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O55071 (CP2BJ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2B19

EC=1.14.14.1
Alternative name(s):
CYPIIB19
Gene names
Name:Cyp2b19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Expressed only in differentiated keratinocytes in skin.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Cytochrome P450 2B19
PRO_0000051689

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue1291Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
O55071 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 9E685AF61EE2DFA2

FASTA49255,997
        10         20         30         40         50         60 
MEFSVLLLLA LTTGFLIFLV SQSQPKTHGH FPPGPRPLPF LGNLLQMDRR GLLSSFIQLQ 

        70         80         90        100        110        120 
EKYGDVFTVH LGPRPVVMLC GTDTIREALV NQAEAFSGRG TVAVLDPIVQ GYGVIFSSGE 

       130        140        150        160        170        180 
RWKTLRRFSL ATMRDFGMGK RSVEERIKEE AQCLVEELKK YKGAPLNPTF YFQCIVANII 

       190        200        210        220        230        240 
CSIVFGERFD YKDHQFLHLL NLIYQTFSLM SSLSSQVFEL FSAILKYFPG AHRQISKNLQ 

       250        260        270        280        290        300 
EILDYIGHSV EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFAG 

       310        320        330        340        350        360 
TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT DAVIHEIQRF 

       370        380        390        400        410        420 
TDLAPIGLPH KVTKDTLFRG YLIPKNTEVY PILSSALHDP RYFEQPDSFN PEHFLDANGA 

       430        440        450        460        470        480 
LKTNEAFMPF STGKRICLGE GIARNELFLF FTTILQNFSL ASPVAPENID LIPNNSGATK 

       490 
TPPQYQIHFL SR 

« Hide

References

« Hide 'large scale' references
[1]"The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes."
Keeney D.S.
Genomics 53:417-419(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047529 mRNA. Translation: AAC78770.1.
BC137965 mRNA. Translation: AAI37966.1.
BC137966 mRNA. Translation: AAI37967.1.
RefSeqNP_031840.1. NM_007814.1.
UniGeneMm.14098.

3D structure databases

ProteinModelPortalO55071.
SMRO55071. Positions 29-492.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO55071.

Proteomic databases

PaxDbO55071.
PRIDEO55071.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077855; ENSMUSP00000077021; ENSMUSG00000066704.
GeneID13090.
KEGGmmu:13090.
UCSCuc009fus.1. mouse.

Organism-specific databases

CTD13090.
MGIMGI:107303. Cyp2b19.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00670000097868.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidB2RQK1.
KOK07412.
OMAIVANIIC.
OrthoDBEOG7RBZ85.
PhylomeDBO55071.
TreeFamTF352043.

Gene expression databases

BgeeO55071.
GenevestigatorO55071.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283066.
PROO55071.
SOURCESearch...

Entry information

Entry nameCP2BJ_MOUSE
AccessionPrimary (citable) accession number: O55071
Secondary accession number(s): B2RQK1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot