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O55134

- PCD12_MOUSE

UniProt

O55134 - PCD12_MOUSE

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Protein
Protocadherin-12
Gene
Pcdh12
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: MGI
  2. glycogen metabolic process Source: MGI
  3. homophilic cell adhesion Source: MGI
  4. labyrinthine layer development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-12
Alternative name(s):
Vascular cadherin-2
Vascular endothelial cadherin-2
Short name:
VE-cad-2
Short name:
VE-cadherin-2
Gene namesi
Name:Pcdh12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1855700. Pcdh12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 716699Extracellular Reviewed prediction
Add
BLAST
Transmembranei717 – 73721Helical; Reviewed prediction
Add
BLAST
Topological domaini738 – 1180443Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 11801163Protocadherin-12
PRO_0000003997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi582 – 5821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi659 – 6591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi662 – 6621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO55134.
PRIDEiO55134.

PTM databases

PhosphoSiteiO55134.

Expressioni

Tissue specificityi

Expressed in endothelial cells.

Gene expression databases

CleanExiMM_PCDH12.
GenevestigatoriO55134.

Interactioni

Protein-protein interaction databases

IntActiO55134. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO55134.
SMRiO55134. Positions 32-566.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 135108Cadherin 1
Add
BLAST
Domaini136 – 244109Cadherin 2
Add
BLAST
Domaini245 – 352108Cadherin 3
Add
BLAST
Domaini355 – 460106Cadherin 4
Add
BLAST
Domaini461 – 565105Cadherin 5
Add
BLAST
Domaini600 – 711112Cadherin 6
Add
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259169.
GeneTreeiENSGT00750000117335.
HOGENOMiHOG000220893.
HOVERGENiHBG101142.
InParanoidiO55134.
KOiK16499.
OMAiWELEIVV.
OrthoDBiEOG7J445X.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55134-1 [UniParc]FASTAAdd to Basket

« Hide

MMLLLPFLLG LLGPGSYLFI SGDCQEVATV MVKFQVTEEV PSGTVIGKLS     50
QELRVEERRG KAGDAFQILQ LPQALPVQMN SEDGLLSTSS RLDREKLCRQ 100
EDPCLVSFDV LATGASALIH VEIQVLDIND HQPQFPKDEQ ELEISESASL 150
HTRIPLDRAL DQDTGPNSLY SYSLSPSEHF ALDVIVGPDE TKHAELVVVK 200
ELDRELHSYF DLVLTAYDNG NPPKSGISVV KVNVLDSNDN SPVFAESSLA 250
LEIPEDTVPG TLLINLTATD PDQGPNGEVE FFFGKHVSPE VMNTFGIDAK 300
TGQIILRQAL DYEKNPAYEV DVQARDLGPN SIPGHCKVLI KVLDVNDNAP 350
SILITWASQT SLVSEDLPRD SFIALVSAND LDSGNNGLVH CWLNQELGHF 400
RLKRTNGNTY MLLTNATLDR EQWPIYTLTV FAQDQGPQPL SAEKELQIQV 450
SDVNDNAPVF EKSRYEVSTW ENNPPSLHLI TLKAHDADLG SNGKVSYRIK 500
DSPVSHLVII DFETGEVTAQ RSLDYEQMAG FEFQVIAEDR GQPQLASSIS 550
VWVSLLDAND NAPEVIQPVL SEGKATLSVL VNASTGHLLL PIENPSGMDP 600
AGTGIPPKAT HSPWSFLLLT IVARDADSGA NGELFYSIQS GNDAHLFFLS 650
PSLGQLFINV TNASSLIGSQ WDLGIVVEDQ GSPSLQTQVS LKVVFVTSVD 700
HLRDSAHEPG VLSTPALALI CLAVLLAIFG LLLALFVSIC RTERKDNRAY 750
NCREAESSYR HQPKRPQKHI QKADIHLVPV LRAHENETDE VRPSHKDTSK 800
ETLMEAGWDS CLQAPFHLTP TLYRTLRNQG NQGELAESQE VLQDTFNFLF 850
NHPRQRNASR ENLNLPESPP AVRQPLLRPL KVPGSPIARA TGDQDKEEAP 900
QSPPASSATL RRQRNFNGKV SPRGESGPHQ ILRSLVRLSV AAFAERNPVE 950
EPAGDSPPVQ QISQLLSLLH QGQFQPKPNH RGNKYLAKPG GSSRGTIPDT 1000
EGLVGLKPSG QAEPDLEEGP PSPEEDLSVK RLLEEELSSL LDPNTGLALD 1050
KLSPPDPAWM ARLSLPLTTN YRDNLSSPDA TTSEEPRTFQ TFGKTVGPGP 1100
ELSPTGTRLA STFVSEMSSL LEMLLGQHTV PVEAASAALR RLSVCGRTLS 1150
LDLATSGASA SEAQGRKKAA ESRLGCGRNL 1180
Length:1,180
Mass (Da):128,673
Last modified:September 18, 2013 - v2
Checksum:i1E2BCC09DFCA4085
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti813 – 8131Q → E in CAA69965. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08715 mRNA. Translation: CAA69965.1.
AC133646 Genomic DNA. No translation available.
AC152450 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL10091.1.
CCDSiCCDS29199.1.
PIRiT31066.
RefSeqiNP_059074.2. NM_017378.2.
UniGeneiMm.12862.

Genome annotation databases

EnsembliENSMUST00000025311; ENSMUSP00000025311; ENSMUSG00000024440.
GeneIDi53601.
KEGGimmu:53601.
UCSCiuc008esb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08715 mRNA. Translation: CAA69965.1 .
AC133646 Genomic DNA. No translation available.
AC152450 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL10091.1 .
CCDSi CCDS29199.1.
PIRi T31066.
RefSeqi NP_059074.2. NM_017378.2.
UniGenei Mm.12862.

3D structure databases

ProteinModelPortali O55134.
SMRi O55134. Positions 32-566.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O55134. 1 interaction.

PTM databases

PhosphoSitei O55134.

Proteomic databases

PaxDbi O55134.
PRIDEi O55134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025311 ; ENSMUSP00000025311 ; ENSMUSG00000024440 .
GeneIDi 53601.
KEGGi mmu:53601.
UCSCi uc008esb.1. mouse.

Organism-specific databases

CTDi 51294.
MGIi MGI:1855700. Pcdh12.

Phylogenomic databases

eggNOGi NOG259169.
GeneTreei ENSGT00750000117335.
HOGENOMi HOG000220893.
HOVERGENi HBG101142.
InParanoidi O55134.
KOi K16499.
OMAi WELEIVV.
OrthoDBi EOG7J445X.
TreeFami TF352008.

Miscellaneous databases

NextBioi 310281.
PROi O55134.
SOURCEi Search...

Gene expression databases

CleanExi MM_PCDH12.
Genevestigatori O55134.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells."
    Telo P., Breviario F., Huber P., Panzeri C., Dejana E.
    J. Biol. Chem. 273:17565-17572(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain capillary.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPCD12_MOUSE
AccessioniPrimary (citable) accession number: O55134
Secondary accession number(s): G5E847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: September 18, 2013
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi