Reviewed, UniProtKB/Swiss-Prot O54967 (ACK1_MOUSE)

Names and origin

Protein names

Recommended name:
    Activated CDC42 kinase 1
      Short name=ACK-1
    EC=2.7.10.2
Alternative name(s):
    Non-receptor protein tyrosine kinase Ack
    Tyrosine kinase non-receptor protein 2

Gene names

Name:	Tnk2
Synonyms:	Ack1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1055 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development. Ref.8
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Cofactor	Magnesium.
Enzyme regulation	The SH3 domain appears to play an autoinhibitory role.
Subunit structure	Interacts with CDC42. Interacts with activated CSPG4 By similarity.
Subcellular location	Cell membrane. Ref.1
Tissue specificity	Ubiquitously present in all tisssues tested. Highly expressed in the hippocampus, neocortex, and cerebellum, both at dendritic spines and presynaptic axon terminals. Levels are strongly up-regulated by increased neural activity. Ref.1 Ref.5
Developmental stage	Highly expressed at E14-E16 in the forebrain, in the proliferative ventricular zone of the neocortex and hippocampus, and in the cortical and hippocampal plates. Also observed in the septal area, the ganglionic eminence, and in the dorsal thalamus and hypothalamus. In the hindbrain, expressed in many nuclei in the brain stem and in the cerebellar anlage, external granule cell layer, in Purkinje cells and the deep cerebellar nuclei. Ref.5
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 CRIB domain. Contains 1 protein kinase domain. Contains 1 SH3 domain.
Sequence caution	The sequence AAH31168.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	SH3 domain
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	axon Ref.5 Inferred from direct assay. Source: MGI cell soma Ref.5 Inferred from direct assay. Source: MGI dendrite Ref.5 Inferred from direct assay. Source: MGI growth cone Ref.5 Inferred from direct assay. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC protein binding Ref.5 Inferred from physical interaction. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O54967-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: O54967-2)

The sequence of this isoform differs from the canonical sequence as follows:
     515-531: REPPPRPPQPAIFTQKT → KP
     980-1011: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O54967-3)

The sequence of this isoform differs from the canonical sequence as follows:
     515-531: REPPPRPPQPAIFTQKT → KP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1055	1055	Activated CDC42 kinase 1		PRO_0000088059
Regions
	Domain	126 – 385	260	Protein kinase
	Domain	386 – 448	63	SH3
	Domain	454 – 466	13	CRIB
	Nucleotide binding	132 – 140	9	ATP By similarity
	Compositional bias	517 – 950	434	Pro-rich
Sites
	Active site	252	1	Proton acceptor By similarity
	Binding site	158	1	ATP
Amino acid modifications
	Modified residue	284	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	533	1	Phosphotyrosine Ref.7
	Modified residue	800	1	Phosphoserine By similarity
	Modified residue	842	1	Phosphotyrosine By similarity
	Modified residue	874	1	Phosphotyrosine Ref.7
	Modified residue	875	1	Phosphotyrosine By similarity
	Modified residue	896	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	515 – 531	17	REPPP…FTQKT → KP in isoform 2 and isoform 3.		VSP_008657
	Alternative sequence	980 – 1011	32	Missing in isoform 2.		VSP_008658
Experimental info
	Mutagenesis	158	1	K → A: Loss of kinase activity. Ref.1
	Mutagenesis	424	1	W → K: Increase in autophosphorylation activity. Ref.1
	Mutagenesis	464	1	H → D: Loss of CDC42-binding and impairment of autophosphorylation. Ref.1
	Sequence conflict	57 – 58	2	RR → SG in AAC04786. Ref.2
	Sequence conflict	531	1	T → P in ABG46266. Ref.1
	Sequence conflict	574	1	K → E in ABG46266. Ref.1
	Sequence conflict	649	1	A → V in AAC04786. Ref.2
	Sequence conflict	818	1	L → V in BAC40063. Ref.3
	Sequence conflict	955	1	A → T in AAH52421. Ref.2
	Sequence conflict	955	1	A → T in BAC40063. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 4A029C67C350B89A	FASTA	1,055	116,975
	10 20 30 40 50 60 MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG MGRPGQRRLW 70 80 90 100 110 120 EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP SQHSQSTFRK PSPTPGSLPG EGTLQSLTCL 130 140 150 160 170 180 IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 190 200 210 220 230 240 MHSLDHRNLI RLYGVVLTLP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 250 260 270 280 290 300 AYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 310 320 330 340 350 360 SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 370 380 390 400 410 420 YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 430 440 450 460 470 480 ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 490 500 510 520 530 540 RIDELYLGNP MDPPDLLSVE LSTSRPTQHL GRVKREPPPR PPQPAIFTQK TTYDPVSEDP 550 560 570 580 590 600 DPLSSDFKRL GLRKPALPRG LWLAKPSARV PGTKADRSSG GEVTLIDFGE EPVVPTPRPC 610 620 630 640 650 660 APSLAQLAMD ACSLLDKTPP QSPTRALPRP LHPTPVVDWD ARPLPPPPAY DDVAQDEDDF 670 680 690 700 710 720 EVCSINSTLV GAGLPAGPSQ GETNYAFVPE QAQMPPALED NLFLPPQGGG KPPSSVQTAE 730 740 750 760 770 780 IFQALQQECM RQLQVPTGQL TPSPTPGGDD KPQVPPRVPI PPRPTRPRVE LSPAPSGEEE 790 800 810 820 830 840 TSRWPGPASP PRVPPREPLS PQGSRTPSPL VPPGSSPLPH RLSSSPGKTM PTTQSFASDP 850 860 870 880 890 900 KYATPQVIQA PGPRAGPCIL PIVRDGRKVS STHYYLLPER PPYLERYQRF LREAQSPEEP 910 920 930 940 950 960 AALPVPPLLP PPSTPAPAAP TATVRPMPQA APDPKANFST NNSNPGARPP SLRAAARLPQ 970 980 990 1000 1010 1020 RGCPGDGQEA ARPADKVQML QAMVHGVTTE ECQAALQSHS WSVQRAAQYL KVEQLFGLGL 1030 1040 1050 RPRVECHKVL EMFDWNLEQA GCHLLGSCGP AHHKR
	Isoform 2. Checksum: 09718C0B88D4F2D1	FASTA	1,008	111,704
	10 20 30 40 50 60 MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG MGRPGQRRLW 70 80 90 100 110 120 EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP SQHSQSTFRK PSPTPGSLPG EGTLQSLTCL 130 140 150 160 170 180 IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 190 200 210 220 230 240 MHSLDHRNLI RLYGVVLTLP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 250 260 270 280 290 300 AYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 310 320 330 340 350 360 SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 370 380 390 400 410 420 YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 430 440 450 460 470 480 ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 490 500 510 520 530 540 RIDELYLGNP MDPPDLLSVE LSTSRPTQHL GRVKKPTYDP VSEDPDPLSS DFKRLGLRKP 550 560 570 580 590 600 ALPRGLWLAK PSARVPGTKA DRSSGGEVTL IDFGEEPVVP TPRPCAPSLA QLAMDACSLL 610 620 630 640 650 660 DKTPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEVCSI NSTLVGAGLP 670 680 690 700 710 720 AGPSQGETNY AFVPEQAQMP PALEDNLFLP PQGGGKPPSS VQTAEIFQAL QQECMRQLQV 730 740 750 760 770 780 PTGQLTPSPT PGGDDKPQVP PRVPIPPRPT RPRVELSPAP SGEEETSRWP GPASPPRVPP 790 800 810 820 830 840 REPLSPQGSR TPSPLVPPGS SPLPHRLSSS PGKTMPTTQS FASDPKYATP QVIQAPGPRA 850 860 870 880 890 900 GPCILPIVRD GRKVSSTHYY LLPERPPYLE RYQRFLREAQ SPEEPAALPV PPLLPPPSTP 910 920 930 940 950 960 APAAPTATVR PMPQAAPDPK ANFSTNNSNP GARPPSLRAA ARLPQRGCPG DGQEAARPAD 970 980 990 1000 KVQMVEQLFG LGLRPRVECH KVLEMFDWNL EQAGCHLLGS CGPAHHKR
	Isoform 3. Checksum: A2401DAFB05715E0	FASTA	1,040	115,258
	10 20 30 40 50 60 MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG MGRPGQRRLW 70 80 90 100 110 120 EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP SQHSQSTFRK PSPTPGSLPG EGTLQSLTCL 130 140 150 160 170 180 IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 190 200 210 220 230 240 MHSLDHRNLI RLYGVVLTLP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 250 260 270 280 290 300 AYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 310 320 330 340 350 360 SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 370 380 390 400 410 420 YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 430 440 450 460 470 480 ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 490 500 510 520 530 540 RIDELYLGNP MDPPDLLSVE LSTSRPTQHL GRVKKPTYDP VSEDPDPLSS DFKRLGLRKP 550 560 570 580 590 600 ALPRGLWLAK PSARVPGTKA DRSSGGEVTL IDFGEEPVVP TPRPCAPSLA QLAMDACSLL 610 620 630 640 650 660 DKTPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEVCSI NSTLVGAGLP 670 680 690 700 710 720 AGPSQGETNY AFVPEQAQMP PALEDNLFLP PQGGGKPPSS VQTAEIFQAL QQECMRQLQV 730 740 750 760 770 780 PTGQLTPSPT PGGDDKPQVP PRVPIPPRPT RPRVELSPAP SGEEETSRWP GPASPPRVPP 790 800 810 820 830 840 REPLSPQGSR TPSPLVPPGS SPLPHRLSSS PGKTMPTTQS FASDPKYATP QVIQAPGPRA 850 860 870 880 890 900 GPCILPIVRD GRKVSSTHYY LLPERPPYLE RYQRFLREAQ SPEEPAALPV PPLLPPPSTP 910 920 930 940 950 960 APAAPTATVR PMPQAAPDPK ANFSTNNSNP GARPPSLRAA ARLPQRGCPG DGQEAARPAD 970 980 990 1000 1010 1020 KVQMLQAMVH GVTTEECQAA LQSHSWSVQR AAQYLKVEQL FGLGLRPRVE CHKVLEMFDW 1030 1040 NLEQAGCHLL GSCGPAHHKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli." Galisteo M.L., Yang Y., Urena J., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 103:9796-9801(2006) [PubMed: 16777958] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-158; TRP-424 AND HIS-464.
[2]	"The protein tyrosine kinase Ack is associated with and activated in vivo by CDC42Hs." Her J.-H., Bolen J.B. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6. Tissue: Brain and Colon.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 121-1055 (ISOFORM 3). Strain: NOD. Tissue: Thymus.
[5]	"Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain." Urena J.M., La Torre A., Martinez A., Lowenstein E., Franco N., Winsky-Sommerer R., Fontana X., Casaroli-Marano R., Ibanez-Sabio M.A., Pascual M., Del Rio J.A., de Lecea L., Soriano E. J. Comp. Neurol. 490:119-132(2005) [PubMed: 16052498] [Abstract] Cited for: INTERACTION WITH CDC42, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[6]	"Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M. Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007) [PubMed: 17389395] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-284, MASS SPECTROMETRY.
[7]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-533 AND TYR-874, MASS SPECTROMETRY. Tissue: Brain.
[8]	"Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation." Shen F., Lin Q., Gu Y., Childress C., Yang W. Mol. Biol. Cell 18:732-742(2007) [PubMed: 17182860] [Abstract] Cited for: FUNCTION, INTERACTION WITH UBA.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ666696 mRNA. Translation: ABG46266.1. AF037260 mRNA. Translation: AAC04786.1. BC031168 mRNA. Translation: AAH31168.1. Sequence problems. BC052421 mRNA. Translation: AAH52421.1. AK087965 mRNA. Translation: BAC40063.1.
IPI	IPI00119965. IPI00856878. IPI00874745.
RefSeq	NP_001103617.1. NP_058068.2.
UniGene	Mm.251115
3D structure databases
HSSP	HSSP built from PDB template 1CF4 based on UniProtKB Q07912.
SMR	O54967. Positions 117-390.
ModBase	Search...
PTM databases
PhosphoSite	O54967.
Genome annotation databases
Ensembl	ENSMUSG00000022791. Mus musculus. [Contig view]
GeneID	51789.
KEGG	mmu:51789.
Organism-specific databases
MGI	MGI:1858308. Tnk2.
Phylogenomic databases
HOGENOM	O54967.
HOVERGEN	O54967.
Enzyme and pathway databases
BRENDA	2.7.10.2. 244.
Gene expression databases
ArrayExpress	O54967.
Bgee	O54967.
CleanEx	MM_TNK2.
Family and domain databases
InterPro	IPR015779. ACK_tyr_kin_N. IPR015116. GTPase_binding. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001452. SH3_domain. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR000449. UBA/transl_elong_EF1B_N. [Graphical view]
PANTHER	PTHR23256:SF265. ACK_tyr_kin_N. 1 hit.
Pfam	PF09027. GTPase_binding. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF00018. SH3_1. 1 hit. PF00627. UBA. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS50108. CRIB. False negative. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	308016.
SOURCE	Search...

Entry information

Entry name

ACK1_MOUSE

Accession

Primary (citable) accession number: O54967
Secondary accession number(s): Q0Z844, Q8C2U0, Q8K0K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	December 4, 2007
Last modified:	June 16, 2009
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)