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Protein

Galectin-7

Gene

Lgals7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Gene namesi
Name:Lgals7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1316742. Lgals7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769411 – 136Galectin-7Add BLAST136

Proteomic databases

MaxQBiO54974.
PeptideAtlasiO54974.
PRIDEiO54974.

PTM databases

PhosphoSitePlusiO54974.

Expressioni

Gene expression databases

CleanExiMM_LGALS7.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO54974.
SMRiO54974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 136GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 76Beta-galactoside bindingSequence analysis7

Phylogenomic databases

HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiO54974.
PhylomeDBiO54974.

Family and domain databases

CDDicd00070. GLECT. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
PANTHERiPTHR11346:SF107. PTHR11346:SF107. 1 hit.
PfamiView protein in Pfam
PF00337. Gal-bind_lectin. 1 hit.
SMARTiView protein in SMART
SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51304. GALECTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

O54974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATHHKTSL PQGVRVGTVM RIRGLVPDQA GRFHVNLLCG EEQGADAALH
60 70 80 90 100
FNPRLDTSEV VFNTKQQGKW GREERGTGIP FQRGQPFEVL LIATEEGFKA
110 120 130
VVGDDEYLHF HHRLPPARVR LVEVGGDVQL HSLNIF
Length:136
Mass (Da):15,173
Last modified:January 23, 2007 - v3
Checksum:i24E105BBF333692A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038562 mRNA. Translation: AAB92566.1.
UniGeneiMm.20973.

Similar proteinsi

Entry informationi

Entry nameiLEG7_MOUSE
AccessioniPrimary (citable) accession number: O54974
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot