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Protein

Septin-7

Gene

Sept7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity).By similarity

Miscellaneous

Coordinated expression with SEPT2 and SEPT6.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei89GTPBy similarity1
Binding sitei115GTP; via amide nitrogenBy similarity1
Binding sitei249GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei264GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 63GTPBy similarity8
Nucleotide bindingi194 – 202GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • collateral sprouting Source: MGI
  • cortical cytoskeleton organization Source: MGI
  • dendritic spine morphogenesis Source: MGI
  • mitotic cytokinesis Source: MGI
  • positive regulation of non-motile cilium assembly Source: MGI
  • protein heterooligomerization Source: MGI
  • pseudopodium retraction Source: MGI
  • regulation of embryonic cell shape Source: UniProtKB
  • spermatogenesis Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Cell division, Differentiation, Mitosis, Spermatogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-7
Alternative name(s):
CDC10 protein homolog
Gene namesi
Name:Sept7
Synonyms:Cdc10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1335094. Sept7.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Chromosomecentromerekinetochore By similarity
  • Cytoplasmcytoskeletonspindle By similarity
  • Cleavage furrow By similarity
  • Midbody By similarity
  • Cytoplasmcytoskeletoncilium axoneme By similarity
  • Cell projectionciliumflagellum By similarity

  • Note: Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase (By similarity). Associated with actin stress fibers. Found in the sperm annulus (By similarity).By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • axoneme Source: UniProtKB
  • axon terminus Source: MGI
  • cell body Source: MGI
  • cell cortex Source: MGI
  • cleavage furrow Source: UniProtKB-SubCell
  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • microtubule cytoskeleton Source: MGI
  • midbody Source: UniProtKB-SubCell
  • myelin sheath Source: UniProtKB
  • neuron projection Source: MGI
  • non-motile cilium Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
  • septin complex Source: MGI
  • septin cytoskeleton Source: MGI
  • septin filament array Source: MGI
  • septin ring Source: MGI
  • sperm annulus Source: MGI
  • spindle Source: UniProtKB-SubCell
  • stress fiber Source: MGI
  • synapse Source: MGI

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001735292 – 436Septin-7Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei29PhosphotyrosineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei372N6-acetyllysineCombined sources1
Modified residuei423PhosphoserineBy similarity1
Modified residuei425PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO55131.
MaxQBiO55131.
PaxDbiO55131.
PeptideAtlasiO55131.
PRIDEiO55131.

PTM databases

iPTMnetiO55131.
PhosphoSitePlusiO55131.
SwissPalmiO55131.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001833.
CleanExiMM_SEPT7.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT6, while interaction with SEPT2 seems indirect. In the absence of SEPT6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7. Interacts with SEPT5, SEPT8, SEPT9 and SEPT11. Component of a septin core octomeric complex consisting of SEPT12, SEPT7, SEPT6 and SEPT2 or SEPT4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus; the SEPT12:SEPT7 association is mediated by the respective GTP-binding domains (By similarity).By similarity

GO - Molecular functioni

  • cadherin binding Source: MGI
  • identical protein binding Source: MGI
  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi231619. 17 interactors.
IntActiO55131. 7 interactors.
MINTiMINT-1865824.
STRINGi10090.ENSMUSP00000127641.

Structurei

3D structure databases

ProteinModelPortaliO55131.
SMRiO55131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 315Septin-type GAdd BLAST270

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 316Interaction with SEPT12By similarityAdd BLAST271

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili331 – 436Sequence analysisAdd BLAST106

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiO55131.
KOiK16944.
PhylomeDBiO55131.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
InterProiView protein in InterPro
IPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008115. Septin7.
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiView protein in Pfam
PF00735. Septin. 1 hit.
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01742. SEPTIN7.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51719. G_SEPTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSARSAAA EERSVNCGTM AQPKNLEGYV GFANLPNQVY RKSVKRGFEF
60 70 80 90 100
TLMVVGESGL GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK
110 120 130 140 150
EGGVQLLLTI VDTPGFGDAV DNSNCWQPVI DYIDSKFEDY LNAESRVNRR
160 170 180 190 200
QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK RLHEKVNIIP LIAKADTLTP
210 220 230 240 250
EECQQFKKQI MKEIQEHKIK IYEFPETDDE EENKLVKKIK DRLPLAVVGS
260 270 280 290 300
NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT
310 320 330 340 350
NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK
360 370 380 390 400
KMEMEMEQVF EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR
410 420 430
RQFEEEKANW EAQQRILEQQ NSSRTLEKNK KKGKIF
Length:436
Mass (Da):50,550
Last modified:June 1, 1998 - v1
Checksum:i1028CCF14023059C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223782
, AJ223783, AJ223784, AJ223785, AJ223786, AJ223787, AJ223788, AJ223789, AJ223790, AJ223791, AJ223792, AJ223793, AJ223794 Genomic DNA. Translation: CAA11547.1.
BC058587 mRNA. Translation: AAH58587.1.
RefSeqiNP_001192296.1. NM_001205367.1.
UniGeneiMm.270259.

Genome annotation databases

GeneIDi235072.
KEGGimmu:235072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223782
, AJ223783, AJ223784, AJ223785, AJ223786, AJ223787, AJ223788, AJ223789, AJ223790, AJ223791, AJ223792, AJ223793, AJ223794 Genomic DNA. Translation: CAA11547.1.
BC058587 mRNA. Translation: AAH58587.1.
RefSeqiNP_001192296.1. NM_001205367.1.
UniGeneiMm.270259.

3D structure databases

ProteinModelPortaliO55131.
SMRiO55131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231619. 17 interactors.
IntActiO55131. 7 interactors.
MINTiMINT-1865824.
STRINGi10090.ENSMUSP00000127641.

PTM databases

iPTMnetiO55131.
PhosphoSitePlusiO55131.
SwissPalmiO55131.

Proteomic databases

EPDiO55131.
MaxQBiO55131.
PaxDbiO55131.
PeptideAtlasiO55131.
PRIDEiO55131.

Protocols and materials databases

DNASUi235072.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi235072.
KEGGimmu:235072.

Organism-specific databases

CTDi989.
MGIiMGI:1335094. Sept7.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiO55131.
KOiK16944.
PhylomeDBiO55131.

Miscellaneous databases

ChiTaRSiSept7. mouse.
PROiPR:O55131.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001833.
CleanExiMM_SEPT7.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
InterProiView protein in InterPro
IPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008115. Septin7.
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiView protein in Pfam
PF00735. Septin. 1 hit.
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01742. SEPTIN7.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51719. G_SEPTIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT7_MOUSE
AccessioniPrimary (citable) accession number: O55131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: June 7, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.