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Protein

Transcription factor SOX-10

Gene

Sox10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 17269HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-10
Gene namesi
Name:Sox10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3735. Sox10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extrinsic component of mitochondrial outer membrane Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Transcription factor SOX-10PRO_0000048748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO55170.

PTM databases

iPTMnetiO55170.

Expressioni

Tissue specificityi

Predominant expression in glial cells of the nervous system.

Gene expression databases

GenevisibleiO55170. RN.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NMIQ132874EBI-1185693,EBI-372942From a different organism.

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi248015. 17 interactions.
IntActiO55170. 2 interactions.
MINTiMINT-3376332.
STRINGi10116.ENSRNOP00000015283.

Structurei

3D structure databases

ProteinModelPortaliO55170.
SMRiO55170. Positions 104-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 417Poly-Gly

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000108876.
HOVERGENiHBG002061.
InParanoidiO55170.
KOiK09270.
OMAiYADQPST.
OrthoDBiEOG7Q2N5K.
PhylomeDBiO55170.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPSSAPS LGPDGGGGGS GLRASPGPGE
60 70 80 90 100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS
110 120 130 140 150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK
160 170 180 190 200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGETDQGGA
210 220 230 240 250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ
260 270 280 290 300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
310 320 330 340 350
LPPNGHPGHV GSYSAAGYGL SSALAVASGH SAWISKPPGV ALPTVSPPAV
360 370 380 390 400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF
410 420 430 440 450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH
460
SPTHWEQPVY TTLSRP
Length:466
Mass (Da):50,039
Last modified:June 1, 1998 - v1
Checksum:i094B0C5E42D83454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001029 mRNA. Translation: CAA04485.1.
BC062067 mRNA. Translation: AAH62067.1.
RefSeqiNP_062066.1. NM_019193.2.
UniGeneiRn.10883.

Genome annotation databases

EnsembliENSRNOT00000015283; ENSRNOP00000015283; ENSRNOG00000011305.
GeneIDi29361.
KEGGirno:29361.
UCSCiRGD:3735. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001029 mRNA. Translation: CAA04485.1.
BC062067 mRNA. Translation: AAH62067.1.
RefSeqiNP_062066.1. NM_019193.2.
UniGeneiRn.10883.

3D structure databases

ProteinModelPortaliO55170.
SMRiO55170. Positions 104-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248015. 17 interactions.
IntActiO55170. 2 interactions.
MINTiMINT-3376332.
STRINGi10116.ENSRNOP00000015283.

PTM databases

iPTMnetiO55170.

Proteomic databases

PaxDbiO55170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015283; ENSRNOP00000015283; ENSRNOG00000011305.
GeneIDi29361.
KEGGirno:29361.
UCSCiRGD:3735. rat.

Organism-specific databases

CTDi6663.
RGDi3735. Sox10.

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000108876.
HOVERGENiHBG002061.
InParanoidiO55170.
KOiK09270.
OMAiYADQPST.
OrthoDBiEOG7Q2N5K.
PhylomeDBiO55170.

Miscellaneous databases

NextBioi608888.
PROiO55170.

Gene expression databases

GenevisibleiO55170. RN.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022151. Sox_N.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12444. Sox_N. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sox10, a novel transcriptional modulator in glial cells."
    Kuhlbrodt K., Herbarth B., Sock E., Hermans-Borgmeyer I., Wegner M.
    J. Neurosci. 18:237-250(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiSOX10_RAT
AccessioniPrimary (citable) accession number: O55170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.