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Protein

Dipeptidyl peptidase 3

Gene

Dpp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (By similarity). Also cleaves Arg-Arg-beta-naphthylamide.By similarity

Catalytic activityi

Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Enzyme regulationi

Inhibited by spinorphin, an opioid peptide derived from hemoglobin.By similarity

pH dependencei

Optimum pH is 9.0.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi450Zinc; catalytic1 Publication1
Active sitei4511 Publication1
Metal bindingi455Zinc; catalytic1 Publication1
Metal bindingi508Zinc; catalyticBy similarity1

GO - Molecular functioni

  • dipeptidyl-peptidase activity Source: GO_Central
  • metallopeptidase activity Source: UniProtKB-KW
  • zinc ion binding Source: RGD

GO - Biological processi

  • proteolysis Source: RGD

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM49.001

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 3 (EC:3.4.14.4)
Alternative name(s):
Dipeptidyl aminopeptidase III
Dipeptidyl arylamidase III
Dipeptidyl peptidase III
Short name:
DPP III
Enkephalinase B
Gene namesi
Name:Dpp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621127 Dpp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi176C → A: 25% to 35% of wild-type activity. 1 Publication1
Mutagenesisi176C → E or G: Loss of activity. 1 Publication1
Mutagenesisi450H → Y: Loss of activity and zinc binding. 1 Publication1
Mutagenesisi451E → A or D: Loss of activity. 1 Publication1
Mutagenesisi455H → Y: Loss of activity and zinc binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000782402 – 738Dipeptidyl peptidase 3Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO55096
PRIDEiO55096

2D gel databases

World-2DPAGE0004:O55096

PTM databases

iPTMnetiO55096
PhosphoSitePlusiO55096

Expressioni

Gene expression databases

BgeeiENSRNOG00000031485
GenevisibleiO55096 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026968

Structurei

3D structure databases

ProteinModelPortaliO55096
SMRiO55096
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M49 family.Curated

Phylogenomic databases

eggNOGiKOG3675 Eukaryota
ENOG410XRK4 LUCA
GeneTreeiENSGT00390000007335
HOGENOMiHOG000187784
HOVERGENiHBG025680
InParanoidiO55096
KOiK01277
OMAiGEWEGFA
OrthoDBiEOG091G0KUS
PhylomeDBiO55096

Family and domain databases

InterProiView protein in InterPro
IPR005317 Dipeptidyl-peptase3
PIRSFiPIRSF007828 Dipeptidyl-peptidase_III, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTQYILPN DIGVSSLDCR EAFRLLSPTE RLYAHHLSRA AWYGGLAVLL
60 70 80 90 100
QTSPEAPYIY ALLSRLFRAQ DPDQLRQHAL AEGLTEEEYQ AFLVYAAGVY
110 120 130 140 150
SNMGNYKSFG DTKFVPNLPK EKLERVILGS KAAQQHPEEV RSLWQTCGEL
160 170 180 190 200
MFSLEPRLRH LGLGKEGVTT YFSGDCAMED AKLAQDFLDS QNLSAYNTRL
210 220 230 240 250
FKVVGQEGKY HYEVRLASVL NTEPALDSEL TSKLKSYEFQ GNHFQVTRGD
260 270 280 290 300
YAPILQKVVE HLEKAKAYAA NSHQEQMLAQ YVESFTQGSI EAHKRGSRFW
310 320 330 340 350
IQDKGPIVES YIGFIESYRD PFGSRGEFEG FVAMVNKDMS AKFERLVASA
360 370 380 390 400
EQLLKELPWP PAFEKDKFLT PDFTSLDVLT FAGSGIPAGI NIPNYDDLRQ
410 420 430 440 450
TEGFKNVSLG NVLAVAYATK REKLTFMEEE DKDLYIRWKG PSFDVQVGLH
460 470 480 490 500
ELLGHGSGKL FVQDEKGAFN FDQETVINPE TGEQIQSWYR SGETWDSKFS
510 520 530 540 550
TIASSYEECR AESVGLYLCL NPQVLQIFGF EGTDAEDVIY VNWLNMVRAG
560 570 580 590 600
LLALEFYTPE TANWRQAHMQ ARFVILRVLL EAGEGLVTVT PTTGSDGRPD
610 620 630 640 650
ARVHLDRSKI RSVGKPALER FLRRLQVLKS TGDVVAGRAL YEGYAAVTDA
660 670 680 690 700
PPECFLTLRD TVLLRKESRK LIVQPNTRLE GSEVQLVEYE ASAAGLIRSF
710 720 730
CERFPEDGPE LEEVLTQLAT ADAQFWRDQV QEAPSGQA
Length:738
Mass (Da):83,039
Last modified:May 1, 2000 - v2
Checksum:i74BA736BA0806B78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89340 mRNA Translation: BAA24608.2
BC107673 mRNA Translation: AAI07674.1
RefSeqiNP_446200.1, NM_053748.1
XP_006230695.1, XM_006230633.3
UniGeneiRn.10902
Rn.145904

Genome annotation databases

EnsembliENSRNOT00000026968; ENSRNOP00000026968; ENSRNOG00000031485
GeneIDi114591
KEGGirno:114591
UCSCiRGD:621127 rat

Similar proteinsi

Entry informationi

Entry nameiDPP3_RAT
AccessioniPrimary (citable) accession number: O55096
Secondary accession number(s): Q32Q87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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