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O55131

- SEPT7_MOUSE

UniProt

O55131 - SEPT7_MOUSE

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Protein
Septin-7
Gene
Sept7, Cdc10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891GTP By similarity
Binding sitei115 – 1151GTP; via amide nitrogen By similarity
Binding sitei249 – 2491GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei264 – 2641GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 638GTP By similarity
Nucleotide bindingi194 – 2029GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. protein binding Source: MGI

GO - Biological processi

  1. cilium morphogenesis Source: UniProtKB
  2. mitotic nuclear division Source: UniProtKB-KW
  3. protein heterooligomerization Source: Ensembl
  4. regulation of embryonic cell shape Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-7
Alternative name(s):
CDC10 protein homolog
Gene namesi
Name:Sept7
Synonyms:Cdc10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1335094. Sept7.

Subcellular locationi

Cytoplasm. Chromosomecentromerekinetochore By similarity. Cytoplasmcytoskeletonspindle By similarity. Cleavage furrow By similarity. Midbody By similarity. Cytoplasmcytoskeletoncilium axoneme By similarity
Note: Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase By similarity. Associated with actin stress fibers By similarity.1 Publication

GO - Cellular componenti

  1. axon terminus Source: MGI
  2. axoneme Source: UniProtKB
  3. cell cortex Source: MGI
  4. cleavage furrow Source: UniProtKB-SubCell
  5. condensed chromosome kinetochore Source: UniProtKB-SubCell
  6. midbody Source: UniProtKB-SubCell
  7. nucleolus Source: Ensembl
  8. plasma membrane Source: Ensembl
  9. septin complex Source: InterPro
  10. spindle Source: UniProtKB-SubCell
  11. stress fiber Source: Ensembl
  12. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 436435Septin-7
PRO_0000173529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei29 – 291Phosphotyrosine1 Publication
Modified residuei333 – 3331Phosphoserine By similarity
Modified residuei372 – 3721N6-acetyllysine1 Publication
Modified residuei423 – 4231Phosphoserine By similarity
Modified residuei425 – 4251Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO55131.
PaxDbiO55131.
PRIDEiO55131.

PTM databases

PhosphoSiteiO55131.

Expressioni

Gene expression databases

ArrayExpressiO55131.
BgeeiO55131.
CleanExiMM_SEPT7.
GenevestigatoriO55131.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5, SEPT8, SEPT9 and SEPT11 By similarity.1 Publication

Protein-protein interaction databases

BioGridi231619. 4 interactions.
IntActiO55131. 5 interactions.
MINTiMINT-1865824.

Structurei

3D structure databases

ProteinModelPortaliO55131.
SMRiO55131. Positions 48-315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 315270Septin-type G
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili331 – 436106 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5019.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
KOiK16944.
PhylomeDBiO55131.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008115. Septin7.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01742. SEPTIN7.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55131-1 [UniParc]FASTAAdd to Basket

« Hide

MSVSARSAAA EERSVNCGTM AQPKNLEGYV GFANLPNQVY RKSVKRGFEF    50
TLMVVGESGL GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK 100
EGGVQLLLTI VDTPGFGDAV DNSNCWQPVI DYIDSKFEDY LNAESRVNRR 150
QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK RLHEKVNIIP LIAKADTLTP 200
EECQQFKKQI MKEIQEHKIK IYEFPETDDE EENKLVKKIK DRLPLAVVGS 250
NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT 300
NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK 350
KMEMEMEQVF EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR 400
RQFEEEKANW EAQQRILEQQ NSSRTLEKNK KKGKIF 436
Length:436
Mass (Da):50,550
Last modified:June 1, 1998 - v1
Checksum:i1028CCF14023059C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223782
, AJ223783, AJ223784, AJ223785, AJ223786, AJ223787, AJ223788, AJ223789, AJ223790, AJ223791, AJ223792, AJ223793, AJ223794 Genomic DNA. Translation: CAA11547.1.
BC058587 mRNA. Translation: AAH58587.1.
RefSeqiNP_001192296.1. NM_001205367.1.
UniGeneiMm.270259.

Genome annotation databases

GeneIDi235072.
KEGGimmu:235072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223782
, AJ223783 , AJ223784 , AJ223785 , AJ223786 , AJ223787 , AJ223788 , AJ223789 , AJ223790 , AJ223791 , AJ223792 , AJ223793 , AJ223794 Genomic DNA. Translation: CAA11547.1 .
BC058587 mRNA. Translation: AAH58587.1 .
RefSeqi NP_001192296.1. NM_001205367.1.
UniGenei Mm.270259.

3D structure databases

ProteinModelPortali O55131.
SMRi O55131. Positions 48-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231619. 4 interactions.
IntActi O55131. 5 interactions.
MINTi MINT-1865824.

PTM databases

PhosphoSitei O55131.

Proteomic databases

MaxQBi O55131.
PaxDbi O55131.
PRIDEi O55131.

Protocols and materials databases

DNASUi 235072.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 235072.
KEGGi mmu:235072.

Organism-specific databases

CTDi 989.
MGIi MGI:1335094. Sept7.

Phylogenomic databases

eggNOGi COG5019.
HOGENOMi HOG000233586.
HOVERGENi HBG065093.
KOi K16944.
PhylomeDBi O55131.

Miscellaneous databases

ChiTaRSi SEPT7. mouse.
NextBioi 382505.
PROi O55131.
SOURCEi Search...

Gene expression databases

ArrayExpressi O55131.
Bgeei O55131.
CleanExi MM_SEPT7.
Genevestigatori O55131.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008115. Septin7.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
PIRSFi PIRSF006698. Septin. 1 hit.
PRINTSi PR01742. SEPTIN7.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of murine CDC10 cDNA, gene organization and expression analysis."
    Soulier S., Vilotte J.-L.
    Biochim. Biophys. Acta 1442:339-346(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 25-41; 63-95; 137-146; 186-207; 221-234; 298-309; 333-342 AND 416-424, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  4. "The septin CDCrel-1 is dispensable for normal development and neurotransmitter release."
    Peng X.-R., Jia Z., Zhang Y., Ware J., Trimble W.S.
    Mol. Cell. Biol. 22:378-387(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEPT2 AND SEPT5.
  5. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."
    Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K.
    Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  8. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  9. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-372, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSEPT7_MOUSE
AccessioniPrimary (citable) accession number: O55131
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Coordinated expression with SEPT2 and SEPT6 By similarity.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi