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O55082

- PTN20_MOUSE

UniProt

O55082 - PTN20_MOUSE

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Protein

Tyrosine-protein phosphatase non-receptor type 20

Gene

Ptpn20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 PublicationPROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei329 – 3291SubstrateBy similarity
Active sitei359 – 3591Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei403 – 4031SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 20 (EC:3.1.3.48)
Alternative name(s):
Testis-specific tyrosine phosphatase
Gene namesi
Name:Ptpn20
Synonyms:Typ
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1196295. Ptpn20.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Colocalizes with the microtubule-organizing center and intracellular membrane compartments.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Tyrosine-protein phosphatase non-receptor type 20PRO_0000295756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO55082.

PTM databases

PhosphoSiteiO55082.

Expressioni

Tissue specificityi

Testis-specific. Specifically expressed in testicular germ cells that undergo meiosis (at protein level).1 Publication

Developmental stagei

Detected between 2 and 3 weeks after birth, in parallel with the onset of meiosis.1 Publication

Gene expression databases

BgeeiO55082.
GenevestigatoriO55082.

Structurei

3D structure databases

ProteinModelPortaliO55082.
SMRiO55082. Positions 150-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 418254Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni359 – 3657Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000119210.
HOGENOMiHOG000243992.
HOVERGENiHBG095763.
InParanoidiO55082.
KOiK18039.
OMAiAPEPVCC.
OrthoDBiEOG7K9K22.
PhylomeDBiO55082.
TreeFamiTF315573.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O55082) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPRKVRGK TGRDNDEEEG NSGNLNLRNS LPSSSQKMTP TKPIFGNKMN
60 70 80 90 100
SENVKPSHHL SFSDKYELVY PEPLESDTDE TVWDVSDRSL RNRWNSMDSE
110 120 130 140 150
TAGPSKTVSP VLSGSSRLSK DTETSVSEKE LTQLAQIRPL IFNSSARSAM
160 170 180 190 200
RDCLNTLQKK EELDIIREFL ELEQMTLPDD FNSGNTLQNR DKNRYRDILP
210 220 230 240 250
YDSTRVPLGK NKDYINASYI RIVNHEEEYF YIATQGPLPE TIEDFWQMVL
260 270 280 290 300
ENNCNVIAMI TREIECGVIK CYSYWPISLK EPLEFEHFSV FLETFHVTQY
310 320 330 340 350
FTVRVFQIVK KSTGKSQCVK HLQFTKWPDH GTPASADFFI KYVRYVRKSH
360 370 380 390 400
ITGPLLVHCS AGVGRTGVFI CVDVVFSAIE KNYSFDIMNI VTQMRKQRCG
410 420
MIQTKEQYQF CYEIVLEVLQ NLLALY
Length:426
Mass (Da):49,119
Last modified:June 1, 1998 - v1
Checksum:i2B35FB13379502F4
GO
Isoform 2 (identifier: O55082-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-133: TETSVSEKELTQ → DIYKVSDTWNIY
     134-426: Missing.

Note: No experimental confirmation available.

Show »
Length:133
Mass (Da):14,972
Checksum:i6924B0278635004A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 13312TETSV…KELTQ → DIYKVSDTWNIY in isoform 2. 1 PublicationVSP_027074Add
BLAST
Alternative sequencei134 – 426293Missing in isoform 2. 1 PublicationVSP_027075Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64141 mRNA. Translation: BAA23761.1.
AK029493 mRNA. Translation: BAC26476.1.
BC139817 mRNA. Translation: AAI39818.1.
CCDSiCCDS36870.1. [O55082-1]
RefSeqiNP_033004.1. NM_008978.2. [O55082-1]
UniGeneiMm.8019.

Genome annotation databases

EnsembliENSMUST00000022508; ENSMUSP00000022508; ENSMUSG00000021940. [O55082-1]
GeneIDi19256.
KEGGimmu:19256.
UCSCiuc007szx.1. mouse. [O55082-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64141 mRNA. Translation: BAA23761.1 .
AK029493 mRNA. Translation: BAC26476.1 .
BC139817 mRNA. Translation: AAI39818.1 .
CCDSi CCDS36870.1. [O55082-1 ]
RefSeqi NP_033004.1. NM_008978.2. [O55082-1 ]
UniGenei Mm.8019.

3D structure databases

ProteinModelPortali O55082.
SMRi O55082. Positions 150-424.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O55082.

Proteomic databases

PRIDEi O55082.

Protocols and materials databases

DNASUi 19256.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022508 ; ENSMUSP00000022508 ; ENSMUSG00000021940 . [O55082-1 ]
GeneIDi 19256.
KEGGi mmu:19256.
UCSCi uc007szx.1. mouse. [O55082-1 ]

Organism-specific databases

CTDi 19256.
MGIi MGI:1196295. Ptpn20.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000119210.
HOGENOMi HOG000243992.
HOVERGENi HBG095763.
InParanoidi O55082.
KOi K18039.
OMAi APEPVCC.
OrthoDBi EOG7K9K22.
PhylomeDBi O55082.
TreeFami TF315573.

Miscellaneous databases

ChiTaRSi DUSP4. mouse.
NextBioi 296104.
PROi O55082.
SOURCEi Search...

Gene expression databases

Bgeei O55082.
Genevestigatori O55082.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytes."
    Ohsugi M., Kuramochi S., Matsuda S., Yamamoto T.
    J. Biol. Chem. 272:33092-33099(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ENZYME ACTIVITY, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiPTN20_MOUSE
AccessioniPrimary (citable) accession number: O55082
Secondary accession number(s): A4QPF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3