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Protein

Multiple PDZ domain protein

Gene

Mpdz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.2 Publications

GO - Biological processi

  • intracellular signal transduction Source: RGD
  • myelination Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple PDZ domain protein
Alternative name(s):
Multi-PDZ domain protein 1
Gene namesi
Name:Mpdz
Synonyms:Mupp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3105. Mpdz.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945961 – 2054Multiple PDZ domain proteinAdd BLAST2054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei782PhosphoserineBy similarity1
Modified residuei1065PhosphoserineBy similarity1
Modified residuei1157Omega-N-methylarginineBy similarity1
Modified residuei1802PhosphoserineBy similarity1
Modified residuei1808PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiO55164.
PRIDEiO55164.

PTM databases

iPTMnetiO55164.
PhosphoSitePlusiO55164.

Expressioni

Tissue specificityi

Abundant in all cerebral cortical layers, especially the piriform cortex, the pyramidal cells of the CA1-CA3 subfields of the hippocampus, as well as the granular layer of the dentate gyrus. Detected in the internal granular layer and the mitral cell layer of the olfactory bulb; in the medial habenular nucleus; and in amygdaloid, thalamic, hypothalamic, and pontine nuclei. In the cerebellum, found at high levels in the granular layer. Detected in the lateral ventricle. Expression overlaps with 5-HT2C receptor expression in all regions of the brain including the choroid plexus, where 5-HT2C receptors are highly enriched.1 Publication

Gene expression databases

BgeeiENSRNOG00000007894.
ExpressionAtlasiO55164. baseline and differential.
GenevisibleiO55164. RN.

Interactioni

Subunit structurei

Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and MPP5, HTR2A, HTR2B, PLEKHA1/TAPP1 and PLEKHA2/TAPP2. Interacts with CXADR (By similarity). Interacts with HTR2C, CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with the adenovirus type 9 E4-ORF1 protein and the HPV18 E6 protein. Interacts with DLL1 (By similarity).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SSTR3P327452EBI-7401093,EBI-6266935From a different organism.

Protein-protein interaction databases

BioGridi248019. 4 interactors.
IntActiO55164. 1 interactor.
MINTiMINT-143896.
STRINGi10116.ENSRNOP00000051321.

Structurei

Secondary structure

12054
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 26Combined sources22
Helixi32 – 43Combined sources12
Helixi45 – 63Combined sources19
Helixi1321 – 1328Combined sources8
Beta strandi1331 – 1341Combined sources11
Beta strandi1349 – 1353Combined sources5
Beta strandi1358 – 1367Combined sources10
Helixi1372 – 1376Combined sources5
Beta strandi1384 – 1388Combined sources5
Helixi1398 – 1407Combined sources10
Beta strandi1410 – 1418Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y76NMR-A/C4-65[»]
5DTHX-ray1.95A/B/C/D1312-1422[»]
ProteinModelPortaliO55164.
SMRiO55164.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO55164.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 63L27PROSITE-ProRule annotationAdd BLAST61
Domaini138 – 225PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini258 – 338PDZ 2PROSITE-ProRule annotationAdd BLAST81
Domaini377 – 463PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini545 – 626PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini692 – 778PDZ 5PROSITE-ProRule annotationAdd BLAST87
Domaini995 – 1076PDZ 6PROSITE-ProRule annotationAdd BLAST82
Domaini1138 – 1230PDZ 7PROSITE-ProRule annotationAdd BLAST93
Domaini1337 – 1420PDZ 8PROSITE-ProRule annotationAdd BLAST84
Domaini1470 – 1551PDZ 9PROSITE-ProRule annotationAdd BLAST82
Domaini1613 – 1696PDZ 10PROSITE-ProRule annotationAdd BLAST84
Domaini1709 – 1791PDZ 11PROSITE-ProRule annotationAdd BLAST83
Domaini1846 – 1932PDZ 12PROSITE-ProRule annotationAdd BLAST87
Domaini1971 – 2054PDZ 13PROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1802 – 1831Ser-richAdd BLAST30

Domaini

The PDZ domain 1 binds NG2. The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds CXADR and SYNGAP1 (By similarity). The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C.By similarity2 Publications

Sequence similaritiesi

Contains 1 L27 domain.PROSITE-ProRule annotation
Contains 13 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000231304.
HOVERGENiHBG080134.
InParanoidiO55164.
KOiK06095.
PhylomeDBiO55164.

Family and domain databases

Gene3Di2.30.42.10. 13 hits.
InterProiIPR015132. L27_2.
IPR004172. L27_dom.
IPR032078. MPDZ.
IPR001478. PDZ.
[Graphical view]
PfamiPF09045. L27_2. 1 hit.
PF16667. MPDZ_u10. 1 hit.
PF00595. PDZ. 12 hits.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 13 hits.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 13 hits.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLETIDKNRA LQAAERLQSK LKERGDVANE DKLSLLKSVL QSPLFSQILS
60 70 80 90 100
LQTSLQQLKD QVNVATLATA NADHAHTPQF SSAIISNLQS ESLLLSPSNG
110 120 130 140 150
NLEAISGPGA PPAMDGKPAC EELDQLIKSM AQGRHVEIFE LLKPPCGGLG
160 170 180 190 200
FSVVGLRSEN RGELGIFVQE IQEGSVAHRD GRLKETDQIL AINGQVLDQT
210 220 230 240 250
ITHQQAISIL QKAKDTIQLV IARGSLPHIS SPRISRSPSA ASTVSAHSNP
260 270 280 290 300
THWQHVETIE LVNDGSGLGF GIIGGKATGV IVKTILPGGV ADQHGRLCSG
310 320 330 340 350
DHILKIGDTD LAGMSSEQVA QVLRQCGNRV KLMIARGAVE ETPAPSSLGI
360 370 380 390 400
TLSSSTSTSE MRVDASTQKN EESETFDVEL TKNVQGLGIT IAGYIGDKKL
410 420 430 440 450
EPSGIFVKSI TKSSAVELDG RIQIGDQIVA VDGTNLQGFT NQQAVEVLRH
460 470 480 490 500
TGQTVRLTLM RKGASQEAEI TSREDTAKDV DLPAENYEKD EESLSLKRST
510 520 530 540 550
SILPIEEEGY PLLSTELEET EDVQQEAALL TKWQRIMGIN YEIVVAHVSK
560 570 580 590 600
FSENSGLGIS LEATVGHHFI RSVLPEGPVG HSGKLFSGDE LLEVNGINLL
610 620 630 640 650
GENHQDVVNI LKELPIDVTM VCCRRTVPPT ALSEVDSLDI HDLELTEKPH
660 670 680 690 700
IDLGEFIGSS ETEDPMLAMS DVDQNAEEIQ TPLAMWEAGI QAIELEKGSR
710 720 730 740 750
GLGFSILDYQ DPIDPANTVI VIRSLVPGGI AEKDGRLFPG DRLMFVNDIN
760 770 780 790 800
LENSTLEEAV EALKGAPSGM VRIGVAKPLP LSPEEGYVSA KEDTFLCSPH
810 820 830 840 850
TCKEMGLSDK ALFRADLALI DTPDAESVAE SRFESQFSPD NDSVYSTQAS
860 870 880 890 900
VLSLHDGACS DGMNYGPSLP SSPPKDVTNS SDLVLGLHLS LEELYTQNLL
910 920 930 940 950
QRQHAGSPPT DMSPAATSGF TVSDYTPANA VEQKYECANT VAWTPSQLPS
960 970 980 990 1000
GLSTTELAPA LPAVAPKYLT EQSSLVSDAE SVTLQSMSQE AFERTVTIAK
1010 1020 1030 1040 1050
GSSSLGMTVS ANKDGLGVIV RSIIHGGAIS RDGRIAVGDC ILSINEESTI
1060 1070 1080 1090 1100
SLTNAQARAM LRRHSLIGPD IKITYVPAEH LEEFRVSFGQ QAGGIMALDI
1110 1120 1130 1140 1150
FSSYTGRDIP ELPEREEGEG EESELQNAAY SSWSQPRRVE LWREPSKSLG
1160 1170 1180 1190 1200
ISIVGGRGMG SRLSNGEVMR GIFIKHVLED SPAGKNGTLK PGDRIVEVDG
1210 1220 1230 1240 1250
MDLRDASHEQ AVEAIRKAGS PVVFMVQSIV NRPRKSPLPS LPHSLYPKCS
1260 1270 1280 1290 1300
FSSTNPFAES LQLTSDKAPS QSESESEKAT LCSVPSSSPS VFSEMSSDYA
1310 1320 1330 1340 1350
QPSATTVAED EDKEDEFGYS WKNIQERYGT LTGQLHMIEL EKGHSGLGLS
1360 1370 1380 1390 1400
LAGNKDRTRM SVFIVGIDPT GAAGRDGRLQ IADELLEING QILYGRSHQN
1410 1420 1430 1440 1450
ASSIIKCAPS KVKIIFIRNA DAVNQMAVCP GSAADPLPST SESPQNKEVE
1460 1470 1480 1490 1500
PSITTSASAV DLSSLTNVYH LELPKDQGGL GIAICEEDTL NGVTIKSLTE
1510 1520 1530 1540 1550
RGGAAKDGRL KPGDRILAVD DELVAGCPIE KFISLLKTAK TTVKLTVGAE
1560 1570 1580 1590 1600
NPGCQAVPSA AVTASGERKD SSQTPAVPAP DLEPIPSTSR SSTPAIFASD
1610 1620 1630 1640 1650
PATCPIIPGC ETTIEISKGQ TGLGLSIVGG SDTLLGAIII HEVYEEGAAC
1660 1670 1680 1690 1700
KDGRLWAGDQ ILEVNGIDLR KATHDEAINV LRQTPQRVRL TLYRDEAPYK
1710 1720 1730 1740 1750
EEDVCDTFTV ELQKRPGKGL GLSIVGKRND TGVFVSDIVK GGIADADGRL
1760 1770 1780 1790 1800
MQGDQILMVN GEDVRNATQE AVAALLKCSL GTVTLEVGRI KAAPFHSERR
1810 1820 1830 1840 1850
PSQSSQVSES SLSSFSLPRS GIHTSESSES SAKKNALASE IQGLRTVEIK
1860 1870 1880 1890 1900
KGPADALGLS IAGGVGSPLG DVPIFIAMMH PNGVAAQTQK LRVGDRIVTI
1910 1920 1930 1940 1950
CGTSTDGMTH TQAVNLMKNA SGSIEVQVVA GGDVSVVTGH QQELANPCLA
1960 1970 1980 1990 2000
FTGLTSSTIF PDDLGPPQSK TITLDRGPDG LGFSIVGGYG SPHGDLPIYV
2010 2020 2030 2040 2050
KTVFAKGAAA EDGRLKRGDQ IIAVNGQSLE GVTHEEAVAI LKRTKGTVTL

MVLS
Length:2,054
Mass (Da):218,592
Last modified:June 1, 1998 - v1
Checksum:i44BD3F42B801F78F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001320 mRNA. Translation: CAA04681.1.
PIRiT46612.
RefSeqiNP_062069.1. NM_019196.1.
UniGeneiRn.6684.

Genome annotation databases

EnsembliENSRNOT00000051028; ENSRNOP00000051321; ENSRNOG00000007894.
GeneIDi29365.
KEGGirno:29365.
UCSCiRGD:3105. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001320 mRNA. Translation: CAA04681.1.
PIRiT46612.
RefSeqiNP_062069.1. NM_019196.1.
UniGeneiRn.6684.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y76NMR-A/C4-65[»]
5DTHX-ray1.95A/B/C/D1312-1422[»]
ProteinModelPortaliO55164.
SMRiO55164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248019. 4 interactors.
IntActiO55164. 1 interactor.
MINTiMINT-143896.
STRINGi10116.ENSRNOP00000051321.

PTM databases

iPTMnetiO55164.
PhosphoSitePlusiO55164.

Proteomic databases

PaxDbiO55164.
PRIDEiO55164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051028; ENSRNOP00000051321; ENSRNOG00000007894.
GeneIDi29365.
KEGGirno:29365.
UCSCiRGD:3105. rat.

Organism-specific databases

CTDi8777.
RGDi3105. Mpdz.

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOGENOMiHOG000231304.
HOVERGENiHBG080134.
InParanoidiO55164.
KOiK06095.
PhylomeDBiO55164.

Miscellaneous databases

EvolutionaryTraceiO55164.
PROiO55164.

Gene expression databases

BgeeiENSRNOG00000007894.
ExpressionAtlasiO55164. baseline and differential.
GenevisibleiO55164. RN.

Family and domain databases

Gene3Di2.30.42.10. 13 hits.
InterProiIPR015132. L27_2.
IPR004172. L27_dom.
IPR032078. MPDZ.
IPR001478. PDZ.
[Graphical view]
PfamiPF09045. L27_2. 1 hit.
PF16667. MPDZ_u10. 1 hit.
PF00595. PDZ. 12 hits.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 13 hits.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 13 hits.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPDZ_RAT
AccessioniPrimary (citable) accession number: O55164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Sequestered into cytoplasmic, detergent-resistant bodies upon Ad9 E4-ORF1 oncoprotein expression. Targeted to degradation upon HPV-18 E6 oncoprotein expression.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.