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Protein

Claudin-5

Gene

Cldn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-5
Alternative name(s):
Brain endothelial cell clone 1 protein
Lung-specific membrane protein
Gene namesi
Name:Cldn5
Synonyms:Bec1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1276112. Cldn5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 160ExtracellularSequence analysisAdd BLAST16
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 218CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447461 – 218Claudin-5Add BLAST218

Proteomic databases

MaxQBiO54942.
PaxDbiO54942.
PRIDEiO54942.

PTM databases

iPTMnetiO54942.
PhosphoSitePlusiO54942.

Expressioni

Tissue specificityi

Widely expressed with highest levels in the lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000041378.
CleanExiMM_CLDN5.
GenevisibleiO54942. MM.

Interactioni

Subunit structurei

Interacts with MPDZ (By similarity). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-113259.
STRINGi10090.ENSMUSP00000041925.

Structurei

3D structure databases

ProteinModelPortaliO54942.
SMRiO54942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 218Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO54942.
KOiK06087.
OMAiLVCCGAW.
OrthoDBiEOG091G0MMR.
PhylomeDBiO54942.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAALEILG LVLCLVGWVG LILACGLPMW QVTAFLDHNI VTAQTTWKGL
60 70 80 90 100
WMSCVVQSTG HMQCKVYESV LALSAEVQAA RALTVGAVLL ALVALFVTLT
110 120 130 140 150
GAQCTTCVAP GPVKARVALT GGALYAVCGL LALVPLCWFA NIVVREFYDP
160 170 180 190 200
TVPVSQKYEL GAALYIGWAA SALLMCGGGL VCCGAWVCTG RPEFSFPVKY
210
SAPRRPTANG DYDKKNYV
Length:218
Mass (Da):23,054
Last modified:May 30, 2000 - v2
Checksum:i8708F69AE282DE87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → N in AAB96653 (PubMed:9520948).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035814 mRNA. Translation: AAB96653.1.
U82758 mRNA. Translation: AAC27545.1.
AF087823 mRNA. Translation: AAD09758.1.
AK077282 mRNA. Translation: BAC36728.1.
BC002016 mRNA. Translation: AAH02016.1.
BC083341 mRNA. Translation: AAH83341.1.
CCDSiCCDS28026.1.
RefSeqiNP_038833.2. NM_013805.4.
UniGeneiMm.22768.

Genome annotation databases

EnsembliENSMUST00000043577; ENSMUSP00000041925; ENSMUSG00000041378.
GeneIDi12741.
KEGGimmu:12741.
UCSCiuc007yok.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035814 mRNA. Translation: AAB96653.1.
U82758 mRNA. Translation: AAC27545.1.
AF087823 mRNA. Translation: AAD09758.1.
AK077282 mRNA. Translation: BAC36728.1.
BC002016 mRNA. Translation: AAH02016.1.
BC083341 mRNA. Translation: AAH83341.1.
CCDSiCCDS28026.1.
RefSeqiNP_038833.2. NM_013805.4.
UniGeneiMm.22768.

3D structure databases

ProteinModelPortaliO54942.
SMRiO54942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-113259.
STRINGi10090.ENSMUSP00000041925.

PTM databases

iPTMnetiO54942.
PhosphoSitePlusiO54942.

Proteomic databases

MaxQBiO54942.
PaxDbiO54942.
PRIDEiO54942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043577; ENSMUSP00000041925; ENSMUSG00000041378.
GeneIDi12741.
KEGGimmu:12741.
UCSCiuc007yok.2. mouse.

Organism-specific databases

CTDi7122.
MGIiMGI:1276112. Cldn5.

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO54942.
KOiK06087.
OMAiLVCCGAW.
OrthoDBiEOG091G0MMR.
PhylomeDBiO54942.
TreeFamiTF331936.

Miscellaneous databases

PROiO54942.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041378.
CleanExiMM_CLDN5.
GenevisibleiO54942. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD5_MOUSE
AccessioniPrimary (citable) accession number: O54942
Secondary accession number(s): O88789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.