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O55111

- DSG2_MOUSE

UniProt

O55111 - DSG2_MOUSE

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Protein
Desmoglein-2
Gene
Dsg2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  2. homophilic cell adhesion Source: InterPro
  3. maternal process involved in female pregnancy Source: Ensembl
  4. regulation of heart rate by cardiac conduction Source: Ensembl
  5. response to progesterone Source: Ensembl
  6. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_212869. Apoptotic cleavage of cell adhesion proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-2
Gene namesi
Name:Dsg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1196466. Dsg2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 618564Extracellular Reviewed prediction
Add
BLAST
Transmembranei619 – 63921Helical; Reviewed prediction
Add
BLAST
Topological domaini640 – 1122483Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. desmosome Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. lateral plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Propeptidei29 – 5426 Reviewed prediction
PRO_0000003847Add
BLAST
Chaini55 – 11221068Desmoglein-2
PRO_0000003848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi467 – 4671N-linked (GlcNAc...)1 Publication
Glycosylationi519 – 5191N-linked (GlcNAc...) Reviewed prediction
Modified residuei685 – 6851Phosphoserine By similarity
Modified residuei709 – 7091Phosphoserine By similarity
Modified residuei1122 – 11221Phosphoserine By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO55111.
PaxDbiO55111.
PRIDEiO55111.

PTM databases

PhosphoSiteiO55111.

Expressioni

Tissue specificityi

Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during.2 Publications

Gene expression databases

ArrayExpressiO55111.
BgeeiO55111.
CleanExiMM_DSG2.
GenevestigatoriO55111.

Structurei

3D structure databases

ProteinModelPortaliO55111.
SMRiO55111. Positions 52-598.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 164110Cadherin 1
Add
BLAST
Domaini165 – 277113Cadherin 2
Add
BLAST
Domaini278 – 398121Cadherin 3
Add
BLAST
Domaini397 – 504108Cadherin 4
Add
BLAST
Repeati885 – 91632Desmoglein repeat 1
Add
BLAST
Repeati917 – 94529Desmoglein repeat 2
Add
BLAST
Repeati946 – 97126Desmoglein repeat 3
Add
BLAST
Repeati972 – 99524Desmoglein repeat 4
Add
BLAST
Repeati996 – 102429Desmoglein repeat 5
Add
BLAST
Repeati1025 – 105531Desmoglein repeat 6
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 4 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293589.
GeneTreeiENSGT00740000114904.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiA2RRJ0.
KOiK07597.
OMAiVMVRERE.
OrthoDBiEOG7HQN78.
TreeFamiTF331809.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55111-1 [UniParc]FASTAAdd to Basket

« Hide

MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV     50
RQKRAWITAP VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT 100
EPPFGIFVFD RNTGELNITS ILDREETPYF LLTGYALDSR GNNLEKPLEL 150
RIKVLDINDN EPVFTQEVFV GSIEELSAAH TLVMKITATD ADDPETLNAK 200
VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY SLTVEARDGN 250
GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV 300
TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM 350
KKLDLSIIVT NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF 400
RASEAMDRSS LSRSIGNFQV FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS 450
EIKLVKIPDF ESRYVQNGTY TAKVVAISKE HPQKTITGTI VITVEDVNDN 500
CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID QPPGTAQKWK 550
ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK 600
GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT 650
PIPGTIEMLH PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG 700
MMKGSSSASV TKGQHELSEV DGRWEEHRSL LTAGATHHVR TAGTIAANEA 750
VRTRATGSSR DMSGARGAVA VNEEFLRSYF TEKAASYNGE DDLHMAKDCL 800
LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL AEVCLGRKID 850
LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE 900
VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP 950
PSTVLLAPRQ PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG 1000
IPKPLEVTQH LKDAQYVMVR ERESILAPSS GVQPTLAMPS VAAGGQNVTV 1050
TERILTPAST LQSSYQIPSE TSITARNTVL SSVGSIGPLP NLDLEESDRP 1100
NSTITTSSTR VTKHSTMQHS YS 1122
Length:1,122
Mass (Da):122,385
Last modified:July 27, 2011 - v3
Checksum:i9EB9CD402632437A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti304 – 3041D → Y in BAB86843. 1 Publication
Sequence conflicti358 – 3581I → L in AAH34056. 1 Publication
Sequence conflicti480 – 4801E → D in AAH34056. 1 Publication
Sequence conflicti491 – 4911V → I in AAH34056. 1 Publication
Sequence conflicti863 – 8631R → T in BAB86843. 1 Publication
Sequence conflicti899 – 8991H → R in BAB86843. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072269 mRNA. Translation: BAB86843.1.
BC034056 mRNA. Translation: AAH34056.1.
BC131653 mRNA. Translation: AAI31654.1.
BC131654 mRNA. Translation: AAI31655.1.
AJ000328 mRNA. Translation: CAA03995.1.
CCDSiCCDS29084.1.
RefSeqiNP_031909.2. NM_007883.2.
UniGeneiMm.345891.

Genome annotation databases

EnsembliENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393.
GeneIDi13511.
KEGGimmu:13511.
UCSCiuc008ees.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB072269 mRNA. Translation: BAB86843.1 .
BC034056 mRNA. Translation: AAH34056.1 .
BC131653 mRNA. Translation: AAI31654.1 .
BC131654 mRNA. Translation: AAI31655.1 .
AJ000328 mRNA. Translation: CAA03995.1 .
CCDSi CCDS29084.1.
RefSeqi NP_031909.2. NM_007883.2.
UniGenei Mm.345891.

3D structure databases

ProteinModelPortali O55111.
SMRi O55111. Positions 52-598.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O55111.

Proteomic databases

MaxQBi O55111.
PaxDbi O55111.
PRIDEi O55111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059787 ; ENSMUSP00000057096 ; ENSMUSG00000044393 .
GeneIDi 13511.
KEGGi mmu:13511.
UCSCi uc008ees.2. mouse.

Organism-specific databases

CTDi 1829.
MGIi MGI:1196466. Dsg2.

Phylogenomic databases

eggNOGi NOG293589.
GeneTreei ENSGT00740000114904.
HOGENOMi HOG000236266.
HOVERGENi HBG005532.
InParanoidi A2RRJ0.
KOi K07597.
OMAi VMVRERE.
OrthoDBi EOG7HQN78.
TreeFami TF331809.

Enzyme and pathway databases

Reactomei REACT_212869. Apoptotic cleavage of cell adhesion proteins.

Miscellaneous databases

ChiTaRSi DSG2. mouse.
NextBioi 284070.
PROi O55111.
SOURCEi Search...

Gene expression databases

ArrayExpressi O55111.
Bgeei O55111.
CleanExi MM_DSG2.
Genevestigatori O55111.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view ]
PANTHERi PTHR24025. PTHR24025. 1 hit.
Pfami PF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Desmosomal cadherins mediate homophilic cell adhesion."
    Zhuxiang N., Garrod D.R.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
    King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
    Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE.
  4. "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
    Whittock N.V.
    J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-467.

Entry informationi

Entry nameiDSG2_MOUSE
AccessioniPrimary (citable) accession number: O55111
Secondary accession number(s): A2RRJ0, Q8K069, Q8R517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi