O55071 (CP2BJ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 2B19
EC=1.14.14.1

Alternative name(s):
CYPIIB19

Gene names

Name:

Cyp2b19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Expressed only in differentiated keratinocytes in skin.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Cytochrome P450 2B19		PRO_0000051689
Sites
	Metal binding	437	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	129	1	Phosphoserine; by PKA By similarity

Sequences

	Sequence		Length	Mass (Da)
	O55071 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 9E685AF61EE2DFA2	FASTA	492	55,997
	10 20 30 40 50 60 MEFSVLLLLA LTTGFLIFLV SQSQPKTHGH FPPGPRPLPF LGNLLQMDRR GLLSSFIQLQ 70 80 90 100 110 120 EKYGDVFTVH LGPRPVVMLC GTDTIREALV NQAEAFSGRG TVAVLDPIVQ GYGVIFSSGE 130 140 150 160 170 180 RWKTLRRFSL ATMRDFGMGK RSVEERIKEE AQCLVEELKK YKGAPLNPTF YFQCIVANII 190 200 210 220 230 240 CSIVFGERFD YKDHQFLHLL NLIYQTFSLM SSLSSQVFEL FSAILKYFPG AHRQISKNLQ 250 260 270 280 290 300 EILDYIGHSV EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFAG 310 320 330 340 350 360 TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT DAVIHEIQRF 370 380 390 400 410 420 TDLAPIGLPH KVTKDTLFRG YLIPKNTEVY PILSSALHDP RYFEQPDSFN PEHFLDANGA 430 440 450 460 470 480 LKTNEAFMPF STGKRICLGE GIARNELFLF FTTILQNFSL ASPVAPENID LIPNNSGATK 490 TPPQYQIHFL SR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes." Keeney D.S. Genomics 53:417-419(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Skin.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF047529 mRNA. Translation: AAC78770.1. BC137965 mRNA. Translation: AAI37966.1. BC137966 mRNA. Translation: AAI37967.1.
IPI	IPI00115249.
RefSeq	NP_031840.1. NM_007814.1.
UniGene	Mm.14098.
3D structure databases
ProteinModelPortal	O55071.
SMR	O55071. Positions 29-492.
ModBase	Search...
PTM databases
PhosphoSite	O55071.
Proteomic databases
PaxDb	O55071.
PRIDE	O55071.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000077855; ENSMUSP00000077021; ENSMUSG00000066704.
GeneID	13090.
KEGG	mmu:13090.
UCSC	uc009fus.1. mouse.
Organism-specific databases
CTD	13090.
MGI	MGI:107303. Cyp2b19.
Phylogenomic databases
eggNOG	COG2124.
GeneTree	ENSGT00670000097868.
HOGENOM	HOG000036992.
HOVERGEN	HBG015789.
InParanoid	B2RQK1.
KO	K07412.
OMA	PRYFEQP.
OrthoDB	EOG4NVZKC.
Gene expression databases
Bgee	O55071.
Genevestigator	O55071.
GermOnline	ENSMUSG00000066704. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008068. Cyt_P450_E_grp-I_CYP2B-like. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01685. EP450ICYP2B. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283066.
SOURCE	Search...

Entry information

Entry name

CP2BJ_MOUSE

Accession

Primary (citable) accession number: O55071
Secondary accession number(s): B2RQK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program