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Protein

T-cell leukemia homeobox protein 3

Gene

Tlx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi166 – 22560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell fate specification Source: MGI
  • central nervous system development Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • neuron differentiation Source: MGI
  • neuron fate specification Source: MGI
  • neuron migration Source: MGI
  • regulation of respiratory gaseous exchange by neurological system process Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
  • respiratory gaseous exchange Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 3
Alternative name(s):
Homeobox TLX-3
Homeobox protein Hox-11L2
Respiratory neuron homeobox protein
Gene namesi
Name:Tlx3
Synonyms:Hox11l2, Rnx, Tlx1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1351209. Tlx3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291T-cell leukemia homeobox protein 3PRO_0000049339Add
BLAST

Proteomic databases

PaxDbiO55144.
PRIDEiO55144.

PTM databases

PhosphoSiteiO55144.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040610.
CleanExiMM_TLX3.
GenevisibleiO55144. MM.

Interactioni

Protein-protein interaction databases

BioGridi205124. 34 interactions.
STRINGi10090.ENSMUSP00000047457.

Structurei

3D structure databases

ProteinModelPortaliO55144.
SMRiO55144. Positions 152-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO55144.
KOiK15607.
OMAiXRQTAEE.
OrthoDBiEOG091G0RNV.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG
60 70 80 90 100
RPGAAYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV
110 120 130 140 150
PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV
160 170 180 190 200
TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA
210 220 230 240 250
KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK
260 270 280 290
SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
Length:291
Mass (Da):31,837
Last modified:October 16, 2013 - v2
Checksum:iA0E3B9103D2FA5E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2332ER → DG in CAA11551 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223801 mRNA. Translation: CAA11551.1.
AK141870 mRNA. Translation: BAE24864.1.
AL772409 Genomic DNA. No translation available.
CH466604 Genomic DNA. Translation: EDL23743.1.
BC141308 mRNA. Translation: AAI41309.1.
BC145631 mRNA. Translation: AAI45632.1.
CCDSiCCDS24533.1.
RefSeqiNP_064300.2. NM_019916.2.
UniGeneiMm.25362.

Genome annotation databases

EnsembliENSMUST00000037746; ENSMUSP00000047457; ENSMUSG00000040610.
GeneIDi27140.
KEGGimmu:27140.
UCSCiuc007ikg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223801 mRNA. Translation: CAA11551.1.
AK141870 mRNA. Translation: BAE24864.1.
AL772409 Genomic DNA. No translation available.
CH466604 Genomic DNA. Translation: EDL23743.1.
BC141308 mRNA. Translation: AAI41309.1.
BC145631 mRNA. Translation: AAI45632.1.
CCDSiCCDS24533.1.
RefSeqiNP_064300.2. NM_019916.2.
UniGeneiMm.25362.

3D structure databases

ProteinModelPortaliO55144.
SMRiO55144. Positions 152-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205124. 34 interactions.
STRINGi10090.ENSMUSP00000047457.

PTM databases

PhosphoSiteiO55144.

Proteomic databases

PaxDbiO55144.
PRIDEiO55144.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037746; ENSMUSP00000047457; ENSMUSG00000040610.
GeneIDi27140.
KEGGimmu:27140.
UCSCiuc007ikg.2. mouse.

Organism-specific databases

CTDi30012.
MGIiMGI:1351209. Tlx3.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00840000129678.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO55144.
KOiK15607.
OMAiXRQTAEE.
OrthoDBiEOG091G0RNV.
TreeFamiTF325347.

Miscellaneous databases

PROiO55144.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040610.
CleanExiMM_TLX3.
GenevisibleiO55144. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLX3_MOUSE
AccessioniPrimary (citable) accession number: O55144
Secondary accession number(s): Q5SQB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 16, 2013
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.