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Protein

Zinc transporter 4

Gene

Slc30a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: RGD

GO - Biological processi

  • lactation Source: RGD
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to vitamin A Source: RGD
  • response to zinc ion Source: RGD
  • zinc ion transport Source: RGD

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 4
Short name:
ZnT-4
Alternative name(s):
Dri 27 protein
Solute carrier family 30 member 4
Gene namesi
Name:Slc30a4
Synonyms:Znt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619750 Slc30a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 113CytoplasmicSequence analysisAdd BLAST113
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 143VacuolarSequence analysis9
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 178CytoplasmicSequence analysisAdd BLAST14
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 216VacuolarSequence analysisAdd BLAST17
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 275CytoplasmicSequence analysisAdd BLAST38
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 311VacuolarSequence analysisAdd BLAST15
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 430CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002061011 – 430Zinc transporter 4Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO55174
PRIDEiO55174

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain and testes. Also expressed in small intestine, medulla, lung, kidney, stomach and colon. Expressed at lower level in other tissues.

Developmental stagei

Developmentally regulated in the intestine.

Inductioni

No change in response to zinc deprivation.

Interactioni

Subunit structurei

Mediates heterodimeric interactions with at least one specific partner.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000184

Structurei

3D structure databases

ProteinModelPortaliO55174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 96Asp-rich (acidic)Add BLAST80
Compositional biasi241 – 249His-rich9

Domaini

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiO55174
KOiK14691
PhylomeDBiO55174

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

O55174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPGAWKRL KSLLRKDDAP LFLNDTSAFD FLDEVSDEGL SRFNKLRVVV
60 70 80 90 100
ADDDSEAPER PVNGAHPALQ ADDDSLLDQE LPLTNSQLSL KMDPCDNCSK
110 120 130 140 150
RRELLKQRKV KTRLTIAAVL YLLFMIGELV GGYMANSLAI MTDALHMLTD
160 170 180 190 200
LSAIILTLLA LWLSSKSPTR RFTFGFHRLE VLSAMISVML VYVLMGFLLY
210 220 230 240 250
EAMQRTIHMN YEINGDVMLI TAAVGVAVNV IMGFLLNQSG HHHSHAHSHS
260 270 280 290 300
LPSNSPSMVS SGHSHGQDSL AVRAAFVHAL GDLVQSVGVL IAAYIIRFKP
310 320 330 340 350
EYKIADPICT YIFSLLVAFT TLRIIWDTVV IILEGVPSHL NVDYIKESLM
360 370 380 390 400
KIEDVYSVED LNIWSLTSGK ATAIVHMQLI PGSSSKWEEV QSKAKHLLLN
410 420 430
TFGMYKCTVQ LQSYRQEATR TCANCQSSST
Length:430
Mass (Da):47,702
Last modified:June 1, 1998 - v1
Checksum:iF34CED3FA4FF05FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16774 mRNA Translation: CAA76372.1
RefSeqiNP_742063.1, NM_172066.1
UniGeneiRn.90036

Genome annotation databases

GeneIDi64469
KEGGirno:64469
UCSCiRGD:619750 rat

Similar proteinsi

Entry informationi

Entry nameiZNT4_RAT
AccessioniPrimary (citable) accession number: O55174
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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