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O55038 (CXL13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 13
Alternative name(s):
B lymphocyte chemoattractant
CXC chemokine BLC
Small-inducible cytokine B13
Gene names
Name:Cxcl13
Synonyms:Blc, Scyb13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length109 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

Subcellular location

Secreted.

Tissue specificity

Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processB cell chemotaxis

Inferred from mutant phenotype PubMed 15972452. Source: BHF-UCL

B cell chemotaxis across high endothelial venule

Inferred from direct assay PubMed 15972452. Source: BHF-UCL

activation of Rap GTPase activity

Inferred from direct assay PubMed 15972452. Source: BHF-UCL

cell-cell signaling

Inferred from sequence or structural similarity. Source: BHF-UCL

chemokine-mediated signaling pathway

Non-traceable author statement PubMed 15972452. Source: BHF-UCL

defense response to bacterium

Inferred from sequence or structural similarity. Source: BHF-UCL

endothelial cell chemotaxis to fibroblast growth factor

Inferred from sequence or structural similarity. Source: BHF-UCL

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

lymph node development

Inferred from direct assay PubMed 19783990. Source: BHF-UCL

lymphocyte chemotaxis across high endothelial venule

Inferred from mutant phenotype PubMed 15972452. Source: BHF-UCL

negative regulation of endothelial cell chemotaxis to fibroblast growth factor

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of cell-cell adhesion mediated by integrin

Inferred from direct assay PubMed 15972452. Source: BHF-UCL

positive regulation of cytosolic calcium ion concentration

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of integrin activation

Inferred from direct assay PubMed 15972452. Source: BHF-UCL

   Cellular_componentextracellular region

Inferred from sequence or structural similarity. Source: BHF-UCL

extracellular space

Inferred from direct assay PubMed 23460747. Source: MGI

   Molecular_functionCCR10 chemokine receptor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

CXCR3 chemokine receptor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

CXCR5 chemokine receptor binding

Inferred from direct assay PubMed 9463416. Source: BHF-UCL

chemokine activity

Inferred from direct assay PubMed 15972452. Source: BHF-UCL

fibroblast growth factor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

heparin binding

Inferred from sequence or structural similarity. Source: BHF-UCL

protein heterodimerization activity

Inferred from sequence or structural similarity. Source: BHF-UCL

receptor agonist activity

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.1
Chain22 – 10988C-X-C motif chemokine 13
PRO_0000005114

Amino acid modifications

Disulfide bond32 ↔ 59 By similarity
Disulfide bond34 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
O55038 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: F5F8AF4411C56BD3

FASTA10911,927
        10         20         30         40         50         60 
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI QVTPPGNGCP 

        70         80         90        100 
KTEVVIWTKM KKVICVNPRA KWLQRLLRHV QSKSLSSTPQ APVSKRRAA 

« Hide

References

« Hide 'large scale' references
[1]"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1."
Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T.
Nature 391:799-803(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF044196 mRNA. Translation: AAC14401.1.
BC012965 mRNA. Translation: AAH12965.1.
CCDSCCDS19447.1.
RefSeqNP_061354.1. NM_018866.2.
UniGeneMm.10116.

3D structure databases

ProteinModelPortalO55038.
SMRO55038. Positions 28-97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO55038. 1 interaction.
STRING10090.ENSMUSP00000023840.

PTM databases

PhosphoSiteO55038.

Proteomic databases

PRIDEO55038.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023840; ENSMUSP00000023840; ENSMUSG00000023078.
GeneID55985.
KEGGmmu:55985.
UCSCuc008yfb.1. mouse.

Organism-specific databases

CTD10563.
MGIMGI:1888499. Cxcl13.

Phylogenomic databases

eggNOGNOG41531.
HOGENOMHOG000220915.
HOVERGENHBG098474.
InParanoidO55038.
KOK10032.
OMADESTSIC.
OrthoDBEOG7P8PBQ.
PhylomeDBO55038.
TreeFamTF335204.

Gene expression databases

ArrayExpressO55038.
BgeeO55038.
CleanExMM_CXCL13.
GenevestigatorO55038.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311698.
PROO55038.
SOURCESearch...

Entry information

Entry nameCXL13_MOUSE
AccessionPrimary (citable) accession number: O55038
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot