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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Gene

Bnip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins (By similarity).By similarity

GO - Molecular functioni

  1. identical protein binding Source: GO_Central

GO - Biological processi

  1. apoptotic process Source: MGI
  2. blastocyst development Source: MGI
  3. centrosome organization Source: MGI
  4. positive regulation of MAPK cascade Source: MGI
  5. positive regulation of neuron differentiation Source: MGI
  6. positive regulation of small GTPase mediated signal transduction Source: MGI
  7. striated muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_258600. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Gene namesi
Name:Bnip2
Synonyms:Nip2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109327. Bnip2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity
Note: Localizes to the nuclear envelope region and to other cytoplasmic structures.By similarity

GO - Cellular componenti

  1. centriole Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: GO_Central
  4. intracellular membrane-bounded organelle Source: UniProtKB
  5. nuclear envelope Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  7. spindle pole centrosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326BCL2/adenovirus E1B 19 kDa protein-interacting protein 2PRO_0000064962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei114 – 1141Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO54940.
PaxDbiO54940.
PRIDEiO54940.

PTM databases

PhosphoSiteiO54940.

Expressioni

Gene expression databases

BgeeiO54940.
CleanExiMM_BNIP2.
ExpressionAtlasiO54940. baseline and differential.
GenevestigatoriO54940.

Structurei

3D structure databases

ProteinModelPortaliO54940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 304158CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG146204.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000230952.
HOVERGENiHBG054692.
InParanoidiO54940.
KOiK18448.
OrthoDBiEOG72RMX4.
TreeFamiTF324164.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54940-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGVELKEEW QDEDFPIPLP EDDSIEADTL DGTDPDRQPG SLEVNGNKVR
60 70 80 90 100
KKLMAPDISL TLDPGEDSLW SDDLDEAGEV DLEGLDTPSE NSDEFEWEDD
110 120 130 140 150
LPKPKTTEVI RKGSITEYTA TEEKGDGRRW RMFRIGEQDH RVDMKAIEPY
160 170 180 190 200
KKVISHGGYY GDGLNAIVVF AVCFMPESGQ PNYRYLMDNL FKYVIGTLEL
210 220 230 240 250
LVAENYMIIY LNGATTRRKM PSLGWLRRCY QQIDRRLRKN LKSLIIVHPS
260 270 280 290 300
WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQYE
310 320
EEKFKKRQKR VDQELNGKQE PPKSEQ
Length:326
Mass (Da):37,769
Last modified:July 27, 2011 - v2
Checksum:iED9CA74520E2913B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671D → G in AAC04329. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035207 mRNA. Translation: AAC04329.1.
AF400107 mRNA. Translation: AAM76082.1.
AY591758 mRNA. Translation: AAT92040.1.
AK054288 mRNA. Translation: BAC35718.1.
CH466522 Genomic DNA. Translation: EDL26178.1.
CCDSiCCDS23319.1.
RefSeqiNP_058067.2. NM_016787.4.
UniGeneiMm.159777.

Genome annotation databases

EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958.
GeneIDi12175.
KEGGimmu:12175.
UCSCiuc009qnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035207 mRNA. Translation: AAC04329.1.
AF400107 mRNA. Translation: AAM76082.1.
AY591758 mRNA. Translation: AAT92040.1.
AK054288 mRNA. Translation: BAC35718.1.
CH466522 Genomic DNA. Translation: EDL26178.1.
CCDSiCCDS23319.1.
RefSeqiNP_058067.2. NM_016787.4.
UniGeneiMm.159777.

3D structure databases

ProteinModelPortaliO54940.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO54940.

Proteomic databases

MaxQBiO54940.
PaxDbiO54940.
PRIDEiO54940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958.
GeneIDi12175.
KEGGimmu:12175.
UCSCiuc009qnl.1. mouse.

Organism-specific databases

CTDi663.
MGIiMGI:109327. Bnip2.

Phylogenomic databases

eggNOGiNOG146204.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000230952.
HOVERGENiHBG054692.
InParanoidiO54940.
KOiK18448.
OrthoDBiEOG72RMX4.
TreeFamiTF324164.

Enzyme and pathway databases

ReactomeiREACT_258600. CDO in myogenesis.

Miscellaneous databases

ChiTaRSiBnip2. mouse.
NextBioi280551.
PROiO54940.
SOURCEiSearch...

Gene expression databases

BgeeiO54940.
CleanExiMM_BNIP2.
ExpressionAtlasiO54940. baseline and differential.
GenevestigatoriO54940.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse Nip2l gene: cloning, sequencing, expression analysis and genetic mapping."
    Barbosa M.D.F.S., Detter J.C., Kingsmore S.F.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway."
    Zhang H.M., Yanagawa B., Cheung P., Luo H., Yuan J., Chau D., Wang A., Bohunek L., Wilson J.E., McManus B.M., Yang D.
    Circ. Res. 90:1251-1258(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A/J.
    Tissue: Heart.
  3. Zhou Y.T., Low B.C.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBNIP2_MOUSE
AccessioniPrimary (citable) accession number: O54940
Secondary accession number(s): Q8K4H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.