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Reviewed, UniProtKB/Swiss-Prot O55102 (BL1S1_MOUSE)

Last modified March 2, 2010. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
Biogenesis of lysosome-related organelles complex 1 subunit 1
Short name=BLOC-1 subunit 1
Alternative name(s):
GCN5-like protein 1
Gene names
Name:Bloc1s1
Synonyms:Gcn5l1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking By similarity.

Subunit structure

Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN.

Sequence similarities

Belongs to the BLOC1S1 family.

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Ontologies

Keywords
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular componentmitochondrion

Inferred from direct assay. Source: MGI

   Molecular functionprotein binding Ref.4

Inferred from physical interaction. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 125125Biogenesis of lysosome-related organelles complex 1 subunit 1
PRO_0000156332

Amino acid modifications

Modified residue1071Phosphothreonine By similarity

Experimental info

Sequence conflict261E → Y in CAA74108. Ref.1
Sequence conflict351T → I in CAA74108. Ref.1
Sequence conflict401D → V in CAA74108. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
O55102-1 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: 754897B17BC9479D

FASTA12514,281
        10         20         30         40         50         60 
MLSRLLKEHQ AKQNERKELQ EKRRREAIAA ATCLTEALVD HLNVGVAQAY MNQRKLDHEV 

        70         80         90        100        110        120 
KTLQVQAAQF AKQTGQWIGM VENFNQALKE IGDVENWARS IELDMRTIAT ALEYVYKGQL 


QSAPS

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References

« Hide 'large scale' references
[1]"Cloning and structural analysis of the murine GCN5L1 gene."
Driessen C.A.G.G., Winkens H.J., Kuhlmann L.D., Janssen B.P.M., van Vught A.H.M., Deutman A.F., Janssen J.J.M.
Gene 203:27-31(1997) [PubMed: 9426003] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
[4]"Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."
Starcevic M., Dell'Angelica E.C.
J. Biol. Chem. 279:28393-28401(2004) [PubMed: 15102850] [Abstract]
Cited for: IDENTIFICATION IN BLOC1 COMPLEX.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y13778 expand/collapse EMBL AC list , Y13779, Y13780, Y13781 Genomic DNA. Translation: CAA74108.1.
AK003035 mRNA. Translation: BAB22523.1.
BC034662 mRNA. Translation: AAH34662.1.
IPIIPI00115766.
PIRJC6514.
RefSeqNP_056555.2.
UniGeneMm.30118

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO55102.

PTM databases

PhosphoSiteO55102.

Proteomic databases

PRIDEO55102.

Genome annotation databases

EnsemblENSMUST00000026405; ENSMUSP00000026405; ENSMUSG00000025349; Mus musculus. [Genome view]
GeneID14533.
KEGGmmu:14533.
UCSCuc007hoz.1. mouse.

Organism-specific databases

CTD14533.
MGIMGI:1195276. Bloc1s1.

Phylogenomic databases

eggNOGroNOG17348.
HOGENOMHBG382987.
HOVERGENHBG050694.
InParanoidO55102.
OMAYVNQRKL.
OrthoDBEOG9616PK.
PhylomeDBO55102.

Gene expression databases

ArrayExpressO55102.
BgeeO55102.
GenevestigatorO55102.
GermOnlineENSMUSG00000025349. Mus musculus.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio286184.
SOURCESearch...

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Entry information

Entry nameBL1S1_MOUSE
AccessionPrimary (citable) accession number: O55102
Secondary accession number(s): Q9DC96
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 4, 2005
Last modified: March 2, 2010
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents