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Protein

Cytochrome P450 2B19

Gene

Cyp2b19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B19 (EC:1.14.14.1)
Alternative name(s):
CYPIIB19
Gene namesi
Name:Cyp2b19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107303. Cyp2b19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Cytochrome P450 2B19PRO_0000051689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO55071.
PaxDbiO55071.
PRIDEiO55071.

PTM databases

PhosphoSiteiO55071.

Expressioni

Tissue specificityi

Expressed only in differentiated keratinocytes in skin.

Gene expression databases

BgeeiO55071.
GenevisibleiO55071. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077021.

Structurei

3D structure databases

ProteinModelPortaliO55071.
SMRiO55071. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiO55071.
KOiK07412.
OMAiIVANIIC.
OrthoDBiEOG7RBZ85.
PhylomeDBiO55071.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSVLLLLA LTTGFLIFLV SQSQPKTHGH FPPGPRPLPF LGNLLQMDRR
60 70 80 90 100
GLLSSFIQLQ EKYGDVFTVH LGPRPVVMLC GTDTIREALV NQAEAFSGRG
110 120 130 140 150
TVAVLDPIVQ GYGVIFSSGE RWKTLRRFSL ATMRDFGMGK RSVEERIKEE
160 170 180 190 200
AQCLVEELKK YKGAPLNPTF YFQCIVANII CSIVFGERFD YKDHQFLHLL
210 220 230 240 250
NLIYQTFSLM SSLSSQVFEL FSAILKYFPG AHRQISKNLQ EILDYIGHSV
260 270 280 290 300
EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFAG
310 320 330 340 350
TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT
360 370 380 390 400
DAVIHEIQRF TDLAPIGLPH KVTKDTLFRG YLIPKNTEVY PILSSALHDP
410 420 430 440 450
RYFEQPDSFN PEHFLDANGA LKTNEAFMPF STGKRICLGE GIARNELFLF
460 470 480 490
FTTILQNFSL ASPVAPENID LIPNNSGATK TPPQYQIHFL SR
Length:492
Mass (Da):55,997
Last modified:June 1, 1998 - v1
Checksum:i9E685AF61EE2DFA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047529 mRNA. Translation: AAC78770.1.
BC137965 mRNA. Translation: AAI37966.1.
BC137966 mRNA. Translation: AAI37967.1.
CCDSiCCDS21006.1.
RefSeqiNP_031840.1. NM_007814.2.
UniGeneiMm.14098.

Genome annotation databases

EnsembliENSMUST00000077855; ENSMUSP00000077021; ENSMUSG00000066704.
GeneIDi13090.
KEGGimmu:13090.
UCSCiuc009fus.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047529 mRNA. Translation: AAC78770.1.
BC137965 mRNA. Translation: AAI37966.1.
BC137966 mRNA. Translation: AAI37967.1.
CCDSiCCDS21006.1.
RefSeqiNP_031840.1. NM_007814.2.
UniGeneiMm.14098.

3D structure databases

ProteinModelPortaliO55071.
SMRiO55071. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077021.

PTM databases

PhosphoSiteiO55071.

Proteomic databases

MaxQBiO55071.
PaxDbiO55071.
PRIDEiO55071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077855; ENSMUSP00000077021; ENSMUSG00000066704.
GeneIDi13090.
KEGGimmu:13090.
UCSCiuc009fus.2. mouse.

Organism-specific databases

CTDi13090.
MGIiMGI:107303. Cyp2b19.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiO55071.
KOiK07412.
OMAiIVANIIC.
OrthoDBiEOG7RBZ85.
PhylomeDBiO55071.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.

Miscellaneous databases

NextBioi283066.
PROiO55071.
SOURCEiSearch...

Gene expression databases

BgeeiO55071.
GenevisibleiO55071. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes."
    Keeney D.S.
    Genomics 53:417-419(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP2BJ_MOUSE
AccessioniPrimary (citable) accession number: O55071
Secondary accession number(s): B2RQK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.