O55040 (NMUR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuromedin-U receptor 1
Short name=NMU-R1

Alternative name(s):
G-protein coupled receptor 66
G-protein coupled receptor FM-3

Gene names

Name:	Nmur1
Synonyms:	Gpr66

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the neuromedin-U and neuromedin-S neuropeptides By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitously expressed. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Ref.1 postulated that the initiator methionine is coded by a non-canonical CTG leucine codon.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Inferred by curator. Source: MGI
Molecular function	neuromedin U receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Neuromedin-U receptor 1		PRO_0000069907
Regions
	Topological domain	1 – 36	36	Extracellular Potential
	Transmembrane	37 – 57	21	Helical; Name=1; Potential
	Topological domain	58 – 73	16	Cytoplasmic Potential
	Transmembrane	74 – 94	21	Helical; Name=2; Potential
	Topological domain	95 – 114	20	Extracellular Potential
	Transmembrane	115 – 135	21	Helical; Name=3; Potential
	Topological domain	136 – 158	23	Cytoplasmic Potential
	Transmembrane	159 – 179	21	Helical; Name=4; Potential
	Topological domain	180 – 212	33	Extracellular Potential
	Transmembrane	213 – 233	21	Helical; Name=5; Potential
	Topological domain	234 – 271	38	Cytoplasmic Potential
	Transmembrane	272 – 292	21	Helical; Name=6; Potential
	Topological domain	293 – 316	24	Extracellular Potential
	Transmembrane	317 – 337	21	Helical; Name=7; Potential
	Topological domain	338 – 405	68	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	111 ↔ 196		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O55040 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: F1BA493D3EB81F34	FASTA	405	45,610
	10 20 30 40 50 60 MVCNISEFKW PYQPEDLNLT DEALRLKYLG PQQMKQFVPI CVTYLLIFVV GTLGNGLTCT 70 80 90 100 110 120 VILRNKTMRT PTNFYLFSLA VSDMLVLLVG LPLELYEMQQ NYPFQLGASA CYFRILLLET 130 140 150 160 170 180 VCLASVLNVT ALSVERYVAV VRPLQAKSVM TRAHVRRMVG AIWVLATLFS LPNTSLHGLS 190 200 210 220 230 240 QLTVPCRGPV PDSAICSLVG PMDFYKLVVL TTALLFFCLP MVTISVLYLL IGLRLRRERM 250 260 270 280 290 300 LLQVEVKGRK TAATQETSHR RIQLQDRGRR QVTKMLFALV VVFGICWAPF HADRIMWSLV 310 320 330 340 350 360 YGHSTEGLHL AYQCVHIASG IFFYLGSAAN PVLYSLMSTR FRETFLQALG LGTQCCHRRQ 370 380 390 400 PYHGSHNHIR LTTGSTLCDV GHRNSRDEPL AVNEDPGCQQ ETDPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors." Tan C.P., McKee K.K., Liu Q., Palyha O.C., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D. Genomics 52:223-229(1998) [PubMed: 9782091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044602 mRNA. Translation: AAC02681.1. BC120822 mRNA. Translation: AAI20823.1. BC137775 mRNA. Translation: AAI37776.1.
IPI	IPI00115156.
RefSeq	NP_034471.1. NM_010341.1.
UniGene	Mm.389159.
3D structure databases
ProteinModelPortal	O55040.
SMR	O55040. Positions 36-350.
ModBase	Search...
Protein-protein interaction databases
STRING	O55040.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	O55040.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	14767.
KEGG	mmu:14767.
UCSC	uc007bvn.1. mouse.
Organism-specific databases
CTD	10316.
MGI	MGI:1341898. Nmur1.
Phylogenomic databases
eggNOG	roNOG09093.
GeneTree	ENSGT00550000074225.
HOGENOM	HBG447291.
HOVERGEN	HBG103506.
InParanoid	O55040.
OrthoDB	EOG49S66R.
Gene expression databases
ArrayExpress	O55040.
Bgee	O55040.
CleanEx	MM_NMUR1.
Genevestigator	O55040.
GermOnline	ENSMUSG00000026237. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR005390. NeuromedU_rcpt. IPR005391. NeuromedU_rcpt_1. [Graphical view]
KO	K05052.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01565. NEUROMEDINUR. PR01566. NEUROMEDNU1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286859.
SOURCE	Search...

Entry information

Entry name

NMUR1_MOUSE

Accession

Primary (citable) accession number: O55040
Secondary accession number(s): Q0VB23

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	June 1, 1998
Last modified:	November 16, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program