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O55038

- CXL13_MOUSE

UniProt

O55038 - CXL13_MOUSE

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Protein

C-X-C motif chemokine 13

Gene
Cxcl13, Blc, Scyb13
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

GO - Molecular functioni

  1. CCR10 chemokine receptor binding Source: BHF-UCL
  2. chemokine activity Source: BHF-UCL
  3. CXCR3 chemokine receptor binding Source: BHF-UCL
  4. CXCR5 chemokine receptor binding Source: BHF-UCL
  5. fibroblast growth factor binding Source: BHF-UCL
  6. heparin binding Source: BHF-UCL
  7. protein heterodimerization activity Source: BHF-UCL
  8. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. activation of Rap GTPase activity Source: BHF-UCL
  2. B cell chemotaxis Source: BHF-UCL
  3. B cell chemotaxis across high endothelial venule Source: BHF-UCL
  4. cell-cell signaling Source: BHF-UCL
  5. chemokine-mediated signaling pathway Source: BHF-UCL
  6. defense response to bacterium Source: BHF-UCL
  7. endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
  8. immune response Source: InterPro
  9. inflammatory response Source: UniProtKB-KW
  10. lymph node development Source: BHF-UCL
  11. lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
  12. negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: Ensembl
  13. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
  14. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  15. positive regulation of integrin activation Source: BHF-UCL
  16. positive regulation of T cell chemotaxis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 13
Alternative name(s):
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene namesi
Name:Cxcl13
Synonyms:Blc, Scyb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1888499. Cxcl13.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: BHF-UCL
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 10988C-X-C motif chemokine 13PRO_0000005114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 59 By similarity
Disulfide bondi34 ↔ 75 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO55038.

PTM databases

PhosphoSiteiO55038.

Expressioni

Tissue specificityi

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Gene expression databases

ArrayExpressiO55038.
BgeeiO55038.
CleanExiMM_CXCL13.
GenevestigatoriO55038.

Interactioni

Protein-protein interaction databases

IntActiO55038. 1 interaction.
STRINGi10090.ENSMUSP00000023840.

Structurei

3D structure databases

ProteinModelPortaliO55038.
SMRiO55038. Positions 28-97.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41531.
HOGENOMiHOG000220915.
HOVERGENiHBG098474.
InParanoidiO55038.
KOiK10032.
OMAiDESTSIC.
OrthoDBiEOG7P8PBQ.
PhylomeDBiO55038.
TreeFamiTF335204.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55038-1 [UniParc]FASTAAdd to Basket

« Hide

MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI    50
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ 100
APVSKRRAA 109
Length:109
Mass (Da):11,927
Last modified:June 1, 1998 - v1
Checksum:iF5F8AF4411C56BD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044196 mRNA. Translation: AAC14401.1.
BC012965 mRNA. Translation: AAH12965.1.
CCDSiCCDS19447.1.
RefSeqiNP_061354.1. NM_018866.2.
UniGeneiMm.10116.

Genome annotation databases

EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
GeneIDi55985.
KEGGimmu:55985.
UCSCiuc008yfb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044196 mRNA. Translation: AAC14401.1 .
BC012965 mRNA. Translation: AAH12965.1 .
CCDSi CCDS19447.1.
RefSeqi NP_061354.1. NM_018866.2.
UniGenei Mm.10116.

3D structure databases

ProteinModelPortali O55038.
SMRi O55038. Positions 28-97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O55038. 1 interaction.
STRINGi 10090.ENSMUSP00000023840.

PTM databases

PhosphoSitei O55038.

Proteomic databases

PRIDEi O55038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023840 ; ENSMUSP00000023840 ; ENSMUSG00000023078 .
GeneIDi 55985.
KEGGi mmu:55985.
UCSCi uc008yfb.1. mouse.

Organism-specific databases

CTDi 10563.
MGIi MGI:1888499. Cxcl13.

Phylogenomic databases

eggNOGi NOG41531.
HOGENOMi HOG000220915.
HOVERGENi HBG098474.
InParanoidi O55038.
KOi K10032.
OMAi DESTSIC.
OrthoDBi EOG7P8PBQ.
PhylomeDBi O55038.
TreeFami TF335204.

Miscellaneous databases

NextBioi 311698.
PROi O55038.
SOURCEi Search...

Gene expression databases

ArrayExpressi O55038.
Bgeei O55038.
CleanExi MM_CXCL13.
Genevestigatori O55038.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
    Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
    Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCXL13_MOUSE
AccessioniPrimary (citable) accession number: O55038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi