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O55038

- CXL13_MOUSE

UniProt

O55038 - CXL13_MOUSE

Protein

C-X-C motif chemokine 13

Gene

Cxcl13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

    GO - Molecular functioni

    1. CCR10 chemokine receptor binding Source: BHF-UCL
    2. chemokine activity Source: BHF-UCL
    3. CXCR3 chemokine receptor binding Source: BHF-UCL
    4. CXCR5 chemokine receptor binding Source: BHF-UCL
    5. fibroblast growth factor binding Source: BHF-UCL
    6. heparin binding Source: BHF-UCL
    7. protein heterodimerization activity Source: BHF-UCL
    8. receptor agonist activity Source: BHF-UCL

    GO - Biological processi

    1. activation of Rap GTPase activity Source: BHF-UCL
    2. B cell chemotaxis Source: BHF-UCL
    3. B cell chemotaxis across high endothelial venule Source: BHF-UCL
    4. cell-cell signaling Source: BHF-UCL
    5. chemokine-mediated signaling pathway Source: BHF-UCL
    6. defense response to bacterium Source: BHF-UCL
    7. endothelial cell chemotaxis to fibroblast growth factor Source: BHF-UCL
    8. immune response Source: InterPro
    9. inflammatory response Source: UniProtKB-KW
    10. lymph node development Source: BHF-UCL
    11. lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
    12. negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: Ensembl
    13. positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
    14. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
    15. positive regulation of integrin activation Source: BHF-UCL
    16. positive regulation of T cell chemotaxis Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 13
    Alternative name(s):
    B lymphocyte chemoattractant
    CXC chemokine BLC
    Small-inducible cytokine B13
    Gene namesi
    Name:Cxcl13
    Synonyms:Blc, Scyb13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1888499. Cxcl13.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: BHF-UCL
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 10988C-X-C motif chemokine 13PRO_0000005114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 59By similarity
    Disulfide bondi34 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO55038.

    PTM databases

    PhosphoSiteiO55038.

    Expressioni

    Tissue specificityi

    Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

    Gene expression databases

    ArrayExpressiO55038.
    BgeeiO55038.
    CleanExiMM_CXCL13.
    GenevestigatoriO55038.

    Interactioni

    Protein-protein interaction databases

    IntActiO55038. 1 interaction.
    STRINGi10090.ENSMUSP00000023840.

    Structurei

    3D structure databases

    ProteinModelPortaliO55038.
    SMRiO55038. Positions 28-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41531.
    HOGENOMiHOG000220915.
    HOVERGENiHBG098474.
    InParanoidiO55038.
    KOiK10032.
    OMAiDESTSIC.
    OrthoDBiEOG7P8PBQ.
    PhylomeDBiO55038.
    TreeFamiTF335204.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O55038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI    50
    QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ 100
    APVSKRRAA 109
    Length:109
    Mass (Da):11,927
    Last modified:June 1, 1998 - v1
    Checksum:iF5F8AF4411C56BD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044196 mRNA. Translation: AAC14401.1.
    BC012965 mRNA. Translation: AAH12965.1.
    CCDSiCCDS19447.1.
    RefSeqiNP_061354.1. NM_018866.2.
    UniGeneiMm.10116.

    Genome annotation databases

    EnsembliENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
    GeneIDi55985.
    KEGGimmu:55985.
    UCSCiuc008yfb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044196 mRNA. Translation: AAC14401.1 .
    BC012965 mRNA. Translation: AAH12965.1 .
    CCDSi CCDS19447.1.
    RefSeqi NP_061354.1. NM_018866.2.
    UniGenei Mm.10116.

    3D structure databases

    ProteinModelPortali O55038.
    SMRi O55038. Positions 28-97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O55038. 1 interaction.
    STRINGi 10090.ENSMUSP00000023840.

    PTM databases

    PhosphoSitei O55038.

    Proteomic databases

    PRIDEi O55038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023840 ; ENSMUSP00000023840 ; ENSMUSG00000023078 .
    GeneIDi 55985.
    KEGGi mmu:55985.
    UCSCi uc008yfb.1. mouse.

    Organism-specific databases

    CTDi 10563.
    MGIi MGI:1888499. Cxcl13.

    Phylogenomic databases

    eggNOGi NOG41531.
    HOGENOMi HOG000220915.
    HOVERGENi HBG098474.
    InParanoidi O55038.
    KOi K10032.
    OMAi DESTSIC.
    OrthoDBi EOG7P8PBQ.
    PhylomeDBi O55038.
    TreeFami TF335204.

    Miscellaneous databases

    NextBioi 311698.
    PROi O55038.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O55038.
    Bgeei O55038.
    CleanExi MM_CXCL13.
    Genevestigatori O55038.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
      Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
      Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiCXL13_MOUSE
    AccessioniPrimary (citable) accession number: O55038
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3