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Protein

Dentin matrix acidic phosphoprotein 1

Gene

Dmp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).By similarity

GO - Molecular functioni

  • extracellular matrix binding Source: MGI

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • extracellular matrix organization Source: MGI
  • ossification Source: InterPro
  • positive regulation of cell-substrate adhesion Source: MGI
  • regulation of enamel mineralization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Enzyme and pathway databases

ReactomeiR-MMU-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Dentin matrix acidic phosphoprotein 1
Short name:
DMP-1
Short name:
Dentin matrix protein 1
Alternative name(s):
AG1
Gene namesi
Name:Dmp1
Synonyms:Dmp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:94910. Dmp1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Secretedextracellular spaceextracellular matrix By similarity

  • Note: In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Nucleus, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display rickets and osteomalacia with isolated renal phosphate wasting associated with elevated FGF23 levels and normocalciuria.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002111117 – 503Dentin matrix acidic phosphoprotein 1Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO55188.
PeptideAtlasiO55188.
PRIDEiO55188.

PTM databases

iPTMnetiO55188.
PhosphoSitePlusiO55188.

Miscellaneous databases

PMAP-CutDBQ3TZB6.

Expressioni

Tissue specificityi

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast. Also expressed in bone particularly in osteoblast.

Gene expression databases

BgeeiENSMUSG00000029307.
CleanExiMM_DMP1.
GenevisibleiO55188. MM.

Interactioni

Subunit structurei

Interacts with importin alpha.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068053.

Structurei

3D structure databases

ProteinModelPortaliO55188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi350 – 352Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 44Poly-Pro4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1181. Eukaryota.
ENOG4111M3T. LUCA.
GeneTreeiENSGT00730000111375.
HOGENOMiHOG000220909.
HOVERGENiHBG073257.
InParanoidiO55188.
OMAiYHNTESE.
OrthoDBiEOG091G0U5E.
TreeFamiTF337029.

Family and domain databases

InterProiIPR009889. DMP1.
[Graphical view]
PANTHERiPTHR23400. PTHR23400. 1 hit.
PfamiPF07263. DMP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVILLVFL WGLSCALPVA RYHNTESESS EERTGDLAGS PPPPTNSESS
60 70 80 90 100
EESQASPEGQ ANSDHTDSSE SGEELGYDRG QYRPAGGLSK STGTGADKED
110 120 130 140 150
DEDDSGDDTF GDEDNDLGPE EGQWGGPSKL DSDEDSTDTT QSSEDSTSQE
160 170 180 190 200
NSAQDTPSDS KDHDSEDEAD SRPEAGDSTQ DSESEEQRVG GGSEGESSHG
210 220 230 240 250
DGSEFDDEGM QSDDPESTRS DRGHARMSSA GIRSEESKGD HEPTSTQDSD
260 270 280 290 300
DSQSVEFSSR KSFRRSHVSE EDYRGELTDS NSRETQSDST EDTASKEESR
310 320 330 340 350
SESQEDTAES QSQEDSPEGQ DPSSESSEEA GEPSQESSSE SQEGVTSESR
360 370 380 390 400
GDNPDNTSQA GDQEDSESSE EDSLNTFSSS ESQSTEEQAD SESNESLSLS
410 420 430 440 450
EESQESAQDG DSSSQEGLQS QSASTESRSQ ESQSEQDSRS EEDSDSQDSS
460 470 480 490 500
RSKEESNSTG SASSSEEDIR PKNMEADSRK LIVDAYHNKP IGDQDDNDCQ

DGY
Length:503
Mass (Da):53,965
Last modified:July 27, 2011 - v2
Checksum:iA8FA932A126F8541
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35G → D in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti59G → A in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti59G → A in CAB59629 (Ref. 2) Curated1
Sequence conflicti67D → H in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti67D → H in CAB59629 (Ref. 2) Curated1
Sequence conflicti99E → D in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti99E → D in CAB59629 (Ref. 2) Curated1
Sequence conflicti116D → G in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti116D → Y in CAB59629 (Ref. 2) Curated1
Sequence conflicti137T → A in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti137T → A in CAB59629 (Ref. 2) Curated1
Sequence conflicti163H → Q in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti163H → Q in CAB59629 (Ref. 2) Curated1
Sequence conflicti168 – 170EAD → DAH in AAB93764 (PubMed:9525343).Curated3
Sequence conflicti168 – 170EAD → DAH in CAB59629 (Ref. 2) Curated3
Sequence conflicti174E → D in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti174E → D in CAB59629 (Ref. 2) Curated1
Sequence conflicti179 – 181TQD → AQH in AAB93764 (PubMed:9525343).Curated3
Sequence conflicti179 – 181TQD → AQH in CAB59629 (Ref. 2) Curated3
Sequence conflicti196E → Q in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti196E → Q in CAB59629 (Ref. 2) Curated1
Sequence conflicti241H → R in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti241H → R in CAB59629 (Ref. 2) Curated1
Sequence conflicti267H → R in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti267H → R in CAB59629 (Ref. 2) Curated1
Sequence conflicti360A → T in AAB93764 (PubMed:9525343).Curated1
Sequence conflicti360A → T in CAB59629 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65020 mRNA. Translation: AAB93764.1.
AJ242625 Genomic DNA. Translation: CAB59629.1.
AK132177 mRNA. Translation: BAE21014.1.
AK157973 mRNA. Translation: BAE34293.1.
CH466529 Genomic DNA. Translation: EDL20228.1.
CCDSiCCDS19484.1.
RefSeqiNP_058059.2. NM_016779.2.
XP_006534829.1. XM_006534766.2.
UniGeneiMm.199008.

Genome annotation databases

EnsembliENSMUST00000066708; ENSMUSP00000068053; ENSMUSG00000029307.
GeneIDi13406.
KEGGimmu:13406.
UCSCiuc008yke.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65020 mRNA. Translation: AAB93764.1.
AJ242625 Genomic DNA. Translation: CAB59629.1.
AK132177 mRNA. Translation: BAE21014.1.
AK157973 mRNA. Translation: BAE34293.1.
CH466529 Genomic DNA. Translation: EDL20228.1.
CCDSiCCDS19484.1.
RefSeqiNP_058059.2. NM_016779.2.
XP_006534829.1. XM_006534766.2.
UniGeneiMm.199008.

3D structure databases

ProteinModelPortaliO55188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068053.

PTM databases

iPTMnetiO55188.
PhosphoSitePlusiO55188.

Proteomic databases

PaxDbiO55188.
PeptideAtlasiO55188.
PRIDEiO55188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066708; ENSMUSP00000068053; ENSMUSG00000029307.
GeneIDi13406.
KEGGimmu:13406.
UCSCiuc008yke.1. mouse.

Organism-specific databases

CTDi1758.
MGIiMGI:94910. Dmp1.

Phylogenomic databases

eggNOGiKOG1181. Eukaryota.
ENOG4111M3T. LUCA.
GeneTreeiENSGT00730000111375.
HOGENOMiHOG000220909.
HOVERGENiHBG073257.
InParanoidiO55188.
OMAiYHNTESE.
OrthoDBiEOG091G0U5E.
TreeFamiTF337029.

Enzyme and pathway databases

ReactomeiR-MMU-3000178. ECM proteoglycans.

Miscellaneous databases

PMAP-CutDBQ3TZB6.
PROiO55188.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029307.
CleanExiMM_DMP1.
GenevisibleiO55188. MM.

Family and domain databases

InterProiIPR009889. DMP1.
[Graphical view]
PANTHERiPTHR23400. PTHR23400. 1 hit.
PfamiPF07263. DMP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMP1_MOUSE
AccessioniPrimary (citable) accession number: O55188
Secondary accession number(s): Q3TZB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.