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Protein

Desmoglein-2

Gene

Dsg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_343176. Apoptotic cleavage of cell adhesion proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-2
Gene namesi
Name:Dsg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1196466. Dsg2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 618564ExtracellularSequence AnalysisAdd
BLAST
Transmembranei619 – 63921HelicalSequence AnalysisAdd
BLAST
Topological domaini640 – 1122483CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Propeptidei29 – 5426Sequence AnalysisPRO_0000003847Add
BLAST
Chaini55 – 11221068Desmoglein-2PRO_0000003848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)1 Publication
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
Modified residuei685 – 6851PhosphoserineBy similarity
Modified residuei706 – 7061PhosphoserineBy similarity
Modified residuei709 – 7091PhosphoserineBy similarity
Modified residuei808 – 8081PhosphothreonineBy similarity
Modified residuei810 – 8101PhosphoserineBy similarity
Modified residuei814 – 8141PhosphoserineBy similarity
Modified residuei819 – 8191PhosphoserineBy similarity
Modified residuei1122 – 11221PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO55111.
PaxDbiO55111.
PRIDEiO55111.

PTM databases

PhosphoSiteiO55111.

Expressioni

Tissue specificityi

Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during.2 Publications

Gene expression databases

BgeeiO55111.
CleanExiMM_DSG2.
ExpressionAtlasiO55111. baseline and differential.
GenevisibleiO55111. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057096.

Structurei

3D structure databases

ProteinModelPortaliO55111.
SMRiO55111. Positions 52-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 164110Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini165 – 277113Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 398121Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini397 – 504108Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Repeati885 – 91632Desmoglein repeat 1Add
BLAST
Repeati917 – 94529Desmoglein repeat 2Add
BLAST
Repeati946 – 97126Desmoglein repeat 3Add
BLAST
Repeati972 – 99524Desmoglein repeat 4Add
BLAST
Repeati996 – 102429Desmoglein repeat 5Add
BLAST
Repeati1025 – 105531Desmoglein repeat 6Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293589.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiO55111.
KOiK07597.
OMAiVMVRERE.
OrthoDBiEOG7HQN78.
TreeFamiTF331809.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV
60 70 80 90 100
RQKRAWITAP VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT
110 120 130 140 150
EPPFGIFVFD RNTGELNITS ILDREETPYF LLTGYALDSR GNNLEKPLEL
160 170 180 190 200
RIKVLDINDN EPVFTQEVFV GSIEELSAAH TLVMKITATD ADDPETLNAK
210 220 230 240 250
VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY SLTVEARDGN
260 270 280 290 300
GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV
310 320 330 340 350
TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM
360 370 380 390 400
KKLDLSIIVT NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF
410 420 430 440 450
RASEAMDRSS LSRSIGNFQV FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS
460 470 480 490 500
EIKLVKIPDF ESRYVQNGTY TAKVVAISKE HPQKTITGTI VITVEDVNDN
510 520 530 540 550
CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID QPPGTAQKWK
560 570 580 590 600
ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK
610 620 630 640 650
GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT
660 670 680 690 700
PIPGTIEMLH PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG
710 720 730 740 750
MMKGSSSASV TKGQHELSEV DGRWEEHRSL LTAGATHHVR TAGTIAANEA
760 770 780 790 800
VRTRATGSSR DMSGARGAVA VNEEFLRSYF TEKAASYNGE DDLHMAKDCL
810 820 830 840 850
LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL AEVCLGRKID
860 870 880 890 900
LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE
910 920 930 940 950
VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP
960 970 980 990 1000
PSTVLLAPRQ PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG
1010 1020 1030 1040 1050
IPKPLEVTQH LKDAQYVMVR ERESILAPSS GVQPTLAMPS VAAGGQNVTV
1060 1070 1080 1090 1100
TERILTPAST LQSSYQIPSE TSITARNTVL SSVGSIGPLP NLDLEESDRP
1110 1120
NSTITTSSTR VTKHSTMQHS YS
Length:1,122
Mass (Da):122,385
Last modified:July 27, 2011 - v3
Checksum:i9EB9CD402632437A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti304 – 3041D → Y in BAB86843 (Ref. 1) Curated
Sequence conflicti358 – 3581I → L in AAH34056 (PubMed:15489334).Curated
Sequence conflicti480 – 4801E → D in AAH34056 (PubMed:15489334).Curated
Sequence conflicti491 – 4911V → I in AAH34056 (PubMed:15489334).Curated
Sequence conflicti863 – 8631R → T in BAB86843 (Ref. 1) Curated
Sequence conflicti899 – 8991H → R in BAB86843 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072269 mRNA. Translation: BAB86843.1.
BC034056 mRNA. Translation: AAH34056.1.
BC131653 mRNA. Translation: AAI31654.1.
BC131654 mRNA. Translation: AAI31655.1.
AJ000328 mRNA. Translation: CAA03995.1.
CCDSiCCDS29084.1.
RefSeqiNP_031909.2. NM_007883.2.
UniGeneiMm.345891.

Genome annotation databases

EnsembliENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393.
GeneIDi13511.
KEGGimmu:13511.
UCSCiuc008ees.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072269 mRNA. Translation: BAB86843.1.
BC034056 mRNA. Translation: AAH34056.1.
BC131653 mRNA. Translation: AAI31654.1.
BC131654 mRNA. Translation: AAI31655.1.
AJ000328 mRNA. Translation: CAA03995.1.
CCDSiCCDS29084.1.
RefSeqiNP_031909.2. NM_007883.2.
UniGeneiMm.345891.

3D structure databases

ProteinModelPortaliO55111.
SMRiO55111. Positions 52-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057096.

PTM databases

PhosphoSiteiO55111.

Proteomic databases

MaxQBiO55111.
PaxDbiO55111.
PRIDEiO55111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393.
GeneIDi13511.
KEGGimmu:13511.
UCSCiuc008ees.2. mouse.

Organism-specific databases

CTDi1829.
MGIiMGI:1196466. Dsg2.

Phylogenomic databases

eggNOGiNOG293589.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiO55111.
KOiK07597.
OMAiVMVRERE.
OrthoDBiEOG7HQN78.
TreeFamiTF331809.

Enzyme and pathway databases

ReactomeiREACT_343176. Apoptotic cleavage of cell adhesion proteins.

Miscellaneous databases

ChiTaRSiDsg2. mouse.
NextBioi284070.
PROiO55111.
SOURCEiSearch...

Gene expression databases

BgeeiO55111.
CleanExiMM_DSG2.
ExpressionAtlasiO55111. baseline and differential.
GenevisibleiO55111. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Desmosomal cadherins mediate homophilic cell adhesion."
    Zhuxiang N., Garrod D.R.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
    King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
    Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE.
  4. "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
    Whittock N.V.
    J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-467.

Entry informationi

Entry nameiDSG2_MOUSE
AccessioniPrimary (citable) accession number: O55111
Secondary accession number(s): A2RRJ0, Q8K069, Q8R517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.