O55038 (CXL13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C motif chemokine 13

Alternative name(s):
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13

Gene names

Name:	Cxcl13
Synonyms:	Blc, Scyb13

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.
Subcellular location	Secreted.
Tissue specificity	Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).
Sequence similarities	Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	B cell chemotaxis across high endothelial venule Inferred from direct assay PubMed 15972452. Source: BHF-UCL activation of Rap GTPase activity Inferred from direct assay PubMed 15972452. Source: BHF-UCL cell-cell signaling Inferred from sequence or structural similarity. Source: BHF-UCL chemokine-mediated signaling pathway Non-traceable author statement PubMed 15972452. Source: BHF-UCL defense response to bacterium Inferred from sequence or structural similarity. Source: BHF-UCL elevation of cytosolic calcium ion concentration Inferred from sequence or structural similarity. Source: BHF-UCL endothelial cell chemotaxis to fibroblast growth factor Inferred from sequence or structural similarity. Source: BHF-UCL immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW lymph node development Inferred from direct assay PubMed 19783990. Source: BHF-UCL negative regulation of endothelial cell chemotaxis to fibroblast growth factor Inferred from electronic annotation. Source: Compara positive regulation of T cell chemotaxis Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of cell-cell adhesion mediated by integrin Inferred from direct assay PubMed 15972452. Source: BHF-UCL positive regulation of integrin activation Inferred from direct assay PubMed 15972452. Source: BHF-UCL
Cellular_component	extracellular region Inferred from sequence or structural similarity. Source: BHF-UCL extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	CCR10 chemokine receptor binding Inferred from sequence or structural similarity. Source: BHF-UCL CXCR3 chemokine receptor binding Inferred from sequence or structural similarity. Source: BHF-UCL CXCR5 chemokine receptor binding Inferred from direct assay PubMed 9463416. Source: BHF-UCL chemokine activity Inferred from direct assay PubMed 15972452. Source: BHF-UCL fibroblast growth factor binding Inferred from sequence or structural similarity. Source: BHF-UCL heparin binding Inferred from sequence or structural similarity. Source: BHF-UCL protein heterodimerization activity Inferred from sequence or structural similarity. Source: BHF-UCL receptor agonist activity Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.1
	Chain	22 – 109	88	C-X-C motif chemokine 13		PRO_0000005114
Amino acid modifications
	Disulfide bond	32 ↔ 59		By similarity
	Disulfide bond	34 ↔ 75		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O55038 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: F5F8AF4411C56BD3	FASTA	109	11,927
	10 20 30 40 50 60 MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI QVTPPGNGCP 70 80 90 100 KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ APVSKRRAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1." Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T. Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044196 mRNA. Translation: AAC14401.1. BC012965 mRNA. Translation: AAH12965.1.
IPI	IPI00115132.
RefSeq	NP_061354.1. NM_018866.2.
UniGene	Mm.10116.
3D structure databases
ProteinModelPortal	O55038.
SMR	O55038. Positions 23-97.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000023840.
PTM databases
PhosphoSite	O55038.
Proteomic databases
PRIDE	O55038.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
GeneID	55985.
KEGG	mmu:55985.
Organism-specific databases
CTD	10563.
MGI	MGI:1888499. Cxcl13.
Phylogenomic databases
eggNOG	NOG41531.
HOGENOM	HOG000220915.
HOVERGEN	HBG098474.
InParanoid	O55038.
KO	K10032.
OMA	EIIVWKK.
OrthoDB	EOG4G1MJ2.
Gene expression databases
ArrayExpress	O55038.
Bgee	O55038.
CleanEx	MM_CXCL13.
Genevestigator	O55038.
GermOnline	ENSMUSG00000023078. Mus musculus.
Family and domain databases
InterPro	IPR001089. Chemokine_CXC. IPR018048. Chemokine_CXC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
PANTHER	PTHR10179. PTHR10179. 1 hit.
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR00437. SMALLCYTKCXC.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00471. SMALL_CYTOKINES_CXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	311698.
SOURCE	Search...

Entry information

Entry name

CXL13_MOUSE

Accession

Primary (citable) accession number: O55038

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program