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Protein

Striatin

Gene

Strn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin
Gene namesi
Name:Strn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1333757. Strn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780StriatinPRO_0000051233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei225 – 2251PhosphothreonineCombined sources
Modified residuei245 – 2451PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO55106.
MaxQBiO55106.
PaxDbiO55106.
PRIDEiO55106.

PTM databases

iPTMnetiO55106.
PhosphoSiteiO55106.

Miscellaneous databases

PMAP-CutDBO55106.

Expressioni

Tissue specificityi

Mainly expressed in brain but is also expressed at low levels in various tissues such as kidney, spleen, skeletal muscle and lung.1 Publication

Gene expression databases

BgeeiO55106.
CleanExiMM_STRN.
ExpressionAtlasiO55106. baseline and differential.
GenevisibleiO55106. MM.

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234590. 2 interactions.
IntActiO55106. 28 interactions.
MINTiMINT-4135965.
STRINGi10090.ENSMUSP00000120830.

Structurei

3D structure databases

ProteinModelPortaliO55106.
SMRiO55106. Positions 42-114, 401-779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati461 – 50040WD 1Add
BLAST
Repeati514 – 55340WD 2Add
BLAST
Repeati567 – 60640WD 3Add
BLAST
Repeati662 – 70140WD 4Add
BLAST
Repeati704 – 74340WD 5Add
BLAST
Repeati750 – 77930WD 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 639Caveolin-bindingSequence analysis
Regioni149 – 16618Calmodulin-bindingSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili53 – 12068Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 459Poly-Ala

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiO55106.
KOiK17608.
OMAiKSKLYLT.
OrthoDBiEOG79KPDR.
PhylomeDBiO55106.
TreeFamiTF313387.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP
60 70 80 90 100
GILHFLQHEW ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR
110 120 130 140 150
RIKMLEYALK QERAKYHKLK YGTELNQGDM KPPSYDSDEG NETEVQPQQN
160 170 180 190 200
SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS KRVRALLGFS SDVTDREDDK
210 220 230 240 250
NQDSVINGTE AEVKETAMIG KSELTDSASV LDNFKFLESA AADVSDEDED
260 270 280 290 300
EDTDGRAKSV IDTSTIVRKK ALPDTSEDRD TKEALKEFDF LVTSEEGDNE
310 320 330 340 350
SRSAGDGTDW EKEDQCLTPE AWNVDQGVIS KLKEQYKKER KGKKGVKRPN
360 370 380 390 400
RSKLQDMLAN LRDVDELPSL QPSVGSPSRP SSSRLPEQEL SRADEVEALT
410 420 430 440 450
FPPSSGKSFI MGADEALESE LGLGELAGLT VANEADSLAY DIANNKDALR
460 470 480 490 500
KTWNPKFTLR SHFDGIRALA FHPIEPVLIT ASEDHTLKMW NLQKTAPAKK
510 520 530 540 550
STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGRI QSWSTTNPNV
560 570 580 590 600
DPYDAYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE
610 620 630 640 650
VAPALSVFND NQELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRV
660 670 680 690 700
LTLESNVDST SSSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH
710 720 730 740 750
SMVAHLEAVT SLAVDPNGLY LMSGSHDCSI RLWNLESKTC IQEFTAHRKK
760 770 780
FEESIHDVAF HPSKCYIASA GADALAKVFV
Length:780
Mass (Da):85,966
Last modified:July 27, 2011 - v2
Checksum:iDC1C1D98E9E5BC08
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441V → F in CAA11545 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223777 mRNA. Translation: CAA11545.1.
BC090968 mRNA. Translation: AAH90968.1.
BC150727 mRNA. Translation: AAI50728.1.
CCDSiCCDS28978.1.
RefSeqiNP_035630.2. NM_011500.2.
UniGeneiMm.311915.
Mm.391038.
Mm.486430.

Genome annotation databases

EnsembliENSMUST00000145910; ENSMUSP00000120830; ENSMUSG00000024077.
GeneIDi268980.
KEGGimmu:268980.
UCSCiuc008doz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223777 mRNA. Translation: CAA11545.1.
BC090968 mRNA. Translation: AAH90968.1.
BC150727 mRNA. Translation: AAI50728.1.
CCDSiCCDS28978.1.
RefSeqiNP_035630.2. NM_011500.2.
UniGeneiMm.311915.
Mm.391038.
Mm.486430.

3D structure databases

ProteinModelPortaliO55106.
SMRiO55106. Positions 42-114, 401-779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234590. 2 interactions.
IntActiO55106. 28 interactions.
MINTiMINT-4135965.
STRINGi10090.ENSMUSP00000120830.

PTM databases

iPTMnetiO55106.
PhosphoSiteiO55106.

Proteomic databases

EPDiO55106.
MaxQBiO55106.
PaxDbiO55106.
PRIDEiO55106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000145910; ENSMUSP00000120830; ENSMUSG00000024077.
GeneIDi268980.
KEGGimmu:268980.
UCSCiuc008doz.1. mouse.

Organism-specific databases

CTDi6801.
MGIiMGI:1333757. Strn.

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
GeneTreeiENSGT00520000055597.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiO55106.
KOiK17608.
OMAiKSKLYLT.
OrthoDBiEOG79KPDR.
PhylomeDBiO55106.
TreeFamiTF313387.

Miscellaneous databases

PMAP-CutDBO55106.
PROiO55106.
SOURCEiSearch...

Gene expression databases

BgeeiO55106.
CleanExiMM_STRN.
ExpressionAtlasiO55106. baseline and differential.
GenevisibleiO55106. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Moqrich A., Mattei M.-G., Bartoli M., Rakitina T., Baillat G., Monneron A., Castets F.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Eye.
  3. "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain."
    Castets F., Rakitina T., Gaillard S., Moqrich A., Mattei M.-G., Monneron A.
    J. Biol. Chem. 275:19970-19977(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; THR-225 AND SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSTRN_MOUSE
AccessioniPrimary (citable) accession number: O55106
Secondary accession number(s): B2RWV9, Q5BKR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.