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Protein

Membrane-associated progesterone receptor component 1

Gene

Pgrmc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs).By similarity

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 1
Short name:
mPRBy similarity
Gene namesi
Name:Pgrmc1Imported
Synonyms:Pgrmc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858305. Pgrmc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24LumenalSequence analysisAdd BLAST24
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19
Topological domaini44 – 195CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217401 – 195Membrane-associated progesterone receptor component 1Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei74PhosphothreonineCombined sources1
Modified residuei181PhosphoserineCombined sources1 Publication1
Modified residuei190PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO55022.
PaxDbiO55022.
PeptideAtlasiO55022.
PRIDEiO55022.

PTM databases

iPTMnetiO55022.
PhosphoSitePlusiO55022.
SwissPalmiO55022.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006373.
CleanExiMM_PGRMC1.
ExpressionAtlasiO55022. baseline and differential.
GenevisibleiO55022. MM.

Interactioni

Subunit structurei

Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.By similarity

Protein-protein interaction databases

IntActiO55022. 14 interactors.
MINTiMINT-4996230.
STRINGi10090.ENSMUSP00000073061.

Structurei

3D structure databases

ProteinModelPortaliO55022.
SMRiO55022.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 171Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiO55022.
KOiK17278.
OMAiCLYLLYK.
OrthoDBiEOG091G0PXT.
PhylomeDBiO55022.
TreeFamiTF314562.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR036400. Cyt_B5-like_heme/steroid_sf.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

O55022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVVATG ADPSELEGGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PGASGDNDDD EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV
110 120 130 140 150
TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTPAQQ
160 170 180 190
ETLSDWDSQF TFKYHHVGKL LKEGEEPTVY SDDEEPKDET ARKNE
Length:195
Mass (Da):21,694
Last modified:January 23, 2007 - v4
Checksum:i1FFD17AFAE6C81FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87P → S in AAB97466 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042491 mRNA. Translation: AAB97466.1.
BC006016 mRNA. Translation: AAH06016.1.
CCDSiCCDS30060.1.
RefSeqiNP_058063.2. NM_016783.4.
UniGeneiMm.9052.

Genome annotation databases

EnsembliENSMUST00000073339; ENSMUSP00000073061; ENSMUSG00000006373.
GeneIDi53328.
KEGGimmu:53328.
UCSCiuc009sxo.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPGRC1_MOUSE
AccessioniPrimary (citable) accession number: O55022
Secondary accession number(s): Q99JN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 145 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families