Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O55111

- DSG2_MOUSE

UniProt

O55111 - DSG2_MOUSE

Protein

Desmoglein-2

Gene

Dsg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. bundle of His cell to Purkinje myocyte communication Source: Ensembl
    2. homophilic cell adhesion Source: InterPro
    3. maternal process involved in female pregnancy Source: Ensembl
    4. regulation of heart rate by cardiac conduction Source: Ensembl
    5. response to progesterone Source: Ensembl
    6. ventricular cardiac muscle cell action potential Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_212869. Apoptotic cleavage of cell adhesion proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmoglein-2
    Gene namesi
    Name:Dsg2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1196466. Dsg2.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctiondesmosome By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. desmosome Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. lateral plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Propeptidei29 – 5426Sequence AnalysisPRO_0000003847Add
    BLAST
    Chaini55 – 11221068Desmoglein-2PRO_0000003848Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi467 – 4671N-linked (GlcNAc...)1 Publication
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
    Modified residuei685 – 6851PhosphoserineBy similarity
    Modified residuei709 – 7091PhosphoserineBy similarity
    Modified residuei1122 – 11221PhosphoserineBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO55111.
    PaxDbiO55111.
    PRIDEiO55111.

    PTM databases

    PhosphoSiteiO55111.

    Expressioni

    Tissue specificityi

    Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis.1 Publication

    Developmental stagei

    Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during.2 Publications

    Gene expression databases

    ArrayExpressiO55111.
    BgeeiO55111.
    CleanExiMM_DSG2.
    GenevestigatoriO55111.

    Structurei

    3D structure databases

    ProteinModelPortaliO55111.
    SMRiO55111. Positions 52-598.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini55 – 618564ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini640 – 1122483CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei619 – 63921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 164110Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini165 – 277113Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 398121Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 504108Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati885 – 91632Desmoglein repeat 1Add
    BLAST
    Repeati917 – 94529Desmoglein repeat 2Add
    BLAST
    Repeati946 – 97126Desmoglein repeat 3Add
    BLAST
    Repeati972 – 99524Desmoglein repeat 4Add
    BLAST
    Repeati996 – 102429Desmoglein repeat 5Add
    BLAST
    Repeati1025 – 105531Desmoglein repeat 6Add
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 4 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293589.
    GeneTreeiENSGT00740000114904.
    HOGENOMiHOG000236266.
    HOVERGENiHBG005532.
    InParanoidiA2RRJ0.
    KOiK07597.
    OMAiVMVRERE.
    OrthoDBiEOG7HQN78.
    TreeFamiTF331809.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view]
    PANTHERiPTHR24025. PTHR24025. 1 hit.
    PfamiPF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTiSM00112. CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O55111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV     50
    RQKRAWITAP VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT 100
    EPPFGIFVFD RNTGELNITS ILDREETPYF LLTGYALDSR GNNLEKPLEL 150
    RIKVLDINDN EPVFTQEVFV GSIEELSAAH TLVMKITATD ADDPETLNAK 200
    VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY SLTVEARDGN 250
    GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV 300
    TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM 350
    KKLDLSIIVT NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF 400
    RASEAMDRSS LSRSIGNFQV FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS 450
    EIKLVKIPDF ESRYVQNGTY TAKVVAISKE HPQKTITGTI VITVEDVNDN 500
    CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID QPPGTAQKWK 550
    ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK 600
    GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT 650
    PIPGTIEMLH PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG 700
    MMKGSSSASV TKGQHELSEV DGRWEEHRSL LTAGATHHVR TAGTIAANEA 750
    VRTRATGSSR DMSGARGAVA VNEEFLRSYF TEKAASYNGE DDLHMAKDCL 800
    LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL AEVCLGRKID 850
    LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE 900
    VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP 950
    PSTVLLAPRQ PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG 1000
    IPKPLEVTQH LKDAQYVMVR ERESILAPSS GVQPTLAMPS VAAGGQNVTV 1050
    TERILTPAST LQSSYQIPSE TSITARNTVL SSVGSIGPLP NLDLEESDRP 1100
    NSTITTSSTR VTKHSTMQHS YS 1122
    Length:1,122
    Mass (Da):122,385
    Last modified:July 27, 2011 - v3
    Checksum:i9EB9CD402632437A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti304 – 3041D → Y in BAB86843. 1 PublicationCurated
    Sequence conflicti358 – 3581I → L in AAH34056. (PubMed:15489334)Curated
    Sequence conflicti480 – 4801E → D in AAH34056. (PubMed:15489334)Curated
    Sequence conflicti491 – 4911V → I in AAH34056. (PubMed:15489334)Curated
    Sequence conflicti863 – 8631R → T in BAB86843. 1 PublicationCurated
    Sequence conflicti899 – 8991H → R in BAB86843. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072269 mRNA. Translation: BAB86843.1.
    BC034056 mRNA. Translation: AAH34056.1.
    BC131653 mRNA. Translation: AAI31654.1.
    BC131654 mRNA. Translation: AAI31655.1.
    AJ000328 mRNA. Translation: CAA03995.1.
    CCDSiCCDS29084.1.
    RefSeqiNP_031909.2. NM_007883.2.
    UniGeneiMm.345891.

    Genome annotation databases

    EnsembliENSMUST00000059787; ENSMUSP00000057096; ENSMUSG00000044393.
    GeneIDi13511.
    KEGGimmu:13511.
    UCSCiuc008ees.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072269 mRNA. Translation: BAB86843.1 .
    BC034056 mRNA. Translation: AAH34056.1 .
    BC131653 mRNA. Translation: AAI31654.1 .
    BC131654 mRNA. Translation: AAI31655.1 .
    AJ000328 mRNA. Translation: CAA03995.1 .
    CCDSi CCDS29084.1.
    RefSeqi NP_031909.2. NM_007883.2.
    UniGenei Mm.345891.

    3D structure databases

    ProteinModelPortali O55111.
    SMRi O55111. Positions 52-598.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O55111.

    Proteomic databases

    MaxQBi O55111.
    PaxDbi O55111.
    PRIDEi O55111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059787 ; ENSMUSP00000057096 ; ENSMUSG00000044393 .
    GeneIDi 13511.
    KEGGi mmu:13511.
    UCSCi uc008ees.2. mouse.

    Organism-specific databases

    CTDi 1829.
    MGIi MGI:1196466. Dsg2.

    Phylogenomic databases

    eggNOGi NOG293589.
    GeneTreei ENSGT00740000114904.
    HOGENOMi HOG000236266.
    HOVERGENi HBG005532.
    InParanoidi A2RRJ0.
    KOi K07597.
    OMAi VMVRERE.
    OrthoDBi EOG7HQN78.
    TreeFami TF331809.

    Enzyme and pathway databases

    Reactomei REACT_212869. Apoptotic cleavage of cell adhesion proteins.

    Miscellaneous databases

    ChiTaRSi DSG2. mouse.
    NextBioi 284070.
    PROi O55111.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O55111.
    Bgeei O55111.
    CleanExi MM_DSG2.
    Genevestigatori O55111.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view ]
    PANTHERi PTHR24025. PTHR24025. 1 hit.
    Pfami PF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTi SM00112. CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Desmosomal cadherins mediate homophilic cell adhesion."
      Zhuxiang N., Garrod D.R.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
      King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
      Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE.
    4. "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
      Whittock N.V.
      J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-467.

    Entry informationi

    Entry nameiDSG2_MOUSE
    AccessioniPrimary (citable) accession number: O55111
    Secondary accession number(s): A2RRJ0, Q8K069, Q8R517
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3