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Protein

Transcription factor SOX-10

Gene

Sox10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 172HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-10
Gene namesi
Name:Sox10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3735. Sox10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487481 – 466Transcription factor SOX-10Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO55170.

PTM databases

iPTMnetiO55170.
PhosphoSitePlusiO55170.

Expressioni

Tissue specificityi

Predominant expression in glial cells of the nervous system.1 Publication

Gene expression databases

BgeeiENSRNOG00000011305.
GenevisibleiO55170. RN.

Interactioni

Subunit structurei

Monomer. Interacts with Armcx3 at the mitochondrial outer membrane surface.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NMIQ132874EBI-1185693,EBI-372942From Homo sapiens.

GO - Molecular functioni

  • identical protein binding Source: Ensembl
  • transcription factor binding Source: RGD

Protein-protein interaction databases

BioGridi248015. 17 interactors.
IntActiO55170. 2 interactors.
MINTiMINT-3376332.
STRINGi10116.ENSRNOP00000015283.

Structurei

3D structure databases

ProteinModelPortaliO55170.
SMRiO55170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 41Poly-Gly7

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000108876.
HOVERGENiHBG002061.
InParanoidiO55170.
KOiK09270.
OMAiRPLYTTI.
OrthoDBiEOG091G0EKD.
PhylomeDBiO55170.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR022151. Sox_N.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O55170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPSSAPS LGPDGGGGGS GLRASPGPGE
60 70 80 90 100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS
110 120 130 140 150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK
160 170 180 190 200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGETDQGGA
210 220 230 240 250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ
260 270 280 290 300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
310 320 330 340 350
LPPNGHPGHV GSYSAAGYGL SSALAVASGH SAWISKPPGV ALPTVSPPAV
360 370 380 390 400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF
410 420 430 440 450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH
460
SPTHWEQPVY TTLSRP
Length:466
Mass (Da):50,039
Last modified:June 1, 1998 - v1
Checksum:i094B0C5E42D83454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001029 mRNA. Translation: CAA04485.1.
BC062067 mRNA. Translation: AAH62067.1.
RefSeqiNP_062066.1. NM_019193.2.
XP_017450187.1. XM_017594698.1.
UniGeneiRn.10883.

Genome annotation databases

EnsembliENSRNOT00000015283; ENSRNOP00000015283; ENSRNOG00000011305.
GeneIDi29361.
KEGGirno:29361.
UCSCiRGD:3735. rat.

Similar proteinsi

Entry informationi

Entry nameiSOX10_RAT
AccessioniPrimary (citable) accession number: O55170
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome