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O55127

- CP26A_MOUSE

UniProt

O55127 - CP26A_MOUSE

Protein

Cytochrome P450 26A1

Gene

Cyp26a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)Sequence Analysis

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. retinoic acid 4-hydroxylase activity Source: Ensembl
    4. retinoic acid binding Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. cellular response to retinoic acid Source: UniProtKB
    3. central nervous system development Source: MGI
    4. neural crest cell development Source: MGI
    5. retinoic acid catabolic process Source: MGI
    6. retinoic acid metabolic process Source: MGI
    7. retinoic acid receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_213027. Vitamins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 26A1 (EC:1.14.-.-)
    Alternative name(s):
    Cytochrome P450RAI
    Retinoic acid 4-hydroxylase
    Retinoic acid-metabolizing cytochrome
    Gene namesi
    Name:Cyp26a1
    Synonyms:Cyp26, P450ra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1096359. Cyp26a1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Cytochrome P450 26A1PRO_0000051981Add
    BLAST

    Proteomic databases

    PRIDEiO55127.

    Expressioni

    Inductioni

    By retinoic acid.

    Gene expression databases

    BgeeiO55127.
    GenevestigatoriO55127.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000025946.

    Structurei

    3D structure databases

    ProteinModelPortaliO55127.
    SMRiO55127. Positions 41-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00660000095370.
    HOGENOMiHOG000220829.
    HOVERGENiHBG051099.
    InParanoidiO55127.
    KOiK07437.
    OrthoDBiEOG7F24SP.
    PhylomeDBiO55127.
    TreeFamiTF105093.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00465. EP450IV.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55127-1 [UniParc]FASTAAdd to Basket

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    MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG    50
    FPFFGETLQM VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI 100
    LLGEHRLVSV HWPASVRTIL GAGCLSNLHD SSHKQRKKVI MQAFSREALQ 150
    CYVLVIAEEV SSCLEQWLSC GERGLLVYPE VKRLMFRIAM RILLGCEPGP 200
    AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR NLIHARIEEN 250
    IRAKIRRLQA TEPDGGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 300
    GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSN QDNKLDMETL 350
    EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD 400
    THDVADIFTN KEEFNPDRFI VPHPEDASRF SFIPFGGGLR SCVGKEFAKI 450
    LLKIFTVELA RHCDWQLLNG PPTMKTSPTV YPVDNLPARF TYFQGDI 497
    Length:497
    Mass (Da):56,178
    Last modified:June 1, 1998 - v1
    Checksum:i33B07D7C29134471
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91S → T in AAD17217. (PubMed:11063033)Curated
    Sequence conflicti154 – 1541L → P in AAH12673. (PubMed:15489334)Curated
    Sequence conflicti356 – 3561I → T in AAH12673. (PubMed:15489334)Curated
    Sequence conflicti492 – 4921Y → H in AAH12673. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12657 mRNA. Translation: CAA73206.1.
    AF115769 mRNA. Translation: AAD17217.1.
    BC012673 mRNA. Translation: AAH12673.1.
    CCDSiCCDS29780.1.
    RefSeqiNP_031837.2. NM_007811.2.
    UniGeneiMm.42230.

    Genome annotation databases

    EnsembliENSMUST00000025946; ENSMUSP00000025946; ENSMUSG00000024987.
    GeneIDi13082.
    KEGGimmu:13082.
    UCSCiuc008his.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12657 mRNA. Translation: CAA73206.1 .
    AF115769 mRNA. Translation: AAD17217.1 .
    BC012673 mRNA. Translation: AAH12673.1 .
    CCDSi CCDS29780.1.
    RefSeqi NP_031837.2. NM_007811.2.
    UniGenei Mm.42230.

    3D structure databases

    ProteinModelPortali O55127.
    SMRi O55127. Positions 41-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000025946.

    Proteomic databases

    PRIDEi O55127.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025946 ; ENSMUSP00000025946 ; ENSMUSG00000024987 .
    GeneIDi 13082.
    KEGGi mmu:13082.
    UCSCi uc008his.2. mouse.

    Organism-specific databases

    CTDi 1592.
    MGIi MGI:1096359. Cyp26a1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00660000095370.
    HOGENOMi HOG000220829.
    HOVERGENi HBG051099.
    InParanoidi O55127.
    KOi K07437.
    OrthoDBi EOG7F24SP.
    PhylomeDBi O55127.
    TreeFami TF105093.

    Enzyme and pathway databases

    Reactomei REACT_213027. Vitamins.

    Miscellaneous databases

    NextBioi 283042.
    PROi O55127.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55127.
    Genevestigatori O55127.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00465. EP450IV.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos."
      Fujii H., Sato T., Kaneko S., Gotoh O., Fujii-Kuriyama Y., Osawa K., Kato S., Hamada H.
      EMBO J. 16:4163-4173(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
    2. "Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha."
      Abu-Abed S.S., Beckett B.R., Chiba H., Chithalen J.V., Jones G., Metzger D., Chambon P., Petkovich M.
      J. Biol. Chem. 273:2409-2415(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system."
      Paine C.T., Paine M.L., Snead M.L.
      Connect. Tissue Res. 38:257-267(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Tooth.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP26A_MOUSE
    AccessioniPrimary (citable) accession number: O55127
    Secondary accession number(s): Q9R1F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3