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O55175 (CNCG_SPETR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Short name=GMP-PDE gamma
EC=3.1.4.35
Gene names
Name:PDE6H
OrganismSpermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) [Reference proteome]
Taxonomic identifier43179 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiSciuridaeXerinaeMarmotiniIctidomys

Protein attributes

Sequence length83 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Subunit structure

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Domain

The C-terminal region is important in conferring inhibition By similarity.

Sequence similarities

Belongs to the rod/cone cGMP-PDE gamma subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
PRO_0000166123

Regions

Compositional bias20 – 4122Arg/Lys-rich (basic)

Sequences

Sequence LengthMass (Da)Tools
O55175 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 5AA76840BFE972DC

FASTA839,015
        10         20         30         40         50         60 
MSDNTTLAPP AASQAPATPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI 

        70         80 
TVICPWEAFS HLELHELAQF GII 

« Hide

References

[1]"Cloning of a cyclic GMP phosphodiesterase gamma subunit from the ground squirrel retina."
von Schantz M., Szel A., van Veen T., Farber D.B.
Brain Res. Mol. Brain Res. 54:327-333(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001390 mRNA. Translation: CAA04720.1.
RefSeqXP_005331938.1. XM_005331881.1.

3D structure databases

ProteinModelPortalO55175.
SMRO55175. Positions 7-83.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSTOT00000009089; ENSSTOP00000008149; ENSSTOG00000009094.
GeneID101975706.

Organism-specific databases

CTD5149.

Phylogenomic databases

GeneTreeENSGT00390000013260.
HOGENOMHOG000261673.
HOVERGENHBG000447.
OMATSNQGPT.
OrthoDBEOG7SN8FW.
TreeFamTF333297.

Family and domain databases

Gene3D4.10.1120.10. 1 hit.
InterProIPR006952. PDE6_gamma.
[Graphical view]
PANTHERPTHR12122. PTHR12122. 1 hit.
PfamPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCNCG_SPETR
AccessionPrimary (citable) accession number: O55175
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families