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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Gene

Bnip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: MGI
  • blastocyst development Source: MGI
  • centrosome organization Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of muscle cell differentiation Source: Reactome
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of small GTPase mediated signal transduction Source: MGI
  • striated muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Gene namesi
Name:Bnip2
Synonyms:Nip2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109327. Bnip2.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: GO_Central
  • intracellular membrane-bounded organelle Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • spindle pole centrosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649621 – 326BCL2/adenovirus E1B 19 kDa protein-interacting protein 2Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei87PhosphothreonineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei114PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO54940.
MaxQBiO54940.
PaxDbiO54940.
PRIDEiO54940.

PTM databases

iPTMnetiO54940.
PhosphoSitePlusiO54940.

Expressioni

Gene expression databases

BgeeiENSMUSG00000011958.
CleanExiMM_BNIP2.
ExpressionAtlasiO54940. baseline and differential.
GenevisibleiO54940. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034754.

Structurei

3D structure databases

ProteinModelPortaliO54940.
SMRiO54940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 304CRAL-TRIOPROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFPU. Eukaryota.
ENOG410YCZE. LUCA.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000230952.
HOVERGENiHBG054692.
InParanoidiO54940.
KOiK18448.
TreeFamiTF324164.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVELKEEW QDEDFPIPLP EDDSIEADTL DGTDPDRQPG SLEVNGNKVR
60 70 80 90 100
KKLMAPDISL TLDPGEDSLW SDDLDEAGEV DLEGLDTPSE NSDEFEWEDD
110 120 130 140 150
LPKPKTTEVI RKGSITEYTA TEEKGDGRRW RMFRIGEQDH RVDMKAIEPY
160 170 180 190 200
KKVISHGGYY GDGLNAIVVF AVCFMPESGQ PNYRYLMDNL FKYVIGTLEL
210 220 230 240 250
LVAENYMIIY LNGATTRRKM PSLGWLRRCY QQIDRRLRKN LKSLIIVHPS
260 270 280 290 300
WFIRTLLAVT RPFISSKFSQ KIRYVFNLAE LAELVPMEYV GIPECIKQYE
310 320
EEKFKKRQKR VDQELNGKQE PPKSEQ
Length:326
Mass (Da):37,769
Last modified:July 27, 2011 - v2
Checksum:iED9CA74520E2913B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67D → G in AAC04329 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035207 mRNA. Translation: AAC04329.1.
AF400107 mRNA. Translation: AAM76082.1.
AY591758 mRNA. Translation: AAT92040.1.
AK054288 mRNA. Translation: BAC35718.1.
CH466522 Genomic DNA. Translation: EDL26178.1.
CCDSiCCDS23319.1.
RefSeqiNP_058067.2. NM_016787.4.
UniGeneiMm.159777.

Genome annotation databases

EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958.
GeneIDi12175.
KEGGimmu:12175.
UCSCiuc009qno.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035207 mRNA. Translation: AAC04329.1.
AF400107 mRNA. Translation: AAM76082.1.
AY591758 mRNA. Translation: AAT92040.1.
AK054288 mRNA. Translation: BAC35718.1.
CH466522 Genomic DNA. Translation: EDL26178.1.
CCDSiCCDS23319.1.
RefSeqiNP_058067.2. NM_016787.4.
UniGeneiMm.159777.

3D structure databases

ProteinModelPortaliO54940.
SMRiO54940.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034754.

PTM databases

iPTMnetiO54940.
PhosphoSitePlusiO54940.

Proteomic databases

EPDiO54940.
MaxQBiO54940.
PaxDbiO54940.
PRIDEiO54940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034754; ENSMUSP00000034754; ENSMUSG00000011958.
GeneIDi12175.
KEGGimmu:12175.
UCSCiuc009qno.3. mouse.

Organism-specific databases

CTDi663.
MGIiMGI:109327. Bnip2.

Phylogenomic databases

eggNOGiENOG410IFPU. Eukaryota.
ENOG410YCZE. LUCA.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000230952.
HOVERGENiHBG054692.
InParanoidiO54940.
KOiK18448.
TreeFamiTF324164.

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Miscellaneous databases

ChiTaRSiBnip2. mouse.
PROiO54940.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011958.
CleanExiMM_BNIP2.
ExpressionAtlasiO54940. baseline and differential.
GenevisibleiO54940. MM.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR022181. Bcl2-/adenovirus-E1B.
IPR001251. CRAL-TRIO_dom.
[Graphical view]
PfamiPF12496. BNIP2. 1 hit.
PF13716. CRAL_TRIO_2. 1 hit.
[Graphical view]
SMARTiSM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBNIP2_MOUSE
AccessioniPrimary (citable) accession number: O54940
Secondary accession number(s): Q8K4H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.