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O54998

- FKBP7_MOUSE

UniProt

O54998 - FKBP7_MOUSE

Protein

Peptidyl-prolyl cis-trans isomerase FKBP7

Gene

Fkbp7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi154 – 165121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi198 – 209122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: MGI
    2. FK506 binding Source: RefGenome
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
    4. protein binding Source: MGI

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)
    Short name:
    PPIase FKBP7
    Alternative name(s):
    23 kDa FK506-binding protein
    Short name:
    23 kDa FKBP
    Short name:
    FKBP-23
    FK506-binding protein 7
    Short name:
    FKBP-7
    Rotamase
    Gene namesi
    Name:Fkbp7
    Synonyms:Fkbp23
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1336879. Fkbp7.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. endoplasmic reticulum membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 218199Peptidyl-prolyl cis-trans isomerase FKBP7PRO_0000025514Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO54998.
    PRIDEiO54998.

    PTM databases

    PhosphoSiteiO54998.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in heart, lung and testis. Weakly expressed in kidney and lymph node. Little or no expression detected in brain, thymus, spleen and liver.1 Publication

    Developmental stagei

    Expression begins at embryonic day 8.5.1 Publication

    Gene expression databases

    ArrayExpressiO54998.
    BgeeiO54998.
    CleanExiMM_FKBP7.
    GenevestigatoriO54998.

    Interactioni

    Protein-protein interaction databases

    BioGridi199688. 1 interaction.
    STRINGi10090.ENSMUSP00000002809.

    Structurei

    3D structure databases

    ProteinModelPortaliO54998.
    SMRiO54998. Positions 30-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 14193PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini141 – 17636EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini185 – 21834EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi215 – 2184Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    HOVERGENiHBG051623.
    InParanoidiO54998.
    KOiK09573.
    OMAiRPENCSK.
    OrthoDBiEOG7T1R9S.
    PhylomeDBiO54998.
    TreeFamiTF105296.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF13499. EF-hand_7. 1 hit.
    PF00254. FKBP_C. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O54998-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLLFRLAVF LSLWCCSDAQ GQTKEESTEE VKIEVLHRPE NCSKTSRKGD    50
    LLNAHYDGYL AKDGSKFYCS RTQDEGHPKW FVLGVGHVIK GLDIAMMDMC 100
    PGEKRKVIIP PSFAYGKEGY AEGKIPPNAT LMFEIELYAV TKGPRSIETF 150
    KQIDTDNDRQ LSKAEIELYL QKDFEKDANP RDKSYQKAVL EDIFKKNDHN 200
    GDGFISPKEY NVHQHDEL 218
    Length:218
    Mass (Da):24,913
    Last modified:June 1, 1998 - v1
    Checksum:iDB0AE509E60EEEBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040252 mRNA. Translation: AAC79959.1.
    BC032961 mRNA. Translation: AAH32961.1.
    CCDSiCCDS16161.1.
    RefSeqiNP_034352.1. NM_010222.2.
    UniGeneiMm.24720.

    Genome annotation databases

    EnsembliENSMUST00000002809; ENSMUSP00000002809; ENSMUSG00000002732.
    GeneIDi14231.
    KEGGimmu:14231.
    UCSCiuc008kfh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040252 mRNA. Translation: AAC79959.1 .
    BC032961 mRNA. Translation: AAH32961.1 .
    CCDSi CCDS16161.1.
    RefSeqi NP_034352.1. NM_010222.2.
    UniGenei Mm.24720.

    3D structure databases

    ProteinModelPortali O54998.
    SMRi O54998. Positions 30-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199688. 1 interaction.
    STRINGi 10090.ENSMUSP00000002809.

    PTM databases

    PhosphoSitei O54998.

    Proteomic databases

    MaxQBi O54998.
    PRIDEi O54998.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002809 ; ENSMUSP00000002809 ; ENSMUSG00000002732 .
    GeneIDi 14231.
    KEGGi mmu:14231.
    UCSCi uc008kfh.2. mouse.

    Organism-specific databases

    CTDi 51661.
    MGIi MGI:1336879. Fkbp7.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    HOVERGENi HBG051623.
    InParanoidi O54998.
    KOi K09573.
    OMAi RPENCSK.
    OrthoDBi EOG7T1R9S.
    PhylomeDBi O54998.
    TreeFami TF105296.

    Miscellaneous databases

    NextBioi 285503.
    PROi O54998.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54998.
    Bgeei O54998.
    CleanExi MM_FKBP7.
    Genevestigatori O54998.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF13499. EF-hand_7. 1 hit.
    PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability."
      Nakamura T., Yabe D., Kanazawa N., Tashiro K., Sasayama S., Honjo T.
      Genomics 54:89-98(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION, CALCIUM-BINDING.
      Strain: NIH Swiss.
      Tissue: Embryonic heart.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiFKBP7_MOUSE
    AccessioniPrimary (citable) accession number: O54998
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds calcium.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3