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Protein

CD59A glycoprotein

Gene

Cd59a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell activation Source: GO_Central
  • negative regulation of activation of membrane attack complex Source: BHF-UCL
  • negative regulation of angiogenesis Source: BHF-UCL
  • negative regulation of complement activation Source: BHF-UCL
  • negative regulation of fibroblast growth factor production Source: BHF-UCL
  • negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
CD59A glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name:
MAC-IP
Membrane attack complex inhibition factor
Short name:
MACIF
Protectin
CD_antigen: CD59
Gene namesi
Name:Cd59a
Synonyms:Cd59
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:109177 Cd59a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003611224 – 96CD59A glycoproteinAdd BLAST73
PropeptideiPRO_000003611397 – 123Removed in mature formBy similarityAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 50By similarity
Disulfide bondi29 ↔ 37By similarity
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi43 ↔ 63By similarity
Disulfide bondi69 ↔ 87By similarity
Disulfide bondi88 ↔ 93By similarity
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi96GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO55186
PaxDbiO55186
PRIDEiO55186

Expressioni

Tissue specificityi

Expressed in all tissues examined (liver, kidney, spleen, thymus, brain and heart). Low levels in thymus. Also expressed in mononuclear cells, erythrocytes and platelets. Barely detected in neutrophils.

Gene expression databases

BgeeiENSMUSG00000032679
CleanExiMM_CD59A
ExpressionAtlasiO55186 baseline and differential
GenevisibleiO55186 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048041

Structurei

3D structure databases

ProteinModelPortaliO55186
SMRiO55186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 96UPAR/Ly6Add BLAST73

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J39P Eukaryota
ENOG410ZEQP LUCA
GeneTreeiENSGT00390000016309
HOGENOMiHOG000232180
HOVERGENiHBG005284
InParanoidiO55186
KOiK04008
OMAiECTFEDS
OrthoDBiEOG091G11NF
PhylomeDBiO55186
TreeFamiTF338524

Family and domain databases

InterProiView protein in InterPro
IPR027101 CD59_glyco
IPR016054 LY6_UPA_recep-like
PANTHERiPTHR10036:SF9 PTHR10036:SF9, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQRGLILL LLLLAVFCST AVSLTCYHCF QPVVSSCNMN STCSPDQDSC
60 70 80 90 100
LYAVAGMQVY QRCWKQSDCH GEIIMDQLEE TKLKFRCCQF NLCNKSDGSL
110 120
GKTPLLGTSV LVAILNLCFL SHL
Length:123
Mass (Da):13,648
Last modified:June 1, 1998 - v1
Checksum:iAA6BF2C96F2A7374
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60473 mRNA Translation: AAC00055.1
AF247652 Genomic DNA Translation: AAG15314.1
AK002743 mRNA Translation: BAB22321.1
AK005507 mRNA Translation: BAB24087.1
AK018136 mRNA Translation: BAB31088.1
AK080728 mRNA Translation: BAC37996.1
CCDSiCCDS16487.1
RefSeqiNP_001104530.1, NM_001111060.2
NP_031678.1, NM_007652.5
XP_006498713.1, XM_006498650.3
XP_006498714.1, XM_006498651.3
UniGeneiMm.247265

Genome annotation databases

EnsembliENSMUST00000040423; ENSMUSP00000048041; ENSMUSG00000032679
ENSMUST00000168176; ENSMUSP00000132774; ENSMUSG00000032679
GeneIDi12509
KEGGimmu:12509
UCSCiuc008ljo.3 mouse

Similar proteinsi

Entry informationi

Entry nameiCD59A_MOUSE
AccessioniPrimary (citable) accession number: O55186
Secondary accession number(s): Q542R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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