ID   BL1S1_MOUSE             Reviewed;         125 AA.
AC   O55102; Q9DC96;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   21-SEP-2011, entry version 66.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;
DE            Short=BLOC-1 subunit 1;
DE   AltName: Full=GCN5-like protein 1;
GN   Name=Bloc1s1; Synonyms=Gcn5l1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ;
RX   MEDLINE=98085972; PubMed=9426003; DOI=10.1016/S0378-1119(97)00486-1;
RA   Driessen C.A.G.G., Winkens H.J., Kuhlmann L.D., Janssen B.P.M.,
RA   van Vught A.H.M., Deutman A.F., Janssen J.J.M.;
RT   "Cloning and structural analysis of the murine GCN5L1 gene.";
RL   Gene 203:27-31(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION IN BLOC1 COMPLEX.
RX   PubMed=15102850; DOI=10.1074/jbc.M402513200;
RA   Starcevic M., Dell'Angelica E.C.;
RT   "Identification of snapin and three novel proteins (BLOS1, BLOS2, and
RT   BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-
RT   related organelles complex-1 (BLOC-1).";
RL   J. Biol. Chem. 279:28393-28401(2004).
CC   -!- FUNCTION: The BLOC-1 complex is required for normal biogenesis of
CC       lysosome-related organelles, such as platelet dense granules and
CC       melanosomes. Plays a role in intracellular vesicle trafficking (By
CC       similarity).
CC   -!- SUBUNIT: Part of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1,
CC       BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN.
CC   -!- SIMILARITY: Belongs to the BLOC1S1 family.
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DR   EMBL; Y13778; CAA74108.1; -; Genomic_DNA.
DR   EMBL; Y13779; CAA74108.1; JOINED; Genomic_DNA.
DR   EMBL; Y13780; CAA74108.1; JOINED; Genomic_DNA.
DR   EMBL; Y13781; CAA74108.1; JOINED; Genomic_DNA.
DR   EMBL; AK003035; BAB22523.1; -; mRNA.
DR   EMBL; BC034662; AAH34662.1; -; mRNA.
DR   IPI; IPI00115766; -.
DR   PIR; JC6514; JC6514.
DR   RefSeq; NP_056555.2; NM_015740.3.
DR   UniGene; Mm.30118; -.
DR   STRING; O55102; -.
DR   PhosphoSite; O55102; -.
DR   PRIDE; O55102; -.
DR   Ensembl; ENSMUST00000026405; ENSMUSP00000026405; ENSMUSG00000090247.
DR   GeneID; 14533; -.
DR   KEGG; mmu:14533; -.
DR   UCSC; uc007hoz.1; mouse.
DR   CTD; 2647; -.
DR   MGI; MGI:1195276; Bloc1s1.
DR   eggNOG; roNOG17348; -.
DR   GeneTree; ENSGT00390000002689; -.
DR   HOGENOM; HBG382987; -.
DR   HOVERGEN; HBG050694; -.
DR   InParanoid; O55102; -.
DR   OMA; GATNFAK; -.
DR   OrthoDB; EOG44TP9C; -.
DR   PhylomeDB; O55102; -.
DR   NextBio; 286184; -.
DR   ArrayExpress; O55102; -.
DR   Genevestigator; O55102; -.
DR   GermOnline; ENSMUSG00000025349; Mus musculus.
DR   GO; GO:0031083; C:BLOC-1 complex; IDA:MGI.
DR   GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   InterPro; IPR009395; GCN5L1.
DR   Pfam; PF06320; GCN5L1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Phosphoprotein; Reference proteome.
FT   CHAIN         1    125       Biogenesis of lysosome-related organelles
FT                                complex 1 subunit 1.
FT                                /FTId=PRO_0000156332.
FT   MOD_RES     107    107       Phosphothreonine (By similarity).
FT   CONFLICT     26     26       E -> Y (in Ref. 1; CAA74108).
FT   CONFLICT     35     35       T -> I (in Ref. 1; CAA74108).
FT   CONFLICT     40     40       D -> V (in Ref. 1; CAA74108).
SQ   SEQUENCE   125 AA;  14281 MW;  754897B17BC9479D CRC64;
     MLSRLLKEHQ AKQNERKELQ EKRRREAIAA ATCLTEALVD HLNVGVAQAY MNQRKLDHEV
     KTLQVQAAQF AKQTGQWIGM VENFNQALKE IGDVENWARS IELDMRTIAT ALEYVYKGQL
     QSAPS
//