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O55055

- TRDMT_MOUSE

UniProt

O55055 - TRDMT_MOUSE

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Protein

tRNA (cytosine(38)-C(5))-methyltransferase

Gene

Trdmt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).By similarity

Catalytic activityi

S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW
  3. tRNA methyltransferase activity Source: MGI

GO - Biological processi

  1. DNA methylation Source: InterPro
  2. response to amphetamine Source: Ensembl
  3. tRNA methylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.37. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (cytosine(38)-C(5))-methyltransferase (EC:2.1.1.204)
Alternative name(s):
DNA (cytosine-5)-methyltransferase-like protein 2
Short name:
Dnmt2
DNA methyltransferase homolog MmuIIP
Short name:
DNA MTase homolog MmuIIP
Short name:
M.MmuIIP
Met-2
Gene namesi
Name:Trdmt1
Synonyms:Dnmt2, Met2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1274787. Trdmt1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415tRNA (cytosine(38)-C(5))-methyltransferasePRO_0000088041Add
BLAST

Proteomic databases

MaxQBiO55055.
PaxDbiO55055.
PRIDEiO55055.

PTM databases

PhosphoSiteiO55055.

Expressioni

Tissue specificityi

Highly expressed in thymus, testis, and at much lower levels in spleen, lung, brain, heart, kidney, liver, skeletal muscle and embryonic stem cells.1 Publication

Gene expression databases

BgeeiO55055.
CleanExiMM_TRDMT1.
ExpressionAtlasiO55055. baseline and differential.
GenevestigatoriO55055.

Structurei

3D structure databases

ProteinModelPortaliO55055.
SMRiO55055. Positions 2-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 396393SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0270.
HOGENOMiHOG000265038.
HOVERGENiHBG051385.
InParanoidiO55055.
KOiK15336.
OMAiFGVPYSR.
OrthoDBiEOG7PZRZ4.
PhylomeDBiO55055.
TreeFamiTF300024.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025813. DNA/tRNA_C5-MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55055-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLRVLELY SGIGGMHHAL RESHIPAHVV AAIDVNTVAN EVYKHNFPHT
60 70 80 90 100
HLLSKTIEGI SLEDFDKLSF NMILMSPPCQ PFTRIGLQGD MTDPRTTSFL
110 120 130 140 150
YILDILPRLQ KLPKYILLEN VKGFEVSSTR GLLIQTIEAC GFQYQEFLLS
160 170 180 190 200
PSSLGIPNSR LRYFLIAKLQ SEPFPFQAPG QILMEFPKIV TVEPQKYAVV
210 220 230 240 250
EESQPRVQRT GPRICAESSS TQSSGKDTIL FKLETVEERD RKHQQDSDLS
260 270 280 290 300
VQMLKDFLED GDTDEYLLPP KLLLRYALLL DIVKPTSRRS MCFTKGYGSY
310 320 330 340 350
IEGTGSVLQA AEDAQIENIY KSLPDLPPEE KIAKLSMLKL RYFTPKEIAN
360 370 380 390 400
LQGFPPEFGF PEKTTVKQRY RLLGNSLNVH VVAKLLTVLC EGFGNASESC
410
HKMPLILDSN SKILS
Length:415
Mass (Da):46,794
Last modified:February 21, 2002 - v2
Checksum:i14FEF78C0D2F8BFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641F → S in AAC40130. (PubMed:9592134)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012129 mRNA. Translation: AAC53529.1.
AF045889 mRNA. Translation: AAC40130.1.
CCDSiCCDS15695.1.
RefSeqiNP_034197.3. NM_010067.4.
UniGeneiMm.6979.

Genome annotation databases

EnsembliENSMUST00000124488; ENSMUSP00000114572; ENSMUSG00000026723.
GeneIDi13434.
KEGGimmu:13434.
UCSCiuc008ika.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012129 mRNA. Translation: AAC53529.1 .
AF045889 mRNA. Translation: AAC40130.1 .
CCDSi CCDS15695.1.
RefSeqi NP_034197.3. NM_010067.4.
UniGenei Mm.6979.

3D structure databases

ProteinModelPortali O55055.
SMRi O55055. Positions 2-391.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O55055.

Proteomic databases

MaxQBi O55055.
PaxDbi O55055.
PRIDEi O55055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000124488 ; ENSMUSP00000114572 ; ENSMUSG00000026723 .
GeneIDi 13434.
KEGGi mmu:13434.
UCSCi uc008ika.2. mouse.

Organism-specific databases

CTDi 1787.
MGIi MGI:1274787. Trdmt1.

Phylogenomic databases

eggNOGi COG0270.
HOGENOMi HOG000265038.
HOVERGENi HBG051385.
InParanoidi O55055.
KOi K15336.
OMAi FGVPYSR.
OrthoDBi EOG7PZRZ4.
PhylomeDBi O55055.
TreeFami TF300024.

Enzyme and pathway databases

BRENDAi 2.1.1.37. 3474.

Miscellaneous databases

NextBioi 283863.
PROi O55055.
SOURCEi Search...

Gene expression databases

Bgeei O55055.
CleanExi MM_TRDMT1.
ExpressionAtlasi O55055. baseline and differential.
Genevestigatori O55055.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025813. DNA/tRNA_C5-MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast."
    Yoder J.A., Bestor T.H.
    Hum. Mol. Genet. 7:279-284(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells."
    Okano M., Xie S., Li E.
    Nucleic Acids Res. 26:2536-2540(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryonic stem cell.

Entry informationi

Entry nameiTRDMT_MOUSE
AccessioniPrimary (citable) accession number: O55055
Secondary accession number(s): O35212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 21, 2002
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3