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O54940

- BNIP2_MOUSE

UniProt

O54940 - BNIP2_MOUSE

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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Gene
Bnip2, Nip2l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins By similarity.

GO - Molecular functioni

  1. identical protein binding Source: RefGenome

GO - Biological processi

  1. apoptotic process Source: MGI
  2. blastocyst development Source: MGI
  3. centrosome organization Source: MGI
  4. positive regulation of MAPK cascade Source: MGI
  5. positive regulation of neuron differentiation Source: MGI
  6. positive regulation of small GTPase mediated signal transduction Source: MGI
  7. striated muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Gene namesi
Name:Bnip2
Synonyms:Nip2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:109327. Bnip2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity
Note: Localizes to the nuclear envelope region and to other cytoplasmic structures By similarity.

GO - Cellular componenti

  1. centriole Source: MGI
  2. cytosol Source: RefGenome
  3. intracellular membrane-bounded organelle Source: UniProtKB
  4. nuclear envelope Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  6. spindle pole centrosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326BCL2/adenovirus E1B 19 kDa protein-interacting protein 2PRO_0000064962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei114 – 1141Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO54940.
PRIDEiO54940.

PTM databases

PhosphoSiteiO54940.

Expressioni

Gene expression databases

ArrayExpressiO54940.
BgeeiO54940.
CleanExiMM_BNIP2.
GenevestigatoriO54940.

Structurei

3D structure databases

ProteinModelPortaliO54940.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 304158CRAL-TRIOAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.

Phylogenomic databases

eggNOGiNOG146204.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000230952.
HOVERGENiHBG054692.
OrthoDBiEOG72RMX4.
TreeFamiTF324164.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54940-1 [UniParc]FASTAAdd to Basket

« Hide

MEGVELKEEW QDEDFPIPLP EDDSIEADTL DGTDPDRQPG SLEVNGNKVR    50
KKLMAPDISL TLDPGEDSLW SDDLDEAGEV DLEGLDTPSE NSDEFEWEDD 100
LPKPKTTEVI RKGSITEYTA TEEKGDGRRW RMFRIGEQDH RVDMKAIEPY 150
KKVISHGGYY GDGLNAIVVF AVCFMPESGQ PNYRYLMDNL FKYVIGTLEL 200
LVAENYMIIY LNGATTRRKM PSLGWLRRCY QQIDRRLRKN LKSLIIVHPS 250
WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQYE 300
EEKFKKRQKR VDQELNGKQE PPKSEQ 326
Length:326
Mass (Da):37,769
Last modified:July 27, 2011 - v2
Checksum:iED9CA74520E2913B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671D → G in AAC04329. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035207 mRNA. Translation: AAC04329.1.
AF400107 mRNA. Translation: AAM76082.1.
AY591758 mRNA. Translation: AAT92040.1.
AK054288 mRNA. Translation: BAC35718.1.
CH466522 Genomic DNA. Translation: EDL26178.1.
CCDSiCCDS23319.1.
RefSeqiNP_058067.2. NM_016787.4.
UniGeneiMm.159777.

Genome annotation databases

EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958.
GeneIDi12175.
KEGGimmu:12175.
UCSCiuc009qnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF035207 mRNA. Translation: AAC04329.1 .
AF400107 mRNA. Translation: AAM76082.1 .
AY591758 mRNA. Translation: AAT92040.1 .
AK054288 mRNA. Translation: BAC35718.1 .
CH466522 Genomic DNA. Translation: EDL26178.1 .
CCDSi CCDS23319.1.
RefSeqi NP_058067.2. NM_016787.4.
UniGenei Mm.159777.

3D structure databases

ProteinModelPortali O54940.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O54940.

Proteomic databases

PaxDbi O54940.
PRIDEi O54940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034754 ; ENSMUSP00000034754 ; ENSMUSG00000011958 .
GeneIDi 12175.
KEGGi mmu:12175.
UCSCi uc009qnl.1. mouse.

Organism-specific databases

CTDi 663.
MGIi MGI:109327. Bnip2.

Phylogenomic databases

eggNOGi NOG146204.
GeneTreei ENSGT00420000029688.
HOGENOMi HOG000230952.
HOVERGENi HBG054692.
OrthoDBi EOG72RMX4.
TreeFami TF324164.

Miscellaneous databases

ChiTaRSi BNIP2. mouse.
NextBioi 280551.
PROi O54940.
SOURCEi Search...

Gene expression databases

ArrayExpressi O54940.
Bgeei O54940.
CleanExi MM_BNIP2.
Genevestigatori O54940.

Family and domain databases

Gene3Di 3.40.525.10. 1 hit.
InterProi IPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view ]
Pfami PF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view ]
SMARTi SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF52087. SSF52087. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse Nip2l gene: cloning, sequencing, expression analysis and genetic mapping."
    Barbosa M.D.F.S., Detter J.C., Kingsmore S.F.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway."
    Zhang H.M., Yanagawa B., Cheung P., Luo H., Yuan J., Chau D., Wang A., Bohunek L., Wilson J.E., McManus B.M., Yang D.
    Circ. Res. 90:1251-1258(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A/J.
    Tissue: Heart.
  3. Zhou Y.T., Low B.C.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBNIP2_MOUSE
AccessioniPrimary (citable) accession number: O54940
Secondary accession number(s): Q8K4H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi