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O55134

- PCD12_MOUSE

UniProt

O55134 - PCD12_MOUSE

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Protein

Protocadherin-12

Gene

Pcdh12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  2. glycogen metabolic process Source: MGI
  3. homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
  4. labyrinthine layer development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-12
Alternative name(s):
Vascular cadherin-2
Vascular endothelial cadherin-2
Short name:
VE-cad-2
Short name:
VE-cadherin-2
Gene namesi
Name:Pcdh12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1855700. Pcdh12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 716699ExtracellularSequence AnalysisAdd
BLAST
Transmembranei717 – 73721HelicalSequence AnalysisAdd
BLAST
Topological domaini738 – 1180443CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 11801163Protocadherin-12PRO_0000003997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi662 – 6621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO55134.
PRIDEiO55134.

PTM databases

PhosphoSiteiO55134.

Expressioni

Tissue specificityi

Expressed in endothelial cells.

Gene expression databases

CleanExiMM_PCDH12.
ExpressionAtlasiO55134. baseline and differential.
GenevestigatoriO55134.

Interactioni

Protein-protein interaction databases

IntActiO55134. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO55134.
SMRiO55134. Positions 32-566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 135108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 244109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini245 – 352108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini355 – 460106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini461 – 565105Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini600 – 711112Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259169.
GeneTreeiENSGT00760000118822.
HOGENOMiHOG000220893.
HOVERGENiHBG101142.
InParanoidiO55134.
KOiK16499.
OMAiWELEIVV.
OrthoDBiEOG7J445X.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55134-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLLLPFLLG LLGPGSYLFI SGDCQEVATV MVKFQVTEEV PSGTVIGKLS
60 70 80 90 100
QELRVEERRG KAGDAFQILQ LPQALPVQMN SEDGLLSTSS RLDREKLCRQ
110 120 130 140 150
EDPCLVSFDV LATGASALIH VEIQVLDIND HQPQFPKDEQ ELEISESASL
160 170 180 190 200
HTRIPLDRAL DQDTGPNSLY SYSLSPSEHF ALDVIVGPDE TKHAELVVVK
210 220 230 240 250
ELDRELHSYF DLVLTAYDNG NPPKSGISVV KVNVLDSNDN SPVFAESSLA
260 270 280 290 300
LEIPEDTVPG TLLINLTATD PDQGPNGEVE FFFGKHVSPE VMNTFGIDAK
310 320 330 340 350
TGQIILRQAL DYEKNPAYEV DVQARDLGPN SIPGHCKVLI KVLDVNDNAP
360 370 380 390 400
SILITWASQT SLVSEDLPRD SFIALVSAND LDSGNNGLVH CWLNQELGHF
410 420 430 440 450
RLKRTNGNTY MLLTNATLDR EQWPIYTLTV FAQDQGPQPL SAEKELQIQV
460 470 480 490 500
SDVNDNAPVF EKSRYEVSTW ENNPPSLHLI TLKAHDADLG SNGKVSYRIK
510 520 530 540 550
DSPVSHLVII DFETGEVTAQ RSLDYEQMAG FEFQVIAEDR GQPQLASSIS
560 570 580 590 600
VWVSLLDAND NAPEVIQPVL SEGKATLSVL VNASTGHLLL PIENPSGMDP
610 620 630 640 650
AGTGIPPKAT HSPWSFLLLT IVARDADSGA NGELFYSIQS GNDAHLFFLS
660 670 680 690 700
PSLGQLFINV TNASSLIGSQ WDLGIVVEDQ GSPSLQTQVS LKVVFVTSVD
710 720 730 740 750
HLRDSAHEPG VLSTPALALI CLAVLLAIFG LLLALFVSIC RTERKDNRAY
760 770 780 790 800
NCREAESSYR HQPKRPQKHI QKADIHLVPV LRAHENETDE VRPSHKDTSK
810 820 830 840 850
ETLMEAGWDS CLQAPFHLTP TLYRTLRNQG NQGELAESQE VLQDTFNFLF
860 870 880 890 900
NHPRQRNASR ENLNLPESPP AVRQPLLRPL KVPGSPIARA TGDQDKEEAP
910 920 930 940 950
QSPPASSATL RRQRNFNGKV SPRGESGPHQ ILRSLVRLSV AAFAERNPVE
960 970 980 990 1000
EPAGDSPPVQ QISQLLSLLH QGQFQPKPNH RGNKYLAKPG GSSRGTIPDT
1010 1020 1030 1040 1050
EGLVGLKPSG QAEPDLEEGP PSPEEDLSVK RLLEEELSSL LDPNTGLALD
1060 1070 1080 1090 1100
KLSPPDPAWM ARLSLPLTTN YRDNLSSPDA TTSEEPRTFQ TFGKTVGPGP
1110 1120 1130 1140 1150
ELSPTGTRLA STFVSEMSSL LEMLLGQHTV PVEAASAALR RLSVCGRTLS
1160 1170 1180
LDLATSGASA SEAQGRKKAA ESRLGCGRNL
Length:1,180
Mass (Da):128,673
Last modified:September 18, 2013 - v2
Checksum:i1E2BCC09DFCA4085
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti813 – 8131Q → E in CAA69965. (PubMed:9651350)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08715 mRNA. Translation: CAA69965.1.
AC133646 Genomic DNA. No translation available.
AC152450 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL10091.1.
CCDSiCCDS29199.1.
PIRiT31066.
RefSeqiNP_059074.2. NM_017378.2.
UniGeneiMm.12862.

Genome annotation databases

EnsembliENSMUST00000025311; ENSMUSP00000025311; ENSMUSG00000024440.
GeneIDi53601.
KEGGimmu:53601.
UCSCiuc008esb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08715 mRNA. Translation: CAA69965.1 .
AC133646 Genomic DNA. No translation available.
AC152450 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL10091.1 .
CCDSi CCDS29199.1.
PIRi T31066.
RefSeqi NP_059074.2. NM_017378.2.
UniGenei Mm.12862.

3D structure databases

ProteinModelPortali O55134.
SMRi O55134. Positions 32-566.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O55134. 1 interaction.

PTM databases

PhosphoSitei O55134.

Proteomic databases

PaxDbi O55134.
PRIDEi O55134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025311 ; ENSMUSP00000025311 ; ENSMUSG00000024440 .
GeneIDi 53601.
KEGGi mmu:53601.
UCSCi uc008esb.1. mouse.

Organism-specific databases

CTDi 51294.
MGIi MGI:1855700. Pcdh12.

Phylogenomic databases

eggNOGi NOG259169.
GeneTreei ENSGT00760000118822.
HOGENOMi HOG000220893.
HOVERGENi HBG101142.
InParanoidi O55134.
KOi K16499.
OMAi WELEIVV.
OrthoDBi EOG7J445X.
TreeFami TF352008.

Miscellaneous databases

NextBioi 310281.
PROi O55134.
SOURCEi Search...

Gene expression databases

CleanExi MM_PCDH12.
ExpressionAtlasi O55134. baseline and differential.
Genevestigatori O55134.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells."
    Telo P., Breviario F., Huber P., Panzeri C., Dejana E.
    J. Biol. Chem. 273:17565-17572(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain capillary.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPCD12_MOUSE
AccessioniPrimary (citable) accession number: O55134
Secondary accession number(s): G5E847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: September 18, 2013
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3