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Protein

Membrane-associated progesterone receptor component 1

Gene

Pgrmc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for progesterone.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lipid-binding, Steroid-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 1
Gene namesi
Name:Pgrmc1
Synonyms:Pgrmc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858305. Pgrmc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 24LumenalSequence analysisAdd BLAST23
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19
Topological domaini44 – 195CytoplasmicSequence analysisAdd BLAST152

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001217402 – 195Membrane-associated progesterone receptor component 1Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei74PhosphothreonineCombined sources1
Modified residuei181PhosphoserineCombined sources1 Publication1
Modified residuei190PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO55022.
PaxDbiO55022.
PeptideAtlasiO55022.
PRIDEiO55022.

PTM databases

iPTMnetiO55022.
PhosphoSitePlusiO55022.
SwissPalmiO55022.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006373.
CleanExiMM_PGRMC1.
ExpressionAtlasiO55022. baseline and differential.
GenevisibleiO55022. MM.

Interactioni

Protein-protein interaction databases

IntActiO55022. 14 interactors.
MINTiMINT-4996230.
STRINGi10090.ENSMUSP00000073061.

Structurei

3D structure databases

ProteinModelPortaliO55022.
SMRiO55022.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 171Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiO55022.
KOiK17278.
OMAiCLYLLYK.
OrthoDBiEOG091G0PXT.
PhylomeDBiO55022.
TreeFamiTF314562.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVVATG ADPSELEGGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PGASGDNDDD EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV
110 120 130 140 150
TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTPAQQ
160 170 180 190
ETLSDWDSQF TFKYHHVGKL LKEGEEPTVY SDDEEPKDET ARKNE
Length:195
Mass (Da):21,694
Last modified:January 23, 2007 - v4
Checksum:i1FFD17AFAE6C81FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87P → S in AAB97466 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042491 mRNA. Translation: AAB97466.1.
BC006016 mRNA. Translation: AAH06016.1.
CCDSiCCDS30060.1.
RefSeqiNP_058063.2. NM_016783.4.
UniGeneiMm.9052.

Genome annotation databases

EnsembliENSMUST00000073339; ENSMUSP00000073061; ENSMUSG00000006373.
GeneIDi53328.
KEGGimmu:53328.
UCSCiuc009sxo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042491 mRNA. Translation: AAB97466.1.
BC006016 mRNA. Translation: AAH06016.1.
CCDSiCCDS30060.1.
RefSeqiNP_058063.2. NM_016783.4.
UniGeneiMm.9052.

3D structure databases

ProteinModelPortaliO55022.
SMRiO55022.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO55022. 14 interactors.
MINTiMINT-4996230.
STRINGi10090.ENSMUSP00000073061.

PTM databases

iPTMnetiO55022.
PhosphoSitePlusiO55022.
SwissPalmiO55022.

Proteomic databases

EPDiO55022.
PaxDbiO55022.
PeptideAtlasiO55022.
PRIDEiO55022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073339; ENSMUSP00000073061; ENSMUSG00000006373.
GeneIDi53328.
KEGGimmu:53328.
UCSCiuc009sxo.1. mouse.

Organism-specific databases

CTDi10857.
MGIiMGI:1858305. Pgrmc1.

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiO55022.
KOiK17278.
OMAiCLYLLYK.
OrthoDBiEOG091G0PXT.
PhylomeDBiO55022.
TreeFamiTF314562.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO55022.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006373.
CleanExiMM_PGRMC1.
ExpressionAtlasiO55022. baseline and differential.
GenevisibleiO55022. MM.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGRC1_MOUSE
AccessioniPrimary (citable) accession number: O55022
Secondary accession number(s): Q99JN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.