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Protein

C-X-C motif chemokine 13

Gene

Cxcl13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:Cxcl13
Synonyms:Blc, Scyb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1888499. Cxcl13.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular region Source: BHF-UCL
  • extracellular space Source: MGI

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000511422 – 109C-X-C motif chemokine 13Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 59By similarity
Disulfide bondi34 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO55038.
PRIDEiO55038.

PTM databases

iPTMnetiO55038.
PhosphoSitePlusiO55038.

Expressioni

Tissue specificityi

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Gene expression databases

BgeeiENSMUSG00000023078.
CleanExiMM_CXCL13.
ExpressionAtlasiO55038. baseline and differential.
GenevisibleiO55038. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-57395N.
IntActiO55038. 1 interactor.
STRINGi10090.ENSMUSP00000023840.

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Turni44 – 46Combined sources3
Beta strandi47 – 53Combined sources7
Beta strandi57 – 61Combined sources5
Beta strandi63 – 68Combined sources6
Beta strandi73 – 76Combined sources4
Helixi81 – 89Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IZBNMR-A22-109[»]
5L7MNMR-A22-109[»]
ProteinModelPortaliO55038.
SMRiO55038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEN1. Eukaryota.
ENOG4111E5H. LUCA.
GeneTreeiENSGT00530000064292.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO55038.
KOiK10032.
OMAiCPRKEII.
OrthoDBiEOG091G0XS0.
PhylomeDBiO55038.
TreeFamiTF335204.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI
60 70 80 90 100
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ

APVSKRRAA
Length:109
Mass (Da):11,927
Last modified:June 1, 1998 - v1
Checksum:iF5F8AF4411C56BD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044196 mRNA. Translation: AAC14401.1.
BC012965 mRNA. Translation: AAH12965.1.
CCDSiCCDS19447.1.
RefSeqiNP_061354.1. NM_018866.2.
UniGeneiMm.10116.

Genome annotation databases

EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
GeneIDi55985.
KEGGimmu:55985.
UCSCiuc008yfb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCXL13_MOUSE
AccessioniPrimary (citable) accession number: O55038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families