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O55111 (DSG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Desmoglein-2
Gene names
Name:Dsg2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1122 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctiondesmosome By similarity.

Tissue specificity

Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis. Ref.4

Developmental stage

Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during. Ref.3 Ref.4

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 4 cadherin domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Propeptide29 – 5426 Potential
PRO_0000003847
Chain55 – 11221068Desmoglein-2
PRO_0000003848

Regions

Topological domain55 – 618564Extracellular Potential
Transmembrane619 – 63921Helical; Potential
Topological domain640 – 1122483Cytoplasmic Potential
Domain55 – 164110Cadherin 1
Domain165 – 277113Cadherin 2
Domain278 – 398121Cadherin 3
Domain397 – 504108Cadherin 4
Repeat885 – 91632Desmoglein repeat 1
Repeat917 – 94529Desmoglein repeat 2
Repeat946 – 97126Desmoglein repeat 3
Repeat972 – 99524Desmoglein repeat 4
Repeat996 – 102429Desmoglein repeat 5
Repeat1025 – 105531Desmoglein repeat 6

Amino acid modifications

Modified residue6851Phosphoserine By similarity
Modified residue7091Phosphoserine By similarity
Modified residue11221Phosphoserine By similarity
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation4671N-linked (GlcNAc...) Ref.5
Glycosylation5191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3041D → Y in BAB86843. Ref.1
Sequence conflict3581I → L in AAH34056. Ref.2
Sequence conflict4801E → D in AAH34056. Ref.2
Sequence conflict4911V → I in AAH34056. Ref.2
Sequence conflict8631R → T in BAB86843. Ref.1
Sequence conflict8991H → R in BAB86843. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O55111 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 9EB9CD402632437A

FASTA1,122122,385
        10         20         30         40         50         60 
MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV RQKRAWITAP 

        70         80         90        100        110        120 
VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT EPPFGIFVFD RNTGELNITS 

       130        140        150        160        170        180 
ILDREETPYF LLTGYALDSR GNNLEKPLEL RIKVLDINDN EPVFTQEVFV GSIEELSAAH 

       190        200        210        220        230        240 
TLVMKITATD ADDPETLNAK VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY 

       250        260        270        280        290        300 
SLTVEARDGN GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV 

       310        320        330        340        350        360 
TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM KKLDLSIIVT 

       370        380        390        400        410        420 
NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF RASEAMDRSS LSRSIGNFQV 

       430        440        450        460        470        480 
FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS EIKLVKIPDF ESRYVQNGTY TAKVVAISKE 

       490        500        510        520        530        540 
HPQKTITGTI VITVEDVNDN CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID 

       550        560        570        580        590        600 
QPPGTAQKWK ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK 

       610        620        630        640        650        660 
GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT PIPGTIEMLH 

       670        680        690        700        710        720 
PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG MMKGSSSASV TKGQHELSEV 

       730        740        750        760        770        780 
DGRWEEHRSL LTAGATHHVR TAGTIAANEA VRTRATGSSR DMSGARGAVA VNEEFLRSYF 

       790        800        810        820        830        840 
TEKAASYNGE DDLHMAKDCL LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL 

       850        860        870        880        890        900 
AEVCLGRKID LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE 

       910        920        930        940        950        960 
VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP PSTVLLAPRQ 

       970        980        990       1000       1010       1020 
PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG IPKPLEVTQH LKDAQYVMVR 

      1030       1040       1050       1060       1070       1080 
ERESILAPSS GVQPTLAMPS VAAGGQNVTV TERILTPAST LQSSYQIPSE TSITARNTVL 

      1090       1100       1110       1120 
SSVGSIGPLP NLDLEESDRP NSTITTSSTR VTKHSTMQHS YS 

« Hide

References

« Hide 'large scale' references
[1]"Desmosomal cadherins mediate homophilic cell adhesion."
Zhuxiang N., Garrod D.R.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[3]"Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE.
[4]"Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
Whittock N.V.
J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[5]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-467.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB072269 mRNA. Translation: BAB86843.1.
BC034056 mRNA. Translation: AAH34056.1.
BC131653 mRNA. Translation: AAI31654.1.
BC131654 mRNA. Translation: AAI31655.1.
AJ000328 mRNA. Translation: CAA03995.1.
RefSeqNP_031909.2. NM_007883.2.
UniGeneMm.345891.

3D structure databases

ProteinModelPortalO55111.
SMRO55111. Positions 24-598, 787-844.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO55111.

Proteomic databases

PaxDbO55111.
PRIDEO55111.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393.
GeneID13511.
KEGGmmu:13511.
UCSCuc008ees.2. mouse.

Organism-specific databases

CTD1829.
MGIMGI:1196466. Dsg2.

Phylogenomic databases

eggNOGNOG293589.
GeneTreeENSGT00740000114904.
HOGENOMHOG000236266.
HOVERGENHBG005532.
InParanoidA2RRJ0.
KOK07597.
OMAVMVRERE.
OrthoDBEOG7HQN78.
TreeFamTF331809.

Gene expression databases

ArrayExpressO55111.
BgeeO55111.
CleanExMM_DSG2.
GenevestigatorO55111.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERPTHR24025. PTHR24025. 1 hit.
PfamPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTSM00112. CA. 4 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDSG2. mouse.
NextBio284070.
PROO55111.
SOURCESearch...

Entry information

Entry nameDSG2_MOUSE
AccessionPrimary (citable) accession number: O55111
Secondary accession number(s): A2RRJ0, Q8K069, Q8R517
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot