Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat and SOCS box-containing protein 2

Gene

Wsb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and SOCS box-containing protein 2
Short name:
WSB-2
Alternative name(s):
SOCS box-containing WD protein SWiP-2
Gene namesi
Name:Wsb2
Synonyms:Swip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2144041. Wsb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404WD repeat and SOCS box-containing protein 2PRO_0000051461Add
BLAST

Proteomic databases

MaxQBiO54929.
PaxDbiO54929.
PRIDEiO54929.

PTM databases

iPTMnetiO54929.
PhosphoSiteiO54929.

Expressioni

Gene expression databases

BgeeiO54929.
CleanExiMM_WSB2.
ExpressionAtlasiO54929. baseline and differential.
GenevisibleiO54929. MM.

Interactioni

Protein-protein interaction databases

BioGridi208507. 2 interactions.
STRINGi10090.ENSMUSP00000031309.

Structurei

3D structure databases

ProteinModelPortaliO54929.
SMRiO54929. Positions 32-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati105 – 14844WD 1Add
BLAST
Repeati151 – 19141WD 2Add
BLAST
Repeati195 – 23440WD 3Add
BLAST
Repeati237 – 27640WD 4Add
BLAST
Repeati291 – 33040WD 5Add
BLAST
Domaini356 – 40449SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SOCS box domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00830000128308.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiO54929.
KOiK10342.
OrthoDBiEOG7J17ZP.
TreeFamiTF329216.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCVV
60 70 80 90 100
KLVPWPLEEQ FIPKGFEAKS RSSKNDPKGR GSLKEKTLDC GQIVWGLAFS
110 120 130 140 150
PWPSPPSRKL WARHHPQAPD VSCLILATGL NDGQIKIWEV QTGLLLLNLS
160 170 180 190 200
GHQDVVRDLS FTPSGSLILV SASRDKTLRI WDLNKHGKQI QVLSGHLQWV
210 220 230 240 250
YCCSISPDCS MLCSAAGEKS VFLWSMRSYT LIRKLEGHQS SVVSCDFSPD
260 270 280 290 300
SALLVTASYD TSVIMWDPYT GERLRSLHHT QLEPTMDDSD VHMSSLRSVC
310 320 330 340 350
FSPEGLYLAT VADDRLLRIW ALELKAPVAF APMTNGLCCT FFPHGGIIAT
360 370 380 390 400
GTRDGHVQFW TAPRVLSSLK HLCRKALRSF LTTYQVLALP IPKKMKEFLT

YRTF
Length:404
Mass (Da):45,261
Last modified:July 27, 2011 - v2
Checksum:i78F66FE09910635A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721E → A in AAB96649 (PubMed:9419338).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033188 mRNA. Translation: AAB96649.1.
AF072881 mRNA. Translation: AAD28809.1.
AK157999 mRNA. Translation: BAE34309.1.
CH466529 Genomic DNA. Translation: EDL19806.1.
BC055100 mRNA. Translation: AAH55100.1.
CCDSiCCDS19604.1.
RefSeqiNP_067514.2. NM_021539.4.
UniGeneiMm.28489.

Genome annotation databases

EnsembliENSMUST00000031309; ENSMUSP00000031309; ENSMUSG00000029364.
GeneIDi59043.
KEGGimmu:59043.
UCSCiuc008zfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033188 mRNA. Translation: AAB96649.1.
AF072881 mRNA. Translation: AAD28809.1.
AK157999 mRNA. Translation: BAE34309.1.
CH466529 Genomic DNA. Translation: EDL19806.1.
BC055100 mRNA. Translation: AAH55100.1.
CCDSiCCDS19604.1.
RefSeqiNP_067514.2. NM_021539.4.
UniGeneiMm.28489.

3D structure databases

ProteinModelPortaliO54929.
SMRiO54929. Positions 32-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208507. 2 interactions.
STRINGi10090.ENSMUSP00000031309.

PTM databases

iPTMnetiO54929.
PhosphoSiteiO54929.

Proteomic databases

MaxQBiO54929.
PaxDbiO54929.
PRIDEiO54929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031309; ENSMUSP00000031309; ENSMUSG00000029364.
GeneIDi59043.
KEGGimmu:59043.
UCSCiuc008zfq.1. mouse.

Organism-specific databases

CTDi55884.
MGIiMGI:2144041. Wsb2.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00830000128308.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiO54929.
KOiK10342.
OrthoDBiEOG7J17ZP.
TreeFamiTF329216.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiO54929.
SOURCEiSearch...

Gene expression databases

BgeeiO54929.
CleanExiMM_WSB2.
ExpressionAtlasiO54929. baseline and differential.
GenevisibleiO54929. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development."
    Vasiliauskas D., Hancock S., Stern C.D.
    Mech. Dev. 82:79-94(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Inner ear.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiWSB2_MOUSE
AccessioniPrimary (citable) accession number: O54929
Secondary accession number(s): Q6GTI7, Q9R1M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.