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Protein

Ectonucleoside triphosphate diphosphohydrolase 2

Gene

Entpd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity).By similarity

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 208ATPBy similarity5

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • nucleoside-diphosphatase activity Source: MGI
  • nucleoside-triphosphatase activity Source: MGI

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • platelet activation Source: MGI
  • purine ribonucleoside diphosphate catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8850843. Phosphate bond hydrolysis by NTPDase proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 2 (EC:3.6.1.-)
Short name:
NTPDase 2
Alternative name(s):
CD39 antigen-like 1
Ecto-ATP diphosphohydrolase 2
Short name:
Ecto-ATPDase 2
Short name:
Ecto-ATPase 2
Gene namesi
Name:Entpd2
Synonyms:Cd39l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1096863. Entpd2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 462ExtracellularSequence analysisAdd BLAST437
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 495CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • basal lamina Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099071 – 495Ectonucleoside triphosphate diphosphohydrolase 2Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi75 ↔ 99By similarity
Glycosylationi129N-linked (GlcNAc...)1 Publication1
Disulfide bondi242 ↔ 284By similarity
Disulfide bondi265 ↔ 310By similarity
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Glycosylationi319N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi323 ↔ 328By similarity
Disulfide bondi377 ↔ 399By similarity
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO55026.
PeptideAtlasiO55026.
PRIDEiO55026.

PTM databases

PhosphoSitePlusiO55026.

Expressioni

Inductioni

By dioxin.

Gene expression databases

BgeeiENSMUSG00000015085.
ExpressionAtlasiO55026. baseline and differential.
GenevisibleiO55026. MM.

Interactioni

Protein-protein interaction databases

IntActiO55026. 1 interactor.
STRINGi10090.ENSMUSP00000028328.

Structurei

3D structure databases

ProteinModelPortaliO55026.
SMRiO55026.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
InParanoidiO55026.
KOiK01509.
OMAiSPCTMAQ.
OrthoDBiEOG091G05FZ.
PhylomeDBiO55026.
TreeFamiTF332859.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O55026-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGKLVSLVP PLLLAAVGLA GLLLLCVPTQ DVREPPALKY GIVLDAGSSH
60 70 80 90 100
TSMFVYKWPA DKENDTGIVG QHSSCDVRGG GISSYANDPS RAGQSLVECL
110 120 130 140 150
EQALRDVPKD RYASTPLYLG ATAGMRLLNL TSPEATAKVL EAVTQTLTRY
160 170 180 190 200
PFDFRGARIL SGQDEGVFGW VTANYLLENF IKYGWVGRWI RPRKGTLGAM
210 220 230 240 250
DLGGASTQIT FETTSPSEDP DNEVHLRLYG QHYRVYTHSF LCYGRDQVLQ
260 270 280 290 300
RLLASALQIH RFHPCWPKGY STQVLLREVY QSPCTMGQRP QTFNSSATVS
310 320 330 340 350
LSGTSNAALC RDLVSGLFNI SSCPFSQCSF NGVFQPPVAG NFIAFSAFYY
360 370 380 390 400
TVDFLKTVMG LPVGTLKQLE DATETTCNQT WAELQARVPG QQTRLPDYCA
410 420 430 440 450
VAMFIHQLLS RGYRFDERSF RGVVFEKKAA DTAVGWALGY MLNLTNLIPA
460 470 480 490
DLPGLRKGTH FSSWVALLLL FTVLILAALV LLLRQVRSAK SPGAL
Length:495
Mass (Da):54,319
Last modified:March 15, 2004 - v2
Checksum:iA76468A0CBF86AAC
GO
Isoform Short (identifier: O55026-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-132: LTS → MAG
     133-495: Missing.

Show »
Length:132
Mass (Da):13,857
Checksum:i12D83F5F057F6A7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti400A → T in AAC24347 (PubMed:9624117).Curated1
Sequence conflicti414R → S in AAC24347 (PubMed:9624117).Curated1
Sequence conflicti437A → T in AAC24347 (PubMed:9624117).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003611130 – 132LTS → MAG in isoform Short. 1 Publication3
Alternative sequenceiVSP_003612133 – 495Missing in isoform Short. 1 PublicationAdd BLAST363

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91511 mRNA. Translation: AAB81014.1.
AF042811 mRNA. Translation: AAC24347.1.
AY376711 mRNA. Translation: AAQ86586.1.
AK002553 mRNA. Translation: BAB22182.1.
CCDSiCCDS15770.1. [O55026-1]
RefSeqiNP_033979.2. NM_009849.2. [O55026-1]
UniGeneiMm.482100.

Genome annotation databases

EnsembliENSMUST00000028328; ENSMUSP00000028328; ENSMUSG00000015085. [O55026-1]
GeneIDi12496.
KEGGimmu:12496.
UCSCiuc008irw.2. mouse. [O55026-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91511 mRNA. Translation: AAB81014.1.
AF042811 mRNA. Translation: AAC24347.1.
AY376711 mRNA. Translation: AAQ86586.1.
AK002553 mRNA. Translation: BAB22182.1.
CCDSiCCDS15770.1. [O55026-1]
RefSeqiNP_033979.2. NM_009849.2. [O55026-1]
UniGeneiMm.482100.

3D structure databases

ProteinModelPortaliO55026.
SMRiO55026.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO55026. 1 interactor.
STRINGi10090.ENSMUSP00000028328.

PTM databases

PhosphoSitePlusiO55026.

Proteomic databases

PaxDbiO55026.
PeptideAtlasiO55026.
PRIDEiO55026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028328; ENSMUSP00000028328; ENSMUSG00000015085. [O55026-1]
GeneIDi12496.
KEGGimmu:12496.
UCSCiuc008irw.2. mouse. [O55026-1]

Organism-specific databases

CTDi954.
MGIiMGI:1096863. Entpd2.

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
InParanoidiO55026.
KOiK01509.
OMAiSPCTMAQ.
OrthoDBiEOG091G05FZ.
PhylomeDBiO55026.
TreeFamiTF332859.

Enzyme and pathway databases

ReactomeiR-MMU-8850843. Phosphate bond hydrolysis by NTPDase proteins.

Miscellaneous databases

PROiO55026.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015085.
ExpressionAtlasiO55026. baseline and differential.
GenevisibleiO55026. MM.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTP2_MOUSE
AccessioniPrimary (citable) accession number: O55026
Secondary accession number(s): O35928, Q9DCR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 15, 2004
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.