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Reviewed, UniProtKB/Swiss-Prot O55170 (SOX10_RAT)

Last modified December 15, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Transcription factor SOX-10
Gene names
Name: Sox10
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia.

Subcellular location

Nucleus.

Tissue specificity

Predominant expression in glial cells of the nervous system.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
Gene Ontology (GO)
   Biological processstem cell differentiation

Inferred from expression pattern. Source: RGD

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from direct assay. Source: RGD

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

NMIQ132871EBI-1185693,EBI-372942From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Transcription factor SOX-10
PRO_0000048748

Regions

DNA binding104 – 17269HMG box
Compositional bias35 – 417Poly-Gly

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Sequences

Sequence LengthMass (Da)Tools
O55170-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 094B0C5E42D83454

FASTA46650,039
        10         20         30         40         50         60 
MAEEQDLSEV ELSPVGSEEP RCLSPSSAPS LGPDGGGGGS GLRASPGPGE LGKVKKEQQD 

        70         80         90        100        110        120 
GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS KPHVKRPMNA FMVWAQAARR 

       130        140        150        160        170        180 
KLADQYPHLH NAELSKTLGK LWRLLNESDK RPFIEEAERL RMQHKKDHPD YKYQPRRRKN 

       190        200        210        220        230        240 
GKAAQGEAEC PGGETDQGGA AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT 

       250        260        270        280        290        300 
PPTTPKTELQ SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY 

       310        320        330        340        350        360 
LPPNGHPGHV GSYSAAGYGL SSALAVASGH SAWISKPPGV ALPTVSPPAV DAKAQVKTET 

       370        380        390        400        410        420 
TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF DYSDHQPSGP YYGHAGQASG 

       430        440        450        460 
LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH SPTHWEQPVY TTLSRP

« Hide

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References

« Hide 'large scale' references
[1]"Sox10, a novel transcriptional modulator in glial cells."
Kuhlbrodt K., Herbarth B., Sock E., Hermans-Borgmeyer I., Wegner M.
J. Neurosci. 18:237-250(1998) [PubMed: 9412504] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AJ001029 mRNA. Translation: CAA04485.1.
BC062067 mRNA. Translation: AAH62067.1.
IPIIPI00195985.
RefSeqNP_062066.1.
UniGeneRn.10883

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO55170. 1 interaction.
STRINGO55170.

Genome annotation databases

EnsemblENSRNOT00000015283; ENSRNOP00000015283; ENSRNOG00000011305; Rattus norvegicus. [Genome view]
GeneID29361.
KEGGrno:29361.
UCSCBC062067. rat.

Organism-specific databases

CTD29361.
RGD3735. Sox10.

Phylogenomic databases

HOVERGENO55170.
InParanoidO55170.
OMAPYYGHSS.
OrthoDBEOG9SXQXX.

Gene expression databases

ArrayExpressO55170.
GenevestigatorO55170.
GermOnlineENSRNOG00000011305. Rattus norvegicus.

Family and domain databases

InterProIPR000910. HMG_HMG1/HMG2.
IPR009071. HMG_superfamily.
[Graphical view]
Gene3DG3DSA:1.10.30.10. HMG-box. 1 hit.
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio608888.

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Entry information

Entry nameSOX10_RAT
AccessionPrimary (citable) accession number: O55170
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: December 15, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents