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Reviewed, UniProtKB/Swiss-Prot O55042 (SYUA_MOUSE)

Last modified July 13, 2010. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
Alpha-synuclein
Alternative name(s):
Non-A beta component of AD amyloid
Non-A4 component of amyloid precursor
Short name=NACP
Gene names
Name:Snca
Synonyms:Syn
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus
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Protein attributesHide

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.
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General annotation (Comments)Hide

Function

May be involved in the regulation of dopamine release and transport.

Subunit structure

Interacts with UCHL1 By similarity.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress By similarity.

Ubiquitinated. The predominant conjugate is the diubiquitinated form By similarity.

Sequence similarities

Belongs to the synuclein family.

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OntologiesHide

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainRepeat
   PTMPhosphoprotein
Ubl conjugation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processadult locomotory behavior

Inferred from genetic interaction. Source: MGI

cellular response to oxidative stress

Inferred from mutant phenotype. Source: MGI

dopamine biosynthetic process

Inferred from mutant phenotype. Source: MGI

fatty acid metabolic process

Inferred from mutant phenotype. Source: MGI

long-term synaptic potentiation

Inferred from mutant phenotype. Source: MGI

microglial cell activation

Inferred from mutant phenotype. Source: MGI

mitochondrial ATP synthesis coupled electron transport

Inferred from mutant phenotype. Source: MGI

mitochondrial membrane organization

Inferred from mutant phenotype. Source: MGI

negative regulation of neuron apoptosis

Inferred from genetic interaction. Source: MGI

neutral lipid metabolic process

Inferred from mutant phenotype. Source: MGI

phospholipid metabolic process

Inferred from mutant phenotype. Source: MGI

positive regulation of neurotransmitter secretion

Inferred from direct assay. Source: MGI

regulation of acyl-CoA biosynthetic process

Inferred from direct assay. Source: MGI

regulation of dopamine secretion

Inferred from genetic interaction. Source: MGI

regulation of excitatory postsynaptic membrane potential

Inferred from mutant phenotype. Source: MGI

regulation of glutamate secretion

Inferred from mutant phenotype. Source: MGI

regulation of locomotion

Inferred from mutant phenotype. Source: MGI

regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype. Source: MGI

regulation of macrophage activation

Inferred from mutant phenotype. Source: MGI

response to drug

Inferred from mutant phenotype. Source: MGI

synaptic transmission, dopaminergic

Inferred from mutant phenotype. Source: MGI

synaptic vesicle endocytosis

Inferred from mutant phenotype. Source: UniProtKB

   Cellular componentcytosol

Inferred from direct assay. Source: UniProtKB

nucleus

Inferred from direct assay. Source: UniProtKB

plasma membrane

Inferred from direct assay. Source: MGI

synaptosome

Inferred from direct assay. Source: MGI

   Molecular functionarachidonic acid binding

Inferred from direct assay. Source: MGI

histone binding

Inferred from direct assay. Source: UniProtKB

identical protein binding

Inferred from direct assay. Source: MGI

Complete GO annotation...
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Alternative productsHide

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O55042-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O55042-2)

The sequence of this isoform differs from the canonical sequence as follows:
     103-121: GEEGYPQEGILEDMPVDPG → VWLPVLCSVITLDTMSLHA
     122-140: Missing.
Note: No experimental confirmation available.
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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Alpha-synuclein
PRO_0000184026

Regions

Repeat20 – 30111
Repeat31 – 41112
Repeat42 – 56153; approximate
Repeat57 – 67114
Region20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)

Amino acid modifications

Modified residue1251Phosphotyrosine By similarity

Natural variations

Alternative sequence103 – 12119GEEGY…PVDPG → VWLPVLCSVITLDTMSLHA in isoform 2.
VSP_025018
Alternative sequence122 – 14019Missing in isoform 2.
VSP_025019

Experimental info

Sequence conflict581K → T in AAC00521. Ref.1
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SequencesHide

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 1FFD19D7E15E636C

FASTA14014,485
        10         20         30         40         50         60 
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 

        70         80         90        100        110        120 
EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP 

       130        140 
GSEAYEMPSE EGYQDYEPEA 

« Hide

Isoform 2.

Checksum: 03CAFC4944C78D63
Show »

FASTA12112,345
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ReferencesHide

« Hide 'large scale' references
[1]"Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development."
Hsu L.J., Mallory M., Xia Y., Veinbergs I., Hashimoto M., Yoshimoto M., Thal L.J., Saitoh T., Masliah E.
J. Neurochem. 71:338-344(1998) [PubMed: 9648883] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The cDNA cloning and ontogeny of mouse alpha-synuclein."
Hong L., Ko H.W., Gwag B.J., Joe E., Lee S., Kim Y.T., Suh Y.-H.
NeuroReport 9:1239-1243(1998) [PubMed: 9601701] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: ICR.
[3]"Genomic cloning of the mouse alpha-synuclein and analysis of the promoter."
Fog J.U., Kallunki P.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
Strain: C57BL/6J and Sv129/Ola.
Tissue: Brain.
[4]"Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element."
Touchman J.W., Dehejia A., Chiba-Falek O., Cabin D.E., Schwartz J.R., Orrison B.M., Polymeropoulos M.H., Nussbaum R.L.
Genome Res. 11:78-86(2001) [PubMed: 11156617] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J and NOD.
Tissue: Liver and Spleen.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[7]"Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice."
Schlueter O.M., Fornai F., Alessandri M.G., Takamori S., Geppert M., Jahn R., Suedhof T.C.
Neuroscience 118:985-1002(2003) [PubMed: 12732244] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
Strain: 129/SvJ.
[8]Lubec G., Klug S.
Submitted (MAR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 61-96, MASS SPECTROMETRY.
Tissue: Hippocampus.
+Additional computationally mapped references.
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
AF044672 mRNA. Translation: AAC00521.1.
AF033261 mRNA. Translation: AAD11254.1.
AF179273 mRNA. Translation: AAD56908.1.
AF179272 expand/collapse EMBL AC list , AF179268, AF179269, AF179270, AF179271 Genomic DNA. Translation: AAD56907.1.
AF163865 Genomic DNA. Translation: AAG30304.1.
AK014472 mRNA. Translation: BAB29375.1.
AK156316 mRNA. Translation: BAE33670.1.
BC046764 mRNA. Translation: AAH46764.1.
AF277451 Genomic DNA. Translation: AAG44833.1.
IPIIPI00115157.
IPI00845803.
RefSeqNP_001035916.1.
NP_033247.1.
UniGeneMm.17484

3D structure databases

SMRO55042. Positions 1-140.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-2736846.
STRINGO55042.

PTM databases

PhosphoSiteO55042.

Proteomic databases

PRIDEO55042.

Genome annotation databases

EnsemblENSMUST00000114268; ENSMUSP00000109907; ENSMUSG00000025889; Mus musculus. [Genome view]
GeneID20617.
KEGGmmu:20617.
UCSCuc009cdn.1. mouse.

Organism-specific databases

CTD20617.
MGIMGI:1277151. Snca.

Phylogenomic databases

eggNOGroNOG16930.
HOGENOMHBG715579.
HOVERGENHBG000481.
InParanoidO55042.
OMAPENEAYE.
OrthoDBEOG9ZPHF6.
PhylomeDBO55042.

Gene expression databases

ArrayExpressO55042.
BgeeO55042.
CleanExMM_SNCA.
GenevestigatorO55042.
GermOnlineENSMUSG00000025889. Mus musculus.

Family and domain databases

InterProIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
Gene3DG3DSA:1.10.287.700. Synuclein. 1 hit.
PANTHERPTHR13820. Synuclein. 1 hit.
PfamPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetSearch...

Other Resources

NextBio298995.
PMAP-CutDBO55042.
SOURCESearch...
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Entry informationHide

Entry nameSYUA_MOUSE
AccessionPrimary (citable) accession number: O55042
Secondary accession number(s): Q3U130 expand/collapse secondary AC list , Q9CXF8, Q9EQC3, Q9QUR3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: July 13, 2010
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
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Relevant documentsHide

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents