O54990 (PROM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prominin-1

Alternative name(s):
Antigen AC133 homolog
Prominin-like protein 1
CD_antigen=CD133

Gene names

Name:	Prom1
Synonyms:	Prom, Proml1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	867 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early during retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner By similarity. Ref.12
Subunit structure	Interacts with CDHR1 and with actin filaments By similarity.
Subcellular location	Apical cell membrane; Multi-pass membrane protein. Cell projection › microvillus membrane; Multi-pass membrane protein. Cell projection › cilium › photoreceptor outer segment. Note: Found in extracellular membrane particles in various body fluids such as ventricular fluid of the developing brain and urine. Ref.5 Ref.6 Ref.8 Ref.10
Tissue specificity	In the submandibular gland, expressed on the apical side of epithelial cells. In the parotid gland, expressed in the intercalated ducts. In the sublingual gland, expressed in intercalated ducts. In the extraorbital lacrimal gland, expressed in the intercalated tubules and larger intralobular ducts. Expressed in the retina. Present in urine within small membrane particles (at protein level). In the embryo, expressed on the apical side of neuroepithelial cells and of other epithelia such as lung buds, gut and ureter buds. In the adult, expressed at the apical side of the kidney tubules and of the ependymal layer of the brain. Not expressed in gut, liver, lung, pituitary, adrenal, heart or spleen. Localized to the nascent disk membranes at the base of the rod outer segment in the retina (at protein level). Ref.6 Ref.9 Ref.11 Ref.12
Developmental stage	At birth, is detected at the interface between the developing neuroretina and the retinal pigment epithelium (RPE) layer. In the postnatal retina (P20) detected in photoreceptors, with particular concentration in the region of plasma membrane evaginations at the basal part of the outer segment (OS). Expressed by rod and cone photoreceptor cells, most abundantly between the OS and inner segment (IS), in close proximity to the connecting cilium. Ref.12
Disruption phenotype	Progressive degeneration and functional deterioration of both cone and rod photoreceptors associated with impaired morphogenesis of the disks and OS. Ref.12
Miscellaneous	Fundus images and light microscopy of retinal sections from transgenic mice expressing mutant PROM1 reveal progressive retinal abnormalities visible as subretinal deposits and photoreceptor atrophy.
Sequence similarities	Belongs to the prominin family.

Ontologies

Keywords
Cellular component	Cell membrane Cell projection Cilium Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	camera-type eye photoreceptor cell differentiation Inferred from mutant phenotype Ref.12. Source: UniProtKB retina layer formation Inferred from mutant phenotype Ref.12. Source: UniProtKB
Cellular_component	apical plasma membrane Inferred from direct assay PubMed 16892058. Source: MGI brush border Inferred from direct assay Ref.2. Source: MGI cell surface Inferred from direct assay Ref.3. Source: MGI extracellular space Inferred from direct assay PubMed 15976444. Source: MGI integral to plasma membrane Inferred from direct assay Ref.2. Source: MGI microvillus membrane Inferred from electronic annotation. Source: UniProtKB-SubCell photoreceptor outer segment Inferred from direct assay Ref.12. Source: UniProtKB prominosome Inferred from direct assay PubMed 15976444Ref.10. Source: UniProtKB stereocilium Inferred from direct assay Ref.3. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O54990-1)

Also known as: S2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O54990-2)

Also known as: S1;

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.

Isoform 3 (identifier: O54990-3)

Also known as: S3;

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.
     833-843: VETVPMKNLEI → SSVSGMWHFTL
     844-867: Missing.

Isoform 4 (identifier: O54990-4)

Also known as: S4;

The sequence of this isoform differs from the canonical sequence as follows:
     94-107: Missing.
     335-360: QLPSVDRELNTVTEVDKTDLESLVKR → Q
     833-843: VETVPMKNLEI → SSVSGMWHFTL
     844-867: Missing.

Isoform 5 (identifier: O54990-5)

Also known as: S5;

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.
     335-360: QLPSVDRELNTVTEVDKTDLESLVKR → Q
     833-843: VETVPMKNLEI → SSVSGMWHFTL
     844-867: Missing.

Isoform 6 (identifier: O54990-6)

Also known as: S6;

The sequence of this isoform differs from the canonical sequence as follows:
     94-102: Missing.
     832-832: D → E
     833-867: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 867	848	Prominin-1		PRO_0000025814
Regions
	Topological domain	20 – 107	88	Extracellular Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Topological domain	129 – 158	30	Cytoplasmic Potential
	Transmembrane	159 – 179	21	Helical; Potential
	Topological domain	180 – 434	255	Extracellular Potential
	Transmembrane	435 – 455	21	Helical; Potential
	Topological domain	456 – 487	32	Cytoplasmic Potential
	Transmembrane	488 – 508	21	Helical; Potential
	Topological domain	509 – 794	286	Extracellular Potential
	Transmembrane	795 – 815	21	Helical; Potential
	Topological domain	816 – 867	52	Cytoplasmic Potential
Amino acid modifications
	Modified residue	865	1	Phosphoserine By similarity
	Glycosylation	273	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	291	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	332	1	N-linked (GlcNAc...) Potential
	Glycosylation	374	1	N-linked (GlcNAc...) Ref.13
	Glycosylation	415	1	N-linked (GlcNAc...) Potential
	Glycosylation	554	1	N-linked (GlcNAc...) Potential
	Glycosylation	581	1	N-linked (GlcNAc...) Potential
	Glycosylation	732	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	94 – 107	14	Missing in isoform 4.		VSP_040005
	Alternative sequence	94 – 102	9	Missing in isoform 2, isoform 3, isoform 5 and isoform 6.		VSP_040006
	Alternative sequence	335 – 360	26	QLPSV…SLVKR → Q in isoform 4 and isoform 5.		VSP_040007
	Alternative sequence	832	1	D → E in isoform 6.		VSP_040008
	Alternative sequence	833 – 867	35	Missing in isoform 6.		VSP_040009
	Alternative sequence	833 – 843	11	VETVPMKNLEI → SSVSGMWHFTL in isoform 3, isoform 4 and isoform 5.		VSP_040010
	Alternative sequence	844 – 867	24	Missing in isoform 3, isoform 4 and isoform 5.		VSP_040011
Experimental info
	Sequence conflict	64	1	S → N in AAB86715. Ref.2
	Sequence conflict	64	1	S → N in AAM28245. Ref.3
	Sequence conflict	64	1	S → N in AAO11840. Ref.3
	Sequence conflict	64	1	S → N in AAO72429. Ref.3
	Sequence conflict	64	1	S → N in AAO72430. Ref.3
	Sequence conflict	64	1	S → N in BAC26745. Ref.4
	Sequence conflict	84	1	K → N in AAB86715. Ref.2
	Sequence conflict	84	1	K → N in AAM28245. Ref.3
	Sequence conflict	84	1	K → N in AAO11840. Ref.3
	Sequence conflict	84	1	K → N in AAO72429. Ref.3
	Sequence conflict	84	1	K → N in AAO72430. Ref.3
	Sequence conflict	84	1	K → N in BAC26745. Ref.4
	Sequence conflict	668	1	P → L in AAB86715. Ref.2
	Sequence conflict	668	1	P → L in AAM28245. Ref.3
	Sequence conflict	668	1	P → L in AAO72429. Ref.3
	Sequence conflict	668	1	P → L in AAO72430. Ref.3
	Sequence conflict	668	1	P → L in BAC26745. Ref.4
	Sequence conflict	844	1	G → D in AAB86715. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (S2) [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D442F6372552B3C8	FASTA	867	97,113
	10 20 30 40 50 60 MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG IVGPLYKMVH 70 80 90 100 110 120 IFLSVVQPND FPLDLIKKLI QNKKFDISVD SKEPEIIVLA LKIALYEIGV LICAILGLLF 130 140 150 160 170 180 IILMPLVGCF FCMCRCCNKC GGEMHQRQKQ NAPCRRKCLG LSLLVICLLM SLGIIYGFVA 190 200 210 220 230 240 NQQTRTRIKG TQKLAKSNFR DFQTLLTETP KQIDYVVEQY TNTKNKAFSD LDGIGSVLGG 250 260 270 280 290 300 RIKDQLKPKV TPVLEEIKAM ATAIKQTKDA LQNMSSSLKS LQDAATQLNT NLSSVRNSIE 310 320 330 340 350 360 NSLSSSDCTS DPASKICDSI RPSLSSLGSS LNSSQLPSVD RELNTVTEVD KTDLESLVKR 370 380 390 400 410 420 GYTTIDEIPN TIQNQTVDVI KDVKNTLDSI SSNIKDMSQS IPIEDMLLQV SHYLNNSNRY 430 440 450 460 470 480 LNQELPKLEE YDSYWWLGGL IVCFLLTLIV TFFFLGLLCG VFGYDKHATP TRRGCVSNTG 490 500 510 520 530 540 GIFLMAGVGF GFLFCWILMI LVVLTFVVGA NVEKLLCEPY ENKKLLQVLD TPYLLKEQWQ 550 560 570 580 590 600 FYLSGMLFNN PDINMTFEQV YRDCKRGRGI YAAFQLENVV NVSDHFNIDQ ISENINTELE 610 620 630 640 650 660 NLNVNIDSIE LLDNTGRKSL EDFAHSGIDT IDYSTYLKET EKSPTEVNLL TFASTLEAKA 670 680 690 700 710 720 NQLPEGKPKQ AFLLDVQNIR AIHQHLLPPV QQSLNTLRQS VWTLQQTSNK LPEKVKKILA 730 740 750 760 770 780 SLDSVQHFLT NNVSLIVIGE TKKFGKTILG YFEHYLHWVF YAITEKMTSC KPMATAMDSA 790 800 810 820 830 840 VNGILCGYVA DPLNLFWFGI GKATVLLLPA VIIAIKLAKY YRRMDSEDVY DDVETVPMKN 850 860 LEIGSNGYHK DHLYGVHNPV MTSPSRY
	Isoform 2 (S1) [UniParc]. Checksum: CAFCAD4C3039848D	FASTA	858	96,136
	10 20 30 40 50 60 MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG IVGPLYKMVH 70 80 90 100 110 120 IFLSVVQPND FPLDLIKKLI QNKKFDISVD SKEIALYEIG VLICAILGLL FIILMPLVGC 130 140 150 160 170 180 FFCMCRCCNK CGGEMHQRQK QNAPCRRKCL GLSLLVICLL MSLGIIYGFV ANQQTRTRIK 190 200 210 220 230 240 GTQKLAKSNF RDFQTLLTET PKQIDYVVEQ YTNTKNKAFS DLDGIGSVLG GRIKDQLKPK 250 260 270 280 290 300 VTPVLEEIKA MATAIKQTKD ALQNMSSSLK SLQDAATQLN TNLSSVRNSI ENSLSSSDCT 310 320 330 340 350 360 SDPASKICDS IRPSLSSLGS SLNSSQLPSV DRELNTVTEV DKTDLESLVK RGYTTIDEIP 370 380 390 400 410 420 NTIQNQTVDV IKDVKNTLDS ISSNIKDMSQ SIPIEDMLLQ VSHYLNNSNR YLNQELPKLE 430 440 450 460 470 480 EYDSYWWLGG LIVCFLLTLI VTFFFLGLLC GVFGYDKHAT PTRRGCVSNT GGIFLMAGVG 490 500 510 520 530 540 FGFLFCWILM ILVVLTFVVG ANVEKLLCEP YENKKLLQVL DTPYLLKEQW QFYLSGMLFN 550 560 570 580 590 600 NPDINMTFEQ VYRDCKRGRG IYAAFQLENV VNVSDHFNID QISENINTEL ENLNVNIDSI 610 620 630 640 650 660 ELLDNTGRKS LEDFAHSGID TIDYSTYLKE TEKSPTEVNL LTFASTLEAK ANQLPEGKPK 670 680 690 700 710 720 QAFLLDVQNI RAIHQHLLPP VQQSLNTLRQ SVWTLQQTSN KLPEKVKKIL ASLDSVQHFL 730 740 750 760 770 780 TNNVSLIVIG ETKKFGKTIL GYFEHYLHWV FYAITEKMTS CKPMATAMDS AVNGILCGYV 790 800 810 820 830 840 ADPLNLFWFG IGKATVLLLP AVIIAIKLAK YYRRMDSEDV YDDVETVPMK NLEIGSNGYH 850 KDHLYGVHNP VMTSPSRY
	Isoform 3 (S3) [UniParc]. Checksum: CAFC85B2596BAB9C	FASTA	834	93,416
	10 20 30 40 50 60 MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG IVGPLYKMVH 70 80 90 100 110 120 IFLSVVQPND FPLDLIKKLI QNKKFDISVD SKEIALYEIG VLICAILGLL FIILMPLVGC 130 140 150 160 170 180 FFCMCRCCNK CGGEMHQRQK QNAPCRRKCL GLSLLVICLL MSLGIIYGFV ANQQTRTRIK 190 200 210 220 230 240 GTQKLAKSNF RDFQTLLTET PKQIDYVVEQ YTNTKNKAFS DLDGIGSVLG GRIKDQLKPK 250 260 270 280 290 300 VTPVLEEIKA MATAIKQTKD ALQNMSSSLK SLQDAATQLN TNLSSVRNSI ENSLSSSDCT 310 320 330 340 350 360 SDPASKICDS IRPSLSSLGS SLNSSQLPSV DRELNTVTEV DKTDLESLVK RGYTTIDEIP 370 380 390 400 410 420 NTIQNQTVDV IKDVKNTLDS ISSNIKDMSQ SIPIEDMLLQ VSHYLNNSNR YLNQELPKLE 430 440 450 460 470 480 EYDSYWWLGG LIVCFLLTLI VTFFFLGLLC GVFGYDKHAT PTRRGCVSNT GGIFLMAGVG 490 500 510 520 530 540 FGFLFCWILM ILVVLTFVVG ANVEKLLCEP YENKKLLQVL DTPYLLKEQW QFYLSGMLFN 550 560 570 580 590 600 NPDINMTFEQ VYRDCKRGRG IYAAFQLENV VNVSDHFNID QISENINTEL ENLNVNIDSI 610 620 630 640 650 660 ELLDNTGRKS LEDFAHSGID TIDYSTYLKE TEKSPTEVNL LTFASTLEAK ANQLPEGKPK 670 680 690 700 710 720 QAFLLDVQNI RAIHQHLLPP VQQSLNTLRQ SVWTLQQTSN KLPEKVKKIL ASLDSVQHFL 730 740 750 760 770 780 TNNVSLIVIG ETKKFGKTIL GYFEHYLHWV FYAITEKMTS CKPMATAMDS AVNGILCGYV 790 800 810 820 830 ADPLNLFWFG IGKATVLLLP AVIIAIKLAK YYRRMDSEDV YDDSSVSGMW HFTL
	Isoform 4 (S4) [UniParc]. Checksum: A8C6925524AE94D5	FASTA	804	89,987
	10 20 30 40 50 60 MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG IVGPLYKMVH 70 80 90 100 110 120 IFLSVVQPND FPLDLIKKLI QNKKFDISVD SKEIGVLICA ILGLLFIILM PLVGCFFCMC 130 140 150 160 170 180 RCCNKCGGEM HQRQKQNAPC RRKCLGLSLL VICLLMSLGI IYGFVANQQT RTRIKGTQKL 190 200 210 220 230 240 AKSNFRDFQT LLTETPKQID YVVEQYTNTK NKAFSDLDGI GSVLGGRIKD QLKPKVTPVL 250 260 270 280 290 300 EEIKAMATAI KQTKDALQNM SSSLKSLQDA ATQLNTNLSS VRNSIENSLS SSDCTSDPAS 310 320 330 340 350 360 KICDSIRPSL SSLGSSLNSS QGYTTIDEIP NTIQNQTVDV IKDVKNTLDS ISSNIKDMSQ 370 380 390 400 410 420 SIPIEDMLLQ VSHYLNNSNR YLNQELPKLE EYDSYWWLGG LIVCFLLTLI VTFFFLGLLC 430 440 450 460 470 480 GVFGYDKHAT PTRRGCVSNT GGIFLMAGVG FGFLFCWILM ILVVLTFVVG ANVEKLLCEP 490 500 510 520 530 540 YENKKLLQVL DTPYLLKEQW QFYLSGMLFN NPDINMTFEQ VYRDCKRGRG IYAAFQLENV 550 560 570 580 590 600 VNVSDHFNID QISENINTEL ENLNVNIDSI ELLDNTGRKS LEDFAHSGID TIDYSTYLKE 610 620 630 640 650 660 TEKSPTEVNL LTFASTLEAK ANQLPEGKPK QAFLLDVQNI RAIHQHLLPP VQQSLNTLRQ 670 680 690 700 710 720 SVWTLQQTSN KLPEKVKKIL ASLDSVQHFL TNNVSLIVIG ETKKFGKTIL GYFEHYLHWV 730 740 750 760 770 780 FYAITEKMTS CKPMATAMDS AVNGILCGYV ADPLNLFWFG IGKATVLLLP AVIIAIKLAK 790 800 YYRRMDSEDV YDDSSVSGMW HFTL
	Isoform 5 (S5) [UniParc]. Checksum: 1FF6FB4EF6CB7095	FASTA	809	90,577
	10 20 30 40 50 60 MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG IVGPLYKMVH 70 80 90 100 110 120 IFLSVVQPND FPLDLIKKLI QNKKFDISVD SKEIALYEIG VLICAILGLL FIILMPLVGC 130 140 150 160 170 180 FFCMCRCCNK CGGEMHQRQK QNAPCRRKCL GLSLLVICLL MSLGIIYGFV ANQQTRTRIK 190 200 210 220 230 240 GTQKLAKSNF RDFQTLLTET PKQIDYVVEQ YTNTKNKAFS DLDGIGSVLG GRIKDQLKPK 250 260 270 280 290 300 VTPVLEEIKA MATAIKQTKD ALQNMSSSLK SLQDAATQLN TNLSSVRNSI ENSLSSSDCT 310 320 330 340 350 360 SDPASKICDS IRPSLSSLGS SLNSSQGYTT IDEIPNTIQN QTVDVIKDVK NTLDSISSNI 370 380 390 400 410 420 KDMSQSIPIE DMLLQVSHYL NNSNRYLNQE LPKLEEYDSY WWLGGLIVCF LLTLIVTFFF 430 440 450 460 470 480 LGLLCGVFGY DKHATPTRRG CVSNTGGIFL MAGVGFGFLF CWILMILVVL TFVVGANVEK 490 500 510 520 530 540 LLCEPYENKK LLQVLDTPYL LKEQWQFYLS GMLFNNPDIN MTFEQVYRDC KRGRGIYAAF 550 560 570 580 590 600 QLENVVNVSD HFNIDQISEN INTELENLNV NIDSIELLDN TGRKSLEDFA HSGIDTIDYS 610 620 630 640 650 660 TYLKETEKSP TEVNLLTFAS TLEAKANQLP EGKPKQAFLL DVQNIRAIHQ HLLPPVQQSL 670 680 690 700 710 720 NTLRQSVWTL QQTSNKLPEK VKKILASLDS VQHFLTNNVS LIVIGETKKF GKTILGYFEH 730 740 750 760 770 780 YLHWVFYAIT EKMTSCKPMA TAMDSAVNGI LCGYVADPLN LFWFGIGKAT VLLLPAVIIA 790 800 IKLAKYYRRM DSEDVYDDSS VSGMWHFTL
	Isoform 6 (S6) [UniParc]. Checksum: E8425D90B970938A	FASTA	823	92,197
	10 20 30 40 50 60 MALVFSALLL LGLCGKISSE GQPAFHNTPG AMNYELPTTK YETQDTFNAG IVGPLYKMVH 70 80 90 100 110 120 IFLSVVQPND FPLDLIKKLI QNKKFDISVD SKEIALYEIG VLICAILGLL FIILMPLVGC 130 140 150 160 170 180 FFCMCRCCNK CGGEMHQRQK QNAPCRRKCL GLSLLVICLL MSLGIIYGFV ANQQTRTRIK 190 200 210 220 230 240 GTQKLAKSNF RDFQTLLTET PKQIDYVVEQ YTNTKNKAFS DLDGIGSVLG GRIKDQLKPK 250 260 270 280 290 300 VTPVLEEIKA MATAIKQTKD ALQNMSSSLK SLQDAATQLN TNLSSVRNSI ENSLSSSDCT 310 320 330 340 350 360 SDPASKICDS IRPSLSSLGS SLNSSQLPSV DRELNTVTEV DKTDLESLVK RGYTTIDEIP 370 380 390 400 410 420 NTIQNQTVDV IKDVKNTLDS ISSNIKDMSQ SIPIEDMLLQ VSHYLNNSNR YLNQELPKLE 430 440 450 460 470 480 EYDSYWWLGG LIVCFLLTLI VTFFFLGLLC GVFGYDKHAT PTRRGCVSNT GGIFLMAGVG 490 500 510 520 530 540 FGFLFCWILM ILVVLTFVVG ANVEKLLCEP YENKKLLQVL DTPYLLKEQW QFYLSGMLFN 550 560 570 580 590 600 NPDINMTFEQ VYRDCKRGRG IYAAFQLENV VNVSDHFNID QISENINTEL ENLNVNIDSI 610 620 630 640 650 660 ELLDNTGRKS LEDFAHSGID TIDYSTYLKE TEKSPTEVNL LTFASTLEAK ANQLPEGKPK 670 680 690 700 710 720 QAFLLDVQNI RAIHQHLLPP VQQSLNTLRQ SVWTLQQTSN KLPEKVKKIL ASLDSVQHFL 730 740 750 760 770 780 TNNVSLIVIG ETKKFGKTIL GYFEHYLHWV FYAITEKMTS CKPMATAMDS AVNGILCGYV 790 800 810 820 ADPLNLFWFG IGKATVLLLP AVIIAIKLAK YYRRMDSEDV YDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning." Miraglia S., Godfrey W., Yin A.H., Atkins K., Warnke R., Holden J.T., Bray R.A., Waller E.K., Buck D.W. Blood 90:5013-5021(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells." Weigmann A., Corbeil D., Hellwig A., Huttner W.B. Proc. Natl. Acad. Sci. U.S.A. 94:12425-12430(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Kidney.
[3]	"Identification of novel Prominin-1/CD133 splice variants with alternative C-termini and their expression in epididymis and testis." Fargeas C.A., Joester A., Missol-Kolka E., Hellwig A., Huttner W.B., Corbeil D. J. Cell Sci. 117:4301-4311(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5 AND 6). Strain: BALB/c. Tissue: Testis.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: C57BL/6J. Tissue: Testis.
[5]	"Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane." Roeper K., Corbeil D., Huttner W.B. Nat. Cell Biol. 2:582-592(2000) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, CHOLESTEROL BINDING.
[6]	"Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins." Fargeas C.A., Florek M., Huttner W.B., Corbeil D. J. Biol. Chem. 278:8586-8596(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[7]	"Nomenclature of prominin-1 (CD133) splice variants - an update." Fargeas C.A., Huttner W.B., Corbeil D. Tissue Antigens 69:602-606(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE OF ISOFORMS.
[8]	"Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine." Florek M., Bauer N., Janich P., Wilsch-Braeuninger M., Fargeas C.A., Marzesco A.-M., Ehninger G., Thiele C., Huttner W.B., Corbeil D. Cell Tissue Res. 328:31-47(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"Differential expression of prominin-1 (CD133) and prominin-2 in major cephalic exocrine glands of adult mice." Jaszai J., Janich P., Farkas L.M., Fargeas C.A., Huttner W.B., Corbeil D. Histochem. Cell Biol. 128:409-419(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[10]	"Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1." Dubreuil V., Marzesco A.M., Corbeil D., Huttner W.B., Wilsch-Braeuninger M. J. Cell Biol. 176:483-495(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[11]	"Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice." Yang Z., Chen Y., Lillo C., Chien J., Yu Z., Michaelides M., Klein M., Howes K.A., Li Y., Kaminoh Y., Chen H., Zhao C., Chen Y., Al-Sheikh Y.T., Karan G., Corbeil D., Escher P., Kamaya S. , Li C., Johnson S., Frederick J.M., Zhao Y., Wang C., Cameron D.J., Huttner W.B., Schorderet D.F., Munier F.L., Moore A.T., Birch D.G., Baehr W., Hunt D.M., Williams D.S., Zhang K. J. Clin. Invest. 118:2908-2916(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[12]	"Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration." Zacchigna S., Oh H., Wilsch-Brauninger M., Missol-Kolka E., Jaszai J., Jansen S., Tanimoto N., Tonagel F., Seeliger M., Huttner W.B., Corbeil D., Dewerchin M., Vinckier S., Moons L., Carmeliet P. J. Neurosci. 29:2297-2308(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[13]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-273; ASN-291 AND ASN-374, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF039663 mRNA. Translation: AAB96916.1. AF026269 mRNA. Translation: AAB86715.1. AF305215 mRNA. Translation: AAO11840.1. AY099088 mRNA. Translation: AAM28245.1. AY223521 mRNA. Translation: AAO72429.1. AY223522 mRNA. Translation: AAO72430.1. AK030027 mRNA. Translation: BAC26745.1.
IPI	IPI00120066. IPI00621410. IPI00944056. IPI00944196. IPI00971271. IPI00971282.
PIR	T08881.
RefSeq	NP_001157050.1. NM_001163578.1. NP_001157053.1. NM_001163581.1. NP_001157054.1. NM_001163582.1. NP_001157055.1. NM_001163583.1.
UniGene	Mm.6250.
3D structure databases
ProteinModelPortal	O54990.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000073751.
PTM databases
PhosphoSite	O54990.
Proteomic databases
PaxDb	O54990.
PRIDE	O54990.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030973; ENSMUSP00000030973; ENSMUSG00000029086. ENSMUST00000087442; ENSMUSP00000084709; ENSMUSG00000029086.
GeneID	19126.
KEGG	mmu:19126.
UCSC	uc008xig.2. mouse.
Organism-specific databases
CTD	8842.
MGI	MGI:1100886. Prom1.
Phylogenomic databases
eggNOG	NOG322325.
GeneTree	ENSGT00530000063586.
HOGENOM	HOG000115704.
HOVERGEN	HBG053690.
InParanoid	O54990.
KO	K06532.
OrthoDB	EOG4HHP1Q.
Gene expression databases
ArrayExpress	O54990.
Bgee	O54990.
CleanEx	MM_PROM1.
Genevestigator	O54990.
GermOnline	ENSMUSG00000029086. Mus musculus.
Family and domain databases
InterPro	IPR008795. Prominin. [Graphical view]
PANTHER	PTHR22730. PTHR22730. 1 hit.
Pfam	PF05478. Prominin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	295734.
SOURCE	Search...

Entry information

Entry name

PROM1_MOUSE

Accession

Primary (citable) accession number: O54990
Secondary accession number(s): O35408 , Q80XB2, Q80XB3, Q80XB6, Q8BH12

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program