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Protein

Growth arrest-specific protein 7

Gene

Gas7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 7
Short name:
GAS-7
Gene namesi
Name:Gas7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621550. Gas7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Growth arrest-specific protein 7PRO_0000076059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei108 – 1081PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO55148.
PRIDEiO55148.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064359.

Structurei

3D structure databases

ProteinModelPortaliO55148.
SMRiO55148. Positions 21-56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 5534WWPROSITE-ProRule annotationAdd
BLAST
Domaini141 – 402262F-BARPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili254 – 32976Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
KOG2398. Eukaryota.
ENOG410Z5NV. LUCA.
HOGENOMiHOG000294146.
HOVERGENiHBG001320.
InParanoidiO55148.
PhylomeDBiO55148.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALQKPGM VPPPPGEESQ TVILPPGWHS YLSPQGRRYY VNTTTNETTW
60 70 80 90 100
ERPSSSPGIS ASPGPHRSSL PTTVNGYHAS GTPAHPPETA HMSLRKSTGD
110 120 130 140 150
SQNLGSSSPG RKQSKENTIT INCVTFPHPD TMPEQQLLKP TEWSYCDYFW
160 170 180 190 200
ADKKDPQGNG TVAGFELLLQ KQLKGKQMQK EMSEFIRERI KIEEEYAKNL
210 220 230 240 250
AKLSQNSLAA QEEGSLGEAW AQVKKSLADE AEVHLKFSAK LHSEVEKPLM
260 270 280 290 300
NFRENFKKDM KKCDHHIADL RKQLGESRYA SVEKARKALT ERQKDLEMKT
310 320 330 340 350
QQLEIKLSNK TEEDIKKARR KSTQAGDDLM RCVDLYNQAQ SKWFEEMVTT
360 370 380 390 400
TLELERLEVE RVEMIRQHLC QYTQLRHETD MFNQSTVEPV DQLLRKVDPA
410 420
KDRELWVREH KTGNIRPVDM EI
Length:422
Mass (Da):48,275
Last modified:January 11, 2001 - v2
Checksum:iFD14E4CB4DFB01F9
GO

Sequence cautioni

The sequence CAA05907.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA10525.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003148 mRNA. Translation: CAA05907.1. Different initiation.
AJ131902 mRNA. Translation: CAA10525.1. Different initiation.
UniGeneiRn.17160.

Genome annotation databases

UCSCiRGD:621550. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003148 mRNA. Translation: CAA05907.1. Different initiation.
AJ131902 mRNA. Translation: CAA10525.1. Different initiation.
UniGeneiRn.17160.

3D structure databases

ProteinModelPortaliO55148.
SMRiO55148. Positions 21-56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064359.

Proteomic databases

PaxDbiO55148.
PRIDEiO55148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621550. rat.

Organism-specific databases

RGDi621550. Gas7.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
KOG2398. Eukaryota.
ENOG410Z5NV. LUCA.
HOGENOMiHOG000294146.
HOVERGENiHBG001320.
InParanoidiO55148.
PhylomeDBiO55148.

Miscellaneous databases

NextBioi13947991.
PROiO55148.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat gas-7: a growth-arrest-specific gene in fibroblasts is preferentially expressed in terminally differentiated Purkinje neurons and associated with the differentiation of cultured PC12 cells."
    Chao C.C.-K., Kuo J.D., Su L.J., Liu C.H., Lih C.J., Cohen S.N., Lin-Chao S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGAS7_RAT
AccessioniPrimary (citable) accession number: O55148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 11, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.