O55102 (BL1S1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Biogenesis of lysosome-related organelles complex 1 subunit 1
Short name=BLOC-1 subunit 1

Alternative name(s):
GCN5-like protein 1

Gene names

Name:	Bloc1s1
Synonyms:	Gcn5l1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 AND NDUFA9. May also be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system By similarity.
Subunit structure	Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) that is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes and is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Interacts with ATP5A1 and NDUFA9; involved in their acetylation on lysine residues By similarity.
Subcellular location	Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm › cytosol By similarity Ref.5.
Sequence similarities	Belongs to the BLOC1S1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from sequence or structural similarity. Source: UniProtKB peptidyl-lysine acetylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	BLOC-1 complex Inferred from direct assay Ref.4. Source: MGI mitochondrial intermembrane space Inferred from direct assay Ref.5. Source: UniProtKB mitochondrial matrix Inferred from direct assay Ref.5. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.4. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Biogenesis of lysosome-related organelles complex 1 subunit 1		PRO_0000156332
Regions
	Coiled coil	1 – 31	31	Potential
Amino acid modifications
	Modified residue	107	1	Phosphothreonine By similarity
Experimental info
	Sequence conflict	26	1	E → Y in CAA74108. Ref.1
	Sequence conflict	35	1	T → I in CAA74108. Ref.1
	Sequence conflict	40	1	D → V in CAA74108. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O55102 [UniParc]. Last modified January 4, 2005. Version 2. Checksum: 754897B17BC9479D	FASTA	125	14,281
	10 20 30 40 50 60 MLSRLLKEHQ AKQNERKELQ EKRRREAIAA ATCLTEALVD HLNVGVAQAY MNQRKLDHEV 70 80 90 100 110 120 KTLQVQAAQF AKQTGQWIGM VENFNQALKE IGDVENWARS IELDMRTIAT ALEYVYKGQL QSAPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and structural analysis of the murine GCN5L1 gene." Driessen C.A.G.G., Winkens H.J., Kuhlmann L.D., Janssen B.P.M., van Vught A.H.M., Deutman A.F., Janssen J.J.M. Gene 203:27-31(1997) [PubMed: 9426003] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
[4]	"Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)." Starcevic M., Dell'Angelica E.C. J. Biol. Chem. 279:28393-28401(2004) [PubMed: 15102850] [Abstract] Cited for: IDENTIFICATION IN BLOC1 COMPLEX.
[5]	"Identification of a molecular component of the mitochondrial acetyl transferase program; a novel role for GCN5L1." Scott I., Webster B.R., Li J.H., Sack M.N. Biochem. J. 0:0-0(2012) [PubMed: 22309213] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13778 , Y13779, Y13780, Y13781 Genomic DNA. Translation: CAA74108.1. AK003035 mRNA. Translation: BAB22523.1. BC034662 mRNA. Translation: AAH34662.1.
IPI	IPI00115766.
PIR	JC6514.
RefSeq	NP_056555.2. NM_015740.3.
UniGene	Mm.30118.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O55102.
PTM databases
PhosphoSite	O55102.
Proteomic databases
PRIDE	O55102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000026405; ENSMUSP00000026405; ENSMUSG00000090247.
GeneID	14533.
KEGG	mmu:14533.
UCSC	uc007hoz.1. mouse.
Organism-specific databases
CTD	2647.
MGI	MGI:1195276. Bloc1s1.
Phylogenomic databases
eggNOG	COG1028.
GeneTree	ENSGT00390000002689.
HOGENOM	HOG000005725.
HOVERGEN	HBG050694.
InParanoid	O55102.
OMA	GATNFAK.
OrthoDB	EOG44TP9C.
Gene expression databases
ArrayExpress	O55102.
Genevestigator	O55102.
GermOnline	ENSMUSG00000025349. Mus musculus.
Family and domain databases
InterPro	IPR009395. GCN5L1. [Graphical view]
Pfam	PF06320. GCN5L1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286184.
SOURCE	Search...

Entry information

Entry name

BL1S1_MOUSE

Accession

Primary (citable) accession number: O55102
Secondary accession number(s): Q9DC96

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 4, 2005
Last modified:	May 16, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program