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Protein

Synaptogyrin-2

Gene

Syngr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-2
Alternative name(s):
Cellugyrin
Gene namesi
Name:Syngr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1328324. Syngr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839941 – 224Synaptogyrin-2Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO55101.
PaxDbiO55101.
PRIDEiO55101.

PTM databases

PhosphoSitePlusiO55101.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048277.
CleanExiMM_SYNGR2.
ExpressionAtlasiO55101. baseline and differential.
GenevisibleiO55101. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026649.

Structurei

3D structure databases

ProteinModelPortaliO55101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 171MARVELPROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITZZ. Eukaryota.
ENOG4111G0F. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiO55101.
OMAiYSNTHES.
OrthoDBiEOG091G0LFH.
PhylomeDBiO55101.
TreeFamiTF320995.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGAYGAAN AGGSFDLRRF LSQPQVVTRL VSMVLALIVF SCIFGEGYTN
60 70 80 90 100
IHTSDQLYCV FNQNEDACRY GSAIGVLAFL ASAFFLVVDA FFSQISNATD
110 120 130 140 150
RKYLVIGDLL FSALWTFLWF VGFCFLTNQW AATKPQDVRV GADSARAAIT
160 170 180 190 200
FSFFSIFSWG VLASLAYQRY KAGVDAFIQN YVDPTPDPNT AYASYPSASV
210 220
ENYQQPPFTQ NVETTEGYQP PPVY
Length:224
Mass (Da):24,778
Last modified:June 1, 1998 - v1
Checksum:i951FE014C9C3EEB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69R → H in BAC40876 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti215T → I.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002307 mRNA. Translation: CAA05324.1.
AF151985 mRNA. Translation: AAD38046.1.
AF364049 mRNA. Translation: AAK50857.1.
AK089424 mRNA. Translation: BAC40876.1.
AK150234 mRNA. Translation: BAE29399.1.
AK170681 mRNA. Translation: BAE41954.1.
BC004829 mRNA. Translation: AAH04829.1.
CCDSiCCDS25691.1.
RefSeqiNP_033330.1. NM_009304.2.
UniGeneiMm.468228.

Genome annotation databases

EnsembliENSMUST00000026649; ENSMUSP00000026649; ENSMUSG00000048277.
GeneIDi20973.
KEGGimmu:20973.
UCSCiuc007mnx.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002307 mRNA. Translation: CAA05324.1.
AF151985 mRNA. Translation: AAD38046.1.
AF364049 mRNA. Translation: AAK50857.1.
AK089424 mRNA. Translation: BAC40876.1.
AK150234 mRNA. Translation: BAE29399.1.
AK170681 mRNA. Translation: BAE41954.1.
BC004829 mRNA. Translation: AAH04829.1.
CCDSiCCDS25691.1.
RefSeqiNP_033330.1. NM_009304.2.
UniGeneiMm.468228.

3D structure databases

ProteinModelPortaliO55101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026649.

PTM databases

PhosphoSitePlusiO55101.

Proteomic databases

MaxQBiO55101.
PaxDbiO55101.
PRIDEiO55101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026649; ENSMUSP00000026649; ENSMUSG00000048277.
GeneIDi20973.
KEGGimmu:20973.
UCSCiuc007mnx.2. mouse.

Organism-specific databases

CTDi9144.
MGIiMGI:1328324. Syngr2.

Phylogenomic databases

eggNOGiENOG410ITZZ. Eukaryota.
ENOG4111G0F. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiO55101.
OMAiYSNTHES.
OrthoDBiEOG091G0LFH.
PhylomeDBiO55101.
TreeFamiTF320995.

Miscellaneous databases

ChiTaRSiSyngr2. mouse.
PROiO55101.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048277.
CleanExiMM_SYNGR2.
ExpressionAtlasiO55101. baseline and differential.
GenevisibleiO55101. MM.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNG2_MOUSE
AccessioniPrimary (citable) accession number: O55101
Secondary accession number(s): Q3TCK2, Q8C225, Q99K83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.