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O55017

- CAC1B_MOUSE

UniProt

O55017 - CAC1B_MOUSE

Protein

Voltage-dependent N-type calcium channel subunit alpha-1B

Gene

Cacna1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei314 – 3141Calcium ion selectivity and permeabilityBy similarity
    Sitei663 – 6631Calcium ion selectivity and permeabilityBy similarity
    Sitei1358 – 13581Calcium ion selectivity and permeabilityBy similarity
    Sitei1646 – 16461Calcium ion selectivity and permeabilityBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi451 – 4588ATPSequence Analysis
    Calcium bindingi1728 – 173912PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. high voltage-gated calcium channel activity Source: RefGenome
    4. protein binding Source: MGI
    5. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. calcium ion import Source: RefGenome
    2. calcium ion transmembrane transport Source: MGI
    3. calcium ion transport Source: MGI
    4. locomotory behavior Source: MGI
    5. membrane depolarization during action potential Source: RefGenome
    6. neurotransmitter secretion Source: MGI
    7. regulation of blood pressure Source: MGI
    8. regulation of calcium ion transport Source: MGI
    9. regulation of heart contraction Source: MGI
    10. response to pain Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

    Protein family/group databases

    TCDBi1.A.1.11.9. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent N-type calcium channel subunit alpha-1B
    Alternative name(s):
    Brain calcium channel III
    Short name:
    BIII
    Calcium channel, L type, alpha-1 polypeptide isoform 5
    Voltage-gated calcium channel subunit alpha Cav2.2
    Gene namesi
    Name:Cacna1b
    Synonyms:Cach5, Cacnl1a5, Cchn1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:88296. Cacna1b.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: MGI
    2. membrane Source: MGI
    3. neuronal cell body Source: MGI
    4. voltage-gated calcium channel complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23272327Voltage-dependent N-type calcium channel subunit alpha-1BPRO_0000053922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Modified residuei783 – 7831Phosphoserine1 Publication
    Glycosylationi1554 – 15541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1666 – 16661N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1710 – 17101Phosphoserine; by PKASequence Analysis

    Post-translational modificationi

    Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO55017.
    PaxDbiO55017.
    PRIDEiO55017.

    PTM databases

    PhosphoSiteiO55017.

    Expressioni

    Tissue specificityi

    Widespread expression throughout the brain. Highest levels in pyramidal cell layers C1, C2 and C3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 et 4, in the subiculum and the habenula.

    Gene expression databases

    ArrayExpressiO55017.
    BgeeiO55017.
    GenevestigatoriO55017.

    Interactioni

    Subunit structurei

    Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198431. 6 interactions.
    IntActiO55017. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO55017.
    SMRiO55017. Positions 97-407, 475-710, 1135-1410, 1466-1700.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 13319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini152 – 16413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1867ExtracellularSequence Analysis
    Topological domaini206 – 22520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 33186ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini357 – 482126CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini503 – 51614ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini537 – 5448CytoplasmicSequence Analysis
    Topological domaini564 – 57411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini593 – 61119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini632 – 68453ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini710 – 1134425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1159 – 117517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1196 – 12038CytoplasmicSequence Analysis
    Topological domaini1227 – 124115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1257 – 127721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1298 – 138386ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1409 – 146557CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1485 – 149814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1519 – 15279CytoplasmicSequence Analysis
    Topological domaini1547 – 15548ExtracellularSequence Analysis
    Topological domaini1574 – 159219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1613 – 167462ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1695 – 2327633CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11419Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei134 – 15118Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei165 – 17915Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei187 – 20519Helical; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei226 – 24520Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei332 – 35625Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei483 – 50220Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei517 – 53620Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei545 – 56319Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei575 – 59218Helical; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei612 – 63120Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei685 – 70925Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei1135 – 115824Helical; Name=S1 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1176 – 119520Helical; Name=S2 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1204 – 122623Helical; Name=S3 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1242 – 125615Helical; Name=S4 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1278 – 129720Helical; Name=S5 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1384 – 140825Helical; Name=S6 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1466 – 148419Helical; Name=S1 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1499 – 151820Helical; Name=S2 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1528 – 154619Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1555 – 157319Helical; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1593 – 161220Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1675 – 169420Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati82 – 359278IAdd
    BLAST
    Repeati468 – 712245IIAdd
    BLAST
    Repeati1126 – 1412287IIIAdd
    BLAST
    Repeati1449 – 1702254IVAdd
    BLAST
    Domaini1715 – 175036EF-handPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni379 – 39618Binding to the beta subunitBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2040 – 20445Poly-His
    Compositional biasi2106 – 21105Poly-Ser

    Domaini

    Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 EF-hand domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00750000117449.
    HOGENOMiHOG000231530.
    HOVERGENiHBG050763.
    KOiK04849.
    TreeFamiTF312805.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR002048. EF_hand_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005447. VDCC_N_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.
    PR01631. NVDCCALPHA1.
    SMARTiSM01062. Ca_chan_IQ. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform NB1 (identifier: O55017-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVRFGDELGG RYGGTGGGER ARGGGAGGAG GPGQGGLPPG QRVLYKQSIA     50
    QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM 100
    ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII 150
    ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL 200
    KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH 250
    KACFPNSTDT EPVGDFPCGK DPPARQCDGD TECREYWPGP NFGITNFDNI 300
    LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL 350
    VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML 400
    AEEDKNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFVD LCAVGSPFAR 450
    ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA 500
    MVHYNQPQRL TTALYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD 550
    FGVIVGSIFE VVWAAIKPGT SFGISVLRAL RLLRIFKVTK YWNSLRNLVV 600
    SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP 650
    AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL 700
    LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA 750
    NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRYA 800
    STRHVRPDMK THMDRPLVVE PGRDGLRGPV GSKSKPEGTE ATESADLPRR 850
    HHRHRDRDKT SATAPAGGEQ DRTESTETGA REERARPRRS HSKETPGADT 900
    QVRCERSRRH HRRGSPEEAT EREPRRHRAH RHAQDSSKEG TAPVLVPKGE 950
    RRARHRGPRT GPREAENNEE PTRRHRARHK VPPTLQPPER EAAEKESNAV 1000
    EGDKETRNHQ PKEPHCDLEA IAVTGVGPLH MLPSTCLQKV DEQPEDADNQ 1050
    RNVTRMGSQP SDPSTTVHVP VTLTGPPGET PVVPSGNMNL EGQAEGKKEA 1100
    EADDVLRRGP RPIVPYSSMF CLSPTNLLRR FCHYIVTMRY FEMVILVVIA 1150
    LSSIALAAED PVRTDSFRNN ALKYMDYIFT GVFTFEMVIK MIDLGLLLHP 1200
    GAYFRDLWNI LDFIVVSGAL VAFAFSSFMG GSKGKDINTI KSLRVLRVLR 1250
    PLKTIKRLPK LKAVFDCVVN SLKNVLNILI VYMLFMFIFA VIAVQLFKGK 1300
    FFYCTDESKE LERDCRGQYL DYEKEEVEAQ PRQWKKYDFH YDNVLWALLT 1350
    LFTVSTGEGW PMVLKHSVDA TYEEQGPSPG FRMELSIFYV VYFVVFPFFF 1400
    VNIFVALIII TFQEQGDKVM SECSLEKNER ACIDFAISAK PLTRYMPQNK 1450
    QSFQYKTWTF VVSPPFEYFI MAMIALNTVV LMMKFYDAPY EYELMLKCLN 1500
    IVFTSMFSME CILKIIAFGV LNYFRDAWNV FDFVTVLGSI TDILVTEIAN 1550
    NFINLSFLRL FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML 1600
    FFIYAIIGMQ VFGNIALDDD TSINRHNNFR TFLQALMLLF RSATGEAWHE 1650
    IMLSCLGNRA CDPHANASEC GSDFAYFYFV SFIFLCSFLM LNLFVAVIMD 1700
    NFEYLTRDSS ILGPHHLDEF IRVWAEYDPA ACGRISYNDM FEMLKHMSPP 1750
    LGLGKKCPAR VAYKRLVRMN MPISNEDMTV HFTSTLMALI RTALEIKLAP 1800
    AGTKQHQCDA ELRKEISSVW ANLPQKTLDL LVPPHKPDEM TVGKVYAALM 1850
    IFDFYKQNKT TRDQTHQAPG GLSQMGPVSL FHPLKATLEQ TQPAVLRGAR 1900
    VFLRQKSATS LSNGGAIQTQ ESGIKESLSW GTQRTQDALY EARAPLERGH 1950
    SAEIPVGQSG TLAVDVQMQN MTLRGPDGEP QPGLESQGRA ASMPRLAAET 2000
    QPAPNASPMK RSISTLAPRP HGTQLCSTVL DRPPPSQASH HHHHRCHRRR 2050
    DKKQRSLEKG PSLSVDPEGA PSTAAGPGLP HGEGSTACRR DRKQERGRSQ 2100
    ERRQPSSSSS EKQRFYSCDR FGSREPPQLM PSLSSHPTSP TAALEPAPHP 2150
    QGSGSVNGSP LMSTSGASTP GRGGRRQLPQ TPLTPRPSIT YKTANSSPVH 2200
    FAEGQSGLPA FSPGRLSRGL SEHNALLQKE PLSQPLAPGS RIGSDPYLGQ 2250
    RLDSEASAHT LPEDTLTFEE AVATNSGRSS RTSYVSSLTS QSHPLRRVPN 2300
    GYHCTLGLST GVRARHSYHH PDQDHWC 2327
    Length:2,327
    Mass (Da):261,481
    Last modified:June 1, 1998 - v1
    Checksum:iAD42CDD38482895A
    GO
    Isoform NB2 (identifier: O55017-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         756-756: A → AFVKQTRGTVSRSSSVSSVNSP

    Show »
    Length:2,348
    Mass (Da):263,674
    Checksum:i16B0576EA8DCACC6
    GO

    Sequence cautioni

    The sequence AAB60437.1 differs from that shown. Reason: Frameshift at positions 1924, 1934, 2121 and 2127.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti238 – 2381A → G in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti645 – 6451N → I in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti757 – 7593RQQ → QE in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti880 – 8801A → P in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1128 – 11281L → F in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1173 – 11731K → E in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1185 – 11851F → C in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1227 – 12304Missing in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1388 – 13881F → L in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1549 – 15491A → AET in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1615 – 16151I → S in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1636 – 16361L → I in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1657 – 16571G → D in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1802 – 183736Missing in AAB60437. (PubMed:8307146)CuratedAdd
    BLAST
    Sequence conflicti1942 – 19421A → G in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1949 – 19491G → D in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1963 – 19631A → L in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1979 – 19791E → D in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti1994 – 19941P → L in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti2021 – 20211H → D in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti2075 – 20751A → AA in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti2141 – 21411T → A in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti2168 – 21681S → I in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti2309 – 23091S → N in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti2313 – 23131R → G in AAB60437. (PubMed:8307146)Curated
    Sequence conflicti2316 – 23161H → A in AAB60437. (PubMed:8307146)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti414 – 4141D → DA.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei756 – 7561A → AFVKQTRGTVSRSSSVSSVN SP in isoform NB2. 1 PublicationVSP_000883

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042317 mRNA. Translation: AAB97840.1.
    U04999 mRNA. Translation: AAB60437.1. Frameshift.
    CCDSiCCDS38065.1. [O55017-1]
    PIRiS41080.
    RefSeqiNP_001035993.1. NM_001042528.2. [O55017-1]
    UniGeneiMm.4424.

    Genome annotation databases

    EnsembliENSMUST00000041342; ENSMUSP00000037416; ENSMUSG00000004113. [O55017-1]
    GeneIDi12287.
    KEGGimmu:12287.
    UCSCiuc008ipe.1. mouse. [O55017-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042317 mRNA. Translation: AAB97840.1 .
    U04999 mRNA. Translation: AAB60437.1 . Frameshift.
    CCDSi CCDS38065.1. [O55017-1 ]
    PIRi S41080.
    RefSeqi NP_001035993.1. NM_001042528.2. [O55017-1 ]
    UniGenei Mm.4424.

    3D structure databases

    ProteinModelPortali O55017.
    SMRi O55017. Positions 97-407, 475-710, 1135-1410, 1466-1700.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198431. 6 interactions.
    IntActi O55017. 1 interaction.

    Protein family/group databases

    TCDBi 1.A.1.11.9. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei O55017.

    Proteomic databases

    MaxQBi O55017.
    PaxDbi O55017.
    PRIDEi O55017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041342 ; ENSMUSP00000037416 ; ENSMUSG00000004113 . [O55017-1 ]
    GeneIDi 12287.
    KEGGi mmu:12287.
    UCSCi uc008ipe.1. mouse. [O55017-1 ]

    Organism-specific databases

    CTDi 774.
    MGIi MGI:88296. Cacna1b.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00750000117449.
    HOGENOMi HOG000231530.
    HOVERGENi HBG050763.
    KOi K04849.
    TreeFami TF312805.

    Enzyme and pathway databases

    Reactomei REACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

    Miscellaneous databases

    NextBioi 280760.
    PROi O55017.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O55017.
    Bgeei O55017.
    Genevestigatori O55017.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR002048. EF_hand_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005447. VDCC_N_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    PR01631. NVDCCALPHA1.
    SMARTi SM01062. Ca_chan_IQ. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence polymorphism of mouse alpha1 B."
      Hong T., Birnbaumer L.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization."
      Coppola T., Waldmann R., Borsotto M., Heurteaux C., Romey G., Mattei M.-G., Lazdunski M.
      FEBS Lett. 338:1-5(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS NB1 AND NB2).
      Tissue: Neuroblastoma.
    3. "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin."
      Coppola T., Magnin-Luethi S., Perret-Menoud V., Gattesco S., Schiavo G., Regazzi R.
      J. Biol. Chem. 276:32756-32762(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIMS1.
      Tissue: Brain.
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiCAC1B_MOUSE
    AccessioniPrimary (citable) accession number: O55017
    Secondary accession number(s): Q60609
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3