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Protein

DNA polymerase epsilon subunit 2

Gene

Pole2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in DNA repair and in chromosomal DNA replication.

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex
R-MMU-174430 Telomere C-strand synthesis initiation
R-MMU-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-68952 DNA replication initiation
R-MMU-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit 2 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit 2
DNA polymerase epsilon subunit B
Gene namesi
Name:Pole2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1197514 Pole2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000715631 – 527DNA polymerase epsilon subunit 2Add BLAST527

Proteomic databases

EPDiO54956
MaxQBiO54956
PaxDbiO54956
PeptideAtlasiO54956
PRIDEiO54956

PTM databases

PhosphoSitePlusiO54956

Expressioni

Gene expression databases

BgeeiENSMUSG00000020974
ExpressionAtlasiO54956 baseline and differential
GenevisibleiO54956 MM

Interactioni

Subunit structurei

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4.

Protein-protein interaction databases

CORUMiO54956
STRINGi10090.ENSMUSP00000021359

Structurei

3D structure databases

ProteinModelPortaliO54956
SMRiO54956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3818 Eukaryota
ENOG410XP7N LUCA
GeneTreeiENSGT00390000012435
HOGENOMiHOG000265254
HOVERGENiHBG061290
InParanoidiO54956
KOiK02325
OMAiPNHFVKT
OrthoDBiEOG091G05Q6
PhylomeDBiO54956
TreeFamiTF103007

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR024639 DNA_pol_e_bsu_N
IPR016266 POLE2
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF12213 Dpoe2NT, 1 hit
PIRSFiPIRSF000799 DNA_pol_eps_2, 1 hit

Sequencei

Sequence statusi: Complete.

O54956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPERLRSRT VSAFKLRGLL LRSEATKYLT EALQSVTELE LEENLGKIID
60 70 80 90 100
AVEKQPLSSN MIERSVVEAA VQECSQSMDE TIEHVFNIIG AFDIPRFIYN
110 120 130 140 150
SERKKFLPLS MTNHAAPTLF GTARDKAELY LERYTILHQR THRHELFTPP
160 170 180 190 200
VIGSHLEESG SKFQLKTIET LLGSTSKVGD VIVLGMITQL KEGKFFLEDP
210 220 230 240 250
TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHANAF GFPPTEPSST
260 270 280 290 300
TRAYYGNINF FGGPSNASVK TYTKLRQLED ENKDAMFVIV SDVWLDQVQV
310 320 330 340 350
LEKFHVMFSG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKSLADIIC
360 370 380 390 400
EYPSIHQSSR FVFVPGPEDP GFGSILPRPP LAESITQEFR QRVPFSVFTT
410 420 430 440 450
NPCRIQYCTQ EIIIFREDLV NKMCRNCVRF PSSSLDIPTH FVKTILSQGH
460 470 480 490 500
LAPLPLYVCP VHWAYDYTLR VYPVPDLLVI ADKYDPFTVT NTDCLCINPG
510 520
SFPRSGFAFK VFYPSSKTVE DSKLQGF
Length:527
Mass (Da):59,387
Last modified:August 30, 2005 - v2
Checksum:i82940B0FD1584350
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78M → V in AAH63772 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077592 mRNA Translation: BAC36883.1
BC063772 mRNA Translation: AAH63772.1
AF036898 mRNA Translation: AAC40045.1
CCDSiCCDS36463.1
RefSeqiNP_035263.1, NM_011133.2
UniGeneiMm.9199

Genome annotation databases

EnsembliENSMUST00000021359; ENSMUSP00000021359; ENSMUSG00000020974
GeneIDi18974
KEGGimmu:18974
UCSCiuc007nrv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDPOE2_MOUSE
AccessioniPrimary (citable) accession number: O54956
Secondary accession number(s): Q6P3Y7, Q8BP72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 30, 2005
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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