Reviewed,
UniProtKB/Swiss-Prot O55111 (DSG2_MOUSE)
Last modified
June 16, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Desmoglein-2 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1122 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein By similarity. Cell junction › desmosome By similarity. |
| Tissue specificity | Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis. Ref.4 |
| Developmental stage | Expressed in embryo at 7 to 17 dpc. Expressed uniformly in all E12.5 epithelia, gradually becoming confined to the basal cell layers during. Ref.4 Ref.3 |
| Domain | Calcium may be bound by the cadherin-like repeats Potential. |
| Sequence similarities | Contains 4 cadherin domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell junction Cell membrane Membrane |
| Domain | Repeat Signal Transmembrane |
| Ligand | Calcium |
| PTM | Cleavage on pair of basic residues Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | homophilic cell adhesion Inferred from electronic annotation. Source: InterPro |
| Cellular component | desmosome Inferred from direct assay. Source: MGI integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 28 | 28 | Potential | ||||||
| Propeptide | 29 – 54 | 26 | Potential | PRO_0000003847 | |||||
| Chain | 55 – 1122 | 1068 | Desmoglein-2 | PRO_0000003848 | |||||
Regions | |||||||||
| Topological domain | 55 – 618 | 564 | Extracellular Potential | ||||||
| Transmembrane | 619 – 639 | 21 | Potential | ||||||
| Topological domain | 640 – 1122 | 483 | Cytoplasmic Potential | ||||||
| Domain | 55 – 164 | 110 | Cadherin 1 | ||||||
| Domain | 165 – 277 | 113 | Cadherin 2 | ||||||
| Domain | 278 – 398 | 121 | Cadherin 3 | ||||||
| Domain | 397 – 504 | 108 | Cadherin 4 | ||||||
| Repeat | 885 – 916 | 32 | Desmoglein repeat 1 | ||||||
| Repeat | 917 – 945 | 29 | Desmoglein repeat 2 | ||||||
| Repeat | 946 – 971 | 26 | Desmoglein repeat 3 | ||||||
| Repeat | 972 – 995 | 24 | Desmoglein repeat 4 | ||||||
| Repeat | 996 – 1024 | 29 | Desmoglein repeat 5 | ||||||
| Repeat | 1025 – 1055 | 31 | Desmoglein repeat 6 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 685 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 971 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 1016 | 1 | Phosphotyrosine By similarity | ||||||
| Glycosylation | 117 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 314 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 467 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 519 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 358 | 1 | I → L in AAH34056. Ref.2 | ||||||
| Sequence conflict | 480 | 1 | E → D in AAH34056. Ref.2 | ||||||
| Sequence conflict | 491 | 1 | V → I in AAH34056. Ref.2 | ||||||
| Sequence conflict | 863 | 1 | T → R in AAH34056. Ref.2 | ||||||
| Sequence conflict | 899 | 1 | R → H in AAH34056. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Desmosomal cadherins mediate homophilic cell adhesion." Zhuxiang N., Garrod D.R. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 348-1122. Strain: C57BL/6J. Tissue: Mammary gland. |
| [3] | "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse." King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S. Differentiation 62:83-96(1997) [PubMed: 9404003] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1042-1122, DEVELOPMENTAL STAGE. |
| [4] | "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6." Whittock N.V. J. Invest. Dermatol. 120:970-980(2003) [PubMed: 12787123] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB072269 mRNA. Translation: BAB86843.1. BC034056 mRNA. Translation: AAH34056.1. AJ000328 mRNA. Translation: CAA03995.1. | |
| IPI | IPI00115793. |
| RefSeq | NP_031909.2. |
| UniGene | Mm.345891 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FF5 based on UniProtKB P09803. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | O55111. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000044393. Mus musculus. [Contig view] |
| GeneID | 13511. |
| KEGG | mmu:13511. |
Organism-specific databases | |
| MGI | MGI:1196466. Dsg2. |
Phylogenomic databases | |
| HOGENOM | O55111. |
| HOVERGEN | O55111. |
Gene expression databases | |
| ArrayExpress | O55111. |
| Bgee | O55111. |
| CleanEx | MM_DSG2. |
| GermOnline | ENSMUSG00000044393. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002126. Cadherin. IPR009122. Desmo_cadherin. IPR009123. Desmoglein. IPR015488. Desmoglein2. [Graphical view] |
| Gene3D | G3DSA:2.60.40.60. Cadherin. 4 hits. |
| PANTHER | PTHR10596:SF33. Desmoglein2. 1 hit. |
| Pfam | PF00028. Cadherin. 4 hits. [Graphical view] |
| PRINTS | PR00205. CADHERIN. PR01818. DESMOCADHERN. PR01819. DESMOGLEIN. |
| SMART | SM00112. CA. 4 hits. [Graphical view] |
| PROSITE | PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 284070. |
| SOURCE | Search... |
Entry information
| Entry name | DSG2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O55111 Secondary accession number(s): Q8K069, Q8R517 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


