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O55038

- CXL13_MOUSE

UniProt

O55038 - CXL13_MOUSE

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Protein

C-X-C motif chemokine 13

Gene

Cxcl13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

GO - Molecular functioni

  1. CCR10 chemokine receptor binding Source: BHF-UCL
  2. chemokine activity Source: BHF-UCL
  3. CXCR3 chemokine receptor binding Source: BHF-UCL
  4. CXCR5 chemokine receptor binding Source: BHF-UCL
  5. fibroblast growth factor binding Source: BHF-UCL
  6. heparin binding Source: BHF-UCL
  7. protein heterodimerization activity Source: BHF-UCL
  8. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. activation of Rap GTPase activity Source: BHF-UCL
  2. B cell chemotaxis Source: BHF-UCL
  3. B cell chemotaxis across high endothelial venule Source: BHF-UCL
  4. cell-cell signaling Source: BHF-UCL
  5. chemokine-mediated signaling pathway Source: BHF-UCL
  6. defense response to bacterium Source: BHF-UCL
  7. endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  8. immune response Source: InterPro
  9. inflammatory response Source: UniProtKB-KW
  10. lymph node development Source: BHF-UCL
  11. lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
  12. negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: Ensembl
  13. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
  14. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  15. positive regulation of integrin activation Source: BHF-UCL
  16. positive regulation of T cell chemotaxis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:Cxcl13
Synonyms:Blc, Scyb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1888499. Cxcl13.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: BHF-UCL
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 10988C-X-C motif chemokine 13PRO_0000005114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 59By similarity
Disulfide bondi34 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO55038.

PTM databases

PhosphoSiteiO55038.

Expressioni

Tissue specificityi

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Gene expression databases

BgeeiO55038.
CleanExiMM_CXCL13.
ExpressionAtlasiO55038. baseline and differential.
GenevestigatoriO55038.

Interactioni

Protein-protein interaction databases

IntActiO55038. 1 interaction.
STRINGi10090.ENSMUSP00000023840.

Structurei

3D structure databases

ProteinModelPortaliO55038.
SMRiO55038. Positions 31-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41531.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO55038.
KOiK10032.
OMAiDESTSIC.
OrthoDBiEOG7P8PBQ.
PhylomeDBiO55038.
TreeFamiTF335204.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55038-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI
60 70 80 90 100
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ

APVSKRRAA
Length:109
Mass (Da):11,927
Last modified:June 1, 1998 - v1
Checksum:iF5F8AF4411C56BD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044196 mRNA. Translation: AAC14401.1.
BC012965 mRNA. Translation: AAH12965.1.
CCDSiCCDS19447.1.
RefSeqiNP_061354.1. NM_018866.2.
UniGeneiMm.10116.

Genome annotation databases

EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
GeneIDi55985.
KEGGimmu:55985.
UCSCiuc008yfb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044196 mRNA. Translation: AAC14401.1 .
BC012965 mRNA. Translation: AAH12965.1 .
CCDSi CCDS19447.1.
RefSeqi NP_061354.1. NM_018866.2.
UniGenei Mm.10116.

3D structure databases

ProteinModelPortali O55038.
SMRi O55038. Positions 31-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O55038. 1 interaction.
STRINGi 10090.ENSMUSP00000023840.

PTM databases

PhosphoSitei O55038.

Proteomic databases

PRIDEi O55038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023840 ; ENSMUSP00000023840 ; ENSMUSG00000023078 .
GeneIDi 55985.
KEGGi mmu:55985.
UCSCi uc008yfb.1. mouse.

Organism-specific databases

CTDi 10563.
MGIi MGI:1888499. Cxcl13.

Phylogenomic databases

eggNOGi NOG41531.
HOGENOMi HOG000220915.
HOVERGENi HBG098474.
InParanoidi O55038.
KOi K10032.
OMAi DESTSIC.
OrthoDBi EOG7P8PBQ.
PhylomeDBi O55038.
TreeFami TF335204.

Enzyme and pathway databases

Reactomei REACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 311698.
PROi O55038.
SOURCEi Search...

Gene expression databases

Bgeei O55038.
CleanExi MM_CXCL13.
ExpressionAtlasi O55038. baseline and differential.
Genevestigatori O55038.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
    Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
    Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCXL13_MOUSE
AccessioniPrimary (citable) accession number: O55038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3