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O55004

- RNAS4_RAT

UniProt

O55004 - RNAS4_RAT

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Protein
Ribonuclease 4
Gene
Rnase4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This RNase has marked specificity towards the 3' side of uridine nucleotides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Substrate By similarity
Active sitei40 – 401Proton acceptor By similarity
Binding sitei93 – 931Substrate By similarity
Binding sitei110 – 1101Substrate By similarity
Active sitei144 – 1441Proton donor By similarity

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 4 (EC:3.1.27.-)
Short name:
RNase 4
Alternative name(s):
RL3
Gene namesi
Name:Rnase4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi61823. Rnase4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 By similarity
Add
BLAST
Chaini29 – 147119Ribonuclease 4
PRO_0000030887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291Pyrrolidone carboxylic acid By similarity
Disulfide bondi53 ↔ 109 By similarity
Disulfide bondi67 ↔ 120 By similarity
Disulfide bondi85 ↔ 135 By similarity
Disulfide bondi92 ↔ 99 By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiO55004.
PRIDEiO55004.

Expressioni

Gene expression databases

GenevestigatoriO55004.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043003.

Structurei

3D structure databases

ProteinModelPortaliO55004.
SMRiO55004. Positions 29-146.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 725Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42321.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiO55004.
KOiK16632.
OMAiVIACEGD.
OrthoDBiEOG7J1826.
PhylomeDBiO55004.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O55004-1 [UniParc]FASTAAdd to Basket

« Hide

MDIQRTQSLL LLLLLTLLGL GLVQPSYGQD RMYQRFLRQH VDPEGTGGSD    50
NYCNVMMQRR RMTSTQCKRF NTFIHEDIWN IRSICDTANI PCKNGNMNCH 100
EGIVRVTDCR ETGSSVPHNC RYRARASTRR VVIACEGTPE VPVHFDR 147
Length:147
Mass (Da):16,903
Last modified:June 1, 1998 - v1
Checksum:i110D54CF7C691BB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041066 mRNA. Translation: AAC23487.1.
BC070953 mRNA. Translation: AAH70953.1.
RefSeqiNP_064467.1. NM_020082.2.
XP_006251968.1. XM_006251906.1.
XP_006251969.1. XM_006251907.1.
UniGeneiRn.1742.

Genome annotation databases

EnsembliENSRNOT00000041495; ENSRNOP00000043003; ENSRNOG00000025625.
GeneIDi56759.
KEGGirno:56759.
UCSCiRGD:61823. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041066 mRNA. Translation: AAC23487.1 .
BC070953 mRNA. Translation: AAH70953.1 .
RefSeqi NP_064467.1. NM_020082.2.
XP_006251968.1. XM_006251906.1.
XP_006251969.1. XM_006251907.1.
UniGenei Rn.1742.

3D structure databases

ProteinModelPortali O55004.
SMRi O55004. Positions 29-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000043003.

Proteomic databases

PaxDbi O55004.
PRIDEi O55004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000041495 ; ENSRNOP00000043003 ; ENSRNOG00000025625 .
GeneIDi 56759.
KEGGi rno:56759.
UCSCi RGD:61823. rat.

Organism-specific databases

CTDi 6038.
RGDi 61823. Rnase4.

Phylogenomic databases

eggNOGi NOG42321.
HOGENOMi HOG000276883.
HOVERGENi HBG008396.
InParanoidi O55004.
KOi K16632.
OMAi VIACEGD.
OrthoDBi EOG7J1826.
PhylomeDBi O55004.
TreeFami TF333393.

Miscellaneous databases

NextBioi 611138.
PROi O55004.

Gene expression databases

Genevestigatori O55004.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ribonucleases from rat and bovine liver: purification, specificity and structural characterization."
    Zhao W., Kote-Jarai Z., van Santen Y., Hofsteenge J., Beintema J.J.
    Biochim. Biophys. Acta 1384:55-65(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiRNAS4_RAT
AccessioniPrimary (citable) accession number: O55004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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