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Protein

Claudin-5

Gene

Cldn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-5
Alternative name(s):
Brain endothelial cell clone 1 protein
Lung-specific membrane protein
Gene namesi
Name:Cldn5
Synonyms:Bec1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1276112 Cldn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 160ExtracellularSequence analysisAdd BLAST16
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 218CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447461 – 218Claudin-5Add BLAST218

Proteomic databases

MaxQBiO54942
PaxDbiO54942
PRIDEiO54942

PTM databases

iPTMnetiO54942
PhosphoSitePlusiO54942

Expressioni

Tissue specificityi

Widely expressed with highest levels in the lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000041378
CleanExiMM_CLDN5
GenevisibleiO54942 MM

Interactioni

Subunit structurei

Interacts with MPDZ (By similarity). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiO54942
STRINGi10090.ENSMUSP00000041925

Structurei

3D structure databases

ProteinModelPortaliO54942
SMRiO54942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 218Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT1 Eukaryota
ENOG410Y9S8 LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiO54942
KOiK06087
OMAiCLVGWVG
OrthoDBiEOG091G0MMR
PhylomeDBiO54942
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003551 Claudin5
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01380 CLAUDIN5
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

O54942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAALEILG LVLCLVGWVG LILACGLPMW QVTAFLDHNI VTAQTTWKGL
60 70 80 90 100
WMSCVVQSTG HMQCKVYESV LALSAEVQAA RALTVGAVLL ALVALFVTLT
110 120 130 140 150
GAQCTTCVAP GPVKARVALT GGALYAVCGL LALVPLCWFA NIVVREFYDP
160 170 180 190 200
TVPVSQKYEL GAALYIGWAA SALLMCGGGL VCCGAWVCTG RPEFSFPVKY
210
SAPRRPTANG DYDKKNYV
Length:218
Mass (Da):23,054
Last modified:May 30, 2000 - v2
Checksum:i8708F69AE282DE87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → N in AAB96653 (PubMed:9520948).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035814 mRNA Translation: AAB96653.1
U82758 mRNA Translation: AAC27545.1
AF087823 mRNA Translation: AAD09758.1
AK077282 mRNA Translation: BAC36728.1
BC002016 mRNA Translation: AAH02016.1
BC083341 mRNA Translation: AAH83341.1
CCDSiCCDS28026.1
RefSeqiNP_038833.2, NM_013805.4
UniGeneiMm.22768

Genome annotation databases

EnsembliENSMUST00000043577; ENSMUSP00000041925; ENSMUSG00000041378
GeneIDi12741
KEGGimmu:12741
UCSCiuc007yok.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCLD5_MOUSE
AccessioniPrimary (citable) accession number: O54942
Secondary accession number(s): O88789
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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