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Protein

Neuromedin-U receptor 1

Gene

Nmur1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

GO - Molecular functioni

  • neuromedin U receptor activity Source: MGI
  • neuropeptide receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 1
Short name:
NMU-R1
Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3
Gene namesi
Name:Nmur1
Synonyms:Gpr66
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1341898. Nmur1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini81 – 9616CytoplasmicSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini118 – 13720ExtracellularSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini159 – 18123CytoplasmicSequence analysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini203 – 23533ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini257 – 29438CytoplasmicSequence analysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini316 – 33924ExtracellularSequence analysisAdd
BLAST
Transmembranei340 – 36021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini361 – 42868CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: MGI
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3351216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Neuromedin-U receptor 1PRO_0000069907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi134 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55040.
PRIDEiO55040.

PTM databases

PhosphoSiteiO55040.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

CleanExiMM_NMUR1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027440.

Structurei

3D structure databases

ProteinModelPortaliO55040.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiO55040.
KOiK05052.
OMAiCNGSAAR.
OrthoDBiEOG7T4MK9.
TreeFamiTF318522.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O55040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPCLNCSI FPGALSPNAS RSPLVCNISE FKWPYQPEDL NLTDEALRLK
60 70 80 90 100
YLGPQQMKQF VPICVTYLLI FVVGTLGNGL TCTVILRNKT MRTPTNFYLF
110 120 130 140 150
SLAVSDMLVL LVGLPLELYE MQQNYPFQLG ASACYFRILL LETVCLASVL
160 170 180 190 200
NVTALSVERY VAVVRPLQAK SVMTRAHVRR MVGAIWVLAT LFSLPNTSLH
210 220 230 240 250
GLSQLTVPCR GPVPDSAICS LVGPMDFYKL VVLTTALLFF CLPMVTISVL
260 270 280 290 300
YLLIGLRLRR ERMLLQVEVK GRKTAATQET SHRRIQLQDR GRRQVTKMLF
310 320 330 340 350
ALVVVFGICW APFHADRIMW SLVYGHSTEG LHLAYQCVHI ASGIFFYLGS
360 370 380 390 400
AANPVLYSLM STRFRETFLQ ALGLGTQCCH RRQPYHGSHN HIRLTTGSTL
410 420
CDVGHRNSRD EPLAVNEDPG CQQETDPS
Length:428
Mass (Da):47,934
Last modified:March 16, 2016 - v2
Checksum:iBB5BD67BCAA1E264
GO

Sequence cautioni

The sequence AAI20823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI37776.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EDL40217.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102609 Genomic DNA. No translation available.
CH466520 Genomic DNA. Translation: EDL40217.1. Sequence problems.
BC120822 mRNA. Translation: AAI20823.1. Different initiation.
BC137775 mRNA. Translation: AAI37776.1. Different initiation.
AF044602 mRNA. Translation: AAC02681.1.
CCDSiCCDS15119.1.
RefSeqiNP_001306156.1. NM_001319227.1.
NP_034471.1. NM_010341.1.
UniGeneiMm.389159.

Genome annotation databases

GeneIDi14767.
KEGGimmu:14767.
UCSCiuc007bvn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102609 Genomic DNA. No translation available.
CH466520 Genomic DNA. Translation: EDL40217.1. Sequence problems.
BC120822 mRNA. Translation: AAI20823.1. Different initiation.
BC137775 mRNA. Translation: AAI37776.1. Different initiation.
AF044602 mRNA. Translation: AAC02681.1.
CCDSiCCDS15119.1.
RefSeqiNP_001306156.1. NM_001319227.1.
NP_034471.1. NM_010341.1.
UniGeneiMm.389159.

3D structure databases

ProteinModelPortaliO55040.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027440.

Chemistry

ChEMBLiCHEMBL3351216.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO55040.

Proteomic databases

PaxDbiO55040.
PRIDEiO55040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14767.
KEGGimmu:14767.
UCSCiuc007bvn.2. mouse.

Organism-specific databases

CTDi10316.
MGIiMGI:1341898. Nmur1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiO55040.
KOiK05052.
OMAiCNGSAAR.
OrthoDBiEOG7T4MK9.
TreeFamiTF318522.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiO55040.
SOURCEiSearch...

Gene expression databases

CleanExiMM_NMUR1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005391. NeuromedU_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01566. NEUROMEDNU1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-428.
    Tissue: Brain.
  4. "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors."
    Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D.
    Genomics 52:223-229(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-428, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNMUR1_MOUSE
AccessioniPrimary (citable) accession number: O55040
Secondary accession number(s): G5E871, Q0VB23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 16, 2016
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.