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O55004 (RNAS4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 4

Short name=RNase 4
EC=3.1.27.-
Alternative name(s):
RL3
Gene names
Name:Rnase4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This RNase has marked specificity towards the 3' side of uridine nucleotides.

Subcellular location

Secreted.

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 By similarity
Chain29 – 147119Ribonuclease 4
PRO_0000030887

Regions

Region68 – 725Substrate binding By similarity

Sites

Active site401Proton acceptor By similarity
Active site1441Proton donor By similarity
Binding site381Substrate By similarity
Binding site931Substrate By similarity
Binding site1101Substrate By similarity

Amino acid modifications

Modified residue291Pyrrolidone carboxylic acid By similarity
Disulfide bond53 ↔ 109 By similarity
Disulfide bond67 ↔ 120 By similarity
Disulfide bond85 ↔ 135 By similarity
Disulfide bond92 ↔ 99 By similarity

Sequences

Sequence LengthMass (Da)Tools
O55004 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 110D54CF7C691BB3

FASTA14716,903
        10         20         30         40         50         60 
MDIQRTQSLL LLLLLTLLGL GLVQPSYGQD RMYQRFLRQH VDPEGTGGSD NYCNVMMQRR 

        70         80         90        100        110        120 
RMTSTQCKRF NTFIHEDIWN IRSICDTANI PCKNGNMNCH EGIVRVTDCR ETGSSVPHNC 

       130        140 
RYRARASTRR VVIACEGTPE VPVHFDR 

« Hide

References

« Hide 'large scale' references
[1]"Ribonucleases from rat and bovine liver: purification, specificity and structural characterization."
Zhao W., Kote-Jarai Z., van Santen Y., Hofsteenge J., Beintema J.J.
Biochim. Biophys. Acta 1384:55-65(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF041066 mRNA. Translation: AAC23487.1.
BC070953 mRNA. Translation: AAH70953.1.
RefSeqNP_064467.1. NM_020082.2.
XP_006251968.1. XM_006251906.1.
XP_006251969.1. XM_006251907.1.
UniGeneRn.1742.

3D structure databases

ProteinModelPortalO55004.
SMRO55004. Positions 29-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000043003.

Proteomic databases

PaxDbO55004.
PRIDEO55004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000041495; ENSRNOP00000043003; ENSRNOG00000025625.
GeneID56759.
KEGGrno:56759.
UCSCRGD:61823. rat.

Organism-specific databases

CTD6038.
RGD61823. Rnase4.

Phylogenomic databases

eggNOGNOG42321.
HOGENOMHOG000276883.
HOVERGENHBG008396.
InParanoidO55004.
KOK16632.
OMASSRAPNC.
OrthoDBEOG7J1826.
PhylomeDBO55004.
TreeFamTF333393.

Gene expression databases

GenevestigatorO55004.

Family and domain databases

Gene3D3.10.130.10. 1 hit.
InterProIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERPTHR11437. PTHR11437. 1 hit.
PfamPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSPR00794. RIBONUCLEASE.
ProDomPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMSSF54076. SSF54076. 1 hit.
PROSITEPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611138.
PROO55004.

Entry information

Entry nameRNAS4_RAT
AccessionPrimary (citable) accession number: O55004
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families