Reviewed,
UniProtKB/Swiss-Prot O55023 (IMPA1_MOUSE)
Last modified
October 13, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Inositol monophosphatase EC=3.1.3.25 Alternative name(s): Inositol-1(or 4)-monophosphatase Short name=IMPase Short name=IMP Lithium-sensitive myo-inositol monophosphatase A1 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 277 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates By similarity. |
| Catalytic activity | Myo-inositol phosphate + H2O = myo-inositol + phosphate. |
| Cofactor | Magnesium. |
| Enzyme regulation | Inhibited by Li+. |
| Pathway | Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Tissue specificity | Mostly expressed in brain, small intestine, testis, kidney, and spleen (at protein level). Ref.3 |
| Induction | By lithium Li+ in hippocamp. Ref.2 |
| Sequence similarities | Belongs to the inositol monophosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Lithium Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | inositol metabolic process Traceable author statement. Source: MGI |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC lithium ion bindingInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 277 | 277 | Inositol monophosphatase | PRO_0000142514 | |||||
Regions | |||||||||
| Region | 92 – 95 | 4 | Substrate binding By similarity | ||||||
| Region | 194 – 196 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 70 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 90 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 90 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 92 | 1 | Magnesium 1; via carbonyl oxygen By similarity | ||||||
| Metal binding | 93 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 220 | 1 | Magnesium 2 By similarity | ||||||
| Binding site | 70 | 1 | Substrate By similarity | ||||||
| Binding site | 213 | 1 | Substrate By similarity | ||||||
| Binding site | 220 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | Parthasarathy L., Parthasarathy R., Vadnal R.E. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model." Shamir A., Shaltiel G., Greenberg M.L., Belmaker R.H., Agam G. Brain Res. Mol. Brain Res. 115:104-110(2003) [PubMed: 12877981] [Abstract] Cited for: INDUCTION. |
| [3] | "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1." Ohnishi T., Ohba H., Seo K.-C., Im J., Sato Y., Iwayama Y., Furuichi T., Chung S.-K., Yoshikawa T. J. Biol. Chem. 282:637-646(2007) [PubMed: 17068342] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF042730 mRNA. Translation: AAB97469.1. | |
| IPI | IPI00115085. |
| UniGene | Mm.183042 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IMF based on UniProtKB P29218. |
| SMR | O55023. Positions 3-276. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O55023. |
PTM databases | |
| PhosphoSite | O55023. |
Proteomic databases | |
| PRIDE | O55023. |
Genome annotation databases | |
| Ensembl | ENSMUST00000065938; ENSMUSP00000068174; ENSMUSG00000027531; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:1933158. Impa1. |
Phylogenomic databases | |
| HOGENOM | O55023. |
| HOVERGEN | O55023. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.25. 244. |
Gene expression databases | |
| ArrayExpress | O55023. |
| Bgee | O55023. |
| CleanEx | MM_IMPA1. |
| Genevestigator | O55023. |
| GermOnline | ENSMUSG00000027531. Mus musculus. |
Family and domain databases | |
| InterPro | IPR020583. Inositol_monoP_metal-BS. IPR020552. Inositol_monoPase_Li-sen. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view] |
| PANTHER | PTHR20854. Inositol_P. 1 hit. |
| Pfam | PF00459. Inositol_P. 1 hit. [Graphical view] |
| PRINTS | PR00377. IMPHPHTASES. PR00378. LIIMPHPHTASE. |
| ProDom | PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | IMPA1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O55023 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


