Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatitis A virus cellular receptor 1 homolog

Gene

Havcr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity).By similarity

GO - Biological processi

  • phagocytosis, engulfment Source: RGD
  • response to antibiotic Source: RGD
  • response to drug Source: RGD
  • response to mycotoxin Source: RGD
  • response to nutrient Source: RGD
  • response to testosterone Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatitis A virus cellular receptor 1 homolog
Short name:
HAVcr-1
Alternative name(s):
Kidney injury molecule 1
Short name:
KIM-1
T cell immunoglobulin and mucin domain-containing protein 1
Short name:
TIMD-1
Gene namesi
Name:Havcr1
Synonyms:Kim1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708425. Havcr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 235214ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 30751CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • phagocytic vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 307286Hepatitis A virus cellular receptor 1 homologPRO_0000014983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 108PROSITE-ProRule annotation
Disulfide bondi49 ↔ 60By similarity
Disulfide bondi55 ↔ 107By similarity
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54947.

Expressioni

Tissue specificityi

Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009573.

Structurei

3D structure databases

ProteinModelPortaliO54947.
SMRiO54947. Positions 19-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 124103Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi133 – 21078Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. TIM family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYS0. Eukaryota.
ENOG4111VB0. LUCA.
HOVERGENiHBG073424.
InParanoidiO54947.
PhylomeDBiO54947.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQLQVFISG LLLLLPGSVD SYEVVKGVVG HPVTIPCTYS TRGGITTTCW
60 70 80 90 100
GRGQCPYSSC QNILIWTNGY QVTYRSSGRY NIKGRISEGD VSLTIENSVD
110 120 130 140 150
SDSGLYCCRV EIPGWFNDQK MTFSLEVKPE IPTSPPTRPT TTRPTTTRPT
160 170 180 190 200
TISTRSTHVP TSTRVSTSTP TPEQTQTHKP EITTFYAHET TAEVTETPSY
210 220 230 240 250
TPADWNGTVT SSEEAWNNHT VRIPLRKPQR NPTKGFYVGM SVAALLLLLL
260 270 280 290 300
ASTVVVTRYI IIRKKMGSLS FVAFHVSKSR ALQNAAIVHP RAEDNIYIIE

DRSRGAE
Length:307
Mass (Da):33,964
Last modified:June 1, 1998 - v1
Checksum:i736D1DD1F1549760
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035963 mRNA. Translation: AAC53546.1.
BC061820 mRNA. Translation: AAH61820.1.
RefSeqiNP_775172.1. NM_173149.2.
UniGeneiRn.11154.

Genome annotation databases

GeneIDi286934.
KEGGirno:286934.
UCSCiRGD:708425. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035963 mRNA. Translation: AAC53546.1.
BC061820 mRNA. Translation: AAH61820.1.
RefSeqiNP_775172.1. NM_173149.2.
UniGeneiRn.11154.

3D structure databases

ProteinModelPortaliO54947.
SMRiO54947. Positions 19-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009573.

Proteomic databases

PaxDbiO54947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi286934.
KEGGirno:286934.
UCSCiRGD:708425. rat.

Organism-specific databases

CTDi26762.
RGDi708425. Havcr1.

Phylogenomic databases

eggNOGiENOG410IYS0. Eukaryota.
ENOG4111VB0. LUCA.
HOVERGENiHBG073424.
InParanoidiO54947.
PhylomeDBiO54947.

Miscellaneous databases

PROiO54947.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAVR1_RAT
AccessioniPrimary (citable) accession number: O54947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.