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O54983

- CRYM_MOUSE

UniProt

O54983 - CRYM_MOUSE

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Protein

Ketimine reductase mu-crystallin

Gene

Crym

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors By similarity.By similarity

Catalytic activityi

Thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H.

Cofactori

NAD or NADP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671NADPBy similarity
Binding sitei168 – 1681NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1476NADPBy similarity

GO - Molecular functioni

  1. hormone binding Source: MGI
  2. NADP binding Source: Ensembl
  3. thiomorpholine-carboxylate dehydrogenase activity Source: UniProtKB-EC
  4. thyroid hormone binding Source: Ensembl
  5. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. sensory perception of sound Source: Ensembl
  3. thyroid hormone metabolic process Source: MGI
  4. thyroid hormone transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ketimine reductase mu-crystallin (EC:1.5.1.25)
Alternative name(s):
NADP-regulated thyroid-hormone-binding protein
Gene namesi
Name:Crym
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:102675. Crym.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrion Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Ketimine reductase mu-crystallinPRO_0000200679Add
BLAST

Proteomic databases

MaxQBiO54983.
PaxDbiO54983.
PRIDEiO54983.

PTM databases

PhosphoSiteiO54983.

Expressioni

Gene expression databases

BgeeiO54983.
CleanExiMM_CRYM.
ExpressionAtlasiO54983. baseline and differential.
GenevestigatoriO54983.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiO54983. 3 interactions.
MINTiMINT-4092055.
STRINGi10090.ENSMUSP00000033198.

Structurei

Secondary structure

1
313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83
Helixi10 – 156
Helixi20 – 3516
Helixi37 – 404
Beta strandi48 – 525
Helixi53 – 553
Beta strandi57 – 6610
Turni67 – 704
Beta strandi71 – 8010
Beta strandi91 – 988
Turni100 – 1023
Beta strandi105 – 1117
Helixi112 – 13019
Beta strandi137 – 1415
Helixi145 – 15713
Beta strandi161 – 1666
Helixi170 – 17910
Beta strandi180 – 1823
Beta strandi184 – 1863
Helixi190 – 1945
Beta strandi198 – 2025
Helixi213 – 2153
Beta strandi221 – 2244
Helixi237 – 2426
Beta strandi243 – 2486
Helixi250 – 2567
Helixi258 – 2636
Helixi271 – 2755
Beta strandi287 – 2904
Helixi295 – 31117

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BV8X-ray2.30A/B1-313[»]
4BV9X-ray2.19A/B1-313[»]
4BVAX-ray1.75A/B1-313[»]
ProteinModelPortaliO54983.
SMRiO54983. Positions 2-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ornithine cyclodeaminase family.Curated

Phylogenomic databases

eggNOGiCOG2423.
HOGENOMiHOG000137263.
HOVERGENiHBG005408.
InParanoidiO54983.
KOiK18258.
OMAiFANEFED.
OrthoDBiEOG7S7SFB.
PhylomeDBiO54983.
TreeFamiTF105309.

Family and domain databases

Gene3Di3.30.1780.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003462. ODC_Mu_crystall.
IPR023401. ODC_N.
[Graphical view]
PfamiPF02423. OCD_Mu_crystall. 1 hit.
[Graphical view]
PIRSFiPIRSF001439. CryM. 1 hit.

Sequencei

Sequence statusi: Complete.

O54983-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRAPAFLSA EEVQDHLRSS SLLIPPLEAA LANFSKGPDG GVMQPVRTVV
60 70 80 90 100
PVAKHRGFLG VMPAYSAAED ALTTKLVTFY EGHSNTAVPS HQASVLLFDP
110 120 130 140 150
SNGSLLAVMD GNVITAKRTA AVSAIATKLL KPPGSDVLCI LGAGVQAYSH
160 170 180 190 200
YEIFTEQFSF KEVRMWNRTR ENAEKFASTV QGDVRVCSSV QEAVTGADVI
210 220 230 240 250
ITVTMATEPI LFGEWVKPGA HINAVGASRP DWRELDDELM RQAVLYVDSR
260 270 280 290 300
EAALKESGDV LLSGADIFAE LGEVISGAKP AHCEKTTVFK SLGMAVEDLV
310
AAKLVYDSWS SGK
Length:313
Mass (Da):33,523
Last modified:June 1, 1998 - v1
Checksum:i0898EDA9E2D34C83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039391 mRNA. Translation: AAB94770.1.
BC045159 mRNA. Translation: AAH45159.1.
CCDSiCCDS21794.1.
RefSeqiNP_057878.1. NM_016669.1.
UniGeneiMm.9114.

Genome annotation databases

EnsembliENSMUST00000033198; ENSMUSP00000033198; ENSMUSG00000030905.
GeneIDi12971.
KEGGimmu:12971.
UCSCiuc009jmk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039391 mRNA. Translation: AAB94770.1 .
BC045159 mRNA. Translation: AAH45159.1 .
CCDSi CCDS21794.1.
RefSeqi NP_057878.1. NM_016669.1.
UniGenei Mm.9114.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BV8 X-ray 2.30 A/B 1-313 [» ]
4BV9 X-ray 2.19 A/B 1-313 [» ]
4BVA X-ray 1.75 A/B 1-313 [» ]
ProteinModelPortali O54983.
SMRi O54983. Positions 2-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O54983. 3 interactions.
MINTi MINT-4092055.
STRINGi 10090.ENSMUSP00000033198.

PTM databases

PhosphoSitei O54983.

Proteomic databases

MaxQBi O54983.
PaxDbi O54983.
PRIDEi O54983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033198 ; ENSMUSP00000033198 ; ENSMUSG00000030905 .
GeneIDi 12971.
KEGGi mmu:12971.
UCSCi uc009jmk.1. mouse.

Organism-specific databases

CTDi 1428.
MGIi MGI:102675. Crym.

Phylogenomic databases

eggNOGi COG2423.
HOGENOMi HOG000137263.
HOVERGENi HBG005408.
InParanoidi O54983.
KOi K18258.
OMAi FANEFED.
OrthoDBi EOG7S7SFB.
PhylomeDBi O54983.
TreeFami TF105309.

Miscellaneous databases

ChiTaRSi CRYM. mouse.
NextBioi 282732.
PROi O54983.
SOURCEi Search...

Gene expression databases

Bgeei O54983.
CleanExi MM_CRYM.
ExpressionAtlasi O54983. baseline and differential.
Genevestigatori O54983.

Family and domain databases

Gene3Di 3.30.1780.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR016040. NAD(P)-bd_dom.
IPR003462. ODC_Mu_crystall.
IPR023401. ODC_N.
[Graphical view ]
Pfami PF02423. OCD_Mu_crystall. 1 hit.
[Graphical view ]
PIRSFi PIRSF001439. CryM. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Sperbeck S.J., Segovia L., Wistow G.J.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 4-18; 37-47; 119-128 AND 176-185, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCRYM_MOUSE
AccessioniPrimary (citable) accession number: O54983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3