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O55004

- RNAS4_RAT

UniProt

O55004 - RNAS4_RAT

Protein

Ribonuclease 4

Gene

Rnase4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This RNase has marked specificity towards the 3' side of uridine nucleotides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateBy similarity
    Active sitei40 – 401Proton acceptorBy similarity
    Binding sitei93 – 931SubstrateBy similarity
    Binding sitei110 – 1101SubstrateBy similarity
    Active sitei144 – 1441Proton donorBy similarity

    GO - Molecular functioni

    1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
    2. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease 4 (EC:3.1.27.-)
    Short name:
    RNase 4
    Alternative name(s):
    RL3
    Gene namesi
    Name:Rnase4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi61823. Rnase4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828By similarityAdd
    BLAST
    Chaini29 – 147119Ribonuclease 4PRO_0000030887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei29 – 291Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi53 ↔ 109By similarity
    Disulfide bondi67 ↔ 120By similarity
    Disulfide bondi85 ↔ 135By similarity
    Disulfide bondi92 ↔ 99By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiO55004.
    PRIDEiO55004.

    Expressioni

    Gene expression databases

    GenevestigatoriO55004.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000043003.

    Structurei

    3D structure databases

    ProteinModelPortaliO55004.
    SMRiO55004. Positions 29-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni68 – 725Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the pancreatic ribonuclease family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42321.
    HOGENOMiHOG000276883.
    HOVERGENiHBG008396.
    InParanoidiO55004.
    KOiK16632.
    OMAiVIACEGD.
    OrthoDBiEOG7J1826.
    PhylomeDBiO55004.
    TreeFamiTF333393.

    Family and domain databases

    Gene3Di3.10.130.10. 1 hit.
    InterProiIPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view]
    PANTHERiPTHR11437. PTHR11437. 1 hit.
    PfamiPF00074. RnaseA. 1 hit.
    [Graphical view]
    PRINTSiPR00794. RIBONUCLEASE.
    ProDomiPD000535. RNaseA. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00092. RNAse_Pc. 1 hit.
    [Graphical view]
    SUPFAMiSSF54076. SSF54076. 1 hit.
    PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O55004-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIQRTQSLL LLLLLTLLGL GLVQPSYGQD RMYQRFLRQH VDPEGTGGSD    50
    NYCNVMMQRR RMTSTQCKRF NTFIHEDIWN IRSICDTANI PCKNGNMNCH 100
    EGIVRVTDCR ETGSSVPHNC RYRARASTRR VVIACEGTPE VPVHFDR 147
    Length:147
    Mass (Da):16,903
    Last modified:June 1, 1998 - v1
    Checksum:i110D54CF7C691BB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041066 mRNA. Translation: AAC23487.1.
    BC070953 mRNA. Translation: AAH70953.1.
    RefSeqiNP_064467.1. NM_020082.2.
    XP_006251968.1. XM_006251906.1.
    XP_006251969.1. XM_006251907.1.
    UniGeneiRn.1742.

    Genome annotation databases

    EnsembliENSRNOT00000041495; ENSRNOP00000043003; ENSRNOG00000025625.
    GeneIDi56759.
    KEGGirno:56759.
    UCSCiRGD:61823. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041066 mRNA. Translation: AAC23487.1 .
    BC070953 mRNA. Translation: AAH70953.1 .
    RefSeqi NP_064467.1. NM_020082.2.
    XP_006251968.1. XM_006251906.1.
    XP_006251969.1. XM_006251907.1.
    UniGenei Rn.1742.

    3D structure databases

    ProteinModelPortali O55004.
    SMRi O55004. Positions 29-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000043003.

    Proteomic databases

    PaxDbi O55004.
    PRIDEi O55004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000041495 ; ENSRNOP00000043003 ; ENSRNOG00000025625 .
    GeneIDi 56759.
    KEGGi rno:56759.
    UCSCi RGD:61823. rat.

    Organism-specific databases

    CTDi 6038.
    RGDi 61823. Rnase4.

    Phylogenomic databases

    eggNOGi NOG42321.
    HOGENOMi HOG000276883.
    HOVERGENi HBG008396.
    InParanoidi O55004.
    KOi K16632.
    OMAi VIACEGD.
    OrthoDBi EOG7J1826.
    PhylomeDBi O55004.
    TreeFami TF333393.

    Miscellaneous databases

    NextBioi 611138.
    PROi O55004.

    Gene expression databases

    Genevestigatori O55004.

    Family and domain databases

    Gene3Di 3.10.130.10. 1 hit.
    InterProi IPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view ]
    PANTHERi PTHR11437. PTHR11437. 1 hit.
    Pfami PF00074. RnaseA. 1 hit.
    [Graphical view ]
    PRINTSi PR00794. RIBONUCLEASE.
    ProDomi PD000535. RNaseA. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00092. RNAse_Pc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54076. SSF54076. 1 hit.
    PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ribonucleases from rat and bovine liver: purification, specificity and structural characterization."
      Zhao W., Kote-Jarai Z., van Santen Y., Hofsteenge J., Beintema J.J.
      Biochim. Biophys. Acta 1384:55-65(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiRNAS4_RAT
    AccessioniPrimary (citable) accession number: O55004
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3