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Protein

Peptidyl-prolyl cis-trans isomerase FKBP7

Gene

Fkbp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi154 – 165121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi198 – 209122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: MGI
  2. FK506 binding Source: GO_Central
  3. peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  1. chaperone-mediated protein folding Source: GO_Central
  2. protein peptidyl-prolyl isomerization Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)
Short name:
PPIase FKBP7
Alternative name(s):
23 kDa FK506-binding protein
Short name:
23 kDa FKBP
Short name:
FKBP-23
FK506-binding protein 7
Short name:
FKBP-7
Rotamase
Gene namesi
Name:Fkbp7
Synonyms:Fkbp23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1336879. Fkbp7.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  3. endoplasmic reticulum membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 218199Peptidyl-prolyl cis-trans isomerase FKBP7PRO_0000025514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO54998.
PRIDEiO54998.

PTM databases

PhosphoSiteiO54998.

Expressioni

Tissue specificityi

Expressed at highest levels in heart, lung and testis. Weakly expressed in kidney and lymph node. Little or no expression detected in brain, thymus, spleen and liver.1 Publication

Developmental stagei

Expression begins at embryonic day 8.5.1 Publication

Gene expression databases

BgeeiO54998.
CleanExiMM_FKBP7.
ExpressionAtlasiO54998. baseline and differential.
GenevestigatoriO54998.

Interactioni

Protein-protein interaction databases

BioGridi199688. 1 interaction.
STRINGi10090.ENSMUSP00000002809.

Structurei

3D structure databases

ProteinModelPortaliO54998.
SMRiO54998. Positions 30-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 14193PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST
Domaini141 – 17636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini185 – 21834EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi215 – 2184Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiO54998.
KOiK09573.
OMAiRPENCSK.
OrthoDBiEOG7T1R9S.
PhylomeDBiO54998.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLFRLAVF LSLWCCSDAQ GQTKEESTEE VKIEVLHRPE NCSKTSRKGD
60 70 80 90 100
LLNAHYDGYL AKDGSKFYCS RTQDEGHPKW FVLGVGHVIK GLDIAMMDMC
110 120 130 140 150
PGEKRKVIIP PSFAYGKEGY AEGKIPPNAT LMFEIELYAV TKGPRSIETF
160 170 180 190 200
KQIDTDNDRQ LSKAEIELYL QKDFEKDANP RDKSYQKAVL EDIFKKNDHN
210
GDGFISPKEY NVHQHDEL
Length:218
Mass (Da):24,913
Last modified:June 1, 1998 - v1
Checksum:iDB0AE509E60EEEBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040252 mRNA. Translation: AAC79959.1.
BC032961 mRNA. Translation: AAH32961.1.
CCDSiCCDS16161.1.
RefSeqiNP_034352.1. NM_010222.2.
UniGeneiMm.24720.

Genome annotation databases

EnsembliENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732.
GeneIDi14231.
KEGGimmu:14231.
UCSCiuc008kfh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040252 mRNA. Translation: AAC79959.1.
BC032961 mRNA. Translation: AAH32961.1.
CCDSiCCDS16161.1.
RefSeqiNP_034352.1. NM_010222.2.
UniGeneiMm.24720.

3D structure databases

ProteinModelPortaliO54998.
SMRiO54998. Positions 30-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199688. 1 interaction.
STRINGi10090.ENSMUSP00000002809.

PTM databases

PhosphoSiteiO54998.

Proteomic databases

MaxQBiO54998.
PRIDEiO54998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732.
GeneIDi14231.
KEGGimmu:14231.
UCSCiuc008kfh.2. mouse.

Organism-specific databases

CTDi51661.
MGIiMGI:1336879. Fkbp7.

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiO54998.
KOiK09573.
OMAiRPENCSK.
OrthoDBiEOG7T1R9S.
PhylomeDBiO54998.
TreeFamiTF105296.

Miscellaneous databases

NextBioi285503.
PROiO54998.
SOURCEiSearch...

Gene expression databases

BgeeiO54998.
CleanExiMM_FKBP7.
ExpressionAtlasiO54998. baseline and differential.
GenevestigatoriO54998.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability."
    Nakamura T., Yabe D., Kanazawa N., Tashiro K., Sasayama S., Honjo T.
    Genomics 54:89-98(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION, CALCIUM-BINDING.
    Strain: NIH Swiss.
    Tissue: Embryonic heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiFKBP7_MOUSE
AccessioniPrimary (citable) accession number: O54998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 1998
Last modified: February 4, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.