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O55023 (IMPA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol monophosphatase 1
Short name=IMP 1
Short name=IMPase 1
EC=3.1.3.25
Alternative name(s):
Inositol-1(or 4)-monophosphatase 1
Lithium-sensitive myo-inositol monophosphatase A1
Gene names
Name:Impa1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates By similarity.

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium.

Enzyme regulation

Inhibited by Li+.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Mostly expressed in brain, small intestine, testis, kidney, and spleen (at protein level). Ref.3

Induction

By lithium Li+ in hippocamp. Ref.2

Sequence similarities

Belongs to the inositol monophosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Inositol monophosphatase 1
PRO_0000142514

Regions

Region92 – 954Substrate binding By similarity
Region194 – 1963Substrate binding By similarity

Sites

Metal binding701Magnesium 1 By similarity
Metal binding901Magnesium 1 By similarity
Metal binding901Magnesium 2 By similarity
Metal binding921Magnesium 1; via carbonyl oxygen By similarity
Metal binding931Magnesium 2 By similarity
Metal binding2201Magnesium 2 By similarity
Binding site701Substrate By similarity
Binding site2131Substrate By similarity
Binding site2201Substrate By similarity

Secondary structure

1 ............................................. 277
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O55023 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: EDBDB7BD24748E9D

FASTA27730,436
        10         20         30         40         50         60 
MADPWQECMD YAVILARQAG EMIREALKNE MDVMIKSSPA DLVTVTDQKV EKMLMSSIKE 

        70         80         90        100        110        120 
KYPCHSFIGE ESVAAGEKTV FTESPTWFID PIDGTTNFVH RFPFVAVSIG FLVNKEMEFG 

       130        140        150        160        170        180 
IVYSCVEDKM YTGRKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRKPE TLRIVLSNME 

       190        200        210        220        230        240 
KLCSIPIHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD MAGAGIIVTE AGGVLMDVTG 

       250        260        270 
GPFDLMSRRI IAANSITLAK RIAKEIEIIP LQRDDES

« Hide

References

[1]Parthasarathy L., Parthasarathy R., Vadnal R.E.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model."
Shamir A., Shaltiel G., Greenberg M.L., Belmaker R.H., Agam G.
Brain Res. Mol. Brain Res. 115:104-110(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[3]"Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."
Ohnishi T., Ohba H., Seo K.-C., Im J., Sato Y., Iwayama Y., Furuichi T., Chung S.-K., Yoshikawa T.
J. Biol. Chem. 282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF042730 mRNA. Translation: AAB97469.1.
IPIIPI00115085.
UniGeneMm.183042.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AS5X-ray2.43A/B/C/D1-277[»]
ProteinModelPortalO55023.
SMRO55023. Positions 3-276.
ModBaseSearch...

Protein-protein interaction databases

IntActO55023. 1 interaction.

PTM databases

PhosphoSiteO55023.

Proteomic databases

PaxDbO55023.
PRIDEO55023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1933158. Impa1.

Phylogenomic databases

eggNOGCOG0483.
HOGENOMHOG000282238.
HOVERGENHBG052123.
InParanoidO55023.
OrthoDBEOG42FSJ2.

Enzyme and pathway databases

UniPathwayUPA00823; UER00788.

Gene expression databases

CleanExMM_IMPA1.
GenevestigatorO55023.
GermOnlineENSMUSG00000027531. Mus musculus.

Family and domain databases

InterProIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. PTHR20854. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIMPA1. mouse.
SOURCESearch...

Entry information

Entry nameIMPA1_MOUSE
AccessionPrimary (citable) accession number: O55023
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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