Desmoglein-2 precursor - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot O55111 (DSG2_MOUSE)

Last modified June 16, 2009. Version 72. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Desmoglein-2

Gene names

Name:

Dsg2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	1122 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Cell junction › desmosome By similarity.
Tissue specificity	Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis. Ref.4
Developmental stage	Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during. Ref.4 Ref.3
Domain	Calcium may be bound by the cadherin-like repeats Potential.
Sequence similarities	Contains 4 cadherin domains.

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Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular component	desmosome Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

Potential

Propeptide

29 – 54

Potential

PRO_0000003847

Chain

55 – 1122

1068

Desmoglein-2

PRO_0000003848

Regions

Topological domain

55 – 618

564

Extracellular Potential

Transmembrane

619 – 639

Potential

Topological domain

640 – 1122

483

Cytoplasmic Potential

Domain

55 – 164

110

Cadherin 1

Domain

165 – 277

113

Cadherin 2

Domain

278 – 398

121

Cadherin 3

Domain

397 – 504

108

Cadherin 4

Repeat

885 – 916

Desmoglein repeat 1

Repeat

917 – 945

Desmoglein repeat 2

Repeat

946 – 971

Desmoglein repeat 3

Repeat

972 – 995

Desmoglein repeat 4

Repeat

996 – 1024

Desmoglein repeat 5

Repeat

1025 – 1055

Desmoglein repeat 6

Amino acid modifications

Modified residue

685

Phosphoserine By similarity

Modified residue

971

Phosphotyrosine By similarity

Modified residue

1016

Phosphotyrosine By similarity

Glycosylation

117

N-linked (GlcNAc...) Potential

Glycosylation

314

N-linked (GlcNAc...) Potential

Glycosylation

467

N-linked (GlcNAc...) Potential

Glycosylation

519

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

358

I → L in AAH34056. Ref.2

Sequence conflict

480

E → D in AAH34056. Ref.2

Sequence conflict

491

V → I in AAH34056. Ref.2

Sequence conflict

863

T → R in AAH34056. Ref.2

Sequence conflict

899

R → H in AAH34056. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

O55111-1 [UniParc].

Last modified November 25, 2002. Version 2.
Checksum: CEC0C489F858ED57
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FASTA

1,122

122,397

        10         20         30         40         50         60 
MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV RQKRAWITAP 

        70         80         90        100        110        120 
VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT EPPFGIFVFD RNTGELNITS 

       130        140        150        160        170        180 
ILDREETPYF LLTGYALDSR GNNLEKPLEL RIKVLDINDN EPVFTQEVFV GSIEELSAAH 

       190        200        210        220        230        240 
TLVMKITATD ADDPETLNAK VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY 

       250        260        270        280        290        300 
SLTVEARDGN GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV 

       310        320        330        340        350        360 
TDAYEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM KKLDLSIIVT 

       370        380        390        400        410        420 
NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF RASEAMDRSS LSRSIGNFQV 

       430        440        450        460        470        480 
FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS EIKLVKIPDF ESRYVQNGTY TAKVVAISKE 

       490        500        510        520        530        540 
HPQKTITGTI VITVEDVNDN CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID 

       550        560        570        580        590        600 
QPPGTAQKWK ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK 

       610        620        630        640        650        660 
GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT PIPGTIEMLH 

       670        680        690        700        710        720 
PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG MMKGSSSASV TKGQHELSEV 

       730        740        750        760        770        780 
DGRWEEHRSL LTAGATHHVR TAGTIAANEA VRTRATGSSR DMSGARGAVA VNEEFLRSYF 

       790        800        810        820        830        840 
TEKAASYNGE DDLHMAKDCL LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL 

       850        860        870        880        890        900 
AEVCLGRKID LDVDIEQRQK PVTEASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLRE 

       910        920        930        940        950        960 
VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP PSTVLLAPRQ 

       970        980        990       1000       1010       1020 
PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG IPKPLEVTQH LKDAQYVMVR 

      1030       1040       1050       1060       1070       1080 
ERESILAPSS GVQPTLAMPS VAAGGQNVTV TERILTPAST LQSSYQIPSE TSITARNTVL 

      1090       1100       1110       1120 
SSVGSIGPLP NLDLEESDRP NSTITTSSTR VTKHSTMQHS YS

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Desmosomal cadherins mediate homophilic cell adhesion." Zhuxiang N., Garrod D.R. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 348-1122. Strain: C57BL/6J. Tissue: Mammary gland.
[3]	"Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse." King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S. Differentiation 62:83-96(1997) [PubMed: 9404003] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE.
[4]	"Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6." Whittock N.V. J. Invest. Dermatol. 120:970-980(2003) [PubMed: 12787123] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AB072269 mRNA. Translation: BAB86843.1. BC034056 mRNA. Translation: AAH34056.1. AJ000328 mRNA. Translation: CAA03995.1.
IPI	IPI00115793.
RefSeq	NP_031909.2.
UniGene	Mm.345891
3D structure databases
HSSP	HSSP built from PDB template 1FF5 based on UniProtKB P09803.
ModBase	Search...
PTM databases
PhosphoSite	O55111.
Genome annotation databases
Ensembl	ENSMUSG00000044393. Mus musculus. [Contig view]
GeneID	13511.
KEGG	mmu:13511.
Organism-specific databases
MGI	MGI:1196466. Dsg2.
Phylogenomic databases
HOGENOM	O55111.
HOVERGEN	O55111.
Gene expression databases
ArrayExpress	O55111.
Bgee	O55111.
CleanEx	MM_DSG2.
GermOnline	ENSMUSG00000044393. Mus musculus.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR009122. Desmo_cadherin. IPR009123. Desmoglein. IPR015488. Desmoglein2. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 4 hits.
PANTHER	PTHR10596:SF33. Desmoglein2. 1 hit.
Pfam	PF00028. Cadherin. 4 hits. [Graphical view]
PRINTS	PR00205. CADHERIN. PR01818. DESMOCADHERN. PR01819. DESMOGLEIN.
SMART	SM00112. CA. 4 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	284070.
SOURCE	Search...

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Entry information

Entry name

DSG2_MOUSE

Accession

Primary (citable) accession number: O55111
Secondary accession number(s): Q8K069, Q8R517

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	November 25, 2002
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents