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Protein

Peptidyl-prolyl cis-trans isomerase FKBP7

Gene

Fkbp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi154 – 1651PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi198 – 2092PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • FK506 binding Source: GO_Central
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)
Short name:
PPIase FKBP7
Alternative name(s):
23 kDa FK506-binding protein
Short name:
23 kDa FKBP
Short name:
FKBP-23
FK506-binding protein 7
Short name:
FKBP-7
Rotamase
Gene namesi
Name:Fkbp7
Synonyms:Fkbp23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1336879. Fkbp7.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum lumen Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002551420 – 218Peptidyl-prolyl cis-trans isomerase FKBP7Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO54998.
PeptideAtlasiO54998.
PRIDEiO54998.

PTM databases

PhosphoSitePlusiO54998.

Expressioni

Tissue specificityi

Expressed at highest levels in heart, lung and testis. Weakly expressed in kidney and lymph node. Little or no expression detected in brain, thymus, spleen and liver.1 Publication

Developmental stagei

Expression begins at embryonic day 8.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000002732.
CleanExiMM_FKBP7.
ExpressionAtlasiO54998. baseline and differential.
GenevisibleiO54998. MM.

Interactioni

Protein-protein interaction databases

BioGridi199688. 1 interactor.
STRINGi10090.ENSMUSP00000002809.

Structurei

3D structure databases

ProteinModelPortaliO54998.
SMRiO54998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 141PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST93
Domaini141 – 176EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini185 – 218EF-hand 2PROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi215 – 218Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiO54998.
KOiK09573.
OMAiHRPENCS.
OrthoDBiEOG091G02W1.
PhylomeDBiO54998.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLFRLAVF LSLWCCSDAQ GQTKEESTEE VKIEVLHRPE NCSKTSRKGD
60 70 80 90 100
LLNAHYDGYL AKDGSKFYCS RTQDEGHPKW FVLGVGHVIK GLDIAMMDMC
110 120 130 140 150
PGEKRKVIIP PSFAYGKEGY AEGKIPPNAT LMFEIELYAV TKGPRSIETF
160 170 180 190 200
KQIDTDNDRQ LSKAEIELYL QKDFEKDANP RDKSYQKAVL EDIFKKNDHN
210
GDGFISPKEY NVHQHDEL
Length:218
Mass (Da):24,913
Last modified:June 1, 1998 - v1
Checksum:iDB0AE509E60EEEBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040252 mRNA. Translation: AAC79959.1.
BC032961 mRNA. Translation: AAH32961.1.
CCDSiCCDS16161.1.
RefSeqiNP_034352.1. NM_010222.2.
UniGeneiMm.24720.

Genome annotation databases

EnsembliENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732.
GeneIDi14231.
KEGGimmu:14231.
UCSCiuc008kfh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040252 mRNA. Translation: AAC79959.1.
BC032961 mRNA. Translation: AAH32961.1.
CCDSiCCDS16161.1.
RefSeqiNP_034352.1. NM_010222.2.
UniGeneiMm.24720.

3D structure databases

ProteinModelPortaliO54998.
SMRiO54998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199688. 1 interactor.
STRINGi10090.ENSMUSP00000002809.

PTM databases

PhosphoSitePlusiO54998.

Proteomic databases

PaxDbiO54998.
PeptideAtlasiO54998.
PRIDEiO54998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732.
GeneIDi14231.
KEGGimmu:14231.
UCSCiuc008kfh.2. mouse.

Organism-specific databases

CTDi51661.
MGIiMGI:1336879. Fkbp7.

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiO54998.
KOiK09573.
OMAiHRPENCS.
OrthoDBiEOG091G02W1.
PhylomeDBiO54998.
TreeFamiTF105296.

Miscellaneous databases

PROiO54998.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002732.
CleanExiMM_FKBP7.
ExpressionAtlasiO54998. baseline and differential.
GenevisibleiO54998. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP7_MOUSE
AccessioniPrimary (citable) accession number: O54998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.