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Protein

Alpha-synuclein

Gene

Snca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of dopamine release and transport.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2 – 21CopperBy similarity
Metal bindingi50 – 501CopperBy similarity

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • adult locomotory behavior Source: MGI
  • aging Source: Ensembl
  • behavioral response to cocaine Source: Ensembl
  • cellular response to copper ion Source: MGI
  • cellular response to fibroblast growth factor stimulus Source: Ensembl
  • cellular response to oxidative stress Source: MGI
  • dopamine biosynthetic process Source: MGI
  • dopamine metabolic process Source: MGI
  • fatty acid metabolic process Source: MGI
  • long-term synaptic potentiation Source: MGI
  • membrane organization Source: MGI
  • microglial cell activation Source: MGI
  • mitochondrial ATP synthesis coupled electron transport Source: MGI
  • mitochondrial membrane organization Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • negative regulation of dopamine metabolic process Source: Ensembl
  • negative regulation of dopamine uptake involved in synaptic transmission Source: MGI
  • negative regulation of exocytosis Source: MGI
  • negative regulation of histone acetylation Source: MGI
  • negative regulation of microtubule polymerization Source: MGI
  • negative regulation of monooxygenase activity Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of norepinephrine uptake Source: MGI
  • negative regulation of platelet-derived growth factor receptor signaling pathway Source: MGI
  • negative regulation of protein phosphorylation Source: Ensembl
  • negative regulation of serotonin uptake Source: MGI
  • negative regulation of thrombin receptor signaling pathway Source: MGI
  • negative regulation of transporter activity Source: MGI
  • neutral lipid metabolic process Source: MGI
  • oxidation-reduction process Source: MGI
  • phospholipid metabolic process Source: MGI
  • positive regulation of endocytosis Source: MGI
  • positive regulation of glutathione peroxidase activity Source: MGI
  • positive regulation of hydrogen peroxide catabolic process Source: MGI
  • positive regulation of inositol phosphate biosynthetic process Source: MGI
  • positive regulation of neurotransmitter secretion Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • positive regulation of protein serine/threonine kinase activity Source: MGI
  • positive regulation of receptor recycling Source: MGI
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  • positive regulation of synaptic transmission Source: MGI
  • protein destabilization Source: MGI
  • receptor internalization Source: MGI
  • regulation of acyl-CoA biosynthetic process Source: MGI
  • regulation of dopamine secretion Source: ParkinsonsUK-UCL
  • regulation of excitatory postsynaptic membrane potential Source: MGI
  • regulation of glutamate secretion Source: MGI
  • regulation of locomotion Source: MGI
  • regulation of long-term neuronal synaptic plasticity Source: MGI
  • regulation of macrophage activation Source: MGI
  • regulation of neuronal synaptic plasticity Source: MGI
  • regulation of neurotransmitter secretion Source: MGI
  • regulation of phospholipase activity Source: MGI
  • regulation of reactive oxygen species metabolic process Source: ParkinsonsUK-UCL
  • response to drug Source: MGI
  • response to interferon-gamma Source: MGI
  • response to interleukin-1 Source: MGI
  • response to iron(II) ion Source: MGI
  • response to lipopolysaccharide Source: MGI
  • response to magnesium ion Source: MGI
  • synapse organization Source: MGI
  • synaptic transmission Source: MGI
  • synaptic transmission, dopaminergic Source: MGI
  • synaptic vesicle endocytosis Source: UniProtKB
  • synaptic vesicle transport Source: MGI
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synuclein
Alternative name(s):
Non-A beta component of AD amyloid
Non-A4 component of amyloid precursor
Short name:
NACP
Gene namesi
Name:Snca
Synonyms:Syn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1277151. Snca.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Membrane By similarity
  • Nucleus By similarity
  • Cell junctionsynapse By similarity
  • Secreted By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • axon Source: MGI
  • cell cortex Source: MGI
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: BHF-UCL
  • cytoskeleton Source: MGI
  • cytosol Source: UniProtKB
  • extracellular space Source: UniProtKB
  • fibril Source: MGI
  • Golgi apparatus Source: Ensembl
  • growth cone Source: MGI
  • inclusion body Source: ParkinsonsUK-UCL
  • membrane Source: MGI
  • mitochondrion Source: Ensembl
  • nuclear outer membrane Source: Ensembl
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: MGI
  • platelet alpha granule membrane Source: Ensembl
  • ribosome Source: Ensembl
  • rough endoplasmic reticulum Source: Ensembl
  • synapse Source: MGI
  • synaptic vesicle Source: Ensembl
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Alpha-synucleinPRO_0000184026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei125 – 1251Phosphotyrosine; by FYNBy similarity
Modified residuei129 – 1291Phosphoserine; by PLK21 Publication

Post-translational modificationi

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress (By similarity).By similarity
Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).By similarity
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO55042.
PaxDbiO55042.
PRIDEiO55042.

PTM databases

PhosphoSiteiO55042.

Miscellaneous databases

PMAP-CutDBO55042.

Expressioni

Gene expression databases

BgeeiO55042.
CleanExiMM_SNCA.
GenevisibleiO55042. MM.

Interactioni

Subunit structurei

Interacts with UCHL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc6a3Q613275EBI-2310271,EBI-7839708
YwhahP685102EBI-2310271,EBI-444641

Protein-protein interaction databases

BioGridi203365. 16 interactions.
IntActiO55042. 5 interactions.
MINTiMINT-2736846.
STRINGi10090.ENSMUSP00000109907.

Structurei

3D structure databases

ProteinModelPortaliO55042.
SMRiO55042. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 56153; approximateAdd
BLAST
Repeati57 – 67114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 67484 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG44393.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiO55042.
KOiK04528.
OMAiMPPEEEY.
OrthoDBiEOG7034KG.
PhylomeDBiO55042.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O55042-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM
110 120 130 140
GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
Length:140
Mass (Da):14,485
Last modified:April 27, 2001 - v2
Checksum:i1FFD19D7E15E636C
GO
Isoform 2 (identifier: O55042-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-121: GEEGYPQEGILEDMPVDPG → VWLPVLCSVITLDTMSLHA
     122-140: Missing.

Note: No experimental confirmation available.
Show »
Length:121
Mass (Da):12,345
Checksum:i03CAFC4944C78D63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581K → T in AAC00521 (PubMed:9648883).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei103 – 12119GEEGY…PVDPG → VWLPVLCSVITLDTMSLHA in isoform 2. 1 PublicationVSP_025018Add
BLAST
Alternative sequencei122 – 14019Missing in isoform 2. 1 PublicationVSP_025019Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044672 mRNA. Translation: AAC00521.1.
AF033261 mRNA. Translation: AAD11254.1.
AF179273 mRNA. Translation: AAD56908.1.
AF179272
, AF179268, AF179269, AF179270, AF179271 Genomic DNA. Translation: AAD56907.1.
AF163865 Genomic DNA. Translation: AAG30304.1.
AK014472 mRNA. Translation: BAB29375.1.
AK156316 mRNA. Translation: BAE33670.1.
BC046764 mRNA. Translation: AAH46764.1.
AF277451 Genomic DNA. Translation: AAG44833.1.
CCDSiCCDS20201.1. [O55042-1]
RefSeqiNP_001035916.1. NM_001042451.2. [O55042-1]
NP_033247.1. NM_009221.2. [O55042-1]
UniGeneiMm.17484.

Genome annotation databases

EnsembliENSMUST00000114268; ENSMUSP00000109907; ENSMUSG00000025889. [O55042-1]
ENSMUST00000163779; ENSMUSP00000126067; ENSMUSG00000025889. [O55042-1]
GeneIDi20617.
KEGGimmu:20617.
UCSCiuc009cdn.2. mouse. [O55042-1]
uc009cdp.2. mouse. [O55042-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044672 mRNA. Translation: AAC00521.1.
AF033261 mRNA. Translation: AAD11254.1.
AF179273 mRNA. Translation: AAD56908.1.
AF179272
, AF179268, AF179269, AF179270, AF179271 Genomic DNA. Translation: AAD56907.1.
AF163865 Genomic DNA. Translation: AAG30304.1.
AK014472 mRNA. Translation: BAB29375.1.
AK156316 mRNA. Translation: BAE33670.1.
BC046764 mRNA. Translation: AAH46764.1.
AF277451 Genomic DNA. Translation: AAG44833.1.
CCDSiCCDS20201.1. [O55042-1]
RefSeqiNP_001035916.1. NM_001042451.2. [O55042-1]
NP_033247.1. NM_009221.2. [O55042-1]
UniGeneiMm.17484.

3D structure databases

ProteinModelPortaliO55042.
SMRiO55042. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203365. 16 interactions.
IntActiO55042. 5 interactions.
MINTiMINT-2736846.
STRINGi10090.ENSMUSP00000109907.

PTM databases

PhosphoSiteiO55042.

Proteomic databases

MaxQBiO55042.
PaxDbiO55042.
PRIDEiO55042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114268; ENSMUSP00000109907; ENSMUSG00000025889. [O55042-1]
ENSMUST00000163779; ENSMUSP00000126067; ENSMUSG00000025889. [O55042-1]
GeneIDi20617.
KEGGimmu:20617.
UCSCiuc009cdn.2. mouse. [O55042-1]
uc009cdp.2. mouse. [O55042-2]

Organism-specific databases

CTDi6622.
MGIiMGI:1277151. Snca.

Phylogenomic databases

eggNOGiNOG44393.
GeneTreeiENSGT00390000016161.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiO55042.
KOiK04528.
OMAiMPPEEEY.
OrthoDBiEOG7034KG.
PhylomeDBiO55042.
TreeFamiTF332776.

Miscellaneous databases

NextBioi298995.
PMAP-CutDBO55042.
PROiO55042.
SOURCEiSearch...

Gene expression databases

BgeeiO55042.
CleanExiMM_SNCA.
GenevisibleiO55042. MM.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development."
    Hsu L.J., Mallory M., Xia Y., Veinbergs I., Hashimoto M., Yoshimoto M., Thal L.J., Saitoh T., Masliah E.
    J. Neurochem. 71:338-344(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The cDNA cloning and ontogeny of mouse alpha-synuclein."
    Hong L., Ko H.W., Gwag B.J., Joe E., Lee S., Kim Y.T., Suh Y.-H.
    NeuroReport 9:1239-1243(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: ICR.
  3. "Genomic cloning of the mouse alpha-synuclein and analysis of the promoter."
    Fog J.U., Kallunki P.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Strain: C57BL/6J and Sv129/Ola.
    Tissue: Brain.
  4. "Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element."
    Touchman J.W., Dehejia A., Chiba-Falek O., Cabin D.E., Schwartz J.R., Orrison B.M., Polymeropoulos M.H., Nussbaum R.L.
    Genome Res. 11:78-86(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Liver and Spleen.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  7. "Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice."
    Schlueter O.M., Fornai F., Alessandri M.G., Takamori S., Geppert M., Jahn R., Suedhof T.C.
    Neuroscience 118:985-1002(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
    Strain: 129/SvJ.
  8. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 61-96, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  9. Cited for: PHOSPHORYLATION AT SER-129.

Entry informationi

Entry nameiSYUA_MOUSE
AccessioniPrimary (citable) accession number: O55042
Secondary accession number(s): Q3U130
, Q9CXF8, Q9EQC3, Q9QUR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: July 22, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.