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Protein

Sodium-dependent noradrenaline transporter

Gene

Slc6a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

  1. monoamine transmembrane transporter activity Source: MGI
  2. neurotransmitter:sodium symporter activity Source: InterPro
  3. norepinephrine transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. monoamine transport Source: MGI
  2. neurotransmitter transport Source: MGI
  3. norepinephrine transport Source: Ensembl
  4. response to drug Source: Ensembl
  5. response to pain Source: MGI
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_253228. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name:
NET
Solute carrier family 6 member 2
Gene namesi
Name:Slc6a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1270850. Slc6a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei93 – 11220Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini157 – 23478ExtracellularSequence AnalysisAdd
BLAST
Transmembranei235 – 25319Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei262 – 27918Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei315 – 33218Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei344 – 36522Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei398 – 41720Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei444 – 46219Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei478 – 49821Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei519 – 53820Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei557 – 57519Helical; Name=12Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of plasma membrane Source: InterPro
  3. membrane raft Source: Ensembl
  4. neuron projection Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Sodium-dependent noradrenaline transporterPRO_0000214749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO55192.
PRIDEiO55192.

PTM databases

PhosphoSiteiO55192.

Expressioni

Gene expression databases

BgeeiO55192.
ExpressionAtlasiO55192. baseline and differential.
GenevestigatoriO55192.

Interactioni

Subunit structurei

Interacts with PRKCABP.By similarity

Protein-protein interaction databases

MINTiMINT-1770608.

Structurei

3D structure databases

ProteinModelPortaliO55192.
SMRiO55192. Positions 56-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO55192.
KOiK05035.
OMAiPPWANWV.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55192-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLARMNPQV QPELGGADPL PEQPLRPCKT ADLLVVKERN GVQCLLASQD
60 70 80 90 100
SDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
110 120 130 140 150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF
160 170 180 190 200
YYNVIIAWSL YYLFASFTLN LPWTNCGHSW NSPNCTDPKL LNASVLGDHT
210 220 230 240 250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVIVVLYF
260 270 280 290 300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY
310 320 330 340 350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSTIN
360 370 380 390 400
CVTSFISGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG
410 420 430 440 450
STFWAVLFFL MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTCVVT
460 470 480 490 500
ISTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR
510 520 530 540 550
FSNDIQQMMG FKPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYTY
560 570 580 590 600
PPWANWVGWG IALSSMILVP AYVIYKFLSI RGSLWERVAY GITPENEHHL
610
VAQRDVRQFQ LRHWLAI
Length:617
Mass (Da):69,255
Last modified:July 27, 2011 - v2
Checksum:i591641246B8DA59C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti609 – 6124FQLR → LPLQ in AAB94302. (PubMed:9603188)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76306 mRNA. Translation: AAB94302.1.
AY525777 mRNA. Translation: AAS17725.1.
AY525778 mRNA. Translation: AAS17726.1.
CH466525 Genomic DNA. Translation: EDL11093.1.
CCDSiCCDS22525.1.
RefSeqiNP_033235.3. NM_009209.3.
UniGeneiMm.57040.

Genome annotation databases

EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368.
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368.
GeneIDi20538.
KEGGimmu:20538.
UCSCiuc009muh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76306 mRNA. Translation: AAB94302.1.
AY525777 mRNA. Translation: AAS17725.1.
AY525778 mRNA. Translation: AAS17726.1.
CH466525 Genomic DNA. Translation: EDL11093.1.
CCDSiCCDS22525.1.
RefSeqiNP_033235.3. NM_009209.3.
UniGeneiMm.57040.

3D structure databases

ProteinModelPortaliO55192.
SMRiO55192. Positions 56-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1770608.

Chemistry

BindingDBiO55192.
ChEMBLiCHEMBL2370.

PTM databases

PhosphoSiteiO55192.

Proteomic databases

PaxDbiO55192.
PRIDEiO55192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072939; ENSMUSP00000072709; ENSMUSG00000055368.
ENSMUST00000165470; ENSMUSP00000129869; ENSMUSG00000055368.
GeneIDi20538.
KEGGimmu:20538.
UCSCiuc009muh.2. mouse.

Organism-specific databases

CTDi6530.
MGIiMGI:1270850. Slc6a2.

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO55192.
KOiK05035.
OMAiPPWANWV.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiREACT_253228. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

ChiTaRSiSlc6a2. mouse.
NextBioi298815.
PROiO55192.
SOURCEiSearch...

Gene expression databases

BgeeiO55192.
ExpressionAtlasiO55192. baseline and differential.
GenevestigatoriO55192.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of the murine norepinephrine transporter."
    Fritz J.D., Jayanthi L.D., Thoreson M.A., Blakely R.D.
    J. Neurochem. 70:2241-2251(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice."
    Haughey H.M., Kaiser A.L., Johnson T.E., Bennett B., Sikela J.M., Zahniser N.R.
    Alcohol. Clin. Exp. Res. 29:1759-1768(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSC6A2_MOUSE
AccessioniPrimary (citable) accession number: O55192
Secondary accession number(s): Q6QU62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: January 7, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.