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Protein

Zinc transporter 4

Gene

Slc30a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: RGD

GO - Biological processi

  • lactation Source: RGD
  • response to vitamin A Source: RGD
  • response to zinc ion Source: RGD
  • zinc II ion transmembrane transport Source: GOC
  • zinc II ion transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 4
Short name:
ZnT-4
Alternative name(s):
Dri 27 protein
Solute carrier family 30 member 4
Gene namesi
Name:Slc30a4
Synonyms:Znt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619750. Slc30a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 113113CytoplasmicSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Topological domaini135 – 1439VacuolarSequence analysis
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Topological domaini165 – 17814CytoplasmicSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 21617VacuolarSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 27538CytoplasmicSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Topological domaini297 – 31115VacuolarSequence analysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Topological domaini333 – 43098CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Zinc transporter 4PRO_0000206101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO55174.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain and testes. Also expressed in small intestine, medulla, lung, kidney, stomach and colon. Expressed at lower level in other tissues.

Developmental stagei

Developmentally regulated in the intestine.

Inductioni

No change in response to zinc deprivation.

Interactioni

Subunit structurei

Mediates heterodimeric interactions with at least one specific partner.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000184.

Structurei

3D structure databases

ProteinModelPortaliO55174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 9680Asp-rich (acidic)Add
BLAST
Compositional biasi241 – 2499His-rich

Domaini

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiO55174.
KOiK14691.
PhylomeDBiO55174.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

O55174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPGAWKRL KSLLRKDDAP LFLNDTSAFD FLDEVSDEGL SRFNKLRVVV
60 70 80 90 100
ADDDSEAPER PVNGAHPALQ ADDDSLLDQE LPLTNSQLSL KMDPCDNCSK
110 120 130 140 150
RRELLKQRKV KTRLTIAAVL YLLFMIGELV GGYMANSLAI MTDALHMLTD
160 170 180 190 200
LSAIILTLLA LWLSSKSPTR RFTFGFHRLE VLSAMISVML VYVLMGFLLY
210 220 230 240 250
EAMQRTIHMN YEINGDVMLI TAAVGVAVNV IMGFLLNQSG HHHSHAHSHS
260 270 280 290 300
LPSNSPSMVS SGHSHGQDSL AVRAAFVHAL GDLVQSVGVL IAAYIIRFKP
310 320 330 340 350
EYKIADPICT YIFSLLVAFT TLRIIWDTVV IILEGVPSHL NVDYIKESLM
360 370 380 390 400
KIEDVYSVED LNIWSLTSGK ATAIVHMQLI PGSSSKWEEV QSKAKHLLLN
410 420 430
TFGMYKCTVQ LQSYRQEATR TCANCQSSST
Length:430
Mass (Da):47,702
Last modified:June 1, 1998 - v1
Checksum:iF34CED3FA4FF05FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16774 mRNA. Translation: CAA76372.1.
RefSeqiNP_742063.1. NM_172066.1.
UniGeneiRn.90036.

Genome annotation databases

GeneIDi64469.
KEGGirno:64469.
UCSCiRGD:619750. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16774 mRNA. Translation: CAA76372.1.
RefSeqiNP_742063.1. NM_172066.1.
UniGeneiRn.90036.

3D structure databases

ProteinModelPortaliO55174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000184.

Proteomic databases

PaxDbiO55174.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64469.
KEGGirno:64469.
UCSCiRGD:619750. rat.

Organism-specific databases

CTDi7782.
RGDi619750. Slc30a4.

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiO55174.
KOiK14691.
PhylomeDBiO55174.

Miscellaneous databases

NextBioi613246.
PROiO55174.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells."
    Murgia C., Vespignani I., Cerase J., Nobili F., Perozzi G.
    Am. J. Physiol. 277:G1231-G1239(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiZNT4_RAT
AccessioniPrimary (citable) accession number: O55174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.