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O55023

- IMPA1_MOUSE

UniProt

O55023 - IMPA1_MOUSE

Protein

Inositol monophosphatase 1

Gene

Impa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates By similarity.By similarity

    Catalytic activityi

    Myo-inositol phosphate + H2O = myo-inositol + phosphate.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Inhibited by Li+.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi70 – 701Magnesium 1By similarity
    Binding sitei70 – 701SubstrateBy similarity
    Metal bindingi90 – 901Magnesium 1By similarity
    Metal bindingi90 – 901Magnesium 2By similarity
    Metal bindingi92 – 921Magnesium 1; via carbonyl oxygenBy similarity
    Metal bindingi93 – 931Magnesium 2By similarity
    Binding sitei213 – 2131SubstrateBy similarity
    Metal bindingi220 – 2201Magnesium 2By similarity
    Binding sitei220 – 2201SubstrateBy similarity

    GO - Molecular functioni

    1. inositol monophosphate 1-phosphatase activity Source: MGI
    2. inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
    3. inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
    4. metal ion binding Source: UniProtKB-KW
    5. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. inositol biosynthetic process Source: UniProtKB-UniPathway
    2. inositol metabolic process Source: MGI
    3. inositol phosphate dephosphorylation Source: MGI
    4. phosphatidylinositol phosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Lithium, Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00823; UER00788.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol monophosphatase 1 (EC:3.1.3.25)
    Short name:
    IMP 1
    Short name:
    IMPase 1
    Alternative name(s):
    Inositol-1(or 4)-monophosphatase 1
    Lithium-sensitive myo-inositol monophosphatase A1
    Gene namesi
    Name:Impa1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1933158. Impa1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Inositol monophosphatase 1PRO_0000142514Add
    BLAST

    Proteomic databases

    MaxQBiO55023.
    PaxDbiO55023.
    PRIDEiO55023.

    PTM databases

    PhosphoSiteiO55023.

    Expressioni

    Tissue specificityi

    Mostly expressed in brain, small intestine, testis, kidney, and spleen (at protein level).1 Publication

    Inductioni

    By lithium Li+ in hippocamp.1 Publication

    Gene expression databases

    CleanExiMM_IMPA1.
    GenevestigatoriO55023.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiO55023. 1 interaction.

    Structurei

    Secondary structure

    1
    277
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 2623
    Beta strandi34 – 385
    Helixi45 – 6117
    Beta strandi65 – 695
    Helixi70 – 745
    Beta strandi86 – 938
    Helixi95 – 1006
    Beta strandi106 – 1138
    Beta strandi116 – 1249
    Turni125 – 1284
    Beta strandi129 – 1346
    Turni135 – 1373
    Beta strandi138 – 1414
    Helixi154 – 1563
    Beta strandi158 – 1603
    Helixi169 – 18315
    Turni184 – 1863
    Beta strandi188 – 1925
    Helixi196 – 2049
    Beta strandi207 – 2159
    Helixi218 – 23013
    Beta strandi234 – 2363
    Beta strandi240 – 2423
    Beta strandi247 – 2548
    Helixi256 – 26510

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AS5X-ray2.43A/B/C/D1-277[»]
    ProteinModelPortaliO55023.
    SMRiO55023. Positions 3-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni92 – 954Substrate bindingBy similarity
    Regioni194 – 1963Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the inositol monophosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG0483.
    HOGENOMiHOG000282238.
    HOVERGENiHBG052123.
    InParanoidiO55023.
    PhylomeDBiO55023.

    Family and domain databases

    InterProiIPR020583. Inositol_monoP_metal-BS.
    IPR020552. Inositol_monoPase_Li-sen.
    IPR000760. Inositol_monophosphatase.
    IPR020550. Inositol_monophosphatase_CS.
    [Graphical view]
    PANTHERiPTHR20854. PTHR20854. 1 hit.
    PfamiPF00459. Inositol_P. 1 hit.
    [Graphical view]
    PRINTSiPR00377. IMPHPHTASES.
    PR00378. LIIMPHPHTASE.
    PROSITEiPS00629. IMP_1. 1 hit.
    PS00630. IMP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O55023-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADPWQECMD YAVILARQAG EMIREALKNE MDVMIKSSPA DLVTVTDQKV    50
    EKMLMSSIKE KYPCHSFIGE ESVAAGEKTV FTESPTWFID PIDGTTNFVH 100
    RFPFVAVSIG FLVNKEMEFG IVYSCVEDKM YTGRKGKGAF CNGQKLQVSQ 150
    QEDITKSLLV TELGSSRKPE TLRIVLSNME KLCSIPIHGI RSVGTAAVNM 200
    CLVATGGADA YYEMGIHCWD MAGAGIIVTE AGGVLMDVTG GPFDLMSRRI 250
    IAANSITLAK RIAKEIEIIP LQRDDES 277
    Length:277
    Mass (Da):30,436
    Last modified:June 1, 1998 - v1
    Checksum:iEDBDB7BD24748E9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042730 mRNA. Translation: AAB97469.1.
    CCDSiCCDS17240.1.
    UniGeneiMm.183042.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042730 mRNA. Translation: AAB97469.1 .
    CCDSi CCDS17240.1.
    UniGenei Mm.183042.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AS5 X-ray 2.43 A/B/C/D 1-277 [» ]
    ProteinModelPortali O55023.
    SMRi O55023. Positions 3-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O55023. 1 interaction.

    PTM databases

    PhosphoSitei O55023.

    Proteomic databases

    MaxQBi O55023.
    PaxDbi O55023.
    PRIDEi O55023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1933158. Impa1.

    Phylogenomic databases

    eggNOGi COG0483.
    HOGENOMi HOG000282238.
    HOVERGENi HBG052123.
    InParanoidi O55023.
    PhylomeDBi O55023.

    Enzyme and pathway databases

    UniPathwayi UPA00823 ; UER00788 .

    Miscellaneous databases

    ChiTaRSi IMPA1. mouse.
    PROi O55023.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_IMPA1.
    Genevestigatori O55023.

    Family and domain databases

    InterProi IPR020583. Inositol_monoP_metal-BS.
    IPR020552. Inositol_monoPase_Li-sen.
    IPR000760. Inositol_monophosphatase.
    IPR020550. Inositol_monophosphatase_CS.
    [Graphical view ]
    PANTHERi PTHR20854. PTHR20854. 1 hit.
    Pfami PF00459. Inositol_P. 1 hit.
    [Graphical view ]
    PRINTSi PR00377. IMPHPHTASES.
    PR00378. LIIMPHPHTASE.
    PROSITEi PS00629. IMP_1. 1 hit.
    PS00630. IMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Parthasarathy L., Parthasarathy R., Vadnal R.E.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model."
      Shamir A., Shaltiel G., Greenberg M.L., Belmaker R.H., Agam G.
      Brain Res. Mol. Brain Res. 115:104-110(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    3. "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1."
      Ohnishi T., Ohba H., Seo K.-C., Im J., Sato Y., Iwayama Y., Furuichi T., Chung S.-K., Yoshikawa T.
      J. Biol. Chem. 282:637-646(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIMPA1_MOUSE
    AccessioniPrimary (citable) accession number: O55023
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3