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Protein

Kinesin-like protein KIF3C

Gene

Kif3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • kinesin binding Source: RGD
  • microtubule binding Source: RGD
  • microtubule motor activity Source: GO_Central

GO - Biological processi

  • microtubule-based movement Source: GO_Central
  • positive regulation of neuron projection development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:Kif3c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621538. Kif3c.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • dendrite Source: RGD
  • growth cone Source: RGD
  • kinesin complex Source: GO_Central
  • membrane Source: RGD
  • microtubule plus-end Source: RGD
  • neuronal cell body Source: MGI
  • neuronal ribonucleoprotein granule Source: MGI
  • synaptic vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Kinesin-like protein KIF3CPRO_0000125399Add
BLAST

Proteomic databases

PaxDbiO55165.
PRIDEiO55165.

PTM databases

iPTMnetiO55165.
PhosphoSiteiO55165.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C.

GO - Molecular functioni

  • kinesin binding Source: RGD
  • microtubule binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015820.

Structurei

3D structure databases

ProteinModelPortaliO55165.
SMRiO55165. Positions 8-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 367358Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni633 – 793161GlobularSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili378 – 632255Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi271 – 2788Poly-Gly
Compositional biasi440 – 4434Poly-Asn
Compositional biasi772 – 7754Poly-Pro

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO55165.
KOiK20197.
PhylomeDBiO55165.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA
60 70 80 90 100
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG
110 120 130 140 150
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ
160 170 180 190 200
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ
210 220 230 240 250
ARAVGSTHMN EVSSRSHAIF VITVECSERG SDGQDHIRVG KLNLVDLAGS
260 270 280 290 300
ERQNKAGPNT PGGPATQSTA GGGGGGGGTS GSGSSGERPK EASKINLSLS
310 320 330 340 350
ALGNVIAALA GNRSTHIPYR DSKLTRLLQD SLGGNAKTIM VATLGPASHS
360 370 380 390 400
YDESLSTLRF ANRAKNIKNK PRVNEDPKDT LLREFQEEIA RLKAQLEKKG
410 420 430 440 450
MLGKRPRRKS SRRKKAVSAP AGYPEGAVIE AWVAEEEDDN NNNHRPPQPT
460 470 480 490 500
LEAALEKNME NYLQEQKERL EEEKAAIQDD RSLVSEEKQK LLEEKEKMLE
510 520 530 540 550
DLKREQQATE LLAAKYKAME SKLLIGGRNI MDHTNEQQKM LELKRQEIAE
560 570 580 590 600
QKRREREMQQ EMLLRDEETM ELRGTYSSLQ QEVEVKTKKL KKLYAKLQAV
610 620 630 640 650
KAEIQDQHEE YIRVRQDLEE AQNEQTRELK LKYLIIENFI PPEEKNKIMN
660 670 680 690 700
RLFLDCEEEQ WKFQPLVPAG VNNSQMKKRP TSAVGYKRPI SQYARVAMAM
710 720 730 740 750
GSHPRYRAEN IMFLELDVSP PAIFEMEFSH DQEQDPRVLH MERLMRLDSF
760 770 780 790
LERPSTSKVR KSRSWCQSPQ RPPPPSTVHA SMASAPLHPA TVVDHD
Length:796
Mass (Da):89,816
Last modified:June 1, 1998 - v1
Checksum:i935A79A01F8BDC0D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti352 – 3521D → DD in AAC33291 (PubMed:9808286).Curated
Sequence conflicti562 – 5632ML → IV in AAC33291 (PubMed:9808286).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223599 mRNA. Translation: CAA11465.1.
AF083330 mRNA. Translation: AAC33291.1.
RefSeqiNP_445938.1. NM_053486.1.
UniGeneiRn.10894.

Genome annotation databases

GeneIDi85248.
KEGGirno:85248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223599 mRNA. Translation: CAA11465.1.
AF083330 mRNA. Translation: AAC33291.1.
RefSeqiNP_445938.1. NM_053486.1.
UniGeneiRn.10894.

3D structure databases

ProteinModelPortaliO55165.
SMRiO55165. Positions 8-383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015820.

PTM databases

iPTMnetiO55165.
PhosphoSiteiO55165.

Proteomic databases

PaxDbiO55165.
PRIDEiO55165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85248.
KEGGirno:85248.

Organism-specific databases

CTDi3797.
RGDi621538. Kif3c.

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO55165.
KOiK20197.
PhylomeDBiO55165.

Miscellaneous databases

PROiO55165.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles."
    Muresan V., Abramson T., Lyass A., Winter D., Porro E., Hong F., Chamberlin N.L., Schnapp B.J.
    Mol. Biol. Cell 9:637-652(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of kinesin-like molecules in myogenic cells."
    Faire K., Gruber D., Bulinski J.C.
    Eur. J. Cell Biol. 77:27-34(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKIF3C_RAT
AccessioniPrimary (citable) accession number: O55165
Secondary accession number(s): O88657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.