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O55127 (CP26A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 26A1

EC=1.14.-.-
Alternative name(s):
Cytochrome P450RAI
Retinoic acid 4-hydroxylase
Retinoic acid-metabolizing cytochrome
Gene names
Name:Cyp26a1
Synonyms:Cyp26, P450ra
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By retinoic acid.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Cytochrome P450 26A1
PRO_0000051981

Sites

Metal binding4421Iron (heme axial ligand) Potential

Experimental info

Sequence conflict91S → T in AAD17217. Ref.3
Sequence conflict1541L → P in AAH12673. Ref.4
Sequence conflict3561I → T in AAH12673. Ref.4
Sequence conflict4921Y → H in AAH12673. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O55127 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 33B07D7C29134471

FASTA49756,178
        10         20         30         40         50         60 
MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG FPFFGETLQM 

        70         80         90        100        110        120 
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL 

       130        140        150        160        170        180 
GAGCLSNLHD SSHKQRKKVI MQAFSREALQ CYVLVIAEEV SSCLEQWLSC GERGLLVYPE 

       190        200        210        220        230        240 
VKRLMFRIAM RILLGCEPGP AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR 

       250        260        270        280        290        300 
NLIHARIEEN IRAKIRRLQA TEPDGGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 

       310        320        330        340        350        360 
GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSN QDNKLDMETL EQLKYIGCVI 

       370        380        390        400        410        420 
KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVADIFTN KEEFNPDRFI 

       430        440        450        460        470        480 
VPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV 

       490 
YPVDNLPARF TYFQGDI 

« Hide

References

« Hide 'large scale' references
[1]"Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos."
Fujii H., Sato T., Kaneko S., Gotoh O., Fujii-Kuriyama Y., Osawa K., Kato S., Hamada H.
EMBO J. 16:4163-4173(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H.
[2]"Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha."
Abu-Abed S.S., Beckett B.R., Chiba H., Chithalen J.V., Jones G., Metzger D., Chambon P., Petkovich M.
J. Biol. Chem. 273:2409-2415(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system."
Paine C.T., Paine M.L., Snead M.L.
Connect. Tissue Res. 38:257-267(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tooth.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12657 mRNA. Translation: CAA73206.1.
AF115769 mRNA. Translation: AAD17217.1.
BC012673 mRNA. Translation: AAH12673.1.
RefSeqNP_031837.2. NM_007811.2.
UniGeneMm.42230.

3D structure databases

ProteinModelPortalO55127.
SMRO55127. Positions 41-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025946.

Proteomic databases

PRIDEO55127.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025946; ENSMUSP00000025946; ENSMUSG00000024987.
GeneID13082.
KEGGmmu:13082.
UCSCuc008his.2. mouse.

Organism-specific databases

CTD1592.
MGIMGI:1096359. Cyp26a1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00660000095370.
HOGENOMHOG000220829.
HOVERGENHBG051099.
InParanoidO55127.
KOK07437.
OrthoDBEOG7F24SP.
PhylomeDBO55127.
TreeFamTF105093.

Gene expression databases

BgeeO55127.
GenevestigatorO55127.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00465. EP450IV.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283042.
PROO55127.
SOURCESearch...

Entry information

Entry nameCP26A_MOUSE
AccessionPrimary (citable) accession number: O55127
Secondary accession number(s): Q9R1F4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot