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Protein
Submitted name:

SFlt-1

Gene

Flt1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-194306. Neurophilin interactions with VEGF and VEGFR.
R-MMU-195399. VEGF binds to VEGFR leading to receptor dimerization.

Names & Taxonomyi

Protein namesi
Submitted name:
SFlt-1Imported
Submitted name:
Vascular endothelial growth factor receptor 1Imported
Gene namesi
Name:Flt1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95558. Flt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000029648.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031653.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12493Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini231 – 32898Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini429 – 550122Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini557 – 656100Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
HOGENOMiHOG000114763.
HOVERGENiHBG053003.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR009135. VEGFR1_rcpt.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
PRINTSiPR01833. VEGFRECEPTR1.
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSCWDTAVL PYALLGCLLL TGYGSGSKLK VPELSLKGTQ HVMQAGQTLF
60 70 80 90 100
LKCRGEAAHS WSLPTTVSQE DKRLSITPPS ACGRDNRQFC STLTLDTAQA
110 120 130 140 150
NHTGLYTCRY LPTSTSKKKK AESSIYIFVS DAGSPFIEMH TDIPKLVHMT
160 170 180 190 200
EGRQLIIPCR VTSPNVTVTL KKFPFDTLTP DGQRITWDSR RGFIIANATY
210 220 230 240 250
KEIGLLNCEA TVNGHLYQTN YLTHRQTNTI LDVQIRPPSP VRLLHGQTLV
260 270 280 290 300
LNCTATTELN TRVQMSWNYP GKATKRASIR QRIDRSHSHN NVFHSVLKIN
310 320 330 340 350
NVESRDKGLY TCRVKSGSSF QSFNTSVHVY EKGFISVKHR KQPVQETTAG
360 370 380 390 400
RRSYRLSMKV KAFPSPEIVW LKDGSPATLK SARYLVHGYS LIIKDVTTED
410 420 430 440 450
AGDYTILLGI KQSRLFKNLT ATLIVNVKPQ IYEKSVSSLP SPPLYPLGSR
460 470 480 490 500
QVLTCTVYGI PRPTITWLWH PCHHNHSKER YDFCTENEES FILDPSSNLG
510 520 530 540 550
NRIESISQRM TVIEGTNKTV STLVVADSQT PGIYSCRAFN KIGTVERNIK
560 570 580 590 600
FYVTDVPNGF HVSLEKMPAE GEDLKLSCVV NKFLYRDITW ILLRTVNNRT
610 620 630 640 650
MHHSISKQKM ATTQDYSITL NLVIKNVSLE DSGTYACRAR NIYTGEDILR
660 670 680
KTEVLVRGEH CGKKAIFSRI SKFKSRRNDC TTQSHVKH
Length:688
Mass (Da):77,522
Last modified:June 1, 1998 - v1
Checksum:i0301825F7F961A99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122299 Genomic DNA. No translation available.
AC131730 Genomic DNA. No translation available.
D88690 mRNA. Translation: BAA24499.1.
AK146906 mRNA. Translation: BAE27519.1.
UniGeneiMm.389712.

Genome annotation databases

EnsembliENSMUST00000110529; ENSMUSP00000106158; ENSMUSG00000029648.
UCSCiuc009aoi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122299 Genomic DNA. No translation available.
AC131730 Genomic DNA. No translation available.
D88690 mRNA. Translation: BAA24499.1.
AK146906 mRNA. Translation: BAE27519.1.
UniGeneiMm.389712.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110529; ENSMUSP00000106158; ENSMUSG00000029648.
UCSCiuc009aoi.2. mouse.

Organism-specific databases

MGIiMGI:95558. Flt1.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
HOGENOMiHOG000114763.
HOVERGENiHBG053003.

Enzyme and pathway databases

ReactomeiR-MMU-194306. Neurophilin interactions with VEGF and VEGFR.
R-MMU-195399. VEGF binds to VEGFR leading to receptor dimerization.

Miscellaneous databases

ChiTaRSiFlt1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029648.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR009135. VEGFR1_rcpt.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
PRINTSiPR01833. VEGFRECEPTR1.
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO55095_MOUSE
AccessioniPrimary (citable) accession number: O55095
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.