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O55017

- CAC1B_MOUSE

UniProt

O55017 - CAC1B_MOUSE

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Protein

Voltage-dependent N-type calcium channel subunit alpha-1B

Gene
Cacna1b, Cach5, Cacnl1a5, Cchn1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei314 – 3141Calcium ion selectivity and permeability By similarity
Sitei663 – 6631Calcium ion selectivity and permeability By similarity
Sitei1358 – 13581Calcium ion selectivity and permeability By similarity
Sitei1646 – 16461Calcium ion selectivity and permeability By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi451 – 4588ATP Reviewed prediction
Calcium bindingi1728 – 173912 By similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. high voltage-gated calcium channel activity Source: RefGenome
  4. protein binding Source: MGI
  5. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. calcium ion import Source: RefGenome
  2. calcium ion transmembrane transport Source: MGI
  3. calcium ion transport Source: MGI
  4. locomotory behavior Source: MGI
  5. membrane depolarization during action potential Source: RefGenome
  6. neurotransmitter secretion Source: MGI
  7. regulation of blood pressure Source: MGI
  8. regulation of calcium ion transport Source: MGI
  9. regulation of heart contraction Source: MGI
  10. response to pain Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Protein family/group databases

TCDBi1.A.1.11.9. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alpha-1B
Alternative name(s):
Brain calcium channel III
Short name:
BIII
Calcium channel, L type, alpha-1 polypeptide isoform 5
Voltage-gated calcium channel subunit alpha Cav2.2
Gene namesi
Name:Cacna1b
Synonyms:Cach5, Cacnl1a5, Cchn1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:88296. Cacna1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9595Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei96 – 11419Helical; Name=S1 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini115 – 13319Extracellular Reviewed predictionAdd
BLAST
Transmembranei134 – 15118Helical; Name=S2 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini152 – 16413Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei165 – 17915Helical; Name=S3 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini180 – 1867Extracellular Reviewed prediction
Transmembranei187 – 20519Helical; Name=S4 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini206 – 22520Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei226 – 24520Helical; Name=S5 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini246 – 33186Extracellular Reviewed predictionAdd
BLAST
Transmembranei332 – 35625Helical; Name=S6 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini357 – 482126Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei483 – 50220Helical; Name=S1 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini503 – 51614Extracellular Reviewed predictionAdd
BLAST
Transmembranei517 – 53620Helical; Name=S2 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini537 – 5448Cytoplasmic Reviewed prediction
Transmembranei545 – 56319Helical; Name=S3 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini564 – 57411Extracellular Reviewed predictionAdd
BLAST
Transmembranei575 – 59218Helical; Name=S4 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini593 – 61119Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei612 – 63120Helical; Name=S5 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini632 – 68453Extracellular Reviewed predictionAdd
BLAST
Transmembranei685 – 70925Helical; Name=S6 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini710 – 1134425Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1135 – 115824Helical; Name=S1 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1159 – 117517Extracellular Reviewed predictionAdd
BLAST
Transmembranei1176 – 119520Helical; Name=S2 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1196 – 12038Cytoplasmic Reviewed prediction
Transmembranei1204 – 122623Helical; Name=S3 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1227 – 124115Extracellular Reviewed predictionAdd
BLAST
Transmembranei1242 – 125615Helical; Name=S4 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1257 – 127721Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1278 – 129720Helical; Name=S5 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1298 – 138386Extracellular Reviewed predictionAdd
BLAST
Transmembranei1384 – 140825Helical; Name=S6 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1409 – 146557Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1466 – 148419Helical; Name=S1 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1485 – 149814Extracellular Reviewed predictionAdd
BLAST
Transmembranei1499 – 151820Helical; Name=S2 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1519 – 15279Cytoplasmic Reviewed prediction
Transmembranei1528 – 154619Helical; Name=S3 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1547 – 15548Extracellular Reviewed prediction
Transmembranei1555 – 157319Helical; Name=S4 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1574 – 159219Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1593 – 161220Helical; Name=S5 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1613 – 167462Extracellular Reviewed predictionAdd
BLAST
Transmembranei1675 – 169420Helical; Name=S6 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1695 – 2327633Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: MGI
  2. membrane Source: MGI
  3. neuronal cell body Source: MGI
  4. voltage-gated calcium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23272327Voltage-dependent N-type calcium channel subunit alpha-1BPRO_0000053922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Modified residuei783 – 7831Phosphoserine1 Publication
Glycosylationi1554 – 15541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1666 – 16661N-linked (GlcNAc...) Reviewed prediction
Modified residuei1710 – 17101Phosphoserine; by PKA Reviewed prediction

Post-translational modificationi

Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO55017.
PaxDbiO55017.
PRIDEiO55017.

PTM databases

PhosphoSiteiO55017.

Expressioni

Tissue specificityi

Widespread expression throughout the brain. Highest levels in pyramidal cell layers C1, C2 and C3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 et 4, in the subiculum and the habenula.

Gene expression databases

ArrayExpressiO55017.
BgeeiO55017.
GenevestigatoriO55017.

Interactioni

Subunit structurei

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 By similarity.1 Publication

Protein-protein interaction databases

BioGridi198431. 6 interactions.
IntActiO55017. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO55017.
SMRiO55017. Positions 97-407, 475-710, 1135-1410, 1466-1700.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati82 – 359278IAdd
BLAST
Repeati468 – 712245IIAdd
BLAST
Repeati1126 – 1412287IIIAdd
BLAST
Repeati1449 – 1702254IVAdd
BLAST
Domaini1715 – 175036EF-handAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 39618Binding to the beta subunit By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2040 – 20445Poly-His
Compositional biasi2106 – 21105Poly-Ser

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 EF-hand domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00750000117449.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
KOiK04849.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform NB1 (identifier: O55017-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVRFGDELGG RYGGTGGGER ARGGGAGGAG GPGQGGLPPG QRVLYKQSIA     50
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM 100
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII 150
ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL 200
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH 250
KACFPNSTDT EPVGDFPCGK DPPARQCDGD TECREYWPGP NFGITNFDNI 300
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL 350
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML 400
AEEDKNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFVD LCAVGSPFAR 450
ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA 500
MVHYNQPQRL TTALYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD 550
FGVIVGSIFE VVWAAIKPGT SFGISVLRAL RLLRIFKVTK YWNSLRNLVV 600
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP 650
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL 700
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA 750
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRYA 800
STRHVRPDMK THMDRPLVVE PGRDGLRGPV GSKSKPEGTE ATESADLPRR 850
HHRHRDRDKT SATAPAGGEQ DRTESTETGA REERARPRRS HSKETPGADT 900
QVRCERSRRH HRRGSPEEAT EREPRRHRAH RHAQDSSKEG TAPVLVPKGE 950
RRARHRGPRT GPREAENNEE PTRRHRARHK VPPTLQPPER EAAEKESNAV 1000
EGDKETRNHQ PKEPHCDLEA IAVTGVGPLH MLPSTCLQKV DEQPEDADNQ 1050
RNVTRMGSQP SDPSTTVHVP VTLTGPPGET PVVPSGNMNL EGQAEGKKEA 1100
EADDVLRRGP RPIVPYSSMF CLSPTNLLRR FCHYIVTMRY FEMVILVVIA 1150
LSSIALAAED PVRTDSFRNN ALKYMDYIFT GVFTFEMVIK MIDLGLLLHP 1200
GAYFRDLWNI LDFIVVSGAL VAFAFSSFMG GSKGKDINTI KSLRVLRVLR 1250
PLKTIKRLPK LKAVFDCVVN SLKNVLNILI VYMLFMFIFA VIAVQLFKGK 1300
FFYCTDESKE LERDCRGQYL DYEKEEVEAQ PRQWKKYDFH YDNVLWALLT 1350
LFTVSTGEGW PMVLKHSVDA TYEEQGPSPG FRMELSIFYV VYFVVFPFFF 1400
VNIFVALIII TFQEQGDKVM SECSLEKNER ACIDFAISAK PLTRYMPQNK 1450
QSFQYKTWTF VVSPPFEYFI MAMIALNTVV LMMKFYDAPY EYELMLKCLN 1500
IVFTSMFSME CILKIIAFGV LNYFRDAWNV FDFVTVLGSI TDILVTEIAN 1550
NFINLSFLRL FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML 1600
FFIYAIIGMQ VFGNIALDDD TSINRHNNFR TFLQALMLLF RSATGEAWHE 1650
IMLSCLGNRA CDPHANASEC GSDFAYFYFV SFIFLCSFLM LNLFVAVIMD 1700
NFEYLTRDSS ILGPHHLDEF IRVWAEYDPA ACGRISYNDM FEMLKHMSPP 1750
LGLGKKCPAR VAYKRLVRMN MPISNEDMTV HFTSTLMALI RTALEIKLAP 1800
AGTKQHQCDA ELRKEISSVW ANLPQKTLDL LVPPHKPDEM TVGKVYAALM 1850
IFDFYKQNKT TRDQTHQAPG GLSQMGPVSL FHPLKATLEQ TQPAVLRGAR 1900
VFLRQKSATS LSNGGAIQTQ ESGIKESLSW GTQRTQDALY EARAPLERGH 1950
SAEIPVGQSG TLAVDVQMQN MTLRGPDGEP QPGLESQGRA ASMPRLAAET 2000
QPAPNASPMK RSISTLAPRP HGTQLCSTVL DRPPPSQASH HHHHRCHRRR 2050
DKKQRSLEKG PSLSVDPEGA PSTAAGPGLP HGEGSTACRR DRKQERGRSQ 2100
ERRQPSSSSS EKQRFYSCDR FGSREPPQLM PSLSSHPTSP TAALEPAPHP 2150
QGSGSVNGSP LMSTSGASTP GRGGRRQLPQ TPLTPRPSIT YKTANSSPVH 2200
FAEGQSGLPA FSPGRLSRGL SEHNALLQKE PLSQPLAPGS RIGSDPYLGQ 2250
RLDSEASAHT LPEDTLTFEE AVATNSGRSS RTSYVSSLTS QSHPLRRVPN 2300
GYHCTLGLST GVRARHSYHH PDQDHWC 2327
Length:2,327
Mass (Da):261,481
Last modified:June 1, 1998 - v1
Checksum:iAD42CDD38482895A
GO
Isoform NB2 (identifier: O55017-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     756-756: A → AFVKQTRGTVSRSSSVSSVNSP

Show »
Length:2,348
Mass (Da):263,674
Checksum:i16B0576EA8DCACC6
GO

Sequence cautioni

The sequence AAB60437.1 differs from that shown. Reason: Frameshift at positions 1924, 1934, 2121 and 2127.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti414 – 4141D → DA.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei756 – 7561A → AFVKQTRGTVSRSSSVSSVN SP in isoform NB2. VSP_000883

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381A → G in AAB60437. 1 Publication
Sequence conflicti645 – 6451N → I in AAB60437. 1 Publication
Sequence conflicti757 – 7593RQQ → QE in AAB60437. 1 Publication
Sequence conflicti880 – 8801A → P in AAB60437. 1 Publication
Sequence conflicti1128 – 11281L → F in AAB60437. 1 Publication
Sequence conflicti1173 – 11731K → E in AAB60437. 1 Publication
Sequence conflicti1185 – 11851F → C in AAB60437. 1 Publication
Sequence conflicti1227 – 12304Missing in AAB60437. 1 Publication
Sequence conflicti1388 – 13881F → L in AAB60437. 1 Publication
Sequence conflicti1549 – 15491A → AET in AAB60437. 1 Publication
Sequence conflicti1615 – 16151I → S in AAB60437. 1 Publication
Sequence conflicti1636 – 16361L → I in AAB60437. 1 Publication
Sequence conflicti1657 – 16571G → D in AAB60437. 1 Publication
Sequence conflicti1802 – 183736Missing in AAB60437. 1 PublicationAdd
BLAST
Sequence conflicti1942 – 19421A → G in AAB60437. 1 Publication
Sequence conflicti1949 – 19491G → D in AAB60437. 1 Publication
Sequence conflicti1963 – 19631A → L in AAB60437. 1 Publication
Sequence conflicti1979 – 19791E → D in AAB60437. 1 Publication
Sequence conflicti1994 – 19941P → L in AAB60437. 1 Publication
Sequence conflicti2021 – 20211H → D in AAB60437. 1 Publication
Sequence conflicti2075 – 20751A → AA in AAB60437. 1 Publication
Sequence conflicti2141 – 21411T → A in AAB60437. 1 Publication
Sequence conflicti2168 – 21681S → I in AAB60437. 1 Publication
Sequence conflicti2309 – 23091S → N in AAB60437. 1 Publication
Sequence conflicti2313 – 23131R → G in AAB60437. 1 Publication
Sequence conflicti2316 – 23161H → A in AAB60437. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042317 mRNA. Translation: AAB97840.1.
U04999 mRNA. Translation: AAB60437.1. Frameshift.
CCDSiCCDS38065.1. [O55017-1]
PIRiS41080.
RefSeqiNP_001035993.1. NM_001042528.2. [O55017-1]
UniGeneiMm.4424.

Genome annotation databases

EnsembliENSMUST00000041342; ENSMUSP00000037416; ENSMUSG00000004113. [O55017-1]
GeneIDi12287.
KEGGimmu:12287.
UCSCiuc008ipe.1. mouse. [O55017-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042317 mRNA. Translation: AAB97840.1 .
U04999 mRNA. Translation: AAB60437.1 . Frameshift.
CCDSi CCDS38065.1. [O55017-1 ]
PIRi S41080.
RefSeqi NP_001035993.1. NM_001042528.2. [O55017-1 ]
UniGenei Mm.4424.

3D structure databases

ProteinModelPortali O55017.
SMRi O55017. Positions 97-407, 475-710, 1135-1410, 1466-1700.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198431. 6 interactions.
IntActi O55017. 1 interaction.

Protein family/group databases

TCDBi 1.A.1.11.9. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei O55017.

Proteomic databases

MaxQBi O55017.
PaxDbi O55017.
PRIDEi O55017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041342 ; ENSMUSP00000037416 ; ENSMUSG00000004113 . [O55017-1 ]
GeneIDi 12287.
KEGGi mmu:12287.
UCSCi uc008ipe.1. mouse. [O55017-1 ]

Organism-specific databases

CTDi 774.
MGIi MGI:88296. Cacna1b.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00750000117449.
HOGENOMi HOG000231530.
HOVERGENi HBG050763.
KOi K04849.
TreeFami TF312805.

Enzyme and pathway databases

Reactomei REACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Miscellaneous databases

NextBioi 280760.
PROi O55017.
SOURCEi Search...

Gene expression databases

ArrayExpressi O55017.
Bgeei O55017.
Genevestigatori O55017.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence polymorphism of mouse alpha1 B."
    Hong T., Birnbaumer L.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization."
    Coppola T., Waldmann R., Borsotto M., Heurteaux C., Romey G., Mattei M.-G., Lazdunski M.
    FEBS Lett. 338:1-5(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS NB1 AND NB2).
    Tissue: Neuroblastoma.
  3. "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin."
    Coppola T., Magnin-Luethi S., Perret-Menoud V., Gattesco S., Schiavo G., Regazzi R.
    J. Biol. Chem. 276:32756-32762(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1.
    Tissue: Brain.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiCAC1B_MOUSE
AccessioniPrimary (citable) accession number: O55017
Secondary accession number(s): Q60609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi