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Protein

WD repeat and SOCS box-containing protein 1

Gene

Wsb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and SOCS box-containing protein 1
Short name:
WSB-1
Gene namesi
Name:Wsb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926139. Wsb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421WD repeat and SOCS box-containing protein 1PRO_0000051458Add
BLAST

Proteomic databases

PaxDbiO54927.
PRIDEiO54927.

PTM databases

iPTMnetiO54927.
PhosphoSiteiO54927.

Expressioni

Gene expression databases

BgeeiO54927.
CleanExiMM_WSB1.
ExpressionAtlasiO54927. baseline and differential.
GenevisibleiO54927. MM.

Interactioni

Subunit structurei

Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Binds to HIPK2 through WD40 repeats (By similarity).By similarity

Protein-protein interaction databases

BioGridi219684. 10 interactions.
IntActiO54927. 5 interactions.
STRINGi10090.ENSMUSP00000017821.

Structurei

3D structure databases

ProteinModelPortaliO54927.
SMRiO54927. Positions 38-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati124 – 16542WD 1Add
BLAST
Repeati168 – 20841WD 2Add
BLAST
Repeati212 – 25140WD 3Add
BLAST
Repeati254 – 29340WD 4Add
BLAST
Repeati309 – 34638WD 5Add
BLAST
Domaini372 – 42150SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SOCS box domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiO54927.
KOiK10341.
OMAiGHHNDVV.
OrthoDBiEOG7J17ZP.
PhylomeDBiO54927.
TreeFamiTF329216.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O54927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGGENWTV AFAPDGSYFA
60 70 80 90 100
WSQGYRIVKL VPWSQCRKNF LLHGSKNVTN SSCLKLARQN SNGGQKNKPP
110 120 130 140 150
EHVIDCGDIV WSLAFGSSVP EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG
160 170 180 190 200
RIKIWDVYTG KLLLNLVDHI EMVRDLTFAP DGSLLLVSAS RDKTLRVWDL
210 220 230 240 250
KDDGNMVKVL RAHQNWVYSC AFSPDCSMLC SVGASKAVFL WNMDKYTMIR
260 270 280 290 300
KLEGHHHDVV ACDFSPDGAL LATASYDTRV YVWDPHNGDL LMEFGHLFPS
310 320 330 340 350
PTPIFAGGAN DRWVRAVSFS HDGLHVASLA DDKMVRFWRI DEDCPVQVAP
360 370 380 390 400
LSNGLCCAFS TDGSVLAAGT HDGSVYFWAT PRQVPSLQHI CRMSIRRVMS
410 420
TQEVQKLPVP SKILAFLSYR G
Length:421
Mass (Da):47,065
Last modified:June 1, 1998 - v1
Checksum:i4003D1FFE7A9A2EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033186 mRNA. Translation: AAB96647.1.
CCDSiCCDS25118.1.
RefSeqiNP_062627.3. NM_019653.3.
UniGeneiMm.307022.
Mm.474790.

Genome annotation databases

EnsembliENSMUST00000017821; ENSMUSP00000017821; ENSMUSG00000017677.
GeneIDi78889.
KEGGimmu:78889.
UCSCiuc007kki.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033186 mRNA. Translation: AAB96647.1.
CCDSiCCDS25118.1.
RefSeqiNP_062627.3. NM_019653.3.
UniGeneiMm.307022.
Mm.474790.

3D structure databases

ProteinModelPortaliO54927.
SMRiO54927. Positions 38-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219684. 10 interactions.
IntActiO54927. 5 interactions.
STRINGi10090.ENSMUSP00000017821.

PTM databases

iPTMnetiO54927.
PhosphoSiteiO54927.

Proteomic databases

PaxDbiO54927.
PRIDEiO54927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017821; ENSMUSP00000017821; ENSMUSG00000017677.
GeneIDi78889.
KEGGimmu:78889.
UCSCiuc007kki.1. mouse.

Organism-specific databases

CTDi26118.
MGIiMGI:1926139. Wsb1.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiO54927.
KOiK10341.
OMAiGHHNDVV.
OrthoDBiEOG7J17ZP.
PhylomeDBiO54927.
TreeFamiTF329216.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO54927.
SOURCEiSearch...

Gene expression databases

BgeeiO54927.
CleanExiMM_WSB1.
ExpressionAtlasiO54927. baseline and differential.
GenevisibleiO54927. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
  2. "The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate."
    Dentice M., Bandyopadhyay A., Gereben B., Callebaut I., Christoffolete M.A., Kim B.W., Nissim S., Mornon J.P., Zavacki A.M., Zeold A., Capelo L.P., Curcio-Morelli C., Ribeiro R., Harney J.W., Tabin C.J., Bianco A.C.
    Nat. Cell Biol. 7:698-705(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DIO2.

Entry informationi

Entry nameiWSB1_MOUSE
AccessioniPrimary (citable) accession number: O54927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.