Protocadherin-12 precursor - Mus musculus (Mouse)

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O55134 (PCD12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protocadherin-12

Alternative name(s):
Vascular cadherin-2
Vascular endothelial cadherin-2
Short name=VE-cad-2
Short name=VE-cadherin-2

Gene names

Name:

Pcdh12

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Cell junction.
Tissue specificity	Expressed in endothelial cells.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Inferred from direct assay Ref.1. Source: MGI glycogen metabolic process Inferred from mutant phenotype PubMed 18477666. Source: MGI homophilic cell adhesion Inferred from direct assay Ref.1. Source: MGI labyrinthine layer development Inferred from mutant phenotype PubMed 18477666. Source: MGI
Cellular_component	cell-cell junction Inferred from direct assay PubMed 16269175 Ref.1. Source: MGI integral to plasma membrane Inferred from sequence or structural similarity Ref.1. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

17

Potential

Chain

1163

Protocadherin-12

PRO_0000003997

Regions

Topological domain

699

Extracellular Potential

Transmembrane

21

Helical; Potential

Topological domain

443

Cytoplasmic Potential

Domain

108

Cadherin 1

Domain

109

Cadherin 2

Domain

108

Cadherin 3

Domain

106

Cadherin 4

Domain

105

Cadherin 5

Domain

112

Cadherin 6

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O55134 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 97927AD41FC38087
Show »

1,180

128,674

        10         20         30         40         50         60 
MMLLLPFLLG LLGPGSYLFI SGDCQEVATV MVKFQVTEEV PSGTVIGKLS QELRVEERRG 

        70         80         90        100        110        120 
KAGDAFQILQ LPQALPVQMN SEDGLLSTSS RLDREKLCRQ EDPCLVSFDV LATGASALIH 

       130        140        150        160        170        180 
VEIQVLDIND HQPQFPKDEQ ELEISESASL HTRIPLDRAL DQDTGPNSLY SYSLSPSEHF 

       190        200        210        220        230        240 
ALDVIVGPDE TKHAELVVVK ELDRELHSYF DLVLTAYDNG NPPKSGISVV KVNVLDSNDN 

       250        260        270        280        290        300 
SPVFAESSLA LEIPEDTVPG TLLINLTATD PDQGPNGEVE FFFGKHVSPE VMNTFGIDAK 

       310        320        330        340        350        360 
TGQIILRQAL DYEKNPAYEV DVQARDLGPN SIPGHCKVLI KVLDVNDNAP SILITWASQT 

       370        380        390        400        410        420 
SLVSEDLPRD SFIALVSAND LDSGNNGLVH CWLNQELGHF RLKRTNGNTY MLLTNATLDR 

       430        440        450        460        470        480 
EQWPIYTLTV FAQDQGPQPL SAEKELQIQV SDVNDNAPVF EKSRYEVSTW ENNPPSLHLI 

       490        500        510        520        530        540 
TLKAHDADLG SNGKVSYRIK DSPVSHLVII DFETGEVTAQ RSLDYEQMAG FEFQVIAEDR 

       550        560        570        580        590        600 
GQPQLASSIS VWVSLLDAND NAPEVIQPVL SEGKATLSVL VNASTGHLLL PIENPSGMDP 

       610        620        630        640        650        660 
AGTGIPPKAT HSPWSFLLLT IVARDADSGA NGELFYSIQS GNDAHLFFLS PSLGQLFINV 

       670        680        690        700        710        720 
TNASSLIGSQ WDLGIVVEDQ GSPSLQTQVS LKVVFVTSVD HLRDSAHEPG VLSTPALALI 

       730        740        750        760        770        780 
CLAVLLAIFG LLLALFVSIC RTERKDNRAY NCREAESSYR HQPKRPQKHI QKADIHLVPV 

       790        800        810        820        830        840 
LRAHENETDE VRPSHKDTSK ETLMEAGWDS CLEAPFHLTP TLYRTLRNQG NQGELAESQE 

       850        860        870        880        890        900 
VLQDTFNFLF NHPRQRNASR ENLNLPESPP AVRQPLLRPL KVPGSPIARA TGDQDKEEAP 

       910        920        930        940        950        960 
QSPPASSATL RRQRNFNGKV SPRGESGPHQ ILRSLVRLSV AAFAERNPVE EPAGDSPPVQ 

       970        980        990       1000       1010       1020 
QISQLLSLLH QGQFQPKPNH RGNKYLAKPG GSSRGTIPDT EGLVGLKPSG QAEPDLEEGP 

      1030       1040       1050       1060       1070       1080 
PSPEEDLSVK RLLEEELSSL LDPNTGLALD KLSPPDPAWM ARLSLPLTTN YRDNLSSPDA 

      1090       1100       1110       1120       1130       1140 
TTSEEPRTFQ TFGKTVGPGP ELSPTGTRLA STFVSEMSSL LEMLLGQHTV PVEAASAALR 

      1150       1160       1170       1180 
RLSVCGRTLS LDLATSGASA SEAQGRKKAA ESRLGCGRNL

References

[1]	"Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells." Telo P., Breviario F., Huber P., Panzeri C., Dejana E. J. Biol. Chem. 273:17565-17572(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain capillary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08715 mRNA. Translation: CAA69965.1.
IPI	IPI00115860.
PIR	T31066.
RefSeq	NP_059074.2. NM_017378.2.
UniGene	Mm.12862.
3D structure databases
ProteinModelPortal	O55134.
SMR	O55134. Positions 32-566.
ModBase	Search...
Protein-protein interaction databases
IntAct	O55134. 1 interaction.
PTM databases
PhosphoSite	O55134.
Proteomic databases
PaxDb	O55134.
PRIDE	O55134.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	53601.
KEGG	mmu:53601.
UCSC	uc008esb.1. mouse.
Organism-specific databases
CTD	51294.
MGI	MGI:1855700. Pcdh12.
Phylogenomic databases
eggNOG	NOG259169.
HOGENOM	HOG000220893.
HOVERGEN	HBG101142.
InParanoid	O55134.
KO	K16499.
OrthoDB	EOG4SF95C.
Gene expression databases
CleanEx	MM_PCDH12.
Genevestigator	O55134.
GermOnline	ENSMUSG00000024440. Mus musculus.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 4 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	310281.
SOURCE	Search...

Entry information

Entry name

PCD12_MOUSE

Accession

Primary (citable) accession number: O55134

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents