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O55112

- AFF2_MOUSE

UniProt

O55112 - AFF2_MOUSE

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Protein

AF4/FMR2 family member 2

Gene

Aff2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.1 Publication

GO - Molecular functioni

  1. G-quadruplex RNA binding Source: UniProtKB

GO - Biological processi

  1. learning or memory Source: MGI
  2. mRNA processing Source: UniProtKB-KW
  3. regulation of RNA splicing Source: UniProtKB
  4. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AF4/FMR2 family member 2
Alternative name(s):
FMR2P
Fragile X mental retardation protein 2 homolog
Short name:
Protein FMR-2
Protein Ox19
Gene namesi
Name:Aff2
Synonyms:Fmr2, Ox19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1202294. Aff2.

Subcellular locationi

Nucleus speckle 1 Publication
Note: When splicing or transcription are inhibited, accumulates in large, rounded speckles and in the nucleolus.By similarity

GO - Cellular componenti

  1. nuclear speck Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12721272AF4/FMR2 family member 2PRO_0000215913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei395 – 3951PhosphoserineBy similarity
Modified residuei396 – 3961PhosphoserineBy similarity
Modified residuei482 – 4821PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO55112.

PTM databases

PhosphoSiteiO55112.

Expressioni

Tissue specificityi

Highly expressed in the hippocampus, the piriform cortex, Purkinje cells and the cingulate gyrus.

Developmental stagei

Expressed before day 7 in the embryo and reached its highest levels at 10.5-11.5 days. In the embryo at day 11, expression is more specific in the roof of the hind brain and the lateral ventricle of the brain.

Gene expression databases

BgeeiO55112.
CleanExiMM_AFF2.
GenevestigatoriO55112.

Interactioni

Protein-protein interaction databases

BioGridi199717. 2 interactions.
STRINGi10090.ENSMUSP00000033532.

Structurei

3D structure databases

ProteinModelPortaliO55112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AF4 family.Curated

Phylogenomic databases

eggNOGiNOG69292.
GeneTreeiENSGT00530000063217.
HOGENOMiHOG000246991.
HOVERGENiHBG004189.
InParanoidiO55112.
KOiK15194.
OMAiDEFTWPK.
OrthoDBiEOG767390.
PhylomeDBiO55112.
TreeFamiTF326216.

Family and domain databases

InterProiIPR007797. TF_AF4/FMR2.
[Graphical view]
PANTHERiPTHR10528. PTHR10528. 1 hit.
PfamiPF05110. AF-4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55112-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLFDFFRDW DLEQQCHYEQ DRSALKKREW ERRNQEVQQE EDLFSSGFDL
60 70 80 90 100
FGEPYKVAEY TNKGDALANR VQNTLGSYDE MKDLLSNHSS QNHLVGIPKN
110 120 130 140 150
SAPQTPISKS EASFYPEQKN RMIPSHQETT HSSTPMPPPS VVILNSTLIH
160 170 180 190 200
SNRKSKSEWP RDSHNTSPAQ ASQTSSQPNK MQTSTQDPPQ TRLEDFFVYP
210 220 230 240 250
AEQPQIGTVE KSNPSSKEEN NPNSGGEDTF KEIFQSNSPE ESEFTVQAPG
260 270 280 290 300
SPLVASSLLA PSSGLSVPTF PPGLYCKTSM GQQKPTAYVR PMDGQDQATD
310 320 330 340 350
ISPTLKPSIE FENSFGNLSF GSLLDGKPSA VSSKTKLPKF TILQTSEVSL
360 370 380 390 400
TSDPSCVEEI LRESQHLTPG FTLQKWSDPS SRASTKMLED DLKLSSDEDD
410 420 430 440 450
LEPVKTLTTQ CTANELYQAV EKAKPKNNPV NPLLATPQST PATQTNVGSG
460 470 480 490 500
SSSESESSSE SDSDTESSTT DSESNEAPRV ATPEPEPPST NKWQLDKWLN
510 520 530 540 550
KVTSQNKSFI CGQNETPTET ISLPPPIIQP VEVQVKVKPN PSQAVAVPKE
560 570 580 590 600
RPLLSLIREK ARPRPTQKTP ETKALKHKLS TSVDTVSQRT IGKKQPKKVE
610 620 630 640 650
KNTSFEEFTW PKPNITNSTP KEKGSVELPD PPRSRNKATA HKPVPRKEPR
660 670 680 690 700
PHVPLATEKK KYRGPGKIVP KSREFIETDS STSDSNTDQE ETLQIKVLPP
710 720 730 740 750
CITSKSKETS NASLTLSTLT NGNSNNLSTS NEETAFSPPP AMQTELLSPL
760 770 780 790 800
RDHENPKNLW VKIDLDLLSR VPGQNSVPVT PAKTDYKETA SKPKRQTAAT
810 820 830 840 850
AVEKPAPKGK RKHKPAETAE KIPEKKQRLE DNTTICLLPP CISPAPPHKP
860 870 880 890 900
PSTRENSSRR ANRKKEEKLF PPALSPLAED PPRRRNVSGN NGHFGQDKNI
910 920 930 940 950
SMAGQITSSK PKRSEGKFCA TFKGISINEG DAPKKAASAT VTVANMALAT
960 970 980 990 1000
ATATATVPAI VTATVTATAT TTATATTTTT TTTISSITPT ITSGLMDSSH
1010 1020 1030 1040 1050
LEMTSWAALP LLSSSSANVR RPKLTFDDSV HNADFYMQEA KKLKHKADAL
1060 1070 1080 1090 1100
FEKFGKAVNY ADAALSFTEC GNAMERDPLE AKSPYTMYSE TVELLRYAMR
1110 1120 1130 1140 1150
LKNFASPLAS DGDKKLAVLC YRCLSLLYLR MFKLKKDHAM KYSRSLMEYF
1160 1170 1180 1190 1200
KQNASKVTQI PSPWVGNGKN TPSPVSLNNV SPINSVGNCN NGPVTIPQRI
1210 1220 1230 1240 1250
HHMAASHVNI TSNVLRGYEH WDMADKLTRD NKEFFGDLDT LMGPLTQHSS
1260 1270
MTNLVRYVRQ GLCWLRIDAH LL
Length:1,272
Mass (Da):140,181
Last modified:February 9, 2010 - v2
Checksum:i1CE41F1AEFE9C2B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti432 – 4321P → S in CAA04821. (PubMed:9467002)Curated
Sequence conflicti544 – 5441A → S in CAA04821. (PubMed:9467002)Curated
Sequence conflicti941 – 9411V → A in CAA04821. (PubMed:9467002)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001549 mRNA. Translation: CAA04821.1.
AL663113
, AL672120, AL808131, BX294655 Genomic DNA. Translation: CAM17463.1.
BX294655
, AL663113, AL672120, AL808131 Genomic DNA. Translation: CAM20870.1.
AL808131
, AL663113, AL672120, BX294655 Genomic DNA. Translation: CAM22352.1.
CCDSiCCDS30173.1.
PIRiT30248.
RefSeqiNP_032058.2. NM_008032.3.
UniGeneiMm.466576.

Genome annotation databases

EnsembliENSMUST00000033532; ENSMUSP00000033532; ENSMUSG00000031189.
GeneIDi14266.
KEGGimmu:14266.
UCSCiuc009tjb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001549 mRNA. Translation: CAA04821.1 .
AL663113
, AL672120 , AL808131 , BX294655 Genomic DNA. Translation: CAM17463.1 .
BX294655
, AL663113 , AL672120 , AL808131 Genomic DNA. Translation: CAM20870.1 .
AL808131
, AL663113 , AL672120 , BX294655 Genomic DNA. Translation: CAM22352.1 .
CCDSi CCDS30173.1.
PIRi T30248.
RefSeqi NP_032058.2. NM_008032.3.
UniGenei Mm.466576.

3D structure databases

ProteinModelPortali O55112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199717. 2 interactions.
STRINGi 10090.ENSMUSP00000033532.

PTM databases

PhosphoSitei O55112.

Proteomic databases

PRIDEi O55112.

Protocols and materials databases

DNASUi 14266.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033532 ; ENSMUSP00000033532 ; ENSMUSG00000031189 .
GeneIDi 14266.
KEGGi mmu:14266.
UCSCi uc009tjb.1. mouse.

Organism-specific databases

CTDi 2334.
MGIi MGI:1202294. Aff2.

Phylogenomic databases

eggNOGi NOG69292.
GeneTreei ENSGT00530000063217.
HOGENOMi HOG000246991.
HOVERGENi HBG004189.
InParanoidi O55112.
KOi K15194.
OMAi DEFTWPK.
OrthoDBi EOG767390.
PhylomeDBi O55112.
TreeFami TF326216.

Miscellaneous databases

NextBioi 285623.
PROi O55112.
SOURCEi Search...

Gene expression databases

Bgeei O55112.
CleanExi MM_AFF2.
Genevestigatori O55112.

Family and domain databases

InterProi IPR007797. TF_AF4/FMR2.
[Graphical view ]
PANTHERi PTHR10528. PTHR10528. 1 hit.
Pfami PF05110. AF-4. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the murine homologue of FMR2 in mouse brain and during development."
    Chakrabarti L., Bristulf J., Foss G.S., Davies K.E.
    Hum. Mol. Genet. 7:441-448(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure."
    Bensaid M., Melko M., Bechara E.G., Davidovic L., Berretta A., Catania M.V., Gecz J., Lalli E., Bardoni B.
    Nucleic Acids Res. 37:1269-1279(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAFF2_MOUSE
AccessioniPrimary (citable) accession number: O55112
Secondary accession number(s): B1ATW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 9, 2010
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3