Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O55071

- CP2BJ_MOUSE

UniProt

O55071 - CP2BJ_MOUSE

Protein

Cytochrome P450 2B19

Gene

Cyp2b19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2B19 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIB19
    Gene namesi
    Name:Cyp2b19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107303. Cyp2b19.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Cytochrome P450 2B19PRO_0000051689Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei129 – 1291Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO55071.
    PRIDEiO55071.

    PTM databases

    PhosphoSiteiO55071.

    Expressioni

    Tissue specificityi

    Expressed only in differentiated keratinocytes in skin.

    Gene expression databases

    BgeeiO55071.
    GenevestigatoriO55071.

    Structurei

    3D structure databases

    ProteinModelPortaliO55071.
    SMRiO55071. Positions 29-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00670000097868.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiB2RQK1.
    KOiK07412.
    OMAiIVANIIC.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiO55071.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55071-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSVLLLLA LTTGFLIFLV SQSQPKTHGH FPPGPRPLPF LGNLLQMDRR    50
    GLLSSFIQLQ EKYGDVFTVH LGPRPVVMLC GTDTIREALV NQAEAFSGRG 100
    TVAVLDPIVQ GYGVIFSSGE RWKTLRRFSL ATMRDFGMGK RSVEERIKEE 150
    AQCLVEELKK YKGAPLNPTF YFQCIVANII CSIVFGERFD YKDHQFLHLL 200
    NLIYQTFSLM SSLSSQVFEL FSAILKYFPG AHRQISKNLQ EILDYIGHSV 250
    EKHRATLDPS APRDFIDTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFAG 300
    TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT 350
    DAVIHEIQRF TDLAPIGLPH KVTKDTLFRG YLIPKNTEVY PILSSALHDP 400
    RYFEQPDSFN PEHFLDANGA LKTNEAFMPF STGKRICLGE GIARNELFLF 450
    FTTILQNFSL ASPVAPENID LIPNNSGATK TPPQYQIHFL SR 492
    Length:492
    Mass (Da):55,997
    Last modified:June 1, 1998 - v1
    Checksum:i9E685AF61EE2DFA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047529 mRNA. Translation: AAC78770.1.
    BC137965 mRNA. Translation: AAI37966.1.
    BC137966 mRNA. Translation: AAI37967.1.
    CCDSiCCDS21006.1.
    RefSeqiNP_031840.1. NM_007814.1.
    UniGeneiMm.14098.

    Genome annotation databases

    EnsembliENSMUST00000077855; ENSMUSP00000077021; ENSMUSG00000066704.
    GeneIDi13090.
    KEGGimmu:13090.
    UCSCiuc009fus.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047529 mRNA. Translation: AAC78770.1 .
    BC137965 mRNA. Translation: AAI37966.1 .
    BC137966 mRNA. Translation: AAI37967.1 .
    CCDSi CCDS21006.1.
    RefSeqi NP_031840.1. NM_007814.1.
    UniGenei Mm.14098.

    3D structure databases

    ProteinModelPortali O55071.
    SMRi O55071. Positions 29-492.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O55071.

    Proteomic databases

    PaxDbi O55071.
    PRIDEi O55071.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077855 ; ENSMUSP00000077021 ; ENSMUSG00000066704 .
    GeneIDi 13090.
    KEGGi mmu:13090.
    UCSCi uc009fus.1. mouse.

    Organism-specific databases

    CTDi 13090.
    MGIi MGI:107303. Cyp2b19.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00670000097868.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi B2RQK1.
    KOi K07412.
    OMAi IVANIIC.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi O55071.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 283066.
    PROi O55071.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55071.
    Genevestigatori O55071.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes."
      Keeney D.S.
      Genomics 53:417-419(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP2BJ_MOUSE
    AccessioniPrimary (citable) accession number: O55071
    Secondary accession number(s): B2RQK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3