Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O55134 (PCD12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin-12
Alternative name(s):
Vascular cadherin-2
Vascular endothelial cadherin-2
Short name=VE-cad-2
Short name=VE-cadherin-2
Gene names
Name:Pcdh12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cell junction.

Tissue specificity

Expressed in endothelial cells.

Sequence similarities

Contains 6 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 11801163Protocadherin-12
PRO_0000003997

Regions

Topological domain18 – 716699Extracellular Potential
Transmembrane717 – 73721Helical; Potential
Topological domain738 – 1180443Cytoplasmic Potential
Domain28 – 135108Cadherin 1
Domain136 – 244109Cadherin 2
Domain245 – 352108Cadherin 3
Domain355 – 460106Cadherin 4
Domain461 – 565105Cadherin 5
Domain600 – 711112Cadherin 6

Amino acid modifications

Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation4151N-linked (GlcNAc...) Potential
Glycosylation5821N-linked (GlcNAc...) Potential
Glycosylation6591N-linked (GlcNAc...) Potential
Glycosylation6621N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict8131Q → E in CAA69965. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O55134 [UniParc].

Last modified September 18, 2013. Version 2.
Checksum: 1E2BCC09DFCA4085

FASTA1,180128,673
        10         20         30         40         50         60 
MMLLLPFLLG LLGPGSYLFI SGDCQEVATV MVKFQVTEEV PSGTVIGKLS QELRVEERRG 

        70         80         90        100        110        120 
KAGDAFQILQ LPQALPVQMN SEDGLLSTSS RLDREKLCRQ EDPCLVSFDV LATGASALIH 

       130        140        150        160        170        180 
VEIQVLDIND HQPQFPKDEQ ELEISESASL HTRIPLDRAL DQDTGPNSLY SYSLSPSEHF 

       190        200        210        220        230        240 
ALDVIVGPDE TKHAELVVVK ELDRELHSYF DLVLTAYDNG NPPKSGISVV KVNVLDSNDN 

       250        260        270        280        290        300 
SPVFAESSLA LEIPEDTVPG TLLINLTATD PDQGPNGEVE FFFGKHVSPE VMNTFGIDAK 

       310        320        330        340        350        360 
TGQIILRQAL DYEKNPAYEV DVQARDLGPN SIPGHCKVLI KVLDVNDNAP SILITWASQT 

       370        380        390        400        410        420 
SLVSEDLPRD SFIALVSAND LDSGNNGLVH CWLNQELGHF RLKRTNGNTY MLLTNATLDR 

       430        440        450        460        470        480 
EQWPIYTLTV FAQDQGPQPL SAEKELQIQV SDVNDNAPVF EKSRYEVSTW ENNPPSLHLI 

       490        500        510        520        530        540 
TLKAHDADLG SNGKVSYRIK DSPVSHLVII DFETGEVTAQ RSLDYEQMAG FEFQVIAEDR 

       550        560        570        580        590        600 
GQPQLASSIS VWVSLLDAND NAPEVIQPVL SEGKATLSVL VNASTGHLLL PIENPSGMDP 

       610        620        630        640        650        660 
AGTGIPPKAT HSPWSFLLLT IVARDADSGA NGELFYSIQS GNDAHLFFLS PSLGQLFINV 

       670        680        690        700        710        720 
TNASSLIGSQ WDLGIVVEDQ GSPSLQTQVS LKVVFVTSVD HLRDSAHEPG VLSTPALALI 

       730        740        750        760        770        780 
CLAVLLAIFG LLLALFVSIC RTERKDNRAY NCREAESSYR HQPKRPQKHI QKADIHLVPV 

       790        800        810        820        830        840 
LRAHENETDE VRPSHKDTSK ETLMEAGWDS CLQAPFHLTP TLYRTLRNQG NQGELAESQE 

       850        860        870        880        890        900 
VLQDTFNFLF NHPRQRNASR ENLNLPESPP AVRQPLLRPL KVPGSPIARA TGDQDKEEAP 

       910        920        930        940        950        960 
QSPPASSATL RRQRNFNGKV SPRGESGPHQ ILRSLVRLSV AAFAERNPVE EPAGDSPPVQ 

       970        980        990       1000       1010       1020 
QISQLLSLLH QGQFQPKPNH RGNKYLAKPG GSSRGTIPDT EGLVGLKPSG QAEPDLEEGP 

      1030       1040       1050       1060       1070       1080 
PSPEEDLSVK RLLEEELSSL LDPNTGLALD KLSPPDPAWM ARLSLPLTTN YRDNLSSPDA 

      1090       1100       1110       1120       1130       1140 
TTSEEPRTFQ TFGKTVGPGP ELSPTGTRLA STFVSEMSSL LEMLLGQHTV PVEAASAALR 

      1150       1160       1170       1180 
RLSVCGRTLS LDLATSGASA SEAQGRKKAA ESRLGCGRNL 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells."
Telo P., Breviario F., Huber P., Panzeri C., Dejana E.
J. Biol. Chem. 273:17565-17572(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain capillary.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08715 mRNA. Translation: CAA69965.1.
AC133646 Genomic DNA. No translation available.
AC152450 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL10091.1.
CCDSCCDS29199.1.
PIRT31066.
RefSeqNP_059074.2. NM_017378.2.
UniGeneMm.12862.

3D structure databases

ProteinModelPortalO55134.
SMRO55134. Positions 32-566.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO55134. 1 interaction.

PTM databases

PhosphoSiteO55134.

Proteomic databases

PaxDbO55134.
PRIDEO55134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025311; ENSMUSP00000025311; ENSMUSG00000024440.
GeneID53601.
KEGGmmu:53601.
UCSCuc008esb.1. mouse.

Organism-specific databases

CTD51294.
MGIMGI:1855700. Pcdh12.

Phylogenomic databases

eggNOGNOG259169.
GeneTreeENSGT00750000117335.
HOGENOMHOG000220893.
HOVERGENHBG101142.
InParanoidO55134.
KOK16499.
OMAWELEIVV.
OrthoDBEOG7J445X.
TreeFamTF352008.

Gene expression databases

CleanExMM_PCDH12.
GenevestigatorO55134.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio310281.
PROO55134.
SOURCESearch...

Entry information

Entry namePCD12_MOUSE
AccessionPrimary (citable) accession number: O55134
Secondary accession number(s): G5E847
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: September 18, 2013
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot