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O54940

- BNIP2_MOUSE

UniProt

O54940 - BNIP2_MOUSE

Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Gene

Bnip2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins By similarity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: RefGenome

    GO - Biological processi

    1. apoptotic process Source: MGI
    2. blastocyst development Source: MGI
    3. centrosome organization Source: MGI
    4. positive regulation of MAPK cascade Source: MGI
    5. positive regulation of neuron differentiation Source: MGI
    6. positive regulation of small GTPase mediated signal transduction Source: MGI
    7. striated muscle cell differentiation Source: MGI

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
    Gene namesi
    Name:Bnip2
    Synonyms:Nip2l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:109327. Bnip2.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmperinuclear region By similarity
    Note: Localizes to the nuclear envelope region and to other cytoplasmic structures.By similarity

    GO - Cellular componenti

    1. centriole Source: MGI
    2. cytosol Source: RefGenome
    3. intracellular membrane-bounded organelle Source: UniProtKB
    4. nuclear envelope Source: UniProtKB
    5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    6. spindle pole centrosome Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326BCL2/adenovirus E1B 19 kDa protein-interacting protein 2PRO_0000064962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei114 – 1141Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO54940.
    PRIDEiO54940.

    PTM databases

    PhosphoSiteiO54940.

    Expressioni

    Gene expression databases

    ArrayExpressiO54940.
    BgeeiO54940.
    CleanExiMM_BNIP2.
    GenevestigatoriO54940.

    Structurei

    3D structure databases

    ProteinModelPortaliO54940.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini147 – 304158CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG146204.
    GeneTreeiENSGT00420000029688.
    HOGENOMiHOG000230952.
    HOVERGENiHBG054692.
    OrthoDBiEOG72RMX4.
    TreeFamiTF324164.

    Family and domain databases

    Gene3Di3.40.525.10. 1 hit.
    InterProiIPR022181. Bcl2-/adenovirus-E1B.
    IPR001251. CRAL-TRIO_dom.
    [Graphical view]
    PfamiPF12496. BNIP2. 1 hit.
    PF13716. CRAL_TRIO_2. 1 hit.
    [Graphical view]
    SMARTiSM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF52087. SSF52087. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O54940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGVELKEEW QDEDFPIPLP EDDSIEADTL DGTDPDRQPG SLEVNGNKVR    50
    KKLMAPDISL TLDPGEDSLW SDDLDEAGEV DLEGLDTPSE NSDEFEWEDD 100
    LPKPKTTEVI RKGSITEYTA TEEKGDGRRW RMFRIGEQDH RVDMKAIEPY 150
    KKVISHGGYY GDGLNAIVVF AVCFMPESGQ PNYRYLMDNL FKYVIGTLEL 200
    LVAENYMIIY LNGATTRRKM PSLGWLRRCY QQIDRRLRKN LKSLIIVHPS 250
    WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQYE 300
    EEKFKKRQKR VDQELNGKQE PPKSEQ 326
    Length:326
    Mass (Da):37,769
    Last modified:July 27, 2011 - v2
    Checksum:iED9CA74520E2913B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671D → G in AAC04329. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035207 mRNA. Translation: AAC04329.1.
    AF400107 mRNA. Translation: AAM76082.1.
    AY591758 mRNA. Translation: AAT92040.1.
    AK054288 mRNA. Translation: BAC35718.1.
    CH466522 Genomic DNA. Translation: EDL26178.1.
    CCDSiCCDS23319.1.
    RefSeqiNP_058067.2. NM_016787.4.
    UniGeneiMm.159777.

    Genome annotation databases

    EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958.
    GeneIDi12175.
    KEGGimmu:12175.
    UCSCiuc009qnl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035207 mRNA. Translation: AAC04329.1 .
    AF400107 mRNA. Translation: AAM76082.1 .
    AY591758 mRNA. Translation: AAT92040.1 .
    AK054288 mRNA. Translation: BAC35718.1 .
    CH466522 Genomic DNA. Translation: EDL26178.1 .
    CCDSi CCDS23319.1.
    RefSeqi NP_058067.2. NM_016787.4.
    UniGenei Mm.159777.

    3D structure databases

    ProteinModelPortali O54940.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O54940.

    Proteomic databases

    PaxDbi O54940.
    PRIDEi O54940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034754 ; ENSMUSP00000034754 ; ENSMUSG00000011958 .
    GeneIDi 12175.
    KEGGi mmu:12175.
    UCSCi uc009qnl.1. mouse.

    Organism-specific databases

    CTDi 663.
    MGIi MGI:109327. Bnip2.

    Phylogenomic databases

    eggNOGi NOG146204.
    GeneTreei ENSGT00420000029688.
    HOGENOMi HOG000230952.
    HOVERGENi HBG054692.
    OrthoDBi EOG72RMX4.
    TreeFami TF324164.

    Miscellaneous databases

    ChiTaRSi BNIP2. mouse.
    NextBioi 280551.
    PROi O54940.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O54940.
    Bgeei O54940.
    CleanExi MM_BNIP2.
    Genevestigatori O54940.

    Family and domain databases

    Gene3Di 3.40.525.10. 1 hit.
    InterProi IPR022181. Bcl2-/adenovirus-E1B.
    IPR001251. CRAL-TRIO_dom.
    [Graphical view ]
    Pfami PF12496. BNIP2. 1 hit.
    PF13716. CRAL_TRIO_2. 1 hit.
    [Graphical view ]
    SMARTi SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52087. SSF52087. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Nip2l gene: cloning, sequencing, expression analysis and genetic mapping."
      Barbosa M.D.F.S., Detter J.C., Kingsmore S.F.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway."
      Zhang H.M., Yanagawa B., Cheung P., Luo H., Yuan J., Chau D., Wang A., Bohunek L., Wilson J.E., McManus B.M., Yang D.
      Circ. Res. 90:1251-1258(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: A/J.
      Tissue: Heart.
    3. Zhou Y.T., Low B.C.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBNIP2_MOUSE
    AccessioniPrimary (citable) accession number: O54940
    Secondary accession number(s): Q8K4H0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3