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O55175

- CNCG_SPETR

UniProt

O55175 - CNCG_SPETR

Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6H

Organism
Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:PDE6H
    OrganismiSpermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus)
    Taxonomic identifieri43179 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiSciuridaeXerinaeMarmotiniIctidomys
    ProteomesiUP000005215: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166123Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

    Structurei

    3D structure databases

    ProteinModelPortaliO55175.
    SMRiO55175. Positions 7-83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
    BLAST

    Domaini

    The C-terminal region is important in conferring inhibition.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00390000013260.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    OMAiTSNQGPT.
    OrthoDBiEOG7SN8FW.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O55175-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDNTTLAPP AASQAPATPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI   50
    PGMEGLGTDI TVICPWEAFS HLELHELAQF GII 83
    Length:83
    Mass (Da):9,015
    Last modified:June 1, 1998 - v1
    Checksum:i5AA76840BFE972DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001390 mRNA. Translation: CAA04720.1.
    RefSeqiXP_005331938.1. XM_005331881.1.

    Genome annotation databases

    EnsembliENSSTOT00000009089; ENSSTOP00000008149; ENSSTOG00000009094.
    GeneIDi101975706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001390 mRNA. Translation: CAA04720.1 .
    RefSeqi XP_005331938.1. XM_005331881.1.

    3D structure databases

    ProteinModelPortali O55175.
    SMRi O55175. Positions 7-83.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSTOT00000009089 ; ENSSTOP00000008149 ; ENSSTOG00000009094 .
    GeneIDi 101975706.

    Organism-specific databases

    CTDi 5149.

    Phylogenomic databases

    GeneTreei ENSGT00390000013260.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    OMAi TSNQGPT.
    OrthoDBi EOG7SN8FW.
    TreeFami TF333297.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cyclic GMP phosphodiesterase gamma subunit from the ground squirrel retina."
      von Schantz M., Szel A., van Veen T., Farber D.B.
      Brain Res. Mol. Brain Res. 54:327-333(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.

    Entry informationi

    Entry nameiCNCG_SPETR
    AccessioniPrimary (citable) accession number: O55175
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3