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O55111

- DSG2_MOUSE

UniProt

O55111 - DSG2_MOUSE

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Protein

Desmoglein-2

Gene

Dsg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  2. homophilic cell adhesion Source: InterPro
  3. maternal process involved in female pregnancy Source: Ensembl
  4. regulation of heart rate by cardiac conduction Source: Ensembl
  5. response to progesterone Source: Ensembl
  6. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_212869. Apoptotic cleavage of cell adhesion proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-2
Gene namesi
Name:Dsg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1196466. Dsg2.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctiondesmosome By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. desmosome Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. lateral plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Propeptidei29 – 5426Sequence AnalysisPRO_0000003847Add
BLAST
Chaini55 – 11221068Desmoglein-2PRO_0000003848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)1 Publication
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
Modified residuei685 – 6851PhosphoserineBy similarity
Modified residuei709 – 7091PhosphoserineBy similarity
Modified residuei1122 – 11221PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO55111.
PaxDbiO55111.
PRIDEiO55111.

PTM databases

PhosphoSiteiO55111.

Expressioni

Tissue specificityi

Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during.2 Publications

Gene expression databases

BgeeiO55111.
CleanExiMM_DSG2.
ExpressionAtlasiO55111. baseline and differential.
GenevestigatoriO55111.

Structurei

3D structure databases

ProteinModelPortaliO55111.
SMRiO55111. Positions 52-598.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 618564ExtracellularSequence AnalysisAdd
BLAST
Topological domaini640 – 1122483CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei619 – 63921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 164110Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini165 – 277113Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 398121Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini397 – 504108Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Repeati885 – 91632Desmoglein repeat 1Add
BLAST
Repeati917 – 94529Desmoglein repeat 2Add
BLAST
Repeati946 – 97126Desmoglein repeat 3Add
BLAST
Repeati972 – 99524Desmoglein repeat 4Add
BLAST
Repeati996 – 102429Desmoglein repeat 5Add
BLAST
Repeati1025 – 105531Desmoglein repeat 6Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293589.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiO55111.
KOiK07597.
OMAiVMVRERE.
OrthoDBiEOG7HQN78.
TreeFamiTF331809.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55111-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV
60 70 80 90 100
RQKRAWITAP VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT
110 120 130 140 150
EPPFGIFVFD RNTGELNITS ILDREETPYF LLTGYALDSR GNNLEKPLEL
160 170 180 190 200
RIKVLDINDN EPVFTQEVFV GSIEELSAAH TLVMKITATD ADDPETLNAK
210 220 230 240 250
VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY SLTVEARDGN
260 270 280 290 300
GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV
310 320 330 340 350
TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM
360 370 380 390 400
KKLDLSIIVT NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF
410 420 430 440 450
RASEAMDRSS LSRSIGNFQV FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS
460 470 480 490 500
EIKLVKIPDF ESRYVQNGTY TAKVVAISKE HPQKTITGTI VITVEDVNDN
510 520 530 540 550
CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID QPPGTAQKWK
560 570 580 590 600
ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK
610 620 630 640 650
GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT
660 670 680 690 700
PIPGTIEMLH PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG
710 720 730 740 750
MMKGSSSASV TKGQHELSEV DGRWEEHRSL LTAGATHHVR TAGTIAANEA
760 770 780 790 800
VRTRATGSSR DMSGARGAVA VNEEFLRSYF TEKAASYNGE DDLHMAKDCL
810 820 830 840 850
LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL AEVCLGRKID
860 870 880 890 900
LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE
910 920 930 940 950
VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP
960 970 980 990 1000
PSTVLLAPRQ PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG
1010 1020 1030 1040 1050
IPKPLEVTQH LKDAQYVMVR ERESILAPSS GVQPTLAMPS VAAGGQNVTV
1060 1070 1080 1090 1100
TERILTPAST LQSSYQIPSE TSITARNTVL SSVGSIGPLP NLDLEESDRP
1110 1120
NSTITTSSTR VTKHSTMQHS YS
Length:1,122
Mass (Da):122,385
Last modified:July 27, 2011 - v3
Checksum:i9EB9CD402632437A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti304 – 3041D → Y in BAB86843. 1 PublicationCurated
Sequence conflicti358 – 3581I → L in AAH34056. (PubMed:15489334)Curated
Sequence conflicti480 – 4801E → D in AAH34056. (PubMed:15489334)Curated
Sequence conflicti491 – 4911V → I in AAH34056. (PubMed:15489334)Curated
Sequence conflicti863 – 8631R → T in BAB86843. 1 PublicationCurated
Sequence conflicti899 – 8991H → R in BAB86843. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072269 mRNA. Translation: BAB86843.1.
BC034056 mRNA. Translation: AAH34056.1.
BC131653 mRNA. Translation: AAI31654.1.
BC131654 mRNA. Translation: AAI31655.1.
AJ000328 mRNA. Translation: CAA03995.1.
CCDSiCCDS29084.1.
RefSeqiNP_031909.2. NM_007883.2.
UniGeneiMm.345891.

Genome annotation databases

EnsembliENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393.
GeneIDi13511.
KEGGimmu:13511.
UCSCiuc008ees.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072269 mRNA. Translation: BAB86843.1 .
BC034056 mRNA. Translation: AAH34056.1 .
BC131653 mRNA. Translation: AAI31654.1 .
BC131654 mRNA. Translation: AAI31655.1 .
AJ000328 mRNA. Translation: CAA03995.1 .
CCDSi CCDS29084.1.
RefSeqi NP_031909.2. NM_007883.2.
UniGenei Mm.345891.

3D structure databases

ProteinModelPortali O55111.
SMRi O55111. Positions 52-598.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O55111.

Proteomic databases

MaxQBi O55111.
PaxDbi O55111.
PRIDEi O55111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059787 ; ENSMUSP00000057096 ; ENSMUSG00000044393 .
GeneIDi 13511.
KEGGi mmu:13511.
UCSCi uc008ees.2. mouse.

Organism-specific databases

CTDi 1829.
MGIi MGI:1196466. Dsg2.

Phylogenomic databases

eggNOGi NOG293589.
GeneTreei ENSGT00760000118906.
HOGENOMi HOG000236266.
HOVERGENi HBG005532.
InParanoidi O55111.
KOi K07597.
OMAi VMVRERE.
OrthoDBi EOG7HQN78.
TreeFami TF331809.

Enzyme and pathway databases

Reactomei REACT_212869. Apoptotic cleavage of cell adhesion proteins.

Miscellaneous databases

ChiTaRSi DSG2. mouse.
NextBioi 284070.
PROi O55111.
SOURCEi Search...

Gene expression databases

Bgeei O55111.
CleanExi MM_DSG2.
ExpressionAtlasi O55111. baseline and differential.
Genevestigatori O55111.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view ]
PANTHERi PTHR24025. PTHR24025. 1 hit.
Pfami PF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Desmosomal cadherins mediate homophilic cell adhesion."
    Zhuxiang N., Garrod D.R.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
    King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
    Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE.
  4. "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
    Whittock N.V.
    J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-467.

Entry informationi

Entry nameiDSG2_MOUSE
AccessioniPrimary (citable) accession number: O55111
Secondary accession number(s): A2RRJ0, Q8K069, Q8R517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3