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Protein

Cytochrome P450 26A1

Gene

Cyp26a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)Sequence Analysis

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. retinoic acid 4-hydroxylase activity Source: MGI
  4. retinoic acid binding Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. cellular response to retinoic acid Source: UniProtKB
  3. central nervous system development Source: MGI
  4. neural crest cell development Source: MGI
  5. retinoic acid catabolic process Source: MGI
  6. retinoic acid metabolic process Source: MGI
  7. retinoic acid receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_310468. RA biosynthesis pathway.
REACT_315248. Vitamins.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26A1 (EC:1.14.-.-)
Alternative name(s):
Cytochrome P450RAI
Retinoic acid 4-hydroxylase
Retinoic acid-metabolizing cytochrome
Gene namesi
Name:Cyp26a1
Synonyms:Cyp26, P450ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1096359. Cyp26a1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Cytochrome P450 26A1PRO_0000051981Add
BLAST

Proteomic databases

PRIDEiO55127.

Expressioni

Inductioni

By retinoic acid.

Gene expression databases

BgeeiO55127.
GenevestigatoriO55127.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025946.

Structurei

3D structure databases

ProteinModelPortaliO55127.
SMRiO55127. Positions 41-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
InParanoidiO55127.
KOiK07437.
OrthoDBiEOG7F24SP.
PhylomeDBiO55127.
TreeFamiTF105093.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG
60 70 80 90 100
FPFFGETLQM VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI
110 120 130 140 150
LLGEHRLVSV HWPASVRTIL GAGCLSNLHD SSHKQRKKVI MQAFSREALQ
160 170 180 190 200
CYVLVIAEEV SSCLEQWLSC GERGLLVYPE VKRLMFRIAM RILLGCEPGP
210 220 230 240 250
AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR NLIHARIEEN
260 270 280 290 300
IRAKIRRLQA TEPDGGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG
310 320 330 340 350
GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSN QDNKLDMETL
360 370 380 390 400
EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD
410 420 430 440 450
THDVADIFTN KEEFNPDRFI VPHPEDASRF SFIPFGGGLR SCVGKEFAKI
460 470 480 490
LLKIFTVELA RHCDWQLLNG PPTMKTSPTV YPVDNLPARF TYFQGDI
Length:497
Mass (Da):56,178
Last modified:June 1, 1998 - v1
Checksum:i33B07D7C29134471
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91S → T in AAD17217 (PubMed:11063033).Curated
Sequence conflicti154 – 1541L → P in AAH12673 (PubMed:15489334).Curated
Sequence conflicti356 – 3561I → T in AAH12673 (PubMed:15489334).Curated
Sequence conflicti492 – 4921Y → H in AAH12673 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12657 mRNA. Translation: CAA73206.1.
AF115769 mRNA. Translation: AAD17217.1.
BC012673 mRNA. Translation: AAH12673.1.
CCDSiCCDS29780.1.
RefSeqiNP_031837.2. NM_007811.2.
UniGeneiMm.42230.

Genome annotation databases

GeneIDi13082.
KEGGimmu:13082.
UCSCiuc008his.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12657 mRNA. Translation: CAA73206.1.
AF115769 mRNA. Translation: AAD17217.1.
BC012673 mRNA. Translation: AAH12673.1.
CCDSiCCDS29780.1.
RefSeqiNP_031837.2. NM_007811.2.
UniGeneiMm.42230.

3D structure databases

ProteinModelPortaliO55127.
SMRiO55127. Positions 41-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025946.

Proteomic databases

PRIDEiO55127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13082.
KEGGimmu:13082.
UCSCiuc008his.2. mouse.

Organism-specific databases

CTDi1592.
MGIiMGI:1096359. Cyp26a1.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
InParanoidiO55127.
KOiK07437.
OrthoDBiEOG7F24SP.
PhylomeDBiO55127.
TreeFamiTF105093.

Enzyme and pathway databases

ReactomeiREACT_310468. RA biosynthesis pathway.
REACT_315248. Vitamins.

Miscellaneous databases

NextBioi283042.
PROiO55127.
SOURCEiSearch...

Gene expression databases

BgeeiO55127.
GenevestigatoriO55127.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos."
    Fujii H., Sato T., Kaneko S., Gotoh O., Fujii-Kuriyama Y., Osawa K., Kato S., Hamada H.
    EMBO J. 16:4163-4173(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
  2. "Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha."
    Abu-Abed S.S., Beckett B.R., Chiba H., Chithalen J.V., Jones G., Metzger D., Chambon P., Petkovich M.
    J. Biol. Chem. 273:2409-2415(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system."
    Paine C.T., Paine M.L., Snead M.L.
    Connect. Tissue Res. 38:257-267(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tooth.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP26A_MOUSE
AccessioniPrimary (citable) accession number: O55127
Secondary accession number(s): Q9R1F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 1, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.