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Protein

DNA topoisomerase 2

Gene
N/A
Organism
Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 2UniRule annotation (EC:5.99.1.3UniRule annotation)
OrganismiCricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)Imported
Taxonomic identifieri10030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO55079.
SMRiO55079. Positions 28-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini454 – 571118ToprimInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation
Contains 1 Toprim domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG052998.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR012542. DTHCT.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR028466. Top2a.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR031660. TOPRIM_C.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR10169:SF46. PTHR10169:SF46. 1 hit.
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
PF16898. TOPRIM_C. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00433. TOP2c. 1 hit.
SM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSPLQPVN ENMQMNKKKN EDAKKRLSIE RIYQKKTQLE HILLRPDTYI
60 70 80 90 100
GSVELVTQQM WVYDEDVGIN YREVTFVPGL YKIFDEILVN AADNKQRDPK
110 120 130 140 150
MSCIRVTIDP ENNLISIWNN GKGIPVVEHK VEKMYVPALI FGQLLTSSNY
160 170 180 190 200
DDDEKKVTGG RNGYGAKLCN IFSTRFTVET ASKEYKKMFK QTWMDNMGRA
210 220 230 240 250
GDMELKPFNG EDYTCITFQP DLSKFKMQSL DKDIVALMVR RAYDIAGSTK
260 270 280 290 300
DVKVFLNGNK LPVKGFRSYV DMYLKDKLDE TGNALKVVHE QVNPRWEVCL
310 320 330 340 350
TMSEKGFQQI SFVNSIATSK GGRHVDYVAD QIVSKLVDVV KKKNKGGVAV
360 370 380 390 400
KAHQVKNHMW IFVNALIENP TFDSQTKENM TLQAKSFGST CQLSEKFIKA
410 420 430 440 450
AIGCGIVESI LNWVKFKAQI QLNKKCSAVK HNRIKGIPKL DDANDAGSRN
460 470 480 490 500
STECTLILTE GDSAKTLAVS GLGVVGRDKY GVFPLGGKIL NVREASHKQI
510 520 530 540 550
MENAEINNII KIVGLQYKKN YEDEDSLKTL RYGKIMIMTD QDQDGSHIKG
560 570 580 590 600
LLINFIHHNW PSLLRHRFLE EFITPIVKVS KNKQELAFYS LPEFEEWKSS
610 620 630 640 650
TPNHKKWKVK YYKGLGTSTS KEAKEYFADM KRHRIQFKYS GPEDDAAISL
660 670 680 690 700
AFSKKQVDDR KEWLTHFMED RRQRKLLGLP EDYLYGQTTT YLTYNDFINK
710 720 730 740 750
ELILFSNSDN ERSIPSMVDG LKPGQRKVLF TCFKRNDKRE VKVAQLAGSV
760 770 780 790 800
AEMSSYHHGE MSLMMTIINL AQNFVGSNNL NLLQPIGQFG TRLHGGKDSA
810 820 830 840 850
SPRYIFTMLS PLTRLLFPPK DDHTLKFLYD DNQRVEPEWY IPIIPMVLIN
860 870 880 890 900
GAEGIGTGWS CKIPNFDIRE VVNNIRRLLD GEEPLPMLPS YKNFKGTIEE
910 920 930 940 950
LASNQYVING EVAILNSTTI EISELPIRTW TQTYKEQVLE PMLNGTEKTP
960 970 980 990 1000
PLITDYREYH TDTTVKFVIK MTEEKLAEAE RVGLHKVFKL QTSLTCNSMV
1010 1020 1030 1040 1050
LFDHVGCLKK YDTVLDILKD FFELRLKYYG LRKEWLLGML GAESAKLNNQ
1060 1070 1080 1090 1100
ARFILEKIDG KIIIENKPKK ELIKVLIQRG YDSDPVKAWK EAQQKVPDEE
1110 1120 1130 1140 1150
ENEESDNENS DSVAESGPTF NYLLDMPLWY LTKEKKDELC KQRNEKEQEL
1160 1170 1180 1190 1200
NTLKNKSPSD LWKEDLAVFI EELEVVEAKE KQDEQVGLPG KGGKAKGKKA
1210 1220 1230 1240 1250
QMSEVLPSPH GKRVIPQVTM EMKAEAEKKI RKKIKSENVE GTPTENGLEL
1260 1270 1280 1290 1300
GSLKQRIEKK QKKEPGAMTK KQTTLAFKPI KKGKKRNPWS DSESDMSSNE
1310 1320 1330 1340 1350
SNVDVPPREK DPRRAATKAK FTMDLDSDED FSGSDGKDED EDFFPLDTTP
1360 1370 1380 1390 1400
PKTKIPQKNT KKALKPQKSA MSGDPESDEK DSVPASPGPP AADLPADTEQ
1410 1420 1430 1440 1450
LKPSSKQTVA VKKTATKSQS STSTAGTKKR AVPKGSKSDS ALNAHGPEKP
1460 1470 1480 1490 1500
VPAKAKNSRK RKQSSSDDSD SDFEKVVSKV AASKKSKGEN QDFRVDLDET
1510 1520
MVPRAKSGRA KKPIKYLEES DDDDLF
Length:1,526
Mass (Da):173,098
Last modified:June 1, 1998 - v1
Checksum:i5E73723C87019929
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16595 mRNA. Translation: CAA76313.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16595 mRNA. Translation: CAA76313.1.

3D structure databases

ProteinModelPortaliO55079.
SMRiO55079. Positions 28-404.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052998.

Family and domain databases

Gene3Di1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
3.90.199.10. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR012542. DTHCT.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR028466. Top2a.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR031660. TOPRIM_C.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR10169:SF46. PTHR10169:SF46. 1 hit.
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00521. DNA_topoisoIV. 1 hit.
PF08070. DTHCT. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
PF16898. TOPRIM_C. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00433. TOP2c. 1 hit.
SM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO55079_CRILO
AccessioniPrimary (citable) accession number: O55079
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.