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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Gene

Smarce1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi66 – 134HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Neurogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Alternative name(s):
BRG1-associated factor 57
Short name:
BAF57
Gene namesi
Name:Smarce1
Synonyms:Baf57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927347. Smarce1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • BAF-type complex Source: MGI
  • nBAF complex Source: UniProtKB
  • npBAF complex Source: UniProtKB
  • nuclear chromatin Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
  • SWI/SNF complex Source: MGI
  • transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485781 – 411SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Omega-N-methylarginineBy similarity1
Modified residuei40Omega-N-methylarginineBy similarity1
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei265PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by TRIP12, leading to its degradation by the proteasome. Ubiquitination is prevented upon interaction between TRIP12 and SMARCC1 (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO54941.
MaxQBiO54941.
PaxDbiO54941.
PeptideAtlasiO54941.
PRIDEiO54941.

PTM databases

iPTMnetiO54941.
PhosphoSitePlusiO54941.
SwissPalmiO54941.

Expressioni

Developmental stagei

Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000037935.
GenevisibleiO54941. MM.

Interactioni

Subunit structurei

Component of a number of multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II). Each of the complexes contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1 (SNF5/INI1). Other subunits specific to each of the complexes may also be present. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Also binds to the SRC/p160 family of histone acetyltransferases (HATs) composed of NCOA1, NCOA2, and NCOA3. NCOA3. Interacts with RCOR1/CoREST, NR3C1 and ZMIM2/ZIMP7. Interacts with BRDT (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208275. 19 interactors.
DIPiDIP-39985N.
IntActiO54941. 10 interactors.
MINTiMINT-1676035.
STRINGi10090.ENSMUSP00000099422.

Structurei

3D structure databases

ProteinModelPortaliO54941.
SMRiO54941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili222 – 319Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi320 – 411Glu-richAdd BLAST92

Domaini

The HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development.

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4715. Eukaryota.
ENOG410Y9B3. LUCA.
GeneTreeiENSGT00390000003628.
HOGENOMiHOG000230965.
HOVERGENiHBG054558.
InParanoidiO54941.
KOiK11651.
OMAiCISIEPA.
OrthoDBiEOG091G0ER1.
PhylomeDBiO54941.
TreeFamiTF321146.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR030089. BAF57.
IPR009071. HMG_box_dom.
[Graphical view]
PANTHERiPTHR13711:SF206. PTHR13711:SF206. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR
60 70 80 90 100
VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII
110 120 130 140 150
GGMWRDLTDE EKQEYLNEYE AEKIEYNESM KAYHNSPAYL AYINAKSRAE
160 170 180 190 200
AALEEESRQR QSRMEKGEPY MSIQPAEDPD DYDDGFSMKH TATARFQRNH
210 220 230 240 250
RLISEILSES VVPDVRSVVT TARMQVLKRQ VQSLMVHQRK LEAELLQIEE
260 270 280 290 300
RHQEKKRKFL ESTDSFNNEL KRLCGLKVEV DMEKIAAEIA QAEEQARKRQ
310 320 330 340 350
EEREKEAAEQ AERSQSSMAP EEEQVANKAE EKKDEESIPM ETEETHLEDT
360 370 380 390 400
AESQQNGEEG TSTPEDKESG QEGVDSMEVE GTSDSNTGSE SNSATVEEPP
410
TDPVPEDEKK E
Length:411
Mass (Da):46,638
Last modified:June 1, 1998 - v1
Checksum:i4099B333A0B63709
GO

Sequence cautioni

The sequence BAC36233 differs from that shown. Sequencing errors.Curated
The sequence BAC36233 differs from that shown. Reason: Frameshift at positions 184, 212, 255, 316 and 353.Curated
The sequence BAC36233 differs from that shown. Reason: Erroneous termination at position 408. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035263 Genomic DNA. Translation: AAC04510.1.
AK076177 mRNA. Translation: BAC36233.1. Sequence problems.
BC047141 mRNA. Translation: AAH47141.1.
BC061498 mRNA. Translation: AAH61498.1.
BC065043 mRNA. Translation: AAH65043.1.
CCDSiCCDS25374.1.
RefSeqiNP_065643.1. NM_020618.4.
UniGeneiMm.379086.
Mm.389717.

Genome annotation databases

EnsembliENSMUST00000103133; ENSMUSP00000099422; ENSMUSG00000037935.
GeneIDi57376.
KEGGimmu:57376.
UCSCiuc007lii.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035263 Genomic DNA. Translation: AAC04510.1.
AK076177 mRNA. Translation: BAC36233.1. Sequence problems.
BC047141 mRNA. Translation: AAH47141.1.
BC061498 mRNA. Translation: AAH61498.1.
BC065043 mRNA. Translation: AAH65043.1.
CCDSiCCDS25374.1.
RefSeqiNP_065643.1. NM_020618.4.
UniGeneiMm.379086.
Mm.389717.

3D structure databases

ProteinModelPortaliO54941.
SMRiO54941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208275. 19 interactors.
DIPiDIP-39985N.
IntActiO54941. 10 interactors.
MINTiMINT-1676035.
STRINGi10090.ENSMUSP00000099422.

PTM databases

iPTMnetiO54941.
PhosphoSitePlusiO54941.
SwissPalmiO54941.

Proteomic databases

EPDiO54941.
MaxQBiO54941.
PaxDbiO54941.
PeptideAtlasiO54941.
PRIDEiO54941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103133; ENSMUSP00000099422; ENSMUSG00000037935.
GeneIDi57376.
KEGGimmu:57376.
UCSCiuc007lii.1. mouse.

Organism-specific databases

CTDi6605.
MGIiMGI:1927347. Smarce1.

Phylogenomic databases

eggNOGiKOG4715. Eukaryota.
ENOG410Y9B3. LUCA.
GeneTreeiENSGT00390000003628.
HOGENOMiHOG000230965.
HOVERGENiHBG054558.
InParanoidiO54941.
KOiK11651.
OMAiCISIEPA.
OrthoDBiEOG091G0ER1.
PhylomeDBiO54941.
TreeFamiTF321146.

Enzyme and pathway databases

ReactomeiR-MMU-3214858. RMTs methylate histone arginines.

Miscellaneous databases

PROiO54941.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037935.
GenevisibleiO54941. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR030089. BAF57.
IPR009071. HMG_box_dom.
[Graphical view]
PANTHERiPTHR13711:SF206. PTHR13711:SF206. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMCE1_MOUSE
AccessioniPrimary (citable) accession number: O54941
Secondary accession number(s): Q8BPD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.