Cytochrome P450 26A1 - Mus musculus (Mouse)

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O55127 (CP26A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome P450 26A1
EC=1.14.-.-

Alternative name(s):
Cytochrome P450RAI
Retinoic acid 4-hydroxylase
Retinoic acid-metabolizing cytochrome

Gene names

Name:	Cyp26a1
Synonyms:	Cyp26, P450ra

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	By retinoic acid.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 17067568. Source: MGI cellular response to retinoic acid Inferred from expression pattern PubMed 18816858. Source: UniProtKB central nervous system development Inferred from mutant phenotype PubMed 17067568. Source: MGI neural crest cell development Inferred from genetic interaction PubMed 17067568. Source: MGI retinoic acid catabolic process Inferred from sequence alignment PubMed 10588879. Source: MGI retinoic acid receptor signaling pathway Inferred from genetic interaction PubMed 17067568. Source: MGI
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro retinoic acid 4-hydroxylase activity Inferred from electronic annotation. Source: Compara retinoic acid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 497

497

Cytochrome P450 26A1

PRO_0000051981

Sites

Metal binding

442

Iron (heme axial ligand) Potential

Experimental info

Sequence conflict

S → T in AAD17217. Ref.3

Sequence conflict

154

L → P in AAH12673. Ref.4

Sequence conflict

356

I → T in AAH12673. Ref.4

Sequence conflict

492

Y → H in AAH12673. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

O55127 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 33B07D7C29134471
Show »

FASTA

497

56,178

        10         20         30         40         50         60 
MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG FPFFGETLQM 

        70         80         90        100        110        120 
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL 

       130        140        150        160        170        180 
GAGCLSNLHD SSHKQRKKVI MQAFSREALQ CYVLVIAEEV SSCLEQWLSC GERGLLVYPE 

       190        200        210        220        230        240 
VKRLMFRIAM RILLGCEPGP AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR 

       250        260        270        280        290        300 
NLIHARIEEN IRAKIRRLQA TEPDGGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 

       310        320        330        340        350        360 
GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSN QDNKLDMETL EQLKYIGCVI 

       370        380        390        400        410        420 
KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVADIFTN KEEFNPDRFI 

       430        440        450        460        470        480 
VPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV 

       490 
YPVDNLPARF TYFQGDI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos." Fujii H., Sato T., Kaneko S., Gotoh O., Fujii-Kuriyama Y., Osawa K., Kato S., Hamada H. EMBO J. 16:4163-4173(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C3H.
[2]	"Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha." Abu-Abed S.S., Beckett B.R., Chiba H., Chithalen J.V., Jones G., Metzger D., Chambon P., Petkovich M. J. Biol. Chem. 273:2409-2415(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system." Paine C.T., Paine M.L., Snead M.L. Connect. Tissue Res. 38:257-267(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Tooth.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y12657 mRNA. Translation: CAA73206.1. AF115769 mRNA. Translation: AAD17217.1. BC012673 mRNA. Translation: AAH12673.1.
IPI	IPI00115829.
RefSeq	NP_031837.2. NM_007811.2.
UniGene	Mm.42230.
3D structure databases
ProteinModelPortal	O55127.
SMR	O55127. Positions 41-490.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000025946.
Proteomic databases
PRIDE	O55127.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025946; ENSMUSP00000025946; ENSMUSG00000024987.
GeneID	13082.
KEGG	mmu:13082.
UCSC	uc008his.2. mouse.
Organism-specific databases
CTD	1592.
MGI	MGI:1096359. Cyp26a1.
Phylogenomic databases
eggNOG	COG2124.
GeneTree	ENSGT00660000095370.
HOGENOM	HOG000220829.
HOVERGEN	HBG051099.
InParanoid	O55127.
KO	K07437.
OrthoDB	EOG4BP1BM.
Gene expression databases
Bgee	O55127.
Genevestigator	O55127.
GermOnline	ENSMUSG00000024987. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002403. Cyt_P450_E_grp-IV. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00465. EP450IV. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283042.
SOURCE	Search...

Entry information

Entry name

CP26A_MOUSE

Accession

Primary (citable) accession number: O55127
Secondary accession number(s): Q9R1F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents