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Protein

Galectin-7

Gene

Lgals7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Gene namesi
Name:Lgals7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1316742. Lgals7.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Secreted By similarity

  • Note: May be secreted by a non-classical secretory pathway.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Galectin-7PRO_0000076941Add
BLAST

Proteomic databases

MaxQBiO54974.
PRIDEiO54974.

PTM databases

PhosphoSiteiO54974.

Expressioni

Gene expression databases

CleanExiMM_LGALS7.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO54974.
SMRiO54974. Positions 6-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 136131GalectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 767Beta-galactoside bindingSequence analysis

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiO54974.
PhylomeDBiO54974.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF107. PTHR11346:SF107. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATHHKTSL PQGVRVGTVM RIRGLVPDQA GRFHVNLLCG EEQGADAALH
60 70 80 90 100
FNPRLDTSEV VFNTKQQGKW GREERGTGIP FQRGQPFEVL LIATEEGFKA
110 120 130
VVGDDEYLHF HHRLPPARVR LVEVGGDVQL HSLNIF
Length:136
Mass (Da):15,173
Last modified:January 23, 2007 - v3
Checksum:i24E105BBF333692A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038562 mRNA. Translation: AAB92566.1.
UniGeneiMm.20973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038562 mRNA. Translation: AAB92566.1.
UniGeneiMm.20973.

3D structure databases

ProteinModelPortaliO54974.
SMRiO54974. Positions 6-136.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO54974.

Proteomic databases

MaxQBiO54974.
PRIDEiO54974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1316742. Lgals7.

Phylogenomic databases

HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiO54974.
PhylomeDBiO54974.

Miscellaneous databases

ChiTaRSiLgals7. mouse.
PROiO54974.
SOURCEiSearch...

Gene expression databases

CleanExiMM_LGALS7.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF107. PTHR11346:SF107. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Galectin-7, a marker of all types of stratified epithelia."
    Magnaldo T., Fowlis D., Darmon M.
    Differentiation 63:159-168(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiLEG7_MOUSE
AccessioniPrimary (citable) accession number: O54974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.