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O54956

- DPOE2_MOUSE

UniProt

O54956 - DPOE2_MOUSE

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Protein
DNA polymerase epsilon subunit 2
Gene
Pole2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in DNA repair and in chromosomal DNA replication.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_224446. Telomere C-strand synthesis initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase epsilon subunit 2 (EC:2.7.7.7)
    Alternative name(s):
    DNA polymerase II subunit 2
    DNA polymerase epsilon subunit B
    Gene namesi
    Name:Pole2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1197514. Pole2.

    Subcellular locationi

    GO - Cellular componenti

    1. epsilon DNA polymerase complex Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527DNA polymerase epsilon subunit 2
    PRO_0000071563Add
    BLAST

    Proteomic databases

    PaxDbiO54956.
    PRIDEiO54956.

    PTM databases

    PhosphoSiteiO54956.

    Expressioni

    Gene expression databases

    BgeeiO54956.
    GenevestigatoriO54956.

    Interactioni

    Subunit structurei

    Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4.

    Structurei

    3D structure databases

    ProteinModelPortaliO54956.
    SMRiO54956. Positions 1-75.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG311342.
    GeneTreeiENSGT00390000012435.
    HOGENOMiHOG000265254.
    HOVERGENiHBG061290.
    InParanoidiO54956.
    KOiK02325.
    OMAiILQQRTH.
    OrthoDBiEOG725DH7.
    PhylomeDBiO54956.
    TreeFamiTF103007.

    Family and domain databases

    InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
    IPR016266. DNA_pol_e_bsu.
    IPR024639. DNA_pol_e_bsu_N.
    [Graphical view]
    PfamiPF04042. DNA_pol_E_B. 1 hit.
    PF12213. Dpoe2NT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000799. DNA_pol_eps_2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O54956-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPERLRSRT VSAFKLRGLL LRSEATKYLT EALQSVTELE LEENLGKIID    50
    AVEKQPLSSN MIERSVVEAA VQECSQSMDE TIEHVFNIIG AFDIPRFIYN 100
    SERKKFLPLS MTNHAAPTLF GTARDKAELY LERYTILHQR THRHELFTPP 150
    VIGSHLEESG SKFQLKTIET LLGSTSKVGD VIVLGMITQL KEGKFFLEDP 200
    TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHANAF GFPPTEPSST 250
    TRAYYGNINF FGGPSNASVK TYTKLRQLED ENKDAMFVIV SDVWLDQVQV 300
    LEKFHVMFSG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKSLADIIC 350
    EYPSIHQSSR FVFVPGPEDP GFGSILPRPP LAESITQEFR QRVPFSVFTT 400
    NPCRIQYCTQ EIIIFREDLV NKMCRNCVRF PSSSLDIPTH FVKTILSQGH 450
    LAPLPLYVCP VHWAYDYTLR VYPVPDLLVI ADKYDPFTVT NTDCLCINPG 500
    SFPRSGFAFK VFYPSSKTVE DSKLQGF 527
    Length:527
    Mass (Da):59,387
    Last modified:August 30, 2005 - v2
    Checksum:i82940B0FD1584350
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781M → V in AAH63772. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077592 mRNA. Translation: BAC36883.1.
    BC063772 mRNA. Translation: AAH63772.1.
    AF036898 mRNA. Translation: AAC40045.1.
    CCDSiCCDS36463.1.
    RefSeqiNP_035263.1. NM_011133.2.
    UniGeneiMm.9199.

    Genome annotation databases

    EnsembliENSMUST00000021359; ENSMUSP00000021359; ENSMUSG00000020974.
    GeneIDi18974.
    KEGGimmu:18974.
    UCSCiuc007nrv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK077592 mRNA. Translation: BAC36883.1 .
    BC063772 mRNA. Translation: AAH63772.1 .
    AF036898 mRNA. Translation: AAC40045.1 .
    CCDSi CCDS36463.1.
    RefSeqi NP_035263.1. NM_011133.2.
    UniGenei Mm.9199.

    3D structure databases

    ProteinModelPortali O54956.
    SMRi O54956. Positions 1-75.
    ModBasei Search...

    PTM databases

    PhosphoSitei O54956.

    Proteomic databases

    PaxDbi O54956.
    PRIDEi O54956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021359 ; ENSMUSP00000021359 ; ENSMUSG00000020974 .
    GeneIDi 18974.
    KEGGi mmu:18974.
    UCSCi uc007nrv.1. mouse.

    Organism-specific databases

    CTDi 5427.
    MGIi MGI:1197514. Pole2.

    Phylogenomic databases

    eggNOGi NOG311342.
    GeneTreei ENSGT00390000012435.
    HOGENOMi HOG000265254.
    HOVERGENi HBG061290.
    InParanoidi O54956.
    KOi K02325.
    OMAi ILQQRTH.
    OrthoDBi EOG725DH7.
    PhylomeDBi O54956.
    TreeFami TF103007.

    Enzyme and pathway databases

    Reactomei REACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_224446. Telomere C-strand synthesis initiation.

    Miscellaneous databases

    NextBioi 295332.
    PROi O54956.
    SOURCEi Search...

    Gene expression databases

    Bgeei O54956.
    Genevestigatori O54956.

    Family and domain databases

    InterProi IPR007185. DNA_pol_alpha/epsilon_bsu.
    IPR016266. DNA_pol_e_bsu.
    IPR024639. DNA_pol_e_bsu_N.
    [Graphical view ]
    Pfami PF04042. DNA_pol_E_B. 1 hit.
    PF12213. Dpoe2NT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000799. DNA_pol_eps_2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Jaw.
    3. "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon."
      Jokela M., Makiniemi M., Lehtonen S., Szpirer C., Hellman U., Syvaeoja J.E.
      Nucleic Acids Res. 26:730-734(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-527.

    Entry informationi

    Entry nameiDPOE2_MOUSE
    AccessioniPrimary (citable) accession number: O54956
    Secondary accession number(s): Q6P3Y7, Q8BP72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 30, 2005
    Last modified: September 3, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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