Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat and SOCS box-containing protein 1

Gene

Wsb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664. Neddylation.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and SOCS box-containing protein 1
Short name:
WSB-1
Gene namesi
Name:Wsb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926139. Wsb1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514581 – 421WD repeat and SOCS box-containing protein 1Add BLAST421

Proteomic databases

PaxDbiO54927.
PRIDEiO54927.

PTM databases

iPTMnetiO54927.
PhosphoSitePlusiO54927.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017677.
CleanExiMM_WSB1.
ExpressionAtlasiO54927. baseline and differential.
GenevisibleiO54927. MM.

Interactioni

Subunit structurei

Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, ELOB and ELOC. Binds to HIPK2 through WD40 repeats (By similarity).By similarity

Protein-protein interaction databases

BioGridi219684. 10 interactors.
IntActiO54927. 5 interactors.
STRINGi10090.ENSMUSP00000017821.

Structurei

3D structure databases

ProteinModelPortaliO54927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati124 – 165WD 1Add BLAST42
Repeati168 – 208WD 2Add BLAST41
Repeati212 – 251WD 3Add BLAST40
Repeati254 – 293WD 4Add BLAST40
Repeati309 – 346WD 5Add BLAST38
Domaini372 – 421SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00890000139406.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiO54927.
KOiK10341.
OMAiGHHNDVV.
OrthoDBiEOG091G06GY.
PhylomeDBiO54927.
TreeFamiTF329216.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

O54927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGGENWTV AFAPDGSYFA
60 70 80 90 100
WSQGYRIVKL VPWSQCRKNF LLHGSKNVTN SSCLKLARQN SNGGQKNKPP
110 120 130 140 150
EHVIDCGDIV WSLAFGSSVP EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG
160 170 180 190 200
RIKIWDVYTG KLLLNLVDHI EMVRDLTFAP DGSLLLVSAS RDKTLRVWDL
210 220 230 240 250
KDDGNMVKVL RAHQNWVYSC AFSPDCSMLC SVGASKAVFL WNMDKYTMIR
260 270 280 290 300
KLEGHHHDVV ACDFSPDGAL LATASYDTRV YVWDPHNGDL LMEFGHLFPS
310 320 330 340 350
PTPIFAGGAN DRWVRAVSFS HDGLHVASLA DDKMVRFWRI DEDCPVQVAP
360 370 380 390 400
LSNGLCCAFS TDGSVLAAGT HDGSVYFWAT PRQVPSLQHI CRMSIRRVMS
410 420
TQEVQKLPVP SKILAFLSYR G
Length:421
Mass (Da):47,065
Last modified:June 1, 1998 - v1
Checksum:i4003D1FFE7A9A2EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033186 mRNA. Translation: AAB96647.1.
CCDSiCCDS25118.1.
RefSeqiNP_062627.3. NM_019653.3.
UniGeneiMm.307022.
Mm.474790.

Genome annotation databases

EnsembliENSMUST00000017821; ENSMUSP00000017821; ENSMUSG00000017677.
GeneIDi78889.
KEGGimmu:78889.
UCSCiuc007kki.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiWSB1_MOUSE
AccessioniPrimary (citable) accession number: O54927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 1998
Last modified: August 30, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways