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Protein

Myocyte-specific enhancer factor 2B

Gene

Mef2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi58 – 8629Mef2-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myocyte-specific enhancer factor 2B
Gene namesi
Name:Mef2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104526. Mef2b.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Myocyte-specific enhancer factor 2BPRO_0000199432Add
BLAST

Proteomic databases

PaxDbiO55087.
PRIDEiO55087.

PTM databases

iPTMnetiO55087.
PhosphoSiteiO55087.

Expressioni

Tissue specificityi

Highest expression found in embryonic heart and skeletal muscle. Low levels found in adult spleen, lung and testis while no expression is found in adult heart, brain or skeletal muscle.3 Publications

Developmental stagei

Higher expression in early embryo than in adult.1 Publication

Gene expression databases

CleanExiMM_MEF2B.

Interactioni

Subunit structurei

Heterodimer. Interacts with HDAC9 (By similarity). Interacts with HDAC7.By similarity1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105773.

Structurei

3D structure databases

ProteinModelPortaliO55087.
SMRiO55087. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5755MADS-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MEF2 family.Curated
Contains 1 MADS-box domain.PROSITE-ProRule annotation
Contains 1 Mef2-type DNA-binding domain.Curated

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000230620.
HOVERGENiHBG053944.
InParanoidiO55087.
PhylomeDBiO55087.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B-1 (identifier: O55087-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRKKIQISR ILDQRNRQVT FTKRKFGLMK KAYELSVLCD CDIALIIFNS
60 70 80 90 100
AQRLFQYASS DMDRVLLKYT EYSEPHESRT NADILQTLKR RGVGLDGPEL
110 120 130 140 150
DMEEGPEGPG EKLLRTLGGD RGSASPRPRI YPVAPAMSVS ELSYRVPPAT
160 170 180 190 200
PGCDPGGLGE VPSVHSRPAY FRPPGLGHPI FSPSHLASKT PPPLYLATDG
210 220 230 240 250
RRPDLPPGLV GARGGLGTSR SLYSGLQSPG APGPALGSFA FLPSGSTDCS
260 270 280 290 300
PGDAAQGPLQ PSPWPPTRDA VDPARPVARS LCKEGPPSRG ASPPTPPVSI
310 320 330 340
KSERLSPVTG TSGDFPRSFP YPLLLARPLA EPLRPSASLH RLTPDSWPR
Length:349
Mass (Da):37,435
Last modified:June 1, 1998 - v1
Checksum:i4C49E2A2A8D493D8
GO
Isoform B-2 (identifier: O55087-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-219: Missing.

Show »
Length:339
Mass (Da):36,579
Checksum:i3FFE22D0527C5609
GO
Isoform B-3 (identifier: O55087-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-242: RSLYSGLQSPGAPGPALGSFAFL → IAARETQLRDPCNPHPGHQRGTL
     243-349: Missing.

Show »
Length:242
Mass (Da):26,459
Checksum:iBEEC20E978590079
GO
Isoform B-4 (identifier: O55087-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-232: VGARGGLGTSRSLYSGLQSPGAP → IAARETQLRDPCNPHPGHQRGTL
     233-349: Missing.

Show »
Length:232
Mass (Da):25,603
Checksum:i3F90E4A68C8658A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911A → G in BAA24542 (PubMed:9443808).Curated
Sequence conflicti291 – 2911A → G in BAA24544 (PubMed:9443808).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei210 – 23223VGARG…SPGAP → IAARETQLRDPCNPHPGHQR GTL in isoform B-4. 1 PublicationVSP_006244Add
BLAST
Alternative sequencei210 – 21910Missing in isoform B-2. 1 PublicationVSP_006243
Alternative sequencei220 – 24223RSLYS…SFAFL → IAARETQLRDPCNPHPGHQR GTL in isoform B-3. 1 PublicationVSP_006245Add
BLAST
Alternative sequencei233 – 349117Missing in isoform B-4. 1 PublicationVSP_006246Add
BLAST
Alternative sequencei243 – 349107Missing in isoform B-3. 1 PublicationVSP_006247Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50311 mRNA. Translation: BAA08850.1.
D87831 Genomic DNA. Translation: BAA24539.1.
D87831 Genomic DNA. Translation: BAA24540.1.
D87831 Genomic DNA. Translation: BAA24541.1.
D87835 mRNA. Translation: BAA24544.1.
D87836 mRNA. Translation: BAA24545.1.
D87834 mRNA. Translation: BAA24543.1.
D87833 mRNA. Translation: BAA24542.1.
CCDSiCCDS22361.1. [O55087-1]
CCDS40368.1. [O55087-2]
PIRiJC5881.
JC5882.
JC5883.
UniGeneiMm.432505.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50311 mRNA. Translation: BAA08850.1.
D87831 Genomic DNA. Translation: BAA24539.1.
D87831 Genomic DNA. Translation: BAA24540.1.
D87831 Genomic DNA. Translation: BAA24541.1.
D87835 mRNA. Translation: BAA24544.1.
D87836 mRNA. Translation: BAA24545.1.
D87834 mRNA. Translation: BAA24543.1.
D87833 mRNA. Translation: BAA24542.1.
CCDSiCCDS22361.1. [O55087-1]
CCDS40368.1. [O55087-2]
PIRiJC5881.
JC5882.
JC5883.
UniGeneiMm.432505.

3D structure databases

ProteinModelPortaliO55087.
SMRiO55087. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105773.

PTM databases

iPTMnetiO55087.
PhosphoSiteiO55087.

Proteomic databases

PaxDbiO55087.
PRIDEiO55087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104526. Mef2b.

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
HOGENOMiHOG000230620.
HOVERGENiHBG053944.
InParanoidiO55087.
PhylomeDBiO55087.

Miscellaneous databases

PROiO55087.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MEF2B.

Family and domain databases

InterProiIPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEF2B_MOUSE
AccessioniPrimary (citable) accession number: O55087
Secondary accession number(s): O55088
, O55089, O55090, O55231, Q61843
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.