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O55112

- AFF2_MOUSE

UniProt

O55112 - AFF2_MOUSE

Protein

AF4/FMR2 family member 2

Gene

Aff2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.1 Publication

    GO - Molecular functioni

    1. G-quadruplex RNA binding Source: UniProtKB

    GO - Biological processi

    1. learning or memory Source: MGI
    2. mRNA processing Source: UniProtKB-KW
    3. regulation of RNA splicing Source: UniProtKB
    4. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AF4/FMR2 family member 2
    Alternative name(s):
    FMR2P
    Fragile X mental retardation protein 2 homolog
    Short name:
    Protein FMR-2
    Protein Ox19
    Gene namesi
    Name:Aff2
    Synonyms:Fmr2, Ox19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1202294. Aff2.

    Subcellular locationi

    Nucleus speckle 1 Publication
    Note: When splicing or transcription are inhibited, accumulates in large, rounded speckles and in the nucleolus.By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12721272AF4/FMR2 family member 2PRO_0000215913Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei395 – 3951PhosphoserineBy similarity
    Modified residuei396 – 3961PhosphoserineBy similarity
    Modified residuei482 – 4821PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO55112.

    PTM databases

    PhosphoSiteiO55112.

    Expressioni

    Tissue specificityi

    Highly expressed in the hippocampus, the piriform cortex, Purkinje cells and the cingulate gyrus.

    Developmental stagei

    Expressed before day 7 in the embryo and reached its highest levels at 10.5-11.5 days. In the embryo at day 11, expression is more specific in the roof of the hind brain and the lateral ventricle of the brain.

    Gene expression databases

    BgeeiO55112.
    CleanExiMM_AFF2.
    GenevestigatoriO55112.

    Interactioni

    Protein-protein interaction databases

    BioGridi199717. 2 interactions.
    STRINGi10090.ENSMUSP00000033532.

    Structurei

    3D structure databases

    ProteinModelPortaliO55112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AF4 family.Curated

    Phylogenomic databases

    eggNOGiNOG69292.
    GeneTreeiENSGT00530000063217.
    HOGENOMiHOG000246991.
    HOVERGENiHBG004189.
    InParanoidiB1ATW0.
    KOiK15194.
    OMAiDEFTWPK.
    OrthoDBiEOG767390.
    PhylomeDBiO55112.
    TreeFamiTF326216.

    Family and domain databases

    InterProiIPR007797. TF_AF4/FMR2.
    [Graphical view]
    PANTHERiPTHR10528. PTHR10528. 1 hit.
    PfamiPF05110. AF-4. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55112-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLFDFFRDW DLEQQCHYEQ DRSALKKREW ERRNQEVQQE EDLFSSGFDL     50
    FGEPYKVAEY TNKGDALANR VQNTLGSYDE MKDLLSNHSS QNHLVGIPKN 100
    SAPQTPISKS EASFYPEQKN RMIPSHQETT HSSTPMPPPS VVILNSTLIH 150
    SNRKSKSEWP RDSHNTSPAQ ASQTSSQPNK MQTSTQDPPQ TRLEDFFVYP 200
    AEQPQIGTVE KSNPSSKEEN NPNSGGEDTF KEIFQSNSPE ESEFTVQAPG 250
    SPLVASSLLA PSSGLSVPTF PPGLYCKTSM GQQKPTAYVR PMDGQDQATD 300
    ISPTLKPSIE FENSFGNLSF GSLLDGKPSA VSSKTKLPKF TILQTSEVSL 350
    TSDPSCVEEI LRESQHLTPG FTLQKWSDPS SRASTKMLED DLKLSSDEDD 400
    LEPVKTLTTQ CTANELYQAV EKAKPKNNPV NPLLATPQST PATQTNVGSG 450
    SSSESESSSE SDSDTESSTT DSESNEAPRV ATPEPEPPST NKWQLDKWLN 500
    KVTSQNKSFI CGQNETPTET ISLPPPIIQP VEVQVKVKPN PSQAVAVPKE 550
    RPLLSLIREK ARPRPTQKTP ETKALKHKLS TSVDTVSQRT IGKKQPKKVE 600
    KNTSFEEFTW PKPNITNSTP KEKGSVELPD PPRSRNKATA HKPVPRKEPR 650
    PHVPLATEKK KYRGPGKIVP KSREFIETDS STSDSNTDQE ETLQIKVLPP 700
    CITSKSKETS NASLTLSTLT NGNSNNLSTS NEETAFSPPP AMQTELLSPL 750
    RDHENPKNLW VKIDLDLLSR VPGQNSVPVT PAKTDYKETA SKPKRQTAAT 800
    AVEKPAPKGK RKHKPAETAE KIPEKKQRLE DNTTICLLPP CISPAPPHKP 850
    PSTRENSSRR ANRKKEEKLF PPALSPLAED PPRRRNVSGN NGHFGQDKNI 900
    SMAGQITSSK PKRSEGKFCA TFKGISINEG DAPKKAASAT VTVANMALAT 950
    ATATATVPAI VTATVTATAT TTATATTTTT TTTISSITPT ITSGLMDSSH 1000
    LEMTSWAALP LLSSSSANVR RPKLTFDDSV HNADFYMQEA KKLKHKADAL 1050
    FEKFGKAVNY ADAALSFTEC GNAMERDPLE AKSPYTMYSE TVELLRYAMR 1100
    LKNFASPLAS DGDKKLAVLC YRCLSLLYLR MFKLKKDHAM KYSRSLMEYF 1150
    KQNASKVTQI PSPWVGNGKN TPSPVSLNNV SPINSVGNCN NGPVTIPQRI 1200
    HHMAASHVNI TSNVLRGYEH WDMADKLTRD NKEFFGDLDT LMGPLTQHSS 1250
    MTNLVRYVRQ GLCWLRIDAH LL 1272
    Length:1,272
    Mass (Da):140,181
    Last modified:February 9, 2010 - v2
    Checksum:i1CE41F1AEFE9C2B4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti432 – 4321P → S in CAA04821. (PubMed:9467002)Curated
    Sequence conflicti544 – 5441A → S in CAA04821. (PubMed:9467002)Curated
    Sequence conflicti941 – 9411V → A in CAA04821. (PubMed:9467002)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001549 mRNA. Translation: CAA04821.1.
    AL663113
    , AL672120, AL808131, BX294655 Genomic DNA. Translation: CAM17463.1.
    BX294655
    , AL663113, AL672120, AL808131 Genomic DNA. Translation: CAM20870.1.
    AL808131
    , AL663113, AL672120, BX294655 Genomic DNA. Translation: CAM22352.1.
    CCDSiCCDS30173.1.
    PIRiT30248.
    RefSeqiNP_032058.2. NM_008032.3.
    UniGeneiMm.466576.

    Genome annotation databases

    EnsembliENSMUST00000033532; ENSMUSP00000033532; ENSMUSG00000031189.
    GeneIDi14266.
    KEGGimmu:14266.
    UCSCiuc009tjb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001549 mRNA. Translation: CAA04821.1 .
    AL663113
    , AL672120 , AL808131 , BX294655 Genomic DNA. Translation: CAM17463.1 .
    BX294655
    , AL663113 , AL672120 , AL808131 Genomic DNA. Translation: CAM20870.1 .
    AL808131
    , AL663113 , AL672120 , BX294655 Genomic DNA. Translation: CAM22352.1 .
    CCDSi CCDS30173.1.
    PIRi T30248.
    RefSeqi NP_032058.2. NM_008032.3.
    UniGenei Mm.466576.

    3D structure databases

    ProteinModelPortali O55112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199717. 2 interactions.
    STRINGi 10090.ENSMUSP00000033532.

    PTM databases

    PhosphoSitei O55112.

    Proteomic databases

    PRIDEi O55112.

    Protocols and materials databases

    DNASUi 14266.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033532 ; ENSMUSP00000033532 ; ENSMUSG00000031189 .
    GeneIDi 14266.
    KEGGi mmu:14266.
    UCSCi uc009tjb.1. mouse.

    Organism-specific databases

    CTDi 2334.
    MGIi MGI:1202294. Aff2.

    Phylogenomic databases

    eggNOGi NOG69292.
    GeneTreei ENSGT00530000063217.
    HOGENOMi HOG000246991.
    HOVERGENi HBG004189.
    InParanoidi B1ATW0.
    KOi K15194.
    OMAi DEFTWPK.
    OrthoDBi EOG767390.
    PhylomeDBi O55112.
    TreeFami TF326216.

    Miscellaneous databases

    NextBioi 285623.
    PROi O55112.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55112.
    CleanExi MM_AFF2.
    Genevestigatori O55112.

    Family and domain databases

    InterProi IPR007797. TF_AF4/FMR2.
    [Graphical view ]
    PANTHERi PTHR10528. PTHR10528. 1 hit.
    Pfami PF05110. AF-4. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the murine homologue of FMR2 in mouse brain and during development."
      Chakrabarti L., Bristulf J., Foss G.S., Davies K.E.
      Hum. Mol. Genet. 7:441-448(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure."
      Bensaid M., Melko M., Bechara E.G., Davidovic L., Berretta A., Catania M.V., Gecz J., Lalli E., Bardoni B.
      Nucleic Acids Res. 37:1269-1279(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAFF2_MOUSE
    AccessioniPrimary (citable) accession number: O55112
    Secondary accession number(s): B1ATW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3