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O55042

- SYUA_MOUSE

UniProt

O55042 - SYUA_MOUSE

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Protein

Alpha-synuclein

Gene

Snca

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the regulation of dopamine release and transport.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2 – 21CopperBy similarity
Metal bindingi50 – 501CopperBy similarity

GO - Molecular functioni

  1. arachidonic acid binding Source: MGI
  2. calcium ion binding Source: Ensembl
  3. copper ion binding Source: UniProtKB
  4. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: Ensembl
  5. ferrous iron binding Source: Ensembl
  6. histone binding Source: UniProtKB
  7. identical protein binding Source: MGI
  8. magnesium ion binding Source: Ensembl
  9. oxidoreductase activity Source: Ensembl
  10. phospholipid binding Source: Ensembl
  11. zinc ion binding Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. adult locomotory behavior Source: MGI
  3. aging Source: Ensembl
  4. behavioral response to cocaine Source: Ensembl
  5. cellular response to copper ion Source: Ensembl
  6. cellular response to fibroblast growth factor stimulus Source: Ensembl
  7. cellular response to oxidative stress Source: MGI
  8. dopamine biosynthetic process Source: MGI
  9. dopamine metabolic process Source: MGI
  10. fatty acid metabolic process Source: MGI
  11. long-term synaptic potentiation Source: MGI
  12. membrane organization Source: MGI
  13. microglial cell activation Source: MGI
  14. mitochondrial ATP synthesis coupled electron transport Source: MGI
  15. mitochondrial membrane organization Source: MGI
  16. negative regulation of dopamine metabolic process Source: Ensembl
  17. negative regulation of dopamine uptake involved in synaptic transmission Source: Ensembl
  18. negative regulation of exocytosis Source: Ensembl
  19. negative regulation of histone acetylation Source: Ensembl
  20. negative regulation of microtubule polymerization Source: Ensembl
  21. negative regulation of monooxygenase activity Source: Ensembl
  22. negative regulation of neuron apoptotic process Source: MGI
  23. negative regulation of norepinephrine uptake Source: Ensembl
  24. negative regulation of platelet-derived growth factor receptor signaling pathway Source: Ensembl
  25. negative regulation of protein phosphorylation Source: Ensembl
  26. negative regulation of serotonin uptake Source: Ensembl
  27. negative regulation of thrombin receptor signaling pathway Source: Ensembl
  28. negative regulation of transporter activity Source: Ensembl
  29. neutral lipid metabolic process Source: MGI
  30. phospholipid metabolic process Source: MGI
  31. positive regulation of endocytosis Source: Ensembl
  32. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
  33. positive regulation of neurotransmitter secretion Source: MGI
  34. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  35. positive regulation of protein serine/threonine kinase activity Source: Ensembl
  36. positive regulation of receptor recycling Source: Ensembl
  37. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  38. positive regulation of synaptic transmission Source: MGI
  39. protein destabilization Source: Ensembl
  40. receptor internalization Source: Ensembl
  41. regulation of acyl-CoA biosynthetic process Source: MGI
  42. regulation of dopamine secretion Source: ParkinsonsUK-UCL
  43. regulation of excitatory postsynaptic membrane potential Source: MGI
  44. regulation of glutamate secretion Source: MGI
  45. regulation of locomotion Source: MGI
  46. regulation of long-term neuronal synaptic plasticity Source: MGI
  47. regulation of macrophage activation Source: MGI
  48. regulation of neuronal synaptic plasticity Source: MGI
  49. regulation of neurotransmitter secretion Source: MGI
  50. regulation of phospholipase activity Source: Ensembl
  51. regulation of reactive oxygen species metabolic process Source: ParkinsonsUK-UCL
  52. response to drug Source: MGI
  53. response to interferon-gamma Source: Ensembl
  54. response to interleukin-1 Source: Ensembl
  55. response to iron(II) ion Source: Ensembl
  56. response to lipopolysaccharide Source: Ensembl
  57. response to magnesium ion Source: Ensembl
  58. synapse organization Source: MGI
  59. synaptic transmission Source: MGI
  60. synaptic transmission, dopaminergic Source: MGI
  61. synaptic vesicle endocytosis Source: UniProtKB
  62. synaptic vesicle transport Source: MGI
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198563. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synuclein
Alternative name(s):
Non-A beta component of AD amyloid
Non-A4 component of amyloid precursor
Short name:
NACP
Gene namesi
Name:Snca
Synonyms:Syn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1277151. Snca.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. cell cortex Source: Ensembl
  3. cytoplasm Source: BHF-UCL
  4. cytoskeleton Source: MGI
  5. cytosol Source: UniProtKB
  6. fibril Source: Ensembl
  7. Golgi apparatus Source: Ensembl
  8. growth cone Source: Ensembl
  9. inclusion body Source: ParkinsonsUK-UCL
  10. mitochondrion Source: Ensembl
  11. nuclear outer membrane Source: Ensembl
  12. nucleus Source: UniProtKB
  13. perinuclear region of cytoplasm Source: Ensembl
  14. plasma membrane Source: MGI
  15. platelet alpha granule membrane Source: Ensembl
  16. ribosome Source: Ensembl
  17. rough endoplasmic reticulum Source: Ensembl
  18. synapse Source: MGI
  19. synaptic vesicle Source: Ensembl
  20. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Alpha-synucleinPRO_0000184026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei125 – 1251Phosphotyrosine; by FYNBy similarity
Modified residuei129 – 1291Phosphoserine; by PLK21 Publication

Post-translational modificationi

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress (By similarity).By similarity
Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).By similarity
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO55042.
PaxDbiO55042.
PRIDEiO55042.

PTM databases

PhosphoSiteiO55042.

Miscellaneous databases

PMAP-CutDBO55042.

Expressioni

Gene expression databases

BgeeiO55042.
CleanExiMM_SNCA.
GenevestigatoriO55042.

Interactioni

Subunit structurei

Interacts with UCHL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc6a3Q613275EBI-2310271,EBI-7839708
YwhahP685102EBI-2310271,EBI-444641

Protein-protein interaction databases

BioGridi203365. 17 interactions.
IntActiO55042. 5 interactions.
MINTiMINT-2736846.

Structurei

3D structure databases

ProteinModelPortaliO55042.
SMRiO55042. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 56153; approximateAdd
BLAST
Repeati57 – 67114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG44393.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiO55042.
KOiK04528.
OMAiMPPEEEY.
OrthoDBiEOG7034KG.
PhylomeDBiO55042.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O55042-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM
110 120 130 140
GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
Length:140
Mass (Da):14,485
Last modified:April 27, 2001 - v2
Checksum:i1FFD19D7E15E636C
GO
Isoform 2 (identifier: O55042-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-121: GEEGYPQEGILEDMPVDPG → VWLPVLCSVITLDTMSLHA
     122-140: Missing.

Note: No experimental confirmation available.

Show »
Length:121
Mass (Da):12,345
Checksum:i03CAFC4944C78D63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581K → T in AAC00521. (PubMed:9648883)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei103 – 12119GEEGY…PVDPG → VWLPVLCSVITLDTMSLHA in isoform 2. 1 PublicationVSP_025018Add
BLAST
Alternative sequencei122 – 14019Missing in isoform 2. 1 PublicationVSP_025019Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044672 mRNA. Translation: AAC00521.1.
AF033261 mRNA. Translation: AAD11254.1.
AF179273 mRNA. Translation: AAD56908.1.
AF179272
, AF179268, AF179269, AF179270, AF179271 Genomic DNA. Translation: AAD56907.1.
AF163865 Genomic DNA. Translation: AAG30304.1.
AK014472 mRNA. Translation: BAB29375.1.
AK156316 mRNA. Translation: BAE33670.1.
BC046764 mRNA. Translation: AAH46764.1.
AF277451 Genomic DNA. Translation: AAG44833.1.
CCDSiCCDS20201.1. [O55042-1]
RefSeqiNP_001035916.1. NM_001042451.2. [O55042-1]
NP_033247.1. NM_009221.2. [O55042-1]
UniGeneiMm.17484.

Genome annotation databases

EnsembliENSMUST00000114268; ENSMUSP00000109907; ENSMUSG00000025889. [O55042-1]
ENSMUST00000163779; ENSMUSP00000126067; ENSMUSG00000025889. [O55042-1]
GeneIDi20617.
KEGGimmu:20617.
UCSCiuc009cdn.1. mouse. [O55042-1]
uc009cdp.1. mouse. [O55042-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044672 mRNA. Translation: AAC00521.1 .
AF033261 mRNA. Translation: AAD11254.1 .
AF179273 mRNA. Translation: AAD56908.1 .
AF179272
, AF179268 , AF179269 , AF179270 , AF179271 Genomic DNA. Translation: AAD56907.1 .
AF163865 Genomic DNA. Translation: AAG30304.1 .
AK014472 mRNA. Translation: BAB29375.1 .
AK156316 mRNA. Translation: BAE33670.1 .
BC046764 mRNA. Translation: AAH46764.1 .
AF277451 Genomic DNA. Translation: AAG44833.1 .
CCDSi CCDS20201.1. [O55042-1 ]
RefSeqi NP_001035916.1. NM_001042451.2. [O55042-1 ]
NP_033247.1. NM_009221.2. [O55042-1 ]
UniGenei Mm.17484.

3D structure databases

ProteinModelPortali O55042.
SMRi O55042. Positions 1-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203365. 17 interactions.
IntActi O55042. 5 interactions.
MINTi MINT-2736846.

PTM databases

PhosphoSitei O55042.

Proteomic databases

MaxQBi O55042.
PaxDbi O55042.
PRIDEi O55042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114268 ; ENSMUSP00000109907 ; ENSMUSG00000025889 . [O55042-1 ]
ENSMUST00000163779 ; ENSMUSP00000126067 ; ENSMUSG00000025889 . [O55042-1 ]
GeneIDi 20617.
KEGGi mmu:20617.
UCSCi uc009cdn.1. mouse. [O55042-1 ]
uc009cdp.1. mouse. [O55042-2 ]

Organism-specific databases

CTDi 6622.
MGIi MGI:1277151. Snca.

Phylogenomic databases

eggNOGi NOG44393.
GeneTreei ENSGT00390000016161.
HOGENOMi HOG000008691.
HOVERGENi HBG000481.
InParanoidi O55042.
KOi K04528.
OMAi MPPEEEY.
OrthoDBi EOG7034KG.
PhylomeDBi O55042.
TreeFami TF332776.

Enzyme and pathway databases

Reactomei REACT_198563. Amyloids.

Miscellaneous databases

NextBioi 298995.
PMAP-CutDB O55042.
PROi O55042.
SOURCEi Search...

Gene expression databases

Bgeei O55042.
CleanExi MM_SNCA.
Genevestigatori O55042.

Family and domain databases

Gene3Di 1.10.287.700. 1 hit.
InterProi IPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view ]
PANTHERi PTHR13820. PTHR13820. 1 hit.
Pfami PF01387. Synuclein. 1 hit.
[Graphical view ]
PRINTSi PR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development."
    Hsu L.J., Mallory M., Xia Y., Veinbergs I., Hashimoto M., Yoshimoto M., Thal L.J., Saitoh T., Masliah E.
    J. Neurochem. 71:338-344(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The cDNA cloning and ontogeny of mouse alpha-synuclein."
    Hong L., Ko H.W., Gwag B.J., Joe E., Lee S., Kim Y.T., Suh Y.-H.
    NeuroReport 9:1239-1243(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: ICR.
  3. "Genomic cloning of the mouse alpha-synuclein and analysis of the promoter."
    Fog J.U., Kallunki P.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Strain: C57BL/6J and Sv129/Ola.
    Tissue: Brain.
  4. "Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element."
    Touchman J.W., Dehejia A., Chiba-Falek O., Cabin D.E., Schwartz J.R., Orrison B.M., Polymeropoulos M.H., Nussbaum R.L.
    Genome Res. 11:78-86(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Liver and Spleen.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  7. "Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice."
    Schlueter O.M., Fornai F., Alessandri M.G., Takamori S., Geppert M., Jahn R., Suedhof T.C.
    Neuroscience 118:985-1002(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
    Strain: 129/SvJ.
  8. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 61-96, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  9. Cited for: PHOSPHORYLATION AT SER-129.

Entry informationi

Entry nameiSYUA_MOUSE
AccessioniPrimary (citable) accession number: O55042
Secondary accession number(s): Q3U130
, Q9CXF8, Q9EQC3, Q9QUR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3