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O54940 (BNIP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Gene names
Name:Bnip2
Synonyms:Nip2l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Note: Localizes to the nuclear envelope region and to other cytoplasmic structures By similarity.

Sequence similarities

Contains 1 CRAL-TRIO domain.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCytoplasm
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from sequence orthology PubMed 7954800. Source: MGI

blastocyst development

Inferred from mutant phenotype PubMed 19117032. Source: MGI

centrosome organization

Inferred from mutant phenotype PubMed 19117032. Source: MGI

positive regulation of MAPK cascade

Inferred from mutant phenotype PubMed 19244314. Source: MGI

positive regulation of neuron differentiation

Inferred from mutant phenotype PubMed 19244314. Source: MGI

positive regulation of small GTPase mediated signal transduction

Inferred from mutant phenotype PubMed 19244314. Source: MGI

striated muscle cell differentiation

Inferred from genetic interaction PubMed 20160094. Source: MGI

   Cellular_componentcentriole

Inferred from direct assay PubMed 19117032. Source: MGI

cytosol

Inferred from Biological aspect of Ancestor. Source: RefGenome

intracellular membrane-bounded organelle

Inferred from sequence or structural similarity. Source: UniProtKB

nuclear envelope

Inferred from sequence or structural similarity. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

spindle pole centrosome

Inferred from direct assay PubMed 19117032. Source: MGI

   Molecular_functionidentical protein binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
PRO_0000064962

Regions

Domain147 – 304158CRAL-TRIO

Amino acid modifications

Modified residue1141Phosphoserine Ref.6 Ref.7

Experimental info

Sequence conflict671D → G in AAC04329. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O54940 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: ED9CA74520E2913B

FASTA32637,769
        10         20         30         40         50         60 
MEGVELKEEW QDEDFPIPLP EDDSIEADTL DGTDPDRQPG SLEVNGNKVR KKLMAPDISL 

        70         80         90        100        110        120 
TLDPGEDSLW SDDLDEAGEV DLEGLDTPSE NSDEFEWEDD LPKPKTTEVI RKGSITEYTA 

       130        140        150        160        170        180 
TEEKGDGRRW RMFRIGEQDH RVDMKAIEPY KKVISHGGYY GDGLNAIVVF AVCFMPESGQ 

       190        200        210        220        230        240 
PNYRYLMDNL FKYVIGTLEL LVAENYMIIY LNGATTRRKM PSLGWLRRCY QQIDRRLRKN 

       250        260        270        280        290        300 
LKSLIIVHPS WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQYE 

       310        320 
EEKFKKRQKR VDQELNGKQE PPKSEQ 

« Hide

References

« Hide 'large scale' references
[1]"The mouse Nip2l gene: cloning, sequencing, expression analysis and genetic mapping."
Barbosa M.D.F.S., Detter J.C., Kingsmore S.F.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway."
Zhang H.M., Yanagawa B., Cheung P., Luo H., Yuan J., Chau D., Wang A., Bohunek L., Wilson J.E., McManus B.M., Yang D.
Circ. Res. 90:1251-1258(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: A/J.
Tissue: Heart.
[3]Zhou Y.T., Low B.C.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[7]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF035207 mRNA. Translation: AAC04329.1.
AF400107 mRNA. Translation: AAM76082.1.
AY591758 mRNA. Translation: AAT92040.1.
AK054288 mRNA. Translation: BAC35718.1.
CH466522 Genomic DNA. Translation: EDL26178.1.
CCDSCCDS23319.1.
RefSeqNP_058067.2. NM_016787.4.
UniGeneMm.159777.

3D structure databases

ProteinModelPortalO54940.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO54940.

Proteomic databases

PaxDbO54940.
PRIDEO54940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958.
GeneID12175.
KEGGmmu:12175.
UCSCuc009qnl.1. mouse.

Organism-specific databases

CTD663.
MGIMGI:109327. Bnip2.

Phylogenomic databases

eggNOGNOG146204.
GeneTreeENSGT00420000029688.
HOGENOMHOG000230952.
HOVERGENHBG054692.
OrthoDBEOG72RMX4.
TreeFamTF324164.

Enzyme and pathway databases

ReactomeREACT_188576. Developmental Biology.

Gene expression databases

ArrayExpressO54940.
BgeeO54940.
CleanExMM_BNIP2.
GenevestigatorO54940.

Family and domain databases

Gene3D3.40.525.10. 1 hit.
InterProIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMSSF52087. SSF52087. 1 hit.
PROSITEPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBNIP2. mouse.
NextBio280551.
PROO54940.
SOURCESearch...

Entry information

Entry nameBNIP2_MOUSE
AccessionPrimary (citable) accession number: O54940
Secondary accession number(s): Q8K4H0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot