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O55071

- CP2BJ_MOUSE

UniProt

O55071 - CP2BJ_MOUSE

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Protein

Cytochrome P450 2B19

Gene

Cyp2b19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B19 (EC:1.14.14.1)
Alternative name(s):
CYPIIB19
Gene namesi
Name:Cyp2b19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:107303. Cyp2b19.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Cytochrome P450 2B19PRO_0000051689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO55071.
PRIDEiO55071.

PTM databases

PhosphoSiteiO55071.

Expressioni

Tissue specificityi

Expressed only in differentiated keratinocytes in skin.

Gene expression databases

BgeeiO55071.
GenevestigatoriO55071.

Structurei

3D structure databases

ProteinModelPortaliO55071.
SMRiO55071. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiO55071.
KOiK07412.
OMAiIVANIIC.
OrthoDBiEOG7RBZ85.
PhylomeDBiO55071.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55071-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFSVLLLLA LTTGFLIFLV SQSQPKTHGH FPPGPRPLPF LGNLLQMDRR
60 70 80 90 100
GLLSSFIQLQ EKYGDVFTVH LGPRPVVMLC GTDTIREALV NQAEAFSGRG
110 120 130 140 150
TVAVLDPIVQ GYGVIFSSGE RWKTLRRFSL ATMRDFGMGK RSVEERIKEE
160 170 180 190 200
AQCLVEELKK YKGAPLNPTF YFQCIVANII CSIVFGERFD YKDHQFLHLL
210 220 230 240 250
NLIYQTFSLM SSLSSQVFEL FSAILKYFPG AHRQISKNLQ EILDYIGHSV
260 270 280 290 300
EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFAG
310 320 330 340 350
TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT
360 370 380 390 400
DAVIHEIQRF TDLAPIGLPH KVTKDTLFRG YLIPKNTEVY PILSSALHDP
410 420 430 440 450
RYFEQPDSFN PEHFLDANGA LKTNEAFMPF STGKRICLGE GIARNELFLF
460 470 480 490
FTTILQNFSL ASPVAPENID LIPNNSGATK TPPQYQIHFL SR
Length:492
Mass (Da):55,997
Last modified:June 1, 1998 - v1
Checksum:i9E685AF61EE2DFA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047529 mRNA. Translation: AAC78770.1.
BC137965 mRNA. Translation: AAI37966.1.
BC137966 mRNA. Translation: AAI37967.1.
CCDSiCCDS21006.1.
RefSeqiNP_031840.1. NM_007814.1.
UniGeneiMm.14098.

Genome annotation databases

EnsembliENSMUST00000077855; ENSMUSP00000077021; ENSMUSG00000066704.
GeneIDi13090.
KEGGimmu:13090.
UCSCiuc009fus.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047529 mRNA. Translation: AAC78770.1 .
BC137965 mRNA. Translation: AAI37966.1 .
BC137966 mRNA. Translation: AAI37967.1 .
CCDSi CCDS21006.1.
RefSeqi NP_031840.1. NM_007814.1.
UniGenei Mm.14098.

3D structure databases

ProteinModelPortali O55071.
SMRi O55071. Positions 29-492.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O55071.

Proteomic databases

PaxDbi O55071.
PRIDEi O55071.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077855 ; ENSMUSP00000077021 ; ENSMUSG00000066704 .
GeneIDi 13090.
KEGGi mmu:13090.
UCSCi uc009fus.1. mouse.

Organism-specific databases

CTDi 13090.
MGIi MGI:107303. Cyp2b19.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi O55071.
KOi K07412.
OMAi IVANIIC.
OrthoDBi EOG7RBZ85.
PhylomeDBi O55071.
TreeFami TF352043.

Miscellaneous databases

NextBioi 283066.
PROi O55071.
SOURCEi Search...

Gene expression databases

Bgeei O55071.
Genevestigatori O55071.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes."
    Keeney D.S.
    Genomics 53:417-419(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP2BJ_MOUSE
AccessioniPrimary (citable) accession number: O55071
Secondary accession number(s): B2RQK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3