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Protein

Trafficking protein particle complex subunit 3

Gene

Trappc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: MGI

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3
Alternative name(s):
BET3 homolog
Gene namesi
Name:Trappc3
Synonyms:Bet3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1351486 Trappc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115731 – 180Trafficking protein particle complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi68S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiO55013
PaxDbiO55013
PeptideAtlasiO55013
PRIDEiO55013
TopDownProteomicsiO55013

2D gel databases

REPRODUCTION-2DPAGEO55013
UCD-2DPAGEO55013

PTM databases

iPTMnetiO55013
PhosphoSitePlusiO55013
SwissPalmiO55013

Expressioni

Gene expression databases

BgeeiENSMUSG00000028847
CleanExiMM_TRAPPC3
ExpressionAtlasiO55013 baseline and differential
GenevisibleiO55013 MM

Interactioni

Subunit structurei

Homodimer. Heterodimer with TRAPPC6A. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L (By similarity).By similarity

Protein-protein interaction databases

BioGridi205122, 4 interactors
IntActiO55013, 5 interactors
STRINGi10090.ENSMUSP00000030660

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Helixi17 – 34Combined sources18
Helixi37 – 61Combined sources25
Helixi71 – 80Combined sources10
Helixi82 – 87Combined sources6
Beta strandi92 – 94Combined sources3
Turni98 – 100Combined sources3
Beta strandi102 – 108Combined sources7
Helixi111 – 113Combined sources3
Helixi120 – 122Combined sources3
Turni127 – 129Combined sources3
Helixi130 – 140Combined sources11
Turni141 – 143Combined sources3
Beta strandi144 – 152Combined sources9
Helixi154 – 156Combined sources3
Beta strandi159 – 170Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WC8X-ray1.90A1-180[»]
1WC9X-ray1.60A8-172[»]
2J3RX-ray2.60A1-180[»]
2J3TX-ray2.40A1-180[»]
2J3WX-ray2.10D/E1-180[»]
2PWNX-ray2.04A1-180[»]
ProteinModelPortaliO55013
SMRiO55013
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO55013

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3330 Eukaryota
ENOG410Z1VV LUCA
GeneTreeiENSGT00390000003880
HOGENOMiHOG000186184
HOVERGENiHBG055045
InParanoidiO55013
KOiK20302
OMAiGLWFSNV
OrthoDBiEOG091G0N4X
PhylomeDBiO55013
TreeFamiTF300091

Family and domain databases

CDDicd14942 TRAPPC3_bet3, 1 hit
InterProiView protein in InterPro
IPR016721 Bet3
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
PANTHERiPTHR13048 PTHR13048, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequencei

Sequence statusi: Complete.

O55013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDRMGYN
60 70 80 90 100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG
110 120 130 140 150
DEFSLILENN PLVDFVELPD NHSALIYSNL LCGVLRGALE MVQMAVEAKF
160 170 180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Length:180
Mass (Da):20,302
Last modified:June 1, 1998 - v1
Checksum:iB8D57A33D68C0D94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041433 mRNA Translation: AAB96937.1
BC003736 mRNA Translation: AAH03736.1
CCDSiCCDS18647.1
RefSeqiNP_038746.1, NM_013718.2
UniGeneiMm.8392

Genome annotation databases

EnsembliENSMUST00000030660; ENSMUSP00000030660; ENSMUSG00000028847
GeneIDi27096
KEGGimmu:27096
UCSCiuc008utc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTPPC3_MOUSE
AccessioniPrimary (citable) accession number: O55013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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