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Protein

Deoxyribonuclease gamma

Gene

Dnase1l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has DNA hydrolytic activity. Does not bind to actin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051By similarity
Active sitei160 – 1601By similarity

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • endodeoxyribonuclease activity Source: Ensembl
  • endonuclease activity Source: MGI

GO - Biological processi

  • apoptotic DNA fragmentation Source: MGI
  • programmed cell death involved in cell development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BRENDAi3.1.21.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease gamma (EC:3.1.21.-)
Short name:
DNase gamma
Alternative name(s):
DNase I homolog protein DHP2
Deoxyribonuclease I-like 3
Short name:
DNase I-like 3
Liver and spleen DNase
Short name:
LS-DNase
Short name:
LSD
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1314633. Dnase1l3.

Subcellular locationi

  • Nucleus By similarity

  • Note: May first pass through the ER membrane before being imported in the nucleus.By similarity

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 310285Deoxyribonuclease gammaPRO_0000007289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi199 ↔ 236Essential for enzymatic activityBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO55070.
PRIDEiO55070.

PTM databases

PhosphoSiteiO55070.

Expressioni

Tissue specificityi

Expressed at high levels in liver and spleen.

Gene expression databases

BgeeiENSMUSG00000025279.
CleanExiMM_DNASE1L3.
GenevisibleiO55070. MM.

Structurei

3D structure databases

ProteinModelPortaliO55070.
SMRiO55070. Positions 26-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5617Bipartite nuclear localization signalSequence analysisAdd
BLAST
Motifi301 – 3077Nuclear localization signalSequence analysis

Sequence similaritiesi

Belongs to the DNase I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHHA. Eukaryota.
ENOG410ZR9A. LUCA.
GeneTreeiENSGT00390000013146.
HOGENOMiHOG000059570.
HOVERGENiHBG051368.
InParanoidiO55070.
KOiK11995.
OMAiQSPHTAV.
OrthoDBiEOG091G0I0B.
PhylomeDBiO55070.
TreeFamiTF329541.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR033125. DNASE_I_2.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PANTHERiPTHR11371. PTHR11371. 1 hit.
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
PRINTSiPR00130. DNASEI.
SMARTiSM00476. DNaseIc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLHPASPRL ASLLLFILAL HDTLALRLCS FNVRSFGASK KENHEAMDII
60 70 80 90 100
VKIIKRCDLI LLMEIKDSSN NICPMLMEKL NGNSRRSTTY NYVISSRLGR
110 120 130 140 150
NTYKEQYAFV YKEKLVSVKT KYHYHDYQDG DTDVFSREPF VVWFHSPFTA
160 170 180 190 200
VKDFVIVPLH TTPETSVKEI DELVDVYTDV RSQWKTENFI FMGDFNAGCS
210 220 230 240 250
YVPKKAWQNI RLRTDPKFVW LIGDQEDTTV KKSTSCAYDR IVLCGQEIVN
260 270 280 290 300
SVVPRSSGVF DFQKAYDLSE EEALDVSDHF PVEFKLQSSR AFTNNRKSVS
310
LKKRKKGNRS
Length:310
Mass (Da):35,760
Last modified:June 1, 1998 - v1
Checksum:iBE483821E045E374
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891T → I in AAH12671 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047355 mRNA. Translation: AAC35753.1.
U76110 mRNA. Translation: AAD09222.1.
AY024355 Genomic DNA. Translation: AAK07733.1.
BC012671 mRNA. Translation: AAH12671.1.
CCDSiCCDS26807.1.
RefSeqiNP_031896.3. NM_007870.3.
XP_006517984.1. XM_006517921.2.
UniGeneiMm.272258.
Mm.490513.

Genome annotation databases

EnsembliENSMUST00000026315; ENSMUSP00000026315; ENSMUSG00000025279.
GeneIDi13421.
KEGGimmu:13421.
UCSCiuc007sem.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047355 mRNA. Translation: AAC35753.1.
U76110 mRNA. Translation: AAD09222.1.
AY024355 Genomic DNA. Translation: AAK07733.1.
BC012671 mRNA. Translation: AAH12671.1.
CCDSiCCDS26807.1.
RefSeqiNP_031896.3. NM_007870.3.
XP_006517984.1. XM_006517921.2.
UniGeneiMm.272258.
Mm.490513.

3D structure databases

ProteinModelPortaliO55070.
SMRiO55070. Positions 26-286.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO55070.

Proteomic databases

PaxDbiO55070.
PRIDEiO55070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026315; ENSMUSP00000026315; ENSMUSG00000025279.
GeneIDi13421.
KEGGimmu:13421.
UCSCiuc007sem.1. mouse.

Organism-specific databases

CTDi1776.
MGIiMGI:1314633. Dnase1l3.

Phylogenomic databases

eggNOGiENOG410IHHA. Eukaryota.
ENOG410ZR9A. LUCA.
GeneTreeiENSGT00390000013146.
HOGENOMiHOG000059570.
HOVERGENiHBG051368.
InParanoidiO55070.
KOiK11995.
OMAiQSPHTAV.
OrthoDBiEOG091G0I0B.
PhylomeDBiO55070.
TreeFamiTF329541.

Enzyme and pathway databases

BRENDAi3.1.21.1. 3474.

Miscellaneous databases

PROiO55070.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025279.
CleanExiMM_DNASE1L3.
GenevisibleiO55070. MM.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR033125. DNASE_I_2.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PANTHERiPTHR11371. PTHR11371. 1 hit.
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
PRINTSiPR00130. DNASEI.
SMARTiSM00476. DNaseIc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNSL3_MOUSE
AccessioniPrimary (citable) accession number: O55070
Secondary accession number(s): Q91X38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.