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Protein

Synaptogyrin-2

Gene

Syngr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-2Curated
Alternative name(s):
Cellugyrin1 Publication
Gene namesi
Name:Syngr2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1328324. Syngr2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839941 – 224Synaptogyrin-2Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphoserineBy similarity1

Post-translational modificationi

May be tyrosine phosphorylated by Src.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO55101.
PaxDbiO55101.
PRIDEiO55101.

PTM databases

PhosphoSitePlusiO55101.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048277.
CleanExiMM_SYNGR2.
ExpressionAtlasiO55101. baseline and differential.
GenevisibleiO55101. MM.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 171MARVELPROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITZZ. Eukaryota.
ENOG4111G0F. LUCA.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG000896.
InParanoidiO55101.
OMAiYSNTHES.
OrthoDBiEOG091G0LFH.
PhylomeDBiO55101.
TreeFamiTF320995.

Family and domain databases

InterProiView protein in InterPro
IPR008253. Marvel.
IPR016579. Synaptogyrin.
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiView protein in Pfam
PF01284. MARVEL. 1 hit.
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiView protein in PROSITE
PS51225. MARVEL. 1 hit.

Sequencei

Sequence statusi: Complete.

O55101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGAYGAAN AGGSFDLRRF LSQPQVVTRL VSMVLALIVF SCIFGEGYTN
60 70 80 90 100
IHTSDQLYCV FNQNEDACRY GSAIGVLAFL ASAFFLVVDA FFSQISNATD
110 120 130 140 150
RKYLVIGDLL FSALWTFLWF VGFCFLTNQW AATKPQDVRV GADSARAAIT
160 170 180 190 200
FSFFSIFSWG VLASLAYQRY KAGVDAFIQN YVDPTPDPNT AYASYPSASV
210 220
ENYQQPPFTQ NVETTEGYQP PPVY
Length:224
Mass (Da):24,778
Last modified:June 1, 1998 - v1
Checksum:i951FE014C9C3EEB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69R → H in BAC40876 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti215T → I1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002307 mRNA. Translation: CAA05324.1.
AF151985 mRNA. Translation: AAD38046.1.
AF364049 mRNA. Translation: AAK50857.1.
AK089424 mRNA. Translation: BAC40876.1.
AK150234 mRNA. Translation: BAE29399.1.
AK170681 mRNA. Translation: BAE41954.1.
BC004829 mRNA. Translation: AAH04829.1.
CCDSiCCDS25691.1.
RefSeqiNP_033330.1. NM_009304.2.
UniGeneiMm.468228.

Genome annotation databases

EnsembliENSMUST00000026649; ENSMUSP00000026649; ENSMUSG00000048277.
GeneIDi20973.
KEGGimmu:20973.
UCSCiuc007mnx.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNG2_MOUSE
AccessioniPrimary (citable) accession number: O55101
Secondary accession number(s): Q3TCK2, Q8C225, Q99K83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families