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Protein

WD repeat and SOCS box-containing protein 2

Gene

Wsb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and SOCS box-containing protein 2
Short name:
WSB-2
Alternative name(s):
SOCS box-containing WD protein SWiP-2
Gene namesi
Name:Wsb2
Synonyms:Swip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2144041. Wsb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514611 – 404WD repeat and SOCS box-containing protein 2Add BLAST404

Proteomic databases

MaxQBiO54929.
PaxDbiO54929.
PRIDEiO54929.

PTM databases

iPTMnetiO54929.
PhosphoSitePlusiO54929.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029364.
CleanExiMM_WSB2.
ExpressionAtlasiO54929. baseline and differential.
GenevisibleiO54929. MM.

Interactioni

Protein-protein interaction databases

BioGridi208507. 2 interactors.
STRINGi10090.ENSMUSP00000031309.

Structurei

3D structure databases

ProteinModelPortaliO54929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati105 – 148WD 1Add BLAST44
Repeati151 – 191WD 2Add BLAST41
Repeati195 – 234WD 3Add BLAST40
Repeati237 – 276WD 4Add BLAST40
Repeati291 – 330WD 5Add BLAST40
Domaini356 – 404SOCS boxPROSITE-ProRule annotationAdd BLAST49

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SOCS box domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00860000133757.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiO54929.
KOiK10342.
TreeFamiTF329216.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCVV
60 70 80 90 100
KLVPWPLEEQ FIPKGFEAKS RSSKNDPKGR GSLKEKTLDC GQIVWGLAFS
110 120 130 140 150
PWPSPPSRKL WARHHPQAPD VSCLILATGL NDGQIKIWEV QTGLLLLNLS
160 170 180 190 200
GHQDVVRDLS FTPSGSLILV SASRDKTLRI WDLNKHGKQI QVLSGHLQWV
210 220 230 240 250
YCCSISPDCS MLCSAAGEKS VFLWSMRSYT LIRKLEGHQS SVVSCDFSPD
260 270 280 290 300
SALLVTASYD TSVIMWDPYT GERLRSLHHT QLEPTMDDSD VHMSSLRSVC
310 320 330 340 350
FSPEGLYLAT VADDRLLRIW ALELKAPVAF APMTNGLCCT FFPHGGIIAT
360 370 380 390 400
GTRDGHVQFW TAPRVLSSLK HLCRKALRSF LTTYQVLALP IPKKMKEFLT

YRTF
Length:404
Mass (Da):45,261
Last modified:July 27, 2011 - v2
Checksum:i78F66FE09910635A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272E → A in AAB96649 (PubMed:9419338).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033188 mRNA. Translation: AAB96649.1.
AF072881 mRNA. Translation: AAD28809.1.
AK157999 mRNA. Translation: BAE34309.1.
CH466529 Genomic DNA. Translation: EDL19806.1.
BC055100 mRNA. Translation: AAH55100.1.
CCDSiCCDS19604.1.
RefSeqiNP_067514.2. NM_021539.4.
UniGeneiMm.28489.

Genome annotation databases

EnsembliENSMUST00000031309; ENSMUSP00000031309; ENSMUSG00000029364.
GeneIDi59043.
KEGGimmu:59043.
UCSCiuc008zfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033188 mRNA. Translation: AAB96649.1.
AF072881 mRNA. Translation: AAD28809.1.
AK157999 mRNA. Translation: BAE34309.1.
CH466529 Genomic DNA. Translation: EDL19806.1.
BC055100 mRNA. Translation: AAH55100.1.
CCDSiCCDS19604.1.
RefSeqiNP_067514.2. NM_021539.4.
UniGeneiMm.28489.

3D structure databases

ProteinModelPortaliO54929.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208507. 2 interactors.
STRINGi10090.ENSMUSP00000031309.

PTM databases

iPTMnetiO54929.
PhosphoSitePlusiO54929.

Proteomic databases

MaxQBiO54929.
PaxDbiO54929.
PRIDEiO54929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031309; ENSMUSP00000031309; ENSMUSG00000029364.
GeneIDi59043.
KEGGimmu:59043.
UCSCiuc008zfq.1. mouse.

Organism-specific databases

CTDi55884.
MGIiMGI:2144041. Wsb2.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00860000133757.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiO54929.
KOiK10342.
TreeFamiTF329216.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiO54929.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029364.
CleanExiMM_WSB2.
ExpressionAtlasiO54929. baseline and differential.
GenevisibleiO54929. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWSB2_MOUSE
AccessioniPrimary (citable) accession number: O54929
Secondary accession number(s): Q6GTI7, Q9R1M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.