Desmoglein-2 precursor - Mus musculus (Mouse)

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O55111 (DSG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Desmoglein-2

Gene names

Name:

Dsg2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1122 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Cell junction › desmosome By similarity.
Tissue specificity	Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis. Ref.4
Developmental stage	Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during. Ref.3 Ref.4
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 4 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Cleavage on pair of basic residues Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bundle of His cell to Purkinje myocyte communication Inferred from electronic annotation. Source: Compara execution phase of apoptosis Inferred from electronic annotation. Source: Compara homophilic cell adhesion Inferred from electronic annotation. Source: InterPro regulation of heart rate by cardiac conduction Inferred from electronic annotation. Source: Compara regulation of ventricular cardiac muscle cell action potential Inferred from electronic annotation. Source: Compara
Cellular_component	desmosome Inferred from direct assay PubMed 12631242 PubMed 14673151 PubMed 15775979 PubMed 22274697 PubMed 9864371. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

Potential

Propeptide

29 – 54

Potential

PRO_0000003847

Chain

55 – 1122

1068

Desmoglein-2

PRO_0000003848

Regions

Topological domain

55 – 618

564

Extracellular Potential

Transmembrane

619 – 639

Helical; Potential

Topological domain

640 – 1122

483

Cytoplasmic Potential

Domain

55 – 164

110

Cadherin 1

Domain

165 – 277

113

Cadherin 2

Domain

278 – 398

121

Cadherin 3

Domain

397 – 504

108

Cadherin 4

Repeat

885 – 916

Desmoglein repeat 1

Repeat

917 – 945

Desmoglein repeat 2

Repeat

946 – 971

Desmoglein repeat 3

Repeat

972 – 995

Desmoglein repeat 4

Repeat

996 – 1024

Desmoglein repeat 5

Repeat

1025 – 1055

Desmoglein repeat 6

Amino acid modifications

Modified residue

685

Phosphoserine By similarity

Modified residue

709

Phosphoserine By similarity

Glycosylation

117

N-linked (GlcNAc...) Potential

Glycosylation

314

N-linked (GlcNAc...) Potential

Glycosylation

467

N-linked (GlcNAc...) Ref.5

Glycosylation

519

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

304

D → Y in BAB86843. Ref.1

Sequence conflict

358

I → L in AAH34056. Ref.2

Sequence conflict

480

E → D in AAH34056. Ref.2

Sequence conflict

491

V → I in AAH34056. Ref.2

Sequence conflict

863

R → T in BAB86843. Ref.1

Sequence conflict

899

H → R in BAB86843. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

O55111 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 9EB9CD402632437A
Show »

FASTA

1,122

122,385

        10         20         30         40         50         60 
MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV RQKRAWITAP 

        70         80         90        100        110        120 
VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT EPPFGIFVFD RNTGELNITS 

       130        140        150        160        170        180 
ILDREETPYF LLTGYALDSR GNNLEKPLEL RIKVLDINDN EPVFTQEVFV GSIEELSAAH 

       190        200        210        220        230        240 
TLVMKITATD ADDPETLNAK VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY 

       250        260        270        280        290        300 
SLTVEARDGN GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV 

       310        320        330        340        350        360 
TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM KKLDLSIIVT 

       370        380        390        400        410        420 
NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF RASEAMDRSS LSRSIGNFQV 

       430        440        450        460        470        480 
FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS EIKLVKIPDF ESRYVQNGTY TAKVVAISKE 

       490        500        510        520        530        540 
HPQKTITGTI VITVEDVNDN CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID 

       550        560        570        580        590        600 
QPPGTAQKWK ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK 

       610        620        630        640        650        660 
GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT PIPGTIEMLH 

       670        680        690        700        710        720 
PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG MMKGSSSASV TKGQHELSEV 

       730        740        750        760        770        780 
DGRWEEHRSL LTAGATHHVR TAGTIAANEA VRTRATGSSR DMSGARGAVA VNEEFLRSYF 

       790        800        810        820        830        840 
TEKAASYNGE DDLHMAKDCL LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL 

       850        860        870        880        890        900 
AEVCLGRKID LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE 

       910        920        930        940        950        960 
VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP PSTVLLAPRQ 

       970        980        990       1000       1010       1020 
PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG IPKPLEVTQH LKDAQYVMVR 

      1030       1040       1050       1060       1070       1080 
ERESILAPSS GVQPTLAMPS VAAGGQNVTV TERILTPAST LQSSYQIPSE TSITARNTVL 

      1090       1100       1110       1120 
SSVGSIGPLP NLDLEESDRP NSTITTSSTR VTKHSTMQHS YS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Desmosomal cadherins mediate homophilic cell adhesion." Zhuxiang N., Garrod D.R. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[3]	"Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse." King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S. Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE.
[4]	"Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6." Whittock N.V. J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[5]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-467, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB072269 mRNA. Translation: BAB86843.1. BC034056 mRNA. Translation: AAH34056.1. BC131653 mRNA. Translation: AAI31654.1. BC131654 mRNA. Translation: AAI31655.1. AJ000328 mRNA. Translation: CAA03995.1.
IPI	IPI00115793.
RefSeq	NP_031909.2. NM_007883.2.
UniGene	Mm.345891.
3D structure databases
ProteinModelPortal	O55111.
SMR	O55111. Positions 52-598.
ModBase	Search...
PTM databases
PhosphoSite	O55111.
Proteomic databases
PaxDb	O55111.
PRIDE	O55111.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393.
GeneID	13511.
KEGG	mmu:13511.
Organism-specific databases
CTD	1829.
MGI	MGI:1196466. Dsg2.
Phylogenomic databases
eggNOG	NOG293589.
GeneTree	ENSGT00700000104341.
HOGENOM	HOG000236266.
HOVERGEN	HBG005532.
InParanoid	A2RRJ0.
KO	K07597.
OMA	RAWITAP.
OrthoDB	EOG4RR6H9.
Gene expression databases
ArrayExpress	O55111.
Bgee	O55111.
CleanEx	MM_DSG2.
Genevestigator	O55111.
GermOnline	ENSMUSG00000044393. Mus musculus.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. IPR009123. Desmoglein. IPR009122. Desmosomal_cadherin. [Graphical view]
PANTHER	PTHR24025. PTHR24025. 1 hit.
Pfam	PF00028. Cadherin. 3 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN. PR01818. DESMOCADHERN. PR01819. DESMOGLEIN.
SMART	SM00112. CA. 4 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DSG2. mouse.
NextBio	284070.
SOURCE	Search...

Entry information

Entry name

DSG2_MOUSE

Accession

Primary (citable) accession number: O55111
Secondary accession number(s): A2RRJ0, Q8K069, Q8R517

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents