O55102 (BL1S1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Biogenesis of lysosome-related organelles complex 1 subunit 1
Short name=BLOC-1 subunit 1

Alternative name(s):
GCN5-like protein 1

Gene names

Name:	Bloc1s1
Synonyms:	Gcn5l1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking By similarity.
Subunit structure	Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN.
Sequence similarities	Belongs to the BLOC1S1 family.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	BLOC-1 complex Inferred from direct assay Ref.4. Source: MGI mitochondrion Inferred from direct assay. Source: MGI
Molecular function	protein binding Inferred from physical interaction Ref.4. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Biogenesis of lysosome-related organelles complex 1 subunit 1		PRO_0000156332
Amino acid modifications
	Modified residue	107	1	Phosphothreonine By similarity
Experimental info
	Sequence conflict	26	1	E → Y in CAA74108. Ref.1
	Sequence conflict	35	1	T → I in CAA74108. Ref.1
	Sequence conflict	40	1	D → V in CAA74108. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O55102 [UniParc]. Last modified January 4, 2005. Version 2. Checksum: 754897B17BC9479D	FASTA	125	14,281
	10 20 30 40 50 60 MLSRLLKEHQ AKQNERKELQ EKRRREAIAA ATCLTEALVD HLNVGVAQAY MNQRKLDHEV 70 80 90 100 110 120 KTLQVQAAQF AKQTGQWIGM VENFNQALKE IGDVENWARS IELDMRTIAT ALEYVYKGQL QSAPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and structural analysis of the murine GCN5L1 gene." Driessen C.A.G.G., Winkens H.J., Kuhlmann L.D., Janssen B.P.M., van Vught A.H.M., Deutman A.F., Janssen J.J.M. Gene 203:27-31(1997) [PubMed: 9426003] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
[4]	"Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)." Starcevic M., Dell'Angelica E.C. J. Biol. Chem. 279:28393-28401(2004) [PubMed: 15102850] [Abstract] Cited for: IDENTIFICATION IN BLOC1 COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y13778 , Y13779, Y13780, Y13781 Genomic DNA. Translation: CAA74108.1. AK003035 mRNA. Translation: BAB22523.1. BC034662 mRNA. Translation: AAH34662.1.
IPI	IPI00115766.
PIR	JC6514.
RefSeq	NP_056555.2. NM_015740.3.
UniGene	Mm.30118.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O55102.
PTM databases
PhosphoSite	O55102.
Proteomic databases
PRIDE	O55102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000026405; ENSMUSP00000026405; ENSMUSG00000090247.
GeneID	14533.
KEGG	mmu:14533.
UCSC	uc007hoz.1. mouse.
Organism-specific databases
CTD	2647.
MGI	MGI:1195276. Bloc1s1.
Phylogenomic databases
eggNOG	roNOG17348.
GeneTree	ENSGT00390000002689.
HOGENOM	HBG382987.
HOVERGEN	HBG050694.
InParanoid	O55102.
OMA	GATNFAK.
OrthoDB	EOG44TP9C.
PhylomeDB	O55102.
Gene expression databases
ArrayExpress	O55102.
Genevestigator	O55102.
GermOnline	ENSMUSG00000025349. Mus musculus.
Family and domain databases
InterPro	IPR009395. GCN5L1. [Graphical view]
Pfam	PF06320. GCN5L1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286184.
SOURCE	Search...

Entry information

Entry name

BL1S1_MOUSE

Accession

Primary (citable) accession number: O55102
Secondary accession number(s): Q9DC96

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 4, 2005
Last modified:	September 21, 2011
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program