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O54998 (FKBP7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7

Short name=PPIase FKBP7
EC=5.2.1.8
Alternative name(s):
23 kDa FK506-binding protein
Short name=23 kDa FKBP
Short name=FKBP-23
FK506-binding protein 7
Short name=FKBP-7
Rotamase
Gene names
Name:Fkbp7
Synonyms:Fkbp23
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Subcellular location

Endoplasmic reticulum lumen Ref.1.

Tissue specificity

Expressed at highest levels in heart, lung and testis. Weakly expressed in kidney and lymph node. Little or no expression detected in brain, thymus, spleen and liver. Ref.1

Developmental stage

Expression begins at embryonic day 8.5. Ref.1

Post-translational modification

Glycosylated. Ref.1

Miscellaneous

Binds calcium.

Sequence similarities

Contains 2 EF-hand domains.

Contains 1 PPIase FKBP-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 218199Peptidyl-prolyl cis-trans isomerase FKBP7
PRO_0000025514

Regions

Domain49 – 14193PPIase FKBP-type
Domain141 – 17636EF-hand 1
Domain185 – 21834EF-hand 2
Calcium binding154 – 165121 Potential
Calcium binding198 – 209122 Potential
Motif215 – 2184Prevents secretion from ER Potential

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O54998 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: DB0AE509E60EEEBA

FASTA21824,913
        10         20         30         40         50         60 
MNLLFRLAVF LSLWCCSDAQ GQTKEESTEE VKIEVLHRPE NCSKTSRKGD LLNAHYDGYL 

        70         80         90        100        110        120 
AKDGSKFYCS RTQDEGHPKW FVLGVGHVIK GLDIAMMDMC PGEKRKVIIP PSFAYGKEGY 

       130        140        150        160        170        180 
AEGKIPPNAT LMFEIELYAV TKGPRSIETF KQIDTDNDRQ LSKAEIELYL QKDFEKDANP 

       190        200        210 
RDKSYQKAVL EDIFKKNDHN GDGFISPKEY NVHQHDEL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability."
Nakamura T., Yabe D., Kanazawa N., Tashiro K., Sasayama S., Honjo T.
Genomics 54:89-98(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION, CALCIUM-BINDING.
Strain: NIH Swiss.
Tissue: Embryonic heart.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF040252 mRNA. Translation: AAC79959.1.
BC032961 mRNA. Translation: AAH32961.1.
CCDSCCDS16161.1.
RefSeqNP_034352.1. NM_010222.2.
UniGeneMm.24720.

3D structure databases

ProteinModelPortalO54998.
SMRO54998. Positions 30-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199688. 1 interaction.
STRING10090.ENSMUSP00000002809.

PTM databases

PhosphoSiteO54998.

Proteomic databases

MaxQBO54998.
PRIDEO54998.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732.
GeneID14231.
KEGGmmu:14231.
UCSCuc008kfh.2. mouse.

Organism-specific databases

CTD51661.
MGIMGI:1336879. Fkbp7.

Phylogenomic databases

eggNOGCOG0545.
HOGENOMHOG000154887.
HOVERGENHBG051623.
InParanoidO54998.
KOK09573.
OMARPENCSK.
OrthoDBEOG7T1R9S.
PhylomeDBO54998.
TreeFamTF105296.

Gene expression databases

ArrayExpressO54998.
BgeeO54998.
CleanExMM_FKBP7.
GenevestigatorO54998.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285503.
PROO54998.
SOURCESearch...

Entry information

Entry nameFKBP7_MOUSE
AccessionPrimary (citable) accession number: O54998
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot