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Protein

Trafficking protein particle complex subunit 3

Gene

Trappc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3
Alternative name(s):
BET3 homolog
Gene namesi
Name:Trappc3
Synonyms:Bet3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1351486. Trappc3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • Golgi apparatus Source: MGI
  • Golgi membrane Source: MGI
  • TRAPP complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115731 – 180Trafficking protein particle complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi68S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiO55013.
PaxDbiO55013.
PeptideAtlasiO55013.
PRIDEiO55013.
TopDownProteomicsiO55013.

2D gel databases

REPRODUCTION-2DPAGEO55013.
UCD-2DPAGEO55013.

PTM databases

iPTMnetiO55013.
PhosphoSitePlusiO55013.
SwissPalmiO55013.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028847.
CleanExiMM_TRAPPC3.
ExpressionAtlasiO55013. baseline and differential.
GenevisibleiO55013. MM.

Interactioni

Subunit structurei

Homodimer. Heterodimer with TRAPPC6A. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L (By similarity).By similarity

Protein-protein interaction databases

BioGridi205122. 3 interactors.
IntActiO55013. 4 interactors.
STRINGi10090.ENSMUSP00000030660.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Helixi17 – 34Combined sources18
Helixi37 – 61Combined sources25
Helixi71 – 80Combined sources10
Helixi82 – 87Combined sources6
Beta strandi92 – 94Combined sources3
Turni98 – 100Combined sources3
Beta strandi102 – 108Combined sources7
Helixi111 – 113Combined sources3
Helixi120 – 122Combined sources3
Turni127 – 129Combined sources3
Helixi130 – 140Combined sources11
Turni141 – 143Combined sources3
Beta strandi144 – 152Combined sources9
Helixi154 – 156Combined sources3
Beta strandi159 – 170Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WC8X-ray1.90A1-180[»]
1WC9X-ray1.60A8-172[»]
2J3RX-ray2.60A1-180[»]
2J3TX-ray2.40A1-180[»]
2J3WX-ray2.10D/E1-180[»]
2PWNX-ray2.04A1-180[»]
ProteinModelPortaliO55013.
SMRiO55013.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO55013.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3330. Eukaryota.
ENOG410Z1VV. LUCA.
GeneTreeiENSGT00390000003880.
HOGENOMiHOG000186184.
HOVERGENiHBG055045.
InParanoidiO55013.
KOiK20302.
OMAiVEAHFIS.
OrthoDBiEOG091G0N4X.
PhylomeDBiO55013.
TreeFamiTF300091.

Family and domain databases

CDDicd14942. TRAPPC3_bet3. 1 hit.
InterProiIPR016721. Bet3.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR13048. PTHR13048. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequencei

Sequence statusi: Complete.

O55013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDRMGYN
60 70 80 90 100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG
110 120 130 140 150
DEFSLILENN PLVDFVELPD NHSALIYSNL LCGVLRGALE MVQMAVEAKF
160 170 180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Length:180
Mass (Da):20,302
Last modified:June 1, 1998 - v1
Checksum:iB8D57A33D68C0D94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041433 mRNA. Translation: AAB96937.1.
BC003736 mRNA. Translation: AAH03736.1.
CCDSiCCDS18647.1.
RefSeqiNP_038746.1. NM_013718.2.
UniGeneiMm.8392.

Genome annotation databases

EnsembliENSMUST00000030660; ENSMUSP00000030660; ENSMUSG00000028847.
GeneIDi27096.
KEGGimmu:27096.
UCSCiuc008utc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041433 mRNA. Translation: AAB96937.1.
BC003736 mRNA. Translation: AAH03736.1.
CCDSiCCDS18647.1.
RefSeqiNP_038746.1. NM_013718.2.
UniGeneiMm.8392.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WC8X-ray1.90A1-180[»]
1WC9X-ray1.60A8-172[»]
2J3RX-ray2.60A1-180[»]
2J3TX-ray2.40A1-180[»]
2J3WX-ray2.10D/E1-180[»]
2PWNX-ray2.04A1-180[»]
ProteinModelPortaliO55013.
SMRiO55013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205122. 3 interactors.
IntActiO55013. 4 interactors.
STRINGi10090.ENSMUSP00000030660.

PTM databases

iPTMnetiO55013.
PhosphoSitePlusiO55013.
SwissPalmiO55013.

2D gel databases

REPRODUCTION-2DPAGEO55013.
UCD-2DPAGEO55013.

Proteomic databases

EPDiO55013.
PaxDbiO55013.
PeptideAtlasiO55013.
PRIDEiO55013.
TopDownProteomicsiO55013.

Protocols and materials databases

DNASUi27096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030660; ENSMUSP00000030660; ENSMUSG00000028847.
GeneIDi27096.
KEGGimmu:27096.
UCSCiuc008utc.1. mouse.

Organism-specific databases

CTDi27095.
MGIiMGI:1351486. Trappc3.

Phylogenomic databases

eggNOGiKOG3330. Eukaryota.
ENOG410Z1VV. LUCA.
GeneTreeiENSGT00390000003880.
HOGENOMiHOG000186184.
HOVERGENiHBG055045.
InParanoidiO55013.
KOiK20302.
OMAiVEAHFIS.
OrthoDBiEOG091G0N4X.
PhylomeDBiO55013.
TreeFamiTF300091.

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiTrappc3. mouse.
EvolutionaryTraceiO55013.
PROiO55013.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028847.
CleanExiMM_TRAPPC3.
ExpressionAtlasiO55013. baseline and differential.
GenevisibleiO55013. MM.

Family and domain databases

CDDicd14942. TRAPPC3_bet3. 1 hit.
InterProiIPR016721. Bet3.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR13048. PTHR13048. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC3_MOUSE
AccessioniPrimary (citable) accession number: O55013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.