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Protein

C-X-C motif chemokine 13

Gene

Cxcl13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:Cxcl13
Synonyms:Blc, Scyb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1888499. Cxcl13.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular region Source: BHF-UCL
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000511422 – 109C-X-C motif chemokine 13Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 59By similarity
Disulfide bondi34 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO55038.
PRIDEiO55038.

PTM databases

iPTMnetiO55038.
PhosphoSitePlusiO55038.

Expressioni

Tissue specificityi

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Gene expression databases

BgeeiENSMUSG00000023078.
CleanExiMM_CXCL13.
ExpressionAtlasiO55038. baseline and differential.
GenevisibleiO55038. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-57395N.
IntActiO55038. 1 interactor.
STRINGi10090.ENSMUSP00000023840.

Structurei

3D structure databases

ProteinModelPortaliO55038.
SMRiO55038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEN1. Eukaryota.
ENOG4111E5H. LUCA.
GeneTreeiENSGT00530000064292.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO55038.
KOiK10032.
OMAiNGCPRKE.
OrthoDBiEOG091G0XS0.
PhylomeDBiO55038.
TreeFamiTF335204.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI
60 70 80 90 100
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ

APVSKRRAA
Length:109
Mass (Da):11,927
Last modified:June 1, 1998 - v1
Checksum:iF5F8AF4411C56BD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044196 mRNA. Translation: AAC14401.1.
BC012965 mRNA. Translation: AAH12965.1.
CCDSiCCDS19447.1.
RefSeqiNP_061354.1. NM_018866.2.
UniGeneiMm.10116.

Genome annotation databases

EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
GeneIDi55985.
KEGGimmu:55985.
UCSCiuc008yfb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044196 mRNA. Translation: AAC14401.1.
BC012965 mRNA. Translation: AAH12965.1.
CCDSiCCDS19447.1.
RefSeqiNP_061354.1. NM_018866.2.
UniGeneiMm.10116.

3D structure databases

ProteinModelPortaliO55038.
SMRiO55038.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-57395N.
IntActiO55038. 1 interactor.
STRINGi10090.ENSMUSP00000023840.

PTM databases

iPTMnetiO55038.
PhosphoSitePlusiO55038.

Proteomic databases

PaxDbiO55038.
PRIDEiO55038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
GeneIDi55985.
KEGGimmu:55985.
UCSCiuc008yfb.1. mouse.

Organism-specific databases

CTDi10563.
MGIiMGI:1888499. Cxcl13.

Phylogenomic databases

eggNOGiENOG410JEN1. Eukaryota.
ENOG4111E5H. LUCA.
GeneTreeiENSGT00530000064292.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO55038.
KOiK10032.
OMAiNGCPRKE.
OrthoDBiEOG091G0XS0.
PhylomeDBiO55038.
TreeFamiTF335204.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiO55038.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023078.
CleanExiMM_CXCL13.
ExpressionAtlasiO55038. baseline and differential.
GenevisibleiO55038. MM.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXL13_MOUSE
AccessioniPrimary (citable) accession number: O55038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.