Chemistry

    BindingDBi O55192.
    ChEMBLi CHEMBL2370.

    PTM databases

    PhosphoSitei O55192.

    Proteomic databases

    PaxDbi O55192.
    PRIDEi O55192.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072939 ; ENSMUSP00000072709 ; ENSMUSG00000055368 .
    ENSMUST00000165470 ; ENSMUSP00000129869 ; ENSMUSG00000055368 .
    GeneIDi 20538.
    KEGGi mmu:20538.
    UCSCi uc009muh.2. mouse.

    Organism-specific databases

    CTDi 6530.
    MGIi MGI:1270850. Slc6a2.

    Phylogenomic databases

    eggNOGi COG0733.
    GeneTreei ENSGT00740000115174.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q6QU62.
    KOi K05035.
    OMAi AYCITPE.
    OrthoDBi EOG793B71.
    TreeFami TF343812.

    Miscellaneous databases

    ChiTaRSi SLC6A2. mouse.
    NextBioi 298815.
    PROi O55192.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O55192.
    Bgeei O55192.
    Genevestigatori O55192.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002435. Na/ntran_symport_noradrenaline.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PR01201. NORTRANSPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal mapping of the murine norepinephrine transporter."
      Fritz J.D., Jayanthi L.D., Thoreson M.A., Blakely R.D.
      J. Neurochem. 70:2241-2251(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice."
      Haughey H.M., Kaiser A.L., Johnson T.E., Bennett B., Sikela J.M., Zahniser N.R.
      Alcohol. Clin. Exp. Res. 29:1759-1768(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSC6A2_MOUSE
    AccessioniPrimary (citable) accession number: O55192
    Secondary accession number(s): Q6QU62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3