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O55042

- SYUA_MOUSE

UniProt

O55042 - SYUA_MOUSE

Protein

Alpha-synuclein

Gene

Snca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be involved in the regulation of dopamine release and transport.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi2 – 21CopperBy similarity
    Metal bindingi50 – 501CopperBy similarity

    GO - Molecular functioni

    1. arachidonic acid binding Source: MGI
    2. calcium ion binding Source: Ensembl
    3. copper ion binding Source: UniProtKB
    4. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: Ensembl
    5. ferrous iron binding Source: Ensembl
    6. histone binding Source: UniProtKB
    7. identical protein binding Source: MGI
    8. magnesium ion binding Source: Ensembl
    9. oxidoreductase activity Source: Ensembl
    10. phospholipid binding Source: Ensembl
    11. protein binding Source: IntAct
    12. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. adult locomotory behavior Source: MGI
    3. aging Source: Ensembl
    4. behavioral response to cocaine Source: Ensembl
    5. cellular response to copper ion Source: Ensembl
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to oxidative stress Source: MGI
    8. dopamine biosynthetic process Source: MGI
    9. dopamine metabolic process Source: MGI
    10. fatty acid metabolic process Source: MGI
    11. long-term synaptic potentiation Source: MGI
    12. membrane organization Source: MGI
    13. microglial cell activation Source: MGI
    14. mitochondrial ATP synthesis coupled electron transport Source: MGI
    15. mitochondrial membrane organization Source: MGI
    16. negative regulation of dopamine metabolic process Source: Ensembl
    17. negative regulation of dopamine uptake involved in synaptic transmission Source: Ensembl
    18. negative regulation of exocytosis Source: Ensembl
    19. negative regulation of histone acetylation Source: Ensembl
    20. negative regulation of microtubule polymerization Source: Ensembl
    21. negative regulation of monooxygenase activity Source: Ensembl
    22. negative regulation of neuron apoptotic process Source: MGI
    23. negative regulation of norepinephrine uptake Source: Ensembl
    24. negative regulation of platelet-derived growth factor receptor signaling pathway Source: Ensembl
    25. negative regulation of protein phosphorylation Source: Ensembl
    26. negative regulation of serotonin uptake Source: Ensembl
    27. negative regulation of thrombin receptor signaling pathway Source: Ensembl
    28. negative regulation of transporter activity Source: Ensembl
    29. neutral lipid metabolic process Source: MGI
    30. phospholipid metabolic process Source: MGI
    31. positive regulation of endocytosis Source: Ensembl
    32. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
    33. positive regulation of neurotransmitter secretion Source: MGI
    34. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    35. positive regulation of protein serine/threonine kinase activity Source: Ensembl
    36. positive regulation of receptor recycling Source: Ensembl
    37. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    38. positive regulation of synaptic transmission Source: MGI
    39. protein destabilization Source: Ensembl
    40. receptor internalization Source: Ensembl
    41. regulation of acyl-CoA biosynthetic process Source: MGI
    42. regulation of dopamine secretion Source: MGI
    43. regulation of excitatory postsynaptic membrane potential Source: MGI
    44. regulation of glutamate secretion Source: MGI
    45. regulation of locomotion Source: MGI
    46. regulation of long-term neuronal synaptic plasticity Source: MGI
    47. regulation of macrophage activation Source: MGI
    48. regulation of neuronal synaptic plasticity Source: MGI
    49. regulation of neurotransmitter secretion Source: MGI
    50. regulation of phospholipase activity Source: Ensembl
    51. response to drug Source: MGI
    52. response to interferon-gamma Source: Ensembl
    53. response to interleukin-1 Source: Ensembl
    54. response to iron(II) ion Source: Ensembl
    55. response to lipopolysaccharide Source: Ensembl
    56. response to magnesium ion Source: Ensembl
    57. synapse organization Source: MGI
    58. synaptic transmission Source: MGI
    59. synaptic transmission, dopaminergic Source: MGI
    60. synaptic vesicle endocytosis Source: UniProtKB
    61. synaptic vesicle transport Source: MGI

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-synuclein
    Alternative name(s):
    Non-A beta component of AD amyloid
    Non-A4 component of amyloid precursor
    Short name:
    NACP
    Gene namesi
    Name:Snca
    Synonyms:Syn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1277151. Snca.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. cell cortex Source: Ensembl
    3. cytoplasm Source: BHF-UCL
    4. cytoskeleton Source: MGI
    5. cytosol Source: UniProtKB
    6. fibril Source: Ensembl
    7. Golgi apparatus Source: Ensembl
    8. growth cone Source: Ensembl
    9. inclusion body Source: MGI
    10. mitochondrion Source: Ensembl
    11. nuclear outer membrane Source: Ensembl
    12. nucleus Source: UniProtKB
    13. perinuclear region of cytoplasm Source: Ensembl
    14. plasma membrane Source: MGI
    15. platelet alpha granule membrane Source: Ensembl
    16. ribosome Source: Ensembl
    17. rough endoplasmic reticulum Source: Ensembl
    18. synapse Source: MGI
    19. synaptic vesicle Source: Ensembl
    20. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Alpha-synucleinPRO_0000184026Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei125 – 1251Phosphotyrosine; by FYNBy similarity
    Modified residuei129 – 1291Phosphoserine; by PLK21 Publication

    Post-translational modificationi

    Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress By similarity.By similarity
    Ubiquitinated. The predominant conjugate is the diubiquitinated form By similarity.By similarity
    Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO55042.
    PaxDbiO55042.
    PRIDEiO55042.

    PTM databases

    PhosphoSiteiO55042.

    Miscellaneous databases

    PMAP-CutDBO55042.

    Expressioni

    Gene expression databases

    BgeeiO55042.
    CleanExiMM_SNCA.
    GenevestigatoriO55042.

    Interactioni

    Subunit structurei

    Interacts with UCHL1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Slc6a3Q613275EBI-2310271,EBI-7839708
    YwhahP685102EBI-2310271,EBI-444641

    Protein-protein interaction databases

    BioGridi203365. 17 interactions.
    IntActiO55042. 5 interactions.
    MINTiMINT-2736846.

    Structurei

    3D structure databases

    ProteinModelPortaliO55042.
    SMRiO55042. Positions 1-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati20 – 30111Add
    BLAST
    Repeati31 – 41112Add
    BLAST
    Repeati42 – 56153; approximateAdd
    BLAST
    Repeati57 – 67114Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add
    BLAST

    Sequence similaritiesi

    Belongs to the synuclein family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG44393.
    GeneTreeiENSGT00390000016161.
    HOGENOMiHOG000008691.
    HOVERGENiHBG000481.
    InParanoidiO55042.
    KOiK04528.
    OMAiMPPEEEY.
    OrthoDBiEOG7034KG.
    PhylomeDBiO55042.
    TreeFamiTF332776.

    Family and domain databases

    Gene3Di1.10.287.700. 1 hit.
    InterProiIPR001058. Synuclein.
    IPR002460. Synuclein_alpha.
    [Graphical view]
    PANTHERiPTHR13820. PTHR13820. 1 hit.
    PfamiPF01387. Synuclein. 1 hit.
    [Graphical view]
    PRINTSiPR01212. ASYNUCLEIN.
    PR01211. SYNUCLEIN.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O55042-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH    50
    GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM 100
    GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA 140
    Length:140
    Mass (Da):14,485
    Last modified:April 27, 2001 - v2
    Checksum:i1FFD19D7E15E636C
    GO
    Isoform 2 (identifier: O55042-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         103-121: GEEGYPQEGILEDMPVDPG → VWLPVLCSVITLDTMSLHA
         122-140: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:121
    Mass (Da):12,345
    Checksum:i03CAFC4944C78D63
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581K → T in AAC00521. (PubMed:9648883)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei103 – 12119GEEGY…PVDPG → VWLPVLCSVITLDTMSLHA in isoform 2. 1 PublicationVSP_025018Add
    BLAST
    Alternative sequencei122 – 14019Missing in isoform 2. 1 PublicationVSP_025019Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044672 mRNA. Translation: AAC00521.1.
    AF033261 mRNA. Translation: AAD11254.1.
    AF179273 mRNA. Translation: AAD56908.1.
    AF179272
    , AF179268, AF179269, AF179270, AF179271 Genomic DNA. Translation: AAD56907.1.
    AF163865 Genomic DNA. Translation: AAG30304.1.
    AK014472 mRNA. Translation: BAB29375.1.
    AK156316 mRNA. Translation: BAE33670.1.
    BC046764 mRNA. Translation: AAH46764.1.
    AF277451 Genomic DNA. Translation: AAG44833.1.
    CCDSiCCDS20201.1. [O55042-1]
    RefSeqiNP_001035916.1. NM_001042451.2. [O55042-1]
    NP_033247.1. NM_009221.2. [O55042-1]
    UniGeneiMm.17484.

    Genome annotation databases

    EnsembliENSMUST00000114268; ENSMUSP00000109907; ENSMUSG00000025889. [O55042-1]
    ENSMUST00000163779; ENSMUSP00000126067; ENSMUSG00000025889. [O55042-1]
    GeneIDi20617.
    KEGGimmu:20617.
    UCSCiuc009cdn.1. mouse. [O55042-1]
    uc009cdp.1. mouse. [O55042-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044672 mRNA. Translation: AAC00521.1 .
    AF033261 mRNA. Translation: AAD11254.1 .
    AF179273 mRNA. Translation: AAD56908.1 .
    AF179272
    , AF179268 , AF179269 , AF179270 , AF179271 Genomic DNA. Translation: AAD56907.1 .
    AF163865 Genomic DNA. Translation: AAG30304.1 .
    AK014472 mRNA. Translation: BAB29375.1 .
    AK156316 mRNA. Translation: BAE33670.1 .
    BC046764 mRNA. Translation: AAH46764.1 .
    AF277451 Genomic DNA. Translation: AAG44833.1 .
    CCDSi CCDS20201.1. [O55042-1 ]
    RefSeqi NP_001035916.1. NM_001042451.2. [O55042-1 ]
    NP_033247.1. NM_009221.2. [O55042-1 ]
    UniGenei Mm.17484.

    3D structure databases

    ProteinModelPortali O55042.
    SMRi O55042. Positions 1-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203365. 17 interactions.
    IntActi O55042. 5 interactions.
    MINTi MINT-2736846.

    PTM databases

    PhosphoSitei O55042.

    Proteomic databases

    MaxQBi O55042.
    PaxDbi O55042.
    PRIDEi O55042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114268 ; ENSMUSP00000109907 ; ENSMUSG00000025889 . [O55042-1 ]
    ENSMUST00000163779 ; ENSMUSP00000126067 ; ENSMUSG00000025889 . [O55042-1 ]
    GeneIDi 20617.
    KEGGi mmu:20617.
    UCSCi uc009cdn.1. mouse. [O55042-1 ]
    uc009cdp.1. mouse. [O55042-2 ]

    Organism-specific databases

    CTDi 6622.
    MGIi MGI:1277151. Snca.

    Phylogenomic databases

    eggNOGi NOG44393.
    GeneTreei ENSGT00390000016161.
    HOGENOMi HOG000008691.
    HOVERGENi HBG000481.
    InParanoidi O55042.
    KOi K04528.
    OMAi MPPEEEY.
    OrthoDBi EOG7034KG.
    PhylomeDBi O55042.
    TreeFami TF332776.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.

    Miscellaneous databases

    NextBioi 298995.
    PMAP-CutDB O55042.
    PROi O55042.
    SOURCEi Search...

    Gene expression databases

    Bgeei O55042.
    CleanExi MM_SNCA.
    Genevestigatori O55042.

    Family and domain databases

    Gene3Di 1.10.287.700. 1 hit.
    InterProi IPR001058. Synuclein.
    IPR002460. Synuclein_alpha.
    [Graphical view ]
    PANTHERi PTHR13820. PTHR13820. 1 hit.
    Pfami PF01387. Synuclein. 1 hit.
    [Graphical view ]
    PRINTSi PR01212. ASYNUCLEIN.
    PR01211. SYNUCLEIN.
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development."
      Hsu L.J., Mallory M., Xia Y., Veinbergs I., Hashimoto M., Yoshimoto M., Thal L.J., Saitoh T., Masliah E.
      J. Neurochem. 71:338-344(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The cDNA cloning and ontogeny of mouse alpha-synuclein."
      Hong L., Ko H.W., Gwag B.J., Joe E., Lee S., Kim Y.T., Suh Y.-H.
      NeuroReport 9:1239-1243(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: ICR.
    3. "Genomic cloning of the mouse alpha-synuclein and analysis of the promoter."
      Fog J.U., Kallunki P.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
      Strain: C57BL/6J and Sv129/Ola.
      Tissue: Brain.
    4. "Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element."
      Touchman J.W., Dehejia A., Chiba-Falek O., Cabin D.E., Schwartz J.R., Orrison B.M., Polymeropoulos M.H., Nussbaum R.L.
      Genome Res. 11:78-86(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J and NOD.
      Tissue: Liver and Spleen.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    7. "Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice."
      Schlueter O.M., Fornai F., Alessandri M.G., Takamori S., Geppert M., Jahn R., Suedhof T.C.
      Neuroscience 118:985-1002(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
      Strain: 129/SvJ.
    8. Lubec G., Klug S.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 61-96, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hippocampus.
    9. Cited for: PHOSPHORYLATION AT SER-129.

    Entry informationi

    Entry nameiSYUA_MOUSE
    AccessioniPrimary (citable) accession number: O55042
    Secondary accession number(s): Q3U130
    , Q9CXF8, Q9EQC3, Q9QUR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3